scholarly journals Hepatitis B Vaccination Response in Hemodialysis Patients: The Impact of Dialysis Shift

2021 ◽  
pp. 1-8
Author(s):  
Maggie Han ◽  
Xiaoling Ye ◽  
Sharon Rao ◽  
Schantel Williams ◽  
Stephan Thijssen ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Multivariate Regression ◽  
Clinical Laboratory ◽  
Seroconversion Rate ◽  
Hemodialysis Patients ◽  
Hepatitis B Vaccination ◽  
Start Time ◽  
Vaccination Response ◽  
Dialysis Vintage ◽  
The Impact

<b><i>Background/Aims:</i></b> Hepatitis B (HB) vaccination in hemodialysis patients is important as they are at a higher risk of contracting HB. However, hemodialysis patients have a lower HB seroconversion rate than their healthy counterparts. As better sleep has been associated with better seroconversion in healthy populations and early hemodialysis start has been linked to significant sleep-wake disturbances in hemodialysis patients, we examined if hemodialysis treatment start time is associated with HB vaccination response. <b><i>Methods:</i></b> Demographics, standard-of-care clinical, laboratory, and treatment parameters, dialysis shift data, HB antigen status, HB vaccination status, and HB titers were collected from hemodialysis patients in Fresenius clinics from January 2010 to December 2015. Patients in our analysis received 90% of dialysis treatments either before or after 8:30 a.m., were negative for HB antigen, and received a complete series of HB vaccination (Engerix B® or Recombivax HB™). Univariate and multivariate regression models examined whether dialysis start time is a predictor of HB vaccination response. <b><i>Results:</i></b> Patients were 65 years old, 57% male, and had a HD vintage of 10 months. Patients whose dialysis treatments started before 8:30 a.m. were more likely to be younger, male, and have a greater dialysis vintage. Patients receiving Engerix B® and starting dialysis before 8:30 a.m. had a significantly higher seroconversion rate compared to patients who started dialysis after 8:30 a.m. Early dialysis start was a significant predictor of seroconversion in univariate and multivariate regression including male gender, but not in multivariate regression including age, neutrophil-to-lymphocyte ratio, and vintage. <b><i>Conclusion:</i></b> While better sleep following vaccination is associated with seroconversion in the general population, this is not the case in hemodialysis patients after multivariate adjustment. In the context of end-stage kidney disease, early dialysis start is not a significant predictor of HB vaccination response. The association between objectively measured postvaccination sleep duration and seroconversion rate should be investigated.

scholarly journals Immune Status of Cohort of Children Vaccinated against Hepatitis B Virus in Ekiti State over Ten Years after Incorporation into National Program on Immunization

2019 ◽  
pp. 1-8
Author(s):  
A. O. Ajayi ◽  
E. E. Emmanuel ◽  
I. O. Oluwayemi ◽  
A. Olu-Taiwo ◽  
M. S. Odimayo
Keyword(s):  
Hepatitis B ◽  
Seroconversion Rate ◽  
Sampling Technique ◽  
Objective Evaluation ◽  
Hbv Infection ◽  
Hepatitis B Vaccination ◽  
Cross Sectional ◽  
Female Ratio ◽  
Hbv Vaccination ◽  
The Impact

