scholarly journals Changes in Clinical and Histological Characteristics of Nasal Polyps in Northern China over the Past 2–3 Decades

2021 ◽  
pp. 1-10
Author(s):  
Jiaqi Yu ◽  
Mu Xian ◽  
Yingshi Piao ◽  
Luo Zhang ◽  
Chengshuo Wang
Keyword(s):  
Nasal Polyps ◽  
Northern China ◽  
Sinus Surgery ◽  
Similar Data ◽  
The Past ◽  
Group A ◽  
Histological Characteristics ◽  
Polyp Recurrence ◽  
Group B ◽  
Over Time

Introduction: Recent studies have shown that inflammatory patterns of nasal polyps from patients with chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) in East Asia have changed over time. However, to date there is a marked lack of similar data for CRSwNP in Northern China. This study thus aimed to assess the changes in the clinical and histological characteristics of CRSwNP patients from Northern China over the past 2–3 decades. Methods: This was a retrospective study, which examined data from 2 groups of 150 CRSwNP patients each, who had undergone endoscopic sinus surgery in Beijing Tongren Hospital from 1993 to 1995 (group A) and from 2015 to 2019 (group B). All relevant data for demographic, clinical, and histological parameters were collected for each patient from the 2 groups and compared for overall changes between the 2 groups. Results: The comorbidity of CRSwNP and asthma increased over time and the cellular phenotype of CRSwNPchanged significantly; in particular, the proportion of eosinophil-dominant CRSwNP increased, lymphocyte-dominant and plasma-dominant CRSwNP decreased significantly, and the proportions of neutrophil-dominant and mixed CRSwNP were not altered. The rate of polyp recurrence increased in CRSwNP but did not in eosinophilic CRSwNP. Smoking and age did not significantly impact the inflammatory patterns of CRSwNP. Conclusions: The inflammatory patterns of CRSwNP patients have changed and comorbidity of asthma significantly increased in CRSwNP patients in Northern China over the past 2–3 decades.

Anterior approach levator plication for congenital ptosis, absorpable versus non absorpable sutures

2021 ◽  
pp. 112067212110053
Author(s):  
Moustafa Salamah ◽  
Ashraf Mahrous Eid ◽  
Hani Albialy ◽  
Sherif Sharaf EL Deen
Keyword(s):  
Randomized Study ◽  
Early Postoperative Period ◽  
Polyglactin 910 ◽  
Exclusion Criteria ◽  
Congenital Ptosis ◽  
History Of ◽  
Group A ◽  
Group B ◽  
Over Time

Purpose: To compare the efficacy of two different suture types in levator plication for correction of congenital ptosis. Subjects and methods: Prospective comparative interventional randomized study involving 42 eyes of 42 patients aged more than 6 years with congenital ptosis and good levator action. The exclusion criteria were as follows: bilateral ptosis, history of previous surgery, fair or poor levator action, and associated other ocular diseases. Patients were randomized into group A, in which double-armed 5/0 polyester Ethibond were used, and group B, in which double-armed 5/0 Coated Vicryl® (polyglactin 910) suture material we used. Outcomes including eyelid height and stability of eyelid height over time were compared with follow-up data. The MRD was 4.05 ± 0.36 mm and 3.95 ± 0.34 after 1 week for both groups A and B, respectively. At the end of study follow up period (24 weeks), the MRD was 3.60 ± 0.42 mm in group A, and 2.52 ± 0.85 mm in group B. Conclusion: No difference in eyelid height between two groups in early postoperative period, but the postoperative eyelid height was more stable over time in the 5/0 polyester Ethibond group (group A) than in the 5/0 Coated Vicryl® (polyglactin 910) group (group B).

scholarly journals Correlation between two physical activity programs in the gait of sedentary elderly subjects

2010 ◽  
Vol 8 (3) ◽  
pp. 281-284
Author(s):  
Mariana Varkala Lanuez ◽  
Fernanda Varkala Lanuez ◽  
Eduardo Gunther Montero ◽  
Wilson Jacob Filho
Keyword(s):  
The Elderly ◽  
Controlled Study ◽  
Elderly Subjects ◽  
Male And Female ◽  
The Past ◽  
Physical Exercises ◽  
Balance Exercises ◽  
Group A ◽  
Group B ◽  
De Medicina

ABSTRACT Objectives: To assess the effect of exercise on gait using two different programs: a group of aerobic exercises (Group A, n = 18) and a group of flexibility and balance exercises (Group B, n = 19). Methods: A casualized controlled study, in which each sample controlled itself, was undertaken. The sample comprised 37 male and female subjects, aged from 60 to 90 years, from the outpatient clinic of the Geriatrics Unit of Hospital das Clínicas of Faculdade de Medicina of Universidade de São Paulo; the patients were sedentary and had not exercised regularly during the past six months. Results: Improvement of gait was seen mainly in the group that did specific exercises. Conclusion: The results of this study underline the importance of physical exercises in sedentary elderly subjects, but show the need for programming the exercises towards specific goals, which can optimize the results of this tool of health promotion for the elderly.

