scholarly journals Acute Liver Failure due to Hepatitis A Virus

2021 ◽  
pp. 927-932
Author(s):  
Reem Shammout ◽  
Turki Alhassoun ◽  
Fadi Rayya
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Viral Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Specific Disease ◽  
Hospital Acquired Pneumonia ◽  
Hospital Acquired ◽  
The Relationship

Acute liver failure (ALF) is a syndrome, rather than a specific disease, with several possible causes, and viral hepatitis is a major cause. The relationship between self-limited and ALF hepatitis A is still poorly understood. A 45-year-old woman presented to our hospital with ALF diagnosis (from another hospital). She suffered from hospital-acquired pneumonia. The patient recovered within 4 weeks and returned to her normal life after 6 months of follow-up.

Acute liver failure in a Mexican family infected with hepatitis A virus

2020 ◽  
Vol 44 (3) ◽  
pp. e61-e63
Author(s):  
Ignacio García-Juárez ◽  
Alejandro Campos-Murguía ◽  
Braulio A. Marfil-Garza ◽  
Godolfino Miranda ◽  
Edgar A. Granados ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Mexican Family

scholarly journals Serological Misdiagnosis of Acute Liver Failure Associated with Echovirus 25 Due to Immunological Similarities to Hepatitis A Virus and Prozone Effect

2014 ◽  
Vol 53 (1) ◽  
pp. 309-310 ◽  
Author(s):  
Susan K. Wollersheim ◽  
Romney M. Humphries ◽  
James D. Cherry ◽  
Paul Krogstad
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Accurate Diagnosis ◽  
Serological Studies ◽  
Prozone Effect ◽  
Prozone Phenomenon

We describe a case of acute liver failure caused by echovirus 25 (E25) in a previously healthy 2-year-old boy. Initial serological studies were consistent with hepatitis A virus (HAV), with prozone phenomenon. The similarity of E25 to HAV may obscure accurate diagnosis in some cases of hepatitis.

Possible widespread presence of hepatitis A virus subgenotype IIIA in Japan: Recent trend of hepatitis A causing acute liver failure

2011 ◽  
Vol 42 (3) ◽  
pp. 248-253 ◽  
Author(s):  
Tatsuo Miyamura ◽  
Koji Ishii ◽  
Tatsuo Kanda ◽  
Akinobu Tawada ◽  
Tadashi Sekimoto ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis A ◽  
Recent Trend ◽  
Hepatitis A Virus

scholarly journals Acute Liver Failure Caused by Hepatitis A Virus with Dengue Coinfection

2016 ◽  
Vol 6 (2) ◽  
pp. 164 ◽  
Author(s):  
Sunil Taneja ◽  
Amritangsu Borakokty ◽  
Ajay Duseja ◽  
Radha Krishan Dhiman ◽  
Yogesh Chawla
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis A ◽  
Hepatitis A Virus

scholarly journals Acute Liver Failure Requiring Liver Transplantation due to Acute Hepatitis A Virus Infection

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Chencheng Xie ◽  
Jonathan M. Fenkel ◽  
Dina L. Halegoua-DeMarzio ◽  
Jesse M. Civan ◽  
Danielle M. Tholey ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Acute Hepatitis ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
University Hospital ◽  
Close Monitoring ◽  
King’S College Criteria ◽  
One Year

Introduction. Hepatitis A infection (HAV) is generally characterized by an acute icteric illness or may have a subclinical self-limited course, although rarely, can result in fulminant hepatitis and death. In 2019, the City of Philadelphia declared a public health emergency due to an HAV outbreak. We are reporting a series of four cases of acute liver failure (ALF) requiring liver transplantation (LT) due to acute HAV. Methods. Chart review and case descriptions of four patients with acute HAV-related ALF who were expeditiously evaluated, listed as Status 1A, and who underwent LT between August 2019 and October 2019 at Thomas Jefferson University Hospital. Results. All four patients presented with acute hepatocellular jaundice and had a positive HAV IgM, and all other causes of ALF were excluded. All four cases met the American Association for the Study of Liver Diseases (AASLD) criteria for ALF. Three of the four cases met King’s College Criteria of poor prognosis for nonacetaminophen-induced ALF. All four patients underwent successful LT and were discharged six to twelve days postoperatively. One patient died of disseminated Aspergillus infection five months after LT, while the others have had excellent clinical outcomes shown by one-year follow-ups. All four explants had remarkably similar histological changes, revealing acute hepatitis with massive necrosis accompanied by a prominent lymphoplasmacytic inflammatory infiltrate and bile ductular proliferation. Conclusion. Although rare, patients presenting with acute HAV need close monitoring as they may rapidly progress to ALF. Early referral to a transplant center afforded timely access to LT and yielded overall good one-year survival. Widespread HAV vaccination for high-risk individuals is an essential strategy for preventing disease and curbing such future outbreaks.