Background: Hepatitis B vaccine has been introduced in Nigeria for over a decade now, yet, data on sero-conversion status of the immunized cohort in the population are scarce. Such data are important for objective evaluation of the impact and effectiveness of the HBV vaccination program. This study therefore aims at determining the sero-conversion status and the prevalence of HBV infection among immunized cohort of children in Ekiti state, Nigeria. Methodology: This cross-sectional study was conducted across the three senatorial districts of Ekiti state, between October and December, 2017. A total of 441 children consisting of 226 males and 215 females (Male to female ratio= 1.1:1). Immunization was confirmed by immunization cards. Multistage sampling technique was used. Questionaire were administered after caregiver’s consent and assent from subjects, 2 to 5 mls of blood samples were then collected and tested for the various hepatitis B viral markers (HBeAg, HBeAb, HBcAb, HBsAb and HBsAg) using Hepatitis B combo kit manufactured by Innovita Biological Technology. Very low levels antibody titres which may not be detectable by qualitative detection method used is a limitation to this study. Results: Subjects were between 5 to 10 years. All subjects had 3 full doses of hepatitis B vaccination before the age of 1 year and all subjects were negative for HBsAg, HBeAg, HBeAB and HBcAb. However, only 47 (10.7%) had detectable HBsAb. Among HBsAb positive patients 22 were males while 25 were females. Our findings showed zero prevalence of hepatitis B but minimal seroconversion rate among vaccinated children in Ekiti state, Nigeria. Conclusion: Hepatitis B vaccination protects children against HBV in the study population. However, seroconversion rate showed that majority of the children may be at risk of HBV infection at a later age. We recommend a booster dose of HBV vaccination.

scholarly journals Hepatitis B status in hemodialysis patients

2017 ◽  
Vol 54 (4) ◽  
pp. 356-358 ◽  
Author(s):  
Maia Nogueira Crown GUIMARÃES ◽  
Tila FACINCANI ◽  
Sigrid De Sousa dos SANTOS
Keyword(s):  
Hepatitis B ◽  
Adverse Effects ◽  
Seroconversion Rate ◽  
Hemodialysis Patients ◽  
Vaccination Status ◽  
Hepatitis B Vaccination ◽  
Occult Hbv Infection ◽  
Cross Sectional ◽  
Hbv Vaccine ◽  
Occult Hbv

ABSTRACT BACKGROUND: Patients on chronic dialysis present a high prevalence of hepatitis B virus infection. Despite infection-control practices, surveillance of serological markers, and hepatitis B vaccination, there are still outbreaks of the disease in dialysis centers. OBJECTIVE: This study aims to assess the serologic and vaccination status for hepatitis B in hemodialysis patients. METHODS: This cross-sectional study assessed serologic markers and hepatitis B vaccination status of chronic kidney disease patients on regular dialysis program in São Carlos, SP, Brazil. Patients without information about hepatitis B status (anti-HBc, HBsAg and anti-HBs) were referred for testing. Individuals with uncertain or incomplete immunization status and without serological conversion (anti-HBs <10mIU/mL) were referred to vaccination, with adverse effects monitored. RESULTS: The study included 130 from a total of 181 dialysis patients. The majority were male (63.8%), mean age 53.9 years. All patients were already screened and negative for HBsAg, and 73.8% were vaccinated against hepatitis B (59.2% complete and 14.6% incomplete schedule), with a seroconversion rate of 75.3%. Only 11 (8.5%) patients had prior dosage of anti-HBc (negative). Among the 47 patients referred for anti-HBc testing, four were anti-HBc positive and one indeterminate. Of the total of patients referred to immunization, 34 have actually received HBV vaccine; among them five had mild adverse effects. CONCLUSION: Despite the benefit of dosing of anti-HBc and anti-HBs before admission to dialysis, economic constraints have reduced the screening to only HBsAg. Since occult HBV infection has already been demonstrated in hemodialysis patients, the measure of anti-HBc should be encouraged.

MODELING THE IMPACT OF AWARENESS CREATED BY MEDIA CAMPAIGNS ON VACCINATION COVERAGE IN A VARIABLE POPULATION

2014 ◽  
Vol 22 (02) ◽  
pp. 249-270 ◽  
Author(s):  
ANUPAMA SHARMA ◽  
A. K. MISRA
Keyword(s):  
Hepatitis B ◽  
Vaccination Coverage ◽  
Total Population ◽  
Hepatitis B Vaccination ◽  
Preventive Strategy ◽  
Successful Implementation ◽  
Global Public Health ◽  
Media Campaigns ◽  
Model Stability ◽  
The Impact