Platelet Function and Adrenoceptors during and after Induced Hypotension using Nitroprusside

1996 ◽  
Vol 85 (6) ◽  
pp. 1334-1340. ◽  
Author(s):  
Gerald V. Dietrich ◽  
Michael Heesen ◽  
Joachim Boldt ◽  
Gunter Hempelmann
Keyword(s):  
Platelet Aggregation ◽  
Blood Loss ◽  
Sodium Nitroprusside ◽  
Sinus Surgery ◽  
Controlled Hypotension ◽  
Lower Shear ◽  
Lower Blood ◽  
Group A ◽  
Group B ◽  
Spontaneous Platelet Aggregation

Background Hypotension induced by sodium nitroprusside can minimize intraoperative blood loss. The release of endogenous catecholamines can influence adrenoceptors of platelets and thus might change the ability of platelets to aggregate. Methods Forty patients undergoing nasal septum, tympanoplastic, or sphenoid sinus surgery were randomly divided into two groups, those having controlled hypotension (A) and those serving as controls (B). Blood samples were drawn before the operation, after induction of anesthesia, 1 h after the start of the operation, and on the day after surgery. Results Epinephrine-induced platelet aggregation only increased in the controls on the day after surgery (A: from 49 +/- 25% to 47 +/- 29%; B: from 53 +/- 24% to 72 +/- 14%; mean +/- SD; P < 0.01). Spontaneous platelet aggregation increased in the controls from a median of 1.2 omega/h to 2.4 during the operation and 2.9 on the day after surgery but not after hypotension. On the day after surgery, alpha 2 receptors reached their maximum (A: 238 +/- 164; B: 234 +/- 80 per platelet). During the operation, the norepinephrine concentrations were significantly greater in group A (median, 419 pg/ml) than in group B (median, 217 pg/ml; P < 0.05). Blood loss was greater in the controls (A: 180 +/- 75; B: 379 +/- 120 ml; P < 0.05). Conclusions Controlled hypotension using sodium nitroprusside reduces epinephrine-induced and spontaneous platelet aggregation. Even on the day after hypotension, the usual postoperative reactive increase in platelet aggregation did not occur. These results may be explained by the direct effect of nitroprusside on platelets, the augmented stress response, lower shear stress on platelets due to the lower blood pressure, or the decreased blood loss compared with the controls.

Carpal tunnel syndrome: matching minimally invasive surgical techniques

2008 ◽  
Vol 108 (5) ◽  
pp. 1033-1036 ◽  
Author(s):  
Vittoria Nazzi ◽  
Angelo Franzini ◽  
Giuseppe Messina ◽  
Giovanni Broggi
Keyword(s):  
Carpal Tunnel Syndrome ◽  
Minimally Invasive ◽  
Median Nerve ◽  
Carpal Tunnel ◽  
Surgical Techniques ◽  
The Past ◽  
Minimally Invasive Surgical ◽  
Group A ◽  
Tunnel Syndrome ◽  
Group B

✓In the past few years, several different minimally invasive surgical techniques have been proposed to decompress the median nerve at the wrist. Use of these techniques has become widespread due to fewer local complications, faster functional recovery, and reduced surgical time. In this paper the authors compare 3 different minimally invasive surgical techniques used at their institution in the past 13 years. Between January 1994 and January 2007, 891 patients underwent 1272 surgeries at the authors' institution for carpal tunnel syndrome (CTS), for which a minimally invasive technique was used. In 473 cases (Group A), the transillumination technique with a single wrist incision and a “carpalotome” (a modified Paine retinaculotome) was used; in 216 cases (Group B), transillumination was abandoned and a single linear wrist incision for access with the carpalotome was performed; and in 583 cases (Group C), the techniques were further modified by making a second incision in the palm using the carpalotome. All 3 groups of patients were homogeneous for age, sex, and duration of the symptomatology. In 90% of the patients in Group A, in 88% of those in Group B, and 99.8% of patients in Group C, complete remission of symptoms was obtained. Due to persistence of symptoms, 44 patients in Group A, 24 in Group B, and only 1 in Group C underwent a repeated operation with the open technique. The only surgical complication requiring repeated operation of the 1272 operations was a lesion of the primitive median artery (1 patient in Group C). The technique of median nerve decompression at the wrist that was used for patients in Group C represents a valid alternative for treatment of CTS.

