Neonatal Jaundice in Preterm Infants with Bilirubin Encephalopathy

Neonatology ◽  
2021 ◽  
pp. 1-9
Author(s):  
Akihisa Okumura ◽  
Shintaro Ichimura ◽  
Masahiro Hayakawa ◽  
Hiroshi Arai ◽  
Yoshihiro Maruo ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Total Bilirubin ◽  
Nationwide Survey ◽  
Albumin Level ◽  
Molar Ratio ◽  
Serum Total Bilirubin ◽  
Additional Information ◽  
Bilirubin Encephalopathy ◽  
Unbound Bilirubin ◽  
G Ratio

Introduction: The aim of this study is to clarify bilirubin parameters and its treatment in preterm infants with bilirubin encephalopathy (pBE). Methods: We asked the responders to an earlier nationwide Japanese survey on pBE to provide additional information. pBE was diagnosed based on the criteria used in the nationwide survey. We collected data on serum total bilirubin (TB), direct bilirubin (DB), albumin, and unbound bilirubin (UB) levels during the first 8 weeks of life, and on phototherapy and exchange transfusion treatments. Results: We obtained clinical data from 75 patients with pBE from 58 hospitals (response rate of 59%), who were born between 2002 and 2016. The average peak TB level was 12.6 mg/dL (215 μmol/L), and the average age at peak attainment was 19.7 days after birth. Albumin level was <2.5 g/dL in 44 patients, and the peak DB level was ≥2 mg/dL (34.2 μmol/L) in 20 patients. The average peak bilirubin/albumin (B/A) (mg/g) ratio was 3.8 (molar ratio of 0.475), and the average age at peak attainment was 18.6 days. The average peak UB level was 0.67 μg/dL (11.5 nmol/L). The median duration of phototherapy was 6 days, and the median day of the last session was 12. The peak TB level occurred after the last day of phototherapy in 30 of the 61 patients available for comparison. Conclusions: Most patients with pBE lacked marked elevations in serum TB levels and the B/A ratio, the peaks of which were sometimes delayed to >4 weeks after birth.

A nationwide survey of bilirubin encephalopathy in preterm infants in Japan

2020 ◽  
Vol 42 (10) ◽  
pp. 730-737
Author(s):  
Akihisa Okumura ◽  
Ichiro Morioka ◽  
Hiroshi Arai ◽  
Masahiro Hayakawa ◽  
Yoshihiro Maruo ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Nationwide Survey ◽  
Bilirubin Encephalopathy

scholarly journals The first 24-hour bilirubin level as a predictor of hyperbilirubinemia in healthy term newborns

2016 ◽  
Vol 43 (3) ◽  
pp. 85
Author(s):  
Rina Triasih ◽  
Ekawaty L Haksari ◽  
Achmad Surjono
Keyword(s):  
Relative Risk ◽  
Bilirubin Level ◽  
Total Bilirubin ◽  
Total Bilirubin Level ◽  
Serum Total Bilirubin ◽  
Term Newborns ◽  
Unbound Bilirubin

Background Early discharging healthy term newborns results ina difficulty to recognize hyperbilirubinemia.Objective The aim of this study was to determine the value of thefirst 24-hour total and unbound bilirubin levels in predicting hyper-bilirubinemia in healthy term newborns.Methods The first 24-hour and the 5 th day total and unboundbilirubin levels were measured in 84 healthy term newborns. Thetotal bilirubin level was measured spectrophotometrically, whereasunbound bilirubin level was determined by peroxidase-oxidationmethod. Hyperbilirubinemia was defined as serum total bilirubin of>12.9 mg/dL or serum unbound bilirubin of >0.5 mg/dL after 24hours of life.Results A correlation between the first 24-hour and the 5 th daytotal bilirubin levels was found (r= 0.53) with a regression equa-tion: Y (total bilirubin on day 5) = 4.69 + 1.15X (total bilirubin in thefirst 24 hours). In unbound bilirubin (r=0.31), the regression equa-tion was Y (unbound bilirubin on day 5) = 0.13 + 0.95X (unboundbilirubin in the first 24-hours). The relative risk for developing hy-perbilirubinemia in newborns whose TB 1 was >4.5 mg/dL was 12(95% CI 2.9;48.4), whereas newborns whose UB 1 was >0.09 mg/dL was 9.5 (95% CI 1.2;77.4).Conclusion Total bilirubin level of >4.5 mg/dL in the first 24 hourscan predict the development of hyperbilirubinemia in term new-borns in the first week of life. Newborns with such level of totalbilirubin need a longer stay or should visit the hospital on day 5-7

scholarly journals Increased serum total bilirubin-albumin ratio was associated with bilirubin encephalopathy in neonates