Vaccines are a core component of any preventive strategy designed to ensure the global public health. A major factor influencing the successful implementation of any immunization program is awareness and public acceptance of the vaccine. The present study focuses on potential impacts of awareness created by media campaigns on vaccination coverage of hepatitis B. In this paper, a SIR model with vital dynamics in a population of varying size is investigated, which couples hepatitis B vaccination and awareness created by media within a single framework. It is assumed that media campaigns propagate awareness about measures requisite for escaping the chances of contracting hepatitis B. The awareness created by media motivates people to get vaccinated and attain full immunization against hepatitis B virus. For analyzing the model, stability theory of differential equations is employed. First, equilibria of the system comprising fractions of the population are obtained and their stability behavior is discussed. Then the asymptotic behavior of total population is discussed in detail. Three threshold parameters R0, R1and R2governing the dynamics of infection and total population are also affirmed. The findings of numerical simulations are also in line with analytically obtained results.

Effect of Oral Levamisole Supplementation to Hepatitis B Vaccination on the Rate of Immune Response in Chronic Hemodialysis Patients

Nephron ◽  
2000 ◽  
Vol 84 (3) ◽  
pp. 291-292 ◽  
Author(s):  
M. Deniz Ayli ◽  
Cüneyt Ensari ◽  
Meltem Ayli ◽  
Fahri Mandiroglu ◽  
Suat Mut
Keyword(s):  
Immune Response ◽  
Hepatitis B ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Hepatitis B Vaccination

scholarly journals Impact of hepatitis B vaccine in Tunisia 20 years after its introduction

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
A Lahchaichi ◽  
M Ben Hadj ◽  
H Bouguerra ◽  
K Talmoudi ◽  
A Bahrini ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Vaccination Coverage ◽  
Vaccine Effectiveness ◽  
Coverage Rate ◽  
Hbv Infection ◽  
Hepatitis B Vaccination ◽  
Reference Laboratory ◽  
Test Results ◽  
Vaccination Coverage Rate ◽  
The Impact

Abstract Introduction Vaccination against hepatitis B represents the most effective preventive measure to reduce the global impact of this infection. In Tunisia hepatitis B vaccination was introduced for health professionals in 1992 and for the general population in 1995. The objectives of this study were to evaluate the impact of vaccination twenty years after its introduction. Methods It was a descriptive study of data provided by the national survey of prevalence of Hepatitis B in Tunisia, which was a household-based study conducted in 2015. Blood samples sent to the reference laboratory to test markers of hepatitis B virus infection. The Vaccine effectiveness rate was calculated using the following formula: VE = 1 - Odds-ratio (OR), where OR = ratio of odds of being vaccinated among subjects with positive HBsAg test results to the odds of being vaccinated among subjects with negative HBsAg test results. Results Approximately a quarter of our population reported having been vaccinated against HBV, a coverage rate of 26.9%. Among subjects above 20 years of age, this rate was 85.3%. Besides, 83.7% of vaccinated subjects had received the three required doses of the HBV vaccine. Analysis of vaccination status by great regions of the country showed that the vaccination coverage rate was higher in the southern region. Regarding HBsAg prevalence, the rate was significantly higher among unvaccinated subjects 0.3% vs 2.2% in those vaccinated (OR = 0.11 [0.07-0.18]). We found that among vaccinated subjects, the serologic response rate at vaccination was only 63.2% which represented 16.2% of the total population. The vaccine effectiveness indicated that vaccination reduced by 88.6% the risk of HBV infection. Conclusions These results demonstrate that vaccination against hepatitis B introduced in the national immunization schedule since 1995 has reduced the infection although the vaccination coverage rate remains below 90%. Key messages Importance of vaccination that reduced by 88.6% the risk of HBV infection. More effort required to raise awareness about vaccination against HBV.

scholarly journals 77 Late results of hepatitis B vaccination in hemodialysis patients

2006 ◽  
Vol 10 ◽  
pp. S43
Author(s):  
M. Zubkin ◽  
E. Balakirev ◽  
V. Chervinko ◽  
F. Baranova ◽  
V. Taranov ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Late Results ◽  
Hemodialysis Patients ◽  
Hepatitis B Vaccination
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