scholarly journals A comparison of self-esteem between patients undergoing fixed orthodontic treatment, to those not receiving orthodontic treatment

2021 ◽  
Vol 7 (4) ◽  
pp. 112-115
Author(s):  
Maleeha Majid ◽  
◽  
Maliha Jamshaid ◽  
Ghina Rizwan ◽  
Zarnab Rizwan ◽  
...  
Keyword(s):  
Sample Size ◽  
Orthodontic Treatment ◽  
Self Esteem ◽  
The Self ◽  
The Other ◽  
Treatment Need ◽  
The Past ◽  
Group A ◽  
And Gender ◽  
Group B

Objective: Comparison of the self-esteem between patients undergoing fixed orthodonticc treatment in the past 6 months or more, to those not receiving orthodontic treatment or the time passed since the commencement of their treatment has been less than six months. Materials and methods: The participants of this study were divided into two groups, group A and group B. The sample size of each group was 75 making the total 150 aged between 16 to 25 years. The malocclusion severity was assessed with the index of orthodontic treatment need aesthetic component (IOTN-AC) which was 6 or more for both groups. Group A involved patients currently receiving no orthodontic treatment or the time elapsed since the start of the treatment was less than 6 months. Group B on the other hand, comprised of patients undergoing orthodontic treatment in the past 6 months or more. Questionnaires were administered among both group A and group B where self-esteem was measured using the Rosenberg Self-esteem (RSE) Scale. Independent Sample T test was applied on both of these variables. Results: The results did not show any statistically significant association between self-esteem and “the time elapsed since the start of the treatment”. Likewise, the additional factors i.e., Age, Education and Gender too had no impact on the Rosenberg score. Conclusion: No association was found between selfesteem of the patients undergoing fixed Orthodontic treatment, to those not receiving it

scholarly journals Pilot Testing of a New App for Prospective Evaluation of Health-related Quality of Life in Breast Cancer

2020 ◽  
Author(s):  
Trine Lund-Jacobsen ◽  
Peter Schwarz
Keyword(s):  
Social Life ◽  
Life Quality ◽  
Primary Treatment ◽  
Neutral Mood ◽  
Related Quality ◽  
Health Related ◽  
Group A ◽  
Group B ◽  
Reported Data ◽  
Over Time

Abstract Background: Given that BC patients now live longer and have a higher survival rate, long-term side effects of primary treatment and patients' Life Quality (LQ) have become a more central issue. The purpose of this study was to investigate whether Life Quality changes after primary BC treatment.Method: A prospective cohort study was conducted including 149 Danish women with BC. Sixty had entered the date since chemotherapy termination and their daily measurement of QoL for mood in the app Bone@BC. All users can only enter the app with a Danish NemID and own mobile device. The app includes self-reported patient baseline characteristics related to BC treatment and simple self-reported data of LQ measured in mood, social life and wellbeing measured by fatigue, pain and appetite and physical activities. Results: During the pilot test period, 149 BC survivors entered baseline data. Of the 149 BC survivors 60 (40%) have entered chemotherapy history and LQ data. The mean age of the BC survivors was 58.2 ±9.6 years (range 27-78 years). Days since chemotherapy termination was with a mean of 450 days (range 54-5.175 days). In group A (n=20) 35% reported 0-365 days and in group B (n=39) 65% reported more than 365 days since chemotherapy termination. In the whole group 65% reported neutral mood. By division into group A vs. B showed that mood improve over time measured by several in group B had a neutral mood achieved. Half (53%) had a good social life. Similar changes were reported for pain with 79% reporting mild to moderate pain in the whole group, group A vs. B showed an increasing level of pain over time with 24% reporting moderate to severe pain in group B vs. 13% in group A. Finally, it was observed that 58% reported mild to moderate appetite and it is decreasing over time, 64% reported mild to moderate appetite in group B vs. 50% in group A. Conclusion: Our results indicate that BC survivors have impaired QoL up to several years after primary BC treatment but there is a trend of some improvement over time. Trial registration: ClinicalTrials.grov:NCT03784651

scholarly journals Role of Hypotensive Anaesthesia in Functional Endoscopic Sinus Surgery in Private Practice

2020 ◽  
Vol 24 (1) ◽  
pp. 8-13
Author(s):  
Md Nurullah ◽  
Md Arif Hossain Bhuyan ◽  
Syed Ariful Islam ◽  
Md Shah Alam
Keyword(s):  
Heart Rate ◽  
Endoscopic Sinus Surgery ◽  
Functional Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
Controlled Hypotension ◽  
Operative Field ◽  
Group A ◽  
The Mean ◽  
Group B

