Evaluation of autologous adipose‐derived stem cells vs. fractional carbon dioxide laser in the treatment of post acne scars: a split‐face study

2019 ◽  
Vol 58 (10) ◽  
pp. 1212-1222 ◽  
Author(s):  
Rania S. Abou Eitta ◽  
Aisha A. Ismail ◽  
Rania A. Abdelmaksoud ◽  
Naser A. Ghezlan ◽  
Radwa A. Mehanna
Keyword(s):  
Carbon Dioxide ◽  
Stem Cells ◽  
Carbon Dioxide Laser ◽  
Adipose Derived Stem Cells ◽  
Acne Scars ◽  
Fractional Carbon Dioxide Laser ◽  
Split Face

scholarly journals The Effect of Conditioned Media of Adipose-Derived Stem Cells on Wound Healing after Ablative Fractional Carbon Dioxide Laser Resurfacing

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Bing-Rong Zhou ◽  
Yang Xu ◽  
Shi-Lei Guo ◽  
Yan Xu ◽  
Ying Wang ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Stem Cells ◽  
Wound Healing ◽  
Skin Color ◽  
Carbon Dioxide Laser ◽  
Transepidermal Water Loss ◽  
Control Group ◽  
Adipose Derived Stem Cells ◽  
Laser Resurfacing ◽  
Fractional Carbon Dioxide Laser

Objective.To evaluate the benefits of conditioned medium of Adipose-derived stem cells (ADSC-CM) on wound healing after fractional carbon dioxide laser resurfacing (FxCR) on human skin.Materials and Methods.Nineteen subjects were treated with FxCR on the bilateral inner arms. ADSC-CM was applied on FxCR site of one randomly selected arm. Transepidermal water loss (TEWL), skin color, and gross-elasticity of FxCR site on both arms were measured. Skin samples were taken by biopsy from three subjects 3 weeks after treatment for histopathological manifestations and mRNA expressions of procollagen types I and III, elastin genes were noted.Results.The index of erythema, melanin, and TEWL of the ADSC-CM-treated skin were significantly lower than those of the control side. The mRNA expression of type III procollagen in ADSC-CM-treated group at 3 weeks posttreatment was 2.6 times of that of the control group.Conclusion.Application of allograft ADSC-CM is an effective method for enhancing wound healing after FxCR, by reducing transient adverse effects such as erythema, hyperpigmentation, and increased TEWL.

Split face comparative study of microneedling with platelet rich plasma versus Fractional carbon dioxide laser with platelet rich plasma in treatment of atrophic post acne scars

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohamed Abd Elnaeem Sallam ◽  
Khaled El Zawahry ◽  
Abdul Rahman Muhammed Ali Mustafa
Keyword(s):  
Carbon Dioxide ◽  
Co2 Laser ◽  
Carbon Dioxide Laser ◽  
Platelet Rich Plasma ◽  
Fractional Co2 Laser ◽  
Acne Scars ◽  
Significant Difference ◽  
Before And After ◽  
The Face ◽  
Fractional Carbon Dioxide Laser

Abstract Background Acne scars, is a challenge for dermatologists, despite having multiple treatment modalities like microneedling, dermabrasion, Fractional CO2 Laser, dermal fillers, etc. However, monotherapy has been hardly satisfactory because of the polymorphism seen with the scars. Objective Comparison between microneedling with platelet rich plasma versus Fractional carbon dioxide laser with platelet rich plasma in treatment of atrophic post acne scars. Patients and methods This study was carried out in department of dermatology, venereology and andrology, in Kobry El-Kobba Military complex during the period (from September 2018 to July 2020 ) on 20 patients of both sexes aged from 20 to 60 years old presenting with Goodman and Baron Grade II, III, IV acne scars . Results The study revealed a statistically significant difference (p = 0.017) between Goodman and Baron scar grades on the right side of the face before and after treatment indicating that microneedling with platelet rich plasma was effective in improving acne scars. Also, there is a statistically significant difference (p = 0.010) between Goodman and Baron scar grades on the left side of the face before and after treatment, indicating that fractional CO2 laser with platelet rich plasma was effective in improving acne scars. Conclusion and recommendation Further controlled and randomized studies are needed to validate our findings in a larger cohort of patients and longer follow up. Also, number of sessions might be more than 3 sessions.