2020 ◽  
Vol 40 (1) ◽  
Author(s):  
Yan Wang ◽  
Guangyao Sheng ◽  
Lina Shi ◽  
Xiuyong Cheng
Keyword(s):  
Total Bilirubin ◽  
Direct Bilirubin ◽  
Control Group ◽  
Case Group ◽  
Serum Total Bilirubin ◽  
Natural Childbirth ◽  
Albumin Ratio ◽  
Indirect Bilirubin ◽  
Bilirubin Encephalopathy ◽  
Epidemiological Characteristics

Abstract We performed the present study to summarize the recent epidemiological characteristics of bilirubin encephalopathy and assess the role of total bilirubin-albumin ratio in the bilirubin encephalopathy. We retrospectively collected clinical data of 669 neonates with hyperbilirubinemia from the First Affiliated Hospital of Zhengzhou University between January 2015 and July 2018, including 153 neonates belonged to bilirubin encephalopathy and 516 ones were treated as control group. Compared with the control group, those with bilirubin encephalopathy have higher bilirubin-albumin ratio (13.8 ± 3.6 vs. 10.6 ± 2.5, P=0.000). The direct bilirubin and indirect bilirubin level were higher in the case group than that in the control group (P=0.000). On the contrary, the hemoglobin level was lower in the case group than that in the control group (P=0.004). There were no significant differences in gestational age (P=0.510), gender rate (P=0.313), maternal gestational diabetes ratio (P=0.071), natural childbirth ratio (P=0.686), and meconium delay (P=0.091). The results from univariate regression indicated the total bilirubin/albumin ratio was positively associated with bilirubin encephalopathy (odds ratio (OR) = 1.67, 95% confidence interval (CI): 1.59–3.14). The total bilirubin, direct bilirubin, and indirect bilirubin were also related to encephalopathy. After adjusting some potential cofounding factors, the total bilirubin-albumin was still associated with bilirubin encephalopathy. The higher total bilirubin-albumin ratio increased the risk of bilirubin encephalopathy by 23% (OR = 1.23, 95% CI: 1.16–2.48). Our results indicated that the bilirubin-albumin ratio is associated with bilirubin encephalopathy in neonates, and could be a potential predictor.

Bilirubin/albumin (B/A) ratios correlate with unbound bilirubin levels in preterm infants

2021 ◽  
Author(s):  
Shinya Abe ◽  
Kazumichi Fujioka ◽  
Ruka Nakasone ◽  
Shutaro Suga ◽  
Mariko Ashina ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Unbound Bilirubin

scholarly journals Unbound bilirubin measurements in term and late-preterm infants

2020 ◽  
pp. 1-7 ◽  
Author(s):  
Thomas Hegyi ◽  
Dalya Chefitz ◽  
Alan Weller ◽  
Andrew Huber ◽  
Mary Carayannopoulos ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Late Preterm ◽  
Late Preterm Infants ◽  
Unbound Bilirubin

scholarly journals Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis

Medicines ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 39
Author(s):  
Akihiko Shibamoto ◽  
Tadashi Namisaki ◽  
Junya Suzuki ◽  
Takahiro Kubo ◽  
Satoshi Iwai ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Biological Markers ◽  
Prediction Accuracy ◽  
Total Bilirubin ◽  
Alcoholic Cirrhosis ◽  
Serum Total Bilirubin ◽  
Excessive Alcohol Consumption ◽  
Significant Difference ◽  
Carbohydrate Deficient Transferrin ◽  
Excessive Alcohol