Background: Functional endoscopic sinus surgery (FESS), effective control of bleeding is essential to maintain a clear operative field and to minimize complications. Intraoperative bleeding is one of the major problems in endoscopic surgery of sinuses. Controlled hypotension is a technique used to limit intraoperative blood loss to provide the best possible field for surgery. Objective: The objective of study was role of Hypotensive Anaesthesia in Functional Endoscopic Sinus Surgery and designed to compare intraoperative hemorrhage and the visibility of the operative field during normotension and hypotension anesthesia. Methods: Prospective randomized study includes a total of 60 ASA I-II patients who underwent elective FESS surgery. Patients randomly assigned in two groups the hypotension group (Group A) and the normotension group (Group B). Intraoperative mean arterial pressure (MAP), heart rate (HR) were recorded. Results : This study shows the mean ages of the patients of group A group B were 33.36±7.61 and 32.46±7.73 years respectively. No statistically significant difference was observed among groups at 0.05 level in term of age. The mean heart rate pre-anaesthesia and preoperative among the patients of different groups in different follows up period. Significance differences were observed among groups in term of heart rate at 5 minute, 15 minute, 30 minute, 45 minute and 60 minute. The mean arterial mean blood pressure before pre-anaesthesia and preoperative estimation among the patients of different groups in different follows up period. Significance differences were observed among groups at 5 minute, 15 minute, 30 minute, 45 minute and 60 minute. Conclusion: This study demonstrated that Controlled hypotension can be achieved equally and effectively by nitroglycerin and labetalol reduced significantly intraoperative hemorrhage and produce hypotensive anesthesia. Both are equally effective in providing ideal surgical field during functional endoscopic sinus surgery (FESS). Bangladesh J Otorhinolaryngol; April 2018; 24(1): 8-13

scholarly journals CLINICAL COMPARISON OF 5% FLUORO CALCIUM PHOSPHOSILICATE VERSUS 5% CALCIUM SODIUM PHOSPHOSILICATE IN THE TREATMENT OF DENTINAL HYPERSENSITIVITY

2019 ◽  
Vol 3 (5) ◽  
Author(s):  
Dr. Huda Hussain ◽  
Prof. Suhail Majid Jan ◽  
Dr. Roobal Behal
Keyword(s):  
Thermal Sensitivity ◽  
Biological Properties ◽  
Pharmacological Agents ◽  
Vas Score ◽  
Promising Agent ◽  
Calcium Phosphosilicate ◽  
Group A ◽  
Group B ◽  
Dentinal Hypersensitivity ◽  
Over Time

Dentinal hypersensitivity is a perplexing problem for the patient as well as clinician. Among the plethora of pharmacological agents developed for the management of this rather common affliction, tubule occluding agents form the mainstay of treatment. Bioglasses (phosphosilicates) with evolving chemical and biological properties, are widely used, with the latest modification being the addition of fluoride to conventional calcium sodium phosphosilicate (Novamin) to result in fluoro calcium phosphosilicate (Biomin), purported to have superior tubule occlusive properties. The present study was designed as randomized clinical trial to compare the efficacy of Biomin and Novamin in reducing the subjective and provoked (thermal) experience of dentinal hypersensitivity. Sixty subjects were randomly prescribed three dentifrices after oral prophylaxis: Group A (20 patients):  dentifrice containing 5% fluoro calcium phosphosilicate (Biomin); Group B (20 patients): dentifrice containing 5% calcium sodium phosphosilicate (Novamin); Group C (20 patients): standard dentifrice containing fluoride. Subjective and thermal sensitivity was assessed using a 10 point VAS score at baseline, at 15 days, 30 days and 60 days of treatment. It was found that though significant reduction in hypersensitivity was observed for all three groups over time, flouro calcium phosphosilicate was most effective in reducing the VAS score, followed by calcium sodium phosphosilicate and fluoride. It was concluded that fluoro calcium phosphosilicate is a promising agent for clinical management of dentinal hypersensitivity.

scholarly journals A Review of Nasal Polyps

2019 ◽  
Vol 4 (11) ◽  
Keyword(s):  
Nasal Polyps ◽  
Severe Disease ◽  
Treatment Options ◽  
Primary Treatment ◽  
Good Evidence ◽  
Sinus Surgery ◽  
Molecular Alterations ◽  
The Past ◽  
Postoperative Prophylaxis ◽  
Underlying Mechanisms