Acute Liver Failure Caused by Hepatitis A Virus (HAV) Infection in Japan: Recent Status Based on Nationwide Surveys

2016 ◽  
Vol 64 (2) ◽  
pp. S374
Author(s):  
N. Nakayama ◽  
M. Nakao ◽  
Y. Uchida ◽  
H. Tsubouchi ◽  
H. Takikawa ◽  
...  
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis A ◽  
Hepatitis A Virus

scholarly journals Atypical presentations of hepatitis A infection in children

2021 ◽  
Vol 61 (6) ◽  
pp. 317-21
Author(s):  
Sayma Rahman Munmun ◽  
Archana Shrestha Yadav ◽  
Mohammad Benzamin ◽  
Abu Sayed Mohammad Bazlul Karim ◽  
Mohammad Rukunuzzaman ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Pleural Effusion ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Hemoglobin Level ◽  
Atypical Presentation ◽  
Related Factors ◽  
Atypical Presentations

Background Hepatitis A is the most common cause of acute viral hepatitis, with a typical simple, self-limiting course. But it is not free from complications. Atypical presentations, such as in the form of prolonged cholestasis, ascites, pleural effusion, relapsing hepatitis, or fulminant hepatic failure, pose challenges to disease management. Knowledge about varying presentations and identification of factors associated with atypical presentations will help to early diagnosis of atypical courses of disease. Objective To describe various atypical clinical presentations, biochemical findings of hepatitis A infection, and possible related factors. Methods Ninety-five children aged 1 to 18 years, diagnosed with hepatitis A infection, and admitted to the Department of Pediatric Gastroenterology & Nutrition, BSMMU, Dhaka, Bangladesh from January 2015 to May 2018 were studied retrospectively. Results Atypical presentations were manifested in 19 (20%) out of 95 children with hepatitis A virus (HAV) infection. The mean age of atypical patients [6.32 (SD 3.45) years] was significantly lower than that of typical patients [8.22 (SD 3.58) years] (P=0.0041). The most common atypical manifestation was ascites (11/19), followed by hepatic encephalopathy (9/19), acute liver failure (719), thrombocytopenia (2/19), pleural effusion (2/19), and cholestasis (1; 1.1%). Children with atypical features had significantly higher international normalized ratio (INR) and serum bilirubin, as well as lower hemoglobin level than the typical group. Children of atypical group had significantly higher number of organomegaly and coagulopathy. Conclusion Ascites, hepatic encephalopathy, acute liver failure, thrombocytopenia, pleural effusion, and prolonged cholestasis were common forms of atypical presentation. Younger age, organomegaly, higher bilirubin level, prolonged PT, and decreased hemoglobin level could be predictive of an atypical presentation of HAV in children.

scholarly journals Clinical characteristics of acute liver failure associated with hepatitis A infection in children in Mogadishu, Somalia: a hospital-based retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Esra Keles ◽  
Mohamed A. Hassan-Kadle ◽  
Marian Muse Osman ◽  
Hasan Huseyin Eker ◽  
Zeynep Abusoglu ◽  
...  
Keyword(s):  
Public Health ◽  
Retrospective Study ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Hospital Stay ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Rare Complication ◽  
Length Of Hospital Stay ◽  
Public Health Problem

Abstract Background Hepatitis A is one of the most common infectious causes of acute hepatitis, and currently, a neglected global public health problem necessitating an urgent response in Somalia. Hepatitis A infection and its rare complication of acute liver failure in children are largely based on very limited data. The aim of the study was therefore to investigate the Hepatitis A infection and its rare complication of acute liver failure in children in Somalia. Methods This retrospective study was conducted on children aged 0–18 years who were admitted to the pediatric departments of the Somalia Mogadishu-Turkey Training and Research Hospital, Somali, from June 2019 and December 2019. Patients who were tested for hepatitis A infection during the study period and had complete data were included. Children with chronic disease, primary or secondary immunodeficiency, blood transfusion history, and missing data were excluded. Abstracted data including patients' demographics, clinical presentation, laboratory results, ultrasonographic findings, length of hospital stay, clinical course and outcome were retrieved from the hospital database system. Results Of the 13,047 children, 219 were analyzed. Of the 219 Hepatitis A cases, 25 (11%) were diagnosed with pediatric acute liver failure (PALF). The mean age of children with Hepatitis A was 6.7 years. The majority of cases were reported in the 5–9 (39.7%) year age range. Hepatic encephalopathy, length of hospital stay, levels of albumin, and values of PT, aPPT, and INR were significantly higher in children with acute live failure. The presence of cholecystitis and cholecystitis with ascites in the sonographic evaluation were poor prognostic markers for acute liver failure. Conclusions This study revealed hepatitis A virus infection and its related acute liver failure among hospitalized children in Somalia of which 11% had PALF. Hence, the introduction of Hepatitis A vaccination, which is the main public health tool, into the national immunization program, the improvement of hygiene conditions, raising awareness of the disease, and increasing health literacy are necessary to prevent the consequence of the Hepatitis A virus in children.

scholarly journals Acute liver failure complicating viral hepatitis A

2004 ◽  
Vol 8 (2) ◽  
Author(s):  
Daniel Rui Diniz-Santos ◽  
Maria Clotildes Nunes de Melo ◽  
Rita Franca Melo ◽  
Luciana Rodrigues Silva
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Viral Hepatitis ◽  
Hepatitis A ◽  
Viral Hepatitis A
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