Fractional carbon dioxide laser‐assisted delivery of lyophilized‐growth factors is a promising treatment modality of post‐acne scars

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Yomna Mazid El‐Hamd Neinaa ◽  
Laila Abd‐elzaher Al‐khayat ◽  
Ghada Abdul Momen Suliman ◽  
Tarek El‐Sayed Ameen
Keyword(s):  
Carbon Dioxide ◽  
Growth Factors ◽  
Treatment Modality ◽  
Carbon Dioxide Laser ◽  
Acne Scars ◽  
Assisted Delivery ◽  
Fractional Carbon Dioxide Laser ◽  
Promising Treatment

Ablative Fractional CO2 Laser for Facial Atrophic Acne Scars

2018 ◽  
Vol 34 (02) ◽  
pp. 205-219 ◽  
Author(s):  
Yaqin Xu ◽  
Yunhua Deng
Keyword(s):  
Carbon Dioxide ◽  
Carbon Dioxide Laser ◽  
Randomized Clinical Trials ◽  
Treatment Plan ◽  
Acne Vulgaris ◽  
Treatment Session ◽  
Efficacy And Safety ◽  
Acne Scars ◽  
Fractional Carbon Dioxide Laser ◽  
Comprehensive Search

AbstractAblative fractional carbon dioxide laser resurfacing is a well-established treatment for acne scars. However, there are limited consensus and guidelines regarding the procedure, such as its treatment plan, efficacy, and safety. In this study, we performed a systematic review to assess the efficacy and safety of the fractional carbon dioxide laser treatment procedure, and to provide evidence-based recommendations concerning its practical use on atrophic acne scars. A comprehensive search was performed in, EMBASE, Ovid, Web of Science, and Cochrane databases, using the keywords “scar(s),” “acne vulgaris,” “carbon dioxide,” and “fraction* laser(s)” for the period from January 1987 to December 2016. The initial literature search identified 337 articles. The final selection included 30 studies: 12 retrospective studies and 18 prospective randomized clinical trials. Ablative fractional carbon dioxide laser is an effective therapy for the treatment of acne scars. The treatment session, interval, and parameters should be customized for each patient. Combination therapy should be considered for ice-pick type acne scars. The use of dermocosmetics in pre- and postoperative care may be beneficial to patients.

scholarly journals Fractional Carbon Dioxide Laser in Treatment of Acne Scars

2015 ◽  
Vol 4 (1) ◽  
pp. 38-42 ◽  
Author(s):  
Andrej Petrov ◽  
Vesna Pljakovska
Keyword(s):  
Carbon Dioxide ◽  
Carbon Dioxide Laser ◽  
The Other ◽  
Hypertrophic Scars ◽  
Skin Damage ◽  
Acne Scars ◽  
The World ◽  
Fractional Carbon Dioxide Laser ◽  
Skin Healing ◽  
Residual Lesions

BACKGROUND: Scars appear as a result of skin damage during the process of the skin healing. There are two types of acne scars, depending on whether there is a loss or accumulation of collagen: atrophic and hypertrophic. In 80-90% it comes to scars with loss of collagen compared to smaller number of hypertrophic scars and keloids.AIM: The aim of the study was to determine efficiency and safety of fractional carbon dioxide laser in the treatment of acne scars.MATERIAL AND METHODS: The study was carried out in Acibadem Sistina Clinical Hospital, Skopje at the Department of Dermatovenerology, with a total of 40 patients treated with fractional carbon dioxide laser (Lutronic eCO2). The study included patients with residual acne scars of a different type.RESULTS: Comedogenic and papular acne in our material were proportionately presented in 50% of cases, while the other half were the more severe clinical forms of acne - pustular inflammatory acne and nodulocystic acne that leave residual lesions in the form of second, third and fourth grade of scars.CONCLUSION: The experiences of our work confirm the world experiences that the best result with this method is achieved in dotted ice pick or V-shaped acne scars.

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