Deteriorated outcome of recent patients with acute liver failure and late‐onset hepatic failure caused by infection with hepatitis A virus: A subanalysis of patients seen between 1998 and 2015 and enrolled in nationwide surveys in Japan

2019 ◽  
Vol 49 (8) ◽  
pp. 844-852 ◽  
Author(s):  
Masamitsu Nakao ◽  
Nobuaki Nakayama ◽  
Yoshihito Uchida ◽  
Tomoaki Tomiya ◽  
Makoto Oketani ◽  
...  
JGH Open ◽  
2021 ◽  
Vol 5 (4) ◽  
pp. 428-433
Author(s):  
Takuro Hisanaga ◽  
Isao Hidaka ◽  
Isao Sakaida ◽  
Nobuaki Nakayama ◽  
Akio Ido ◽  
...  

2017 ◽  
Vol 53 (6) ◽  
pp. 752-769 ◽  
Author(s):  
Masamitsu Nakao ◽  
Nobuaki Nakayama ◽  
Yoshihito Uchida ◽  
Tomoaki Tomiya ◽  
Akio Ido ◽  
...  

2020 ◽  
Vol 44 (3) ◽  
pp. e61-e63
Author(s):  
Ignacio García-Juárez ◽  
Alejandro Campos-Murguía ◽  
Braulio A. Marfil-Garza ◽  
Godolfino Miranda ◽  
Edgar A. Granados ◽  
...  

2014 ◽  
Vol 53 (1) ◽  
pp. 309-310 ◽  
Author(s):  
Susan K. Wollersheim ◽  
Romney M. Humphries ◽  
James D. Cherry ◽  
Paul Krogstad

We describe a case of acute liver failure caused by echovirus 25 (E25) in a previously healthy 2-year-old boy. Initial serological studies were consistent with hepatitis A virus (HAV), with prozone phenomenon. The similarity of E25 to HAV may obscure accurate diagnosis in some cases of hepatitis.


2011 ◽  
Vol 42 (3) ◽  
pp. 248-253 ◽  
Author(s):  
Tatsuo Miyamura ◽  
Koji Ishii ◽  
Tatsuo Kanda ◽  
Akinobu Tawada ◽  
Tadashi Sekimoto ◽  
...  

2016 ◽  
Vol 6 (2) ◽  
pp. 164 ◽  
Author(s):  
Sunil Taneja ◽  
Amritangsu Borakokty ◽  
Ajay Duseja ◽  
Radha Krishan Dhiman ◽  
Yogesh Chawla

2021 ◽  
pp. 927-932
Author(s):  
Reem Shammout ◽  
Turki Alhassoun ◽  
Fadi Rayya

Acute liver failure (ALF) is a syndrome, rather than a specific disease, with several possible causes, and viral hepatitis is a major cause. The relationship between self-limited and ALF hepatitis A is still poorly understood. A 45-year-old woman presented to our hospital with ALF diagnosis (from another hospital). She suffered from hospital-acquired pneumonia. The patient recovered within 4 weeks and returned to her normal life after 6 months of follow-up.


2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Chencheng Xie ◽  
Jonathan M. Fenkel ◽  
Dina L. Halegoua-DeMarzio ◽  
Jesse M. Civan ◽  
Danielle M. Tholey ◽  
...  

Introduction. Hepatitis A infection (HAV) is generally characterized by an acute icteric illness or may have a subclinical self-limited course, although rarely, can result in fulminant hepatitis and death. In 2019, the City of Philadelphia declared a public health emergency due to an HAV outbreak. We are reporting a series of four cases of acute liver failure (ALF) requiring liver transplantation (LT) due to acute HAV. Methods. Chart review and case descriptions of four patients with acute HAV-related ALF who were expeditiously evaluated, listed as Status 1A, and who underwent LT between August 2019 and October 2019 at Thomas Jefferson University Hospital. Results. All four patients presented with acute hepatocellular jaundice and had a positive HAV IgM, and all other causes of ALF were excluded. All four cases met the American Association for the Study of Liver Diseases (AASLD) criteria for ALF. Three of the four cases met King’s College Criteria of poor prognosis for nonacetaminophen-induced ALF. All four patients underwent successful LT and were discharged six to twelve days postoperatively. One patient died of disseminated Aspergillus infection five months after LT, while the others have had excellent clinical outcomes shown by one-year follow-ups. All four explants had remarkably similar histological changes, revealing acute hepatitis with massive necrosis accompanied by a prominent lymphoplasmacytic inflammatory infiltrate and bile ductular proliferation. Conclusion. Although rare, patients presenting with acute HAV need close monitoring as they may rapidly progress to ALF. Early referral to a transplant center afforded timely access to LT and yielded overall good one-year survival. Widespread HAV vaccination for high-risk individuals is an essential strategy for preventing disease and curbing such future outbreaks.


2016 ◽  
Vol 64 (2) ◽  
pp. S374
Author(s):  
N. Nakayama ◽  
M. Nakao ◽  
Y. Uchida ◽  
H. Tsubouchi ◽  
H. Takikawa ◽  
...  

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