: Background: This study aimed to compare the diagnostic performance of carbohydrate-deficient transferrin (CDT) and gamma-glutamyltranspeptidase (γ-GTP) to assess the single and combined benefits of these biological markers for the detection of chronic excessive alcohol consumption in patients with alcoholic cirrhosis. Methods: Biological markers were determined in blood samples from patients with alcoholic cirrhosis (drinking group, n = 35; nondrinking group, n = 81). The prediction accuracy of %CDT alone, γ-GTP alone, and their combination for the detection of excessive alcohol consumption was determined in patients with alcoholic cirrhosis. Results: Serum total bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-GTP, and alkaline phosphatase levels and %CDT were significantly higher and serum albumin levels were significantly lower in the drinking group than in the nondrinking group. The combination of %CDT and γ-GTP compared with %CDT or γ-GTP alone showed a higher prediction accuracy. The combination of %CDT and γ-GTP exhibited a higher specificity than γ-GTP alone. However, in terms of sensitivity, no significant difference was found between single or combined markers. Conclusions: The combination of %CDT and γ-GTP is considered a useful biomarker of chronic excessive alcohol consumption in patients with alcoholic cirrhosis.

Child-Pugh classification and serum total bilirubin levels are prognostic factors following tips

2000 ◽  
Vol 118 (4) ◽  
pp. A1454
Author(s):  
Zeki Karasu ◽  
Ahmet O. Gurakar ◽  
Ahmad S. Jazzar ◽  
Barbara Kerwin ◽  
Saadettin Hulagu ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Total Bilirubin ◽  
Serum Total Bilirubin

scholarly journals Association of Serum Total Bilirubin with Serum High Sensitivity C-reactive Protein in Middle-aged Men

2011 ◽  
Vol 32 (6) ◽  
pp. 327 ◽  
Author(s):  
Kiwoong Yu ◽  
Cheolhwan Kim ◽  
Eunju Sung ◽  
Hocheol Shin ◽  
Hyewon Lee
Keyword(s):  
Total Bilirubin ◽  
High Sensitivity ◽  
Serum Total Bilirubin ◽  
C Reactive Protein ◽  
Middle Aged ◽  
Reactive Protein

scholarly journals Relationship Between Unbound Bilirubin Levels and Acute Bilirubin Encephalopathy in Exchange Transfusion Neonates

2021 ◽  
Author(s):  
Yiyi Ding ◽  
Shuo Wang ◽  
Rui Guo ◽  
Aizhen Zhang ◽  
Yufang Zhu
Keyword(s):  
Logistic Regression ◽  
Blood Glucose ◽  
Odds Ratio ◽  
Exchange Transfusion ◽  
Binary Logistic Regression ◽  
P Value ◽  
Bilirubin Encephalopathy ◽  
Unbound Bilirubin ◽  
Independent Variable ◽  
The Relationship

Abstract BACKGROUND: Evidence regarding the relationship between unbound bilirubin levels and acute bilirubin encephalopathy was limited. Therefore, this study set out to investigate whether the unbound bilirubin level was independently related to acute bilirubin encephalopathy in children who underwent exchange transfusion after adjusting for other covariates. METHODS: A total of 46 neonates who underwent exchange transfusion were involved in The First People's Hospital Of Changde City in China from 2016-1-1 to 2018-12-31. The target independent variable and the dependent variable were unbound bilirubin levels measured at baseline and acute bilirubin encephalopathy respectively. Covariates involved in this study included sex, age, birth weight, blood glucose, red blood cell, hemolysis, receive phototherapy before exchange transfusion. RESULTS: The average gestational age of 46 selected participants was 38.6 ± 1.3 weeks old, the average age was 146.5 ± 86.9 hours old, 52.17% of them were male. Result of fully-adjusted binary logistic regression showed unbound bilirubin levels were positively associated with risk of acute bilirubin encephalopathy after adjusting confounders (Odds ratio = 1.41, 95% confidence intervals 1.05-1.91, P value <0.05). CONCLUSION: Unbound bilirubin levels are associated with neonatal acute bilirubin encephalopathy. The mechanism of unbound bilirubin levels leading to neonatal acute bilirubin encephalopathy needs to be further explored.

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