Nasal polyps (NP) are one of the most common inflammatory lesions of the nose, affecting up to 4% of the population. Their etiology remains unclear, but they are known to have associations with allergy, asthma, infection, cystic fibrosis, and aspirin sensitivity. However, the underlying mechanisms interlinking these pathologic conditions to NP formation remain unclear. Also strong genetic factors are implicated in the pathogenesis of NP, but genetic and molecular alterations required for its development and progression are still unclear. They present with nasal obstruction, anosmia, rhinorrhea, post nasal drip, and less commonly facial pain. Management of polyposis involves a combination of medical therapy and surgery. There is good evidence for the use of corticosteroids (systemic and topical) both as primary treatment and as postoperative prophylaxis against recurrence. Surgical treatment has been refined significantly over the past twenty years with the advent of endoscopic sinus surgery and, in general, is reserved for cases refractory to medical treatment. Recurrence of the polyposis is common with severe disease recurring in up to ten percent of patients. In this talk I will present the newer treatment options available for better control and possibly cure of the disease.

scholarly journals Pulmonary arterial hypertension associated with congenital heart disease in children: clinical characterisation, outcomes and changes in demographics over time

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
A Constantine ◽  
K Dimopoulos ◽  
R Condliffe ◽  
P Clift ◽  
G Chaplin ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Free Survival ◽  
Paediatric Cohort ◽  
Group A ◽  
Pulmonary Arterial ◽  
Group B ◽  
Group D ◽  
Over Time

Abstract Background/Introduction Pulmonary arterial hypertension (PAH) is a common complication of congenital heart disease (CHD) in children and is associated with significant morbidity and mortality. The impact of different phenotypes on management and survival remains unclear. Purpose To examine the clinical features, management and outcomes of paediatric PAH-CHD patients based on the 20-year experience of the UK National Paediatric Pulmonary Hypertension (PH) Service. Methods Consecutive PAH-CHD patients entering the service between January 2001 and January 2021 were included and classified into: Eisenmenger syndrome (ES, group A), PAH related to a significant systemic-pulmonary shunt (group B), PAH with small or co-incidental CHD (group C) and PAH following defect repair (group D). Incident patients (without pre-existing PAH) were included in survival analysis. Results Of the overall PH paediatric cohort of 1104 patients, 819 (74.2%) had co-existing CHD and 354 (32.1%) patients received a diagnosis of PAH-CHD: 57.1% female, median [IQR] 4.6 [1.7–10.9] years. Group D PAH-CHD was the commonest subgroup, accounting for 36%, while the least frequent subtype was group C (14%). Group A and group B PAH-CHD represented 26% and 24%, respectively. Down syndrome was present in over one third (122, 34.5%) of PAH-CHD patients and was more commonly associated with ES (p=0.02). PAH therapy was started in 79.9% of PAH-CHD patients. At the end of follow-up, patients with group C PAH-CHD were more likely to be on combination therapy than any other group (64.6% vs. 28.4%, p<0.0001). Prostanoid therapy was used in a minority (11%) of patients. The subgroup distribution of PAH-CHD at diagnosis changed from the early (2000–2005) to late (2015–2020) period (Figure 1). The proportion of ES patients decreased from 43.4% to 14.6% of PAH-CHD (p<0.0001). The proportion of group B PAH-CHD patients increased (9.4% vs. 33.3%, p<0.0001), with the majority (59.3%) deemed “operable” on specialist assessment. There was a trend for an increase in repaired PAH-CHD patients between the early and late era (31.1% vs. 43.8%, p=0.09). Transplant-free survival in PAH-CHD was 90.9% (95% CI: 87.8–94%) at 1 year, 77.9% (95% CI: 73.1–83.1%) at 5 years, and 74.9% (95% CI: 69.6–80.7%) at 10 years (Figure 2). Group C PAH-CHD had a lower transplant-free survival than the other 3 groups (HR 2.54, 95% CI: 1.51–4.28, p=0.0005). There was no difference in outcome between group A and group D PAH-CHD (HR 1.19, 95% CI: 0.62–2.28, p=0.6). Conclusions Repaired PAH-CHD, not ES, was the most common subtype in this large paediatric cohort. Over time, there were fewer ES patients and more “operable” patients with left-right shunts, suggesting an improvement in early diagnosis and management. Despite widespread use of PAH therapy, PAH-CHD remains a life-limiting disease with the poorest outcomes in PAH with co-incidental CHD. FUNDunding Acknowledgement Type of funding sources: Private grant(s) and/or Sponsorship. Main funding source(s): Dr Constantine received a personal PhD fellowship grant (CHAMPION PhD Fellowship) Figure 1 Figure 2

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