scholarly journals Impact of SARS-CoV-2 Infection on patients suffering from Liver Injury

2020 ◽  
Author(s):  
Ashish Kumar Vyas ◽  
Anirudh Singh
Keyword(s):  
Liver Injury ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Recent Article ◽  
Multiple Organ ◽  
Severe Liver ◽  
Vascular Events

With great interest, we have read the recent article by Olympia E. Anastasioua et al(1), wherein the authors described the effect of SARS-CoV-2 infection on mortality in patients suffering from Mild or severe liver injury. They demonstrated that while the mild liver injury was not associated with worse outcomes in their cohort, a cohort with severe liver injury showed multiple-organ failure and acute vascular events leading to higher mortality(1).

scholarly journals Hypoinsulinemic hypoglycemia triggered by liver injury in elderly subjects with low body weight: case reports

2018 ◽  
Vol 2018 ◽  
Author(s):  
Takatoshi Anno ◽  
Hideaki Kaneto ◽  
Ryo Shigemoto ◽  
Fumiko Kawasaki ◽  
Yasuhiro Kawai ◽  
...  
Keyword(s):  
Body Weight ◽  
Clinical Practice ◽  
Liver Injury ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Liver Glycogen ◽  
Multiple Organ ◽  
Hypoglycemic Agents ◽  
Elderly Subjects ◽  
Severe Liver

Summary Hypoglycemia is induced by many causes, especially over-dose of insulin or oral hypoglycemic agents in diabetic subjects. In such a case, hyperinsulinemic hypoglycemia is usually observed. On the other hand, it is important to classify secondary hypoglycemia and hypoinsulinemic hypoglycemia. Liver injury-induced hypoglycemia is one of the causes of hypoinsulinemic hypoglycemia but rarely observed in clinical practice. Herein, we experienced similar 2 cases of non-diabetic hypoinsulinemic hypoglycemia. Both of them were elderly subjects with low body weight. Furthermore, it is likely that hypoinsulinemic hypoglycemia in both subjects was triggered by severe liver injury, at least in part, due to possible limited liver glycogen store. In elderly subjects with low body weight and/or malnutrition, metabolism in the liver is reduced and glycogen accumulation is decreased. Such alteration brings out acute and marked liver injury, which finally leads to the onset of severe hypoglycemia. It is known that not only liver injury but also multiple organ failure could be induced due to extreme emaciation in subjects. It is likely that in elderly subjects with low body weight and/or malnutrition, multiple organ failure including liver failure could be induced due to the similar reason. Therefore, we should be very careful of such subjects in order to avoid the development of multiple organ failure which leads to life-threatening situations. In conclusion, we should keep in mind the possibility of hypoinsulinemic hypoglycemia when we examine severe liver injury, especially in elderly or starving subjects with low body weight and limited liver glycogen stores. Learning points: It is important to classify secondary hypoglycemia and hypoinsulinemic hypoglycemia. Liver injury-induced hypoglycemia is one of the causes of hypoinsulinemic hypoglycemia but rarely observed in everyday clinical practice. Herein, we reported similar 2 cases of hypoinsulinemic hypoglycemia without diabetes presumably triggered by severe liver injury. In both cases, hypoglycemia was improved by glucose infusion, although their liver injury was not improved. We should keep in mind the possibility of hypoinsulinemic hypoglycemia when we examine severe liver injury, especially in elderly subjects with low body weight.

scholarly journals Toll-Like Receptor Ligand-Induced Liver Injury in D-Galactosamine-Sensitized Mice: Differences between TLR7/8 and TLR9 Ligands, Cytokine Patterns, and Cross-Tolerance Induction by TLR2 Ligand Pretreatment

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Reiko Seki
Keyword(s):  
Liver Injury ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Tolerance Induction ◽  
Serum Levels ◽  
Multiple Organ ◽  
Toll Like Receptor ◽  
Cross Tolerance ◽  
Cpg Dna ◽  
Tlr2 Ligand

Administration of Toll-like receptor ligands (TLRLs) is known to cause liver injury in D-galN-sensitized mice. In the present study, we aimed to complement preceding reports on the TLRL/D-galN system by analyzing comparisons among TLRLs, mouse strain dependence, effects on serum levels of cytokines, and effects of sequential administrations of different TLRLs. In a preliminary set of analyses, we first confirmed that liver failure can be induced by diverse TLRLs, including LTA and R848 in combination with D-galN. Analysis using TLR4-deficient mice excluded potential confounding effects of endogenous TLR4Ls that include those referred to as DAMPs in CpG DNA/D-galN hepatotoxicity. Subsequently, we showed that LTA pretreatment could prevent mortality in both CpG DNA/D-galN- and R848/D-galN-treated mice compared to without pretreatment. Incidentally, we observed that without the LTA pretreatment, CpG DNA/D-galN showed relatively higher liver-specific toxicity whereas R848/D-galN showed more symptoms of multiple organ failure. These findings suggest that, in D-galN-sensitized mice, different TLRLs not only show similarity in the ability to induce hepatic injury but also exhibit distinctive abilities in inducing systemic inflammation and multiple organ failure. These findings also suggest the potential usefulness of cross-tolerance induction using LTA in the prevention of organ failure in TLRL-mediated acute inflammation.

Bongkrekic acid poisoning: Severe liver function damage combined with multiple organ failure caused by eating spoiled food

2019 ◽  
Vol 41 ◽  
pp. 101622 ◽  
Author(s):  
Ruijuan Shi ◽  
Chaoyang Long ◽  
Yunda Dai ◽  
Qiong Huang ◽  
Yuzhen Gao ◽  
...  
Keyword(s):  
Liver Function ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
Severe Liver ◽  
Bongkrekic Acid

Clinical case of periostitis in pregnant women complicated by sepsis

2020 ◽  
pp. 61-63
Author(s):  
S. Sh. Kakvaeva ◽  
M. A. Magomedova ◽  
A. N. Dzhalilova
Keyword(s):  
Pregnant Woman ◽  
Multiple Organ Failure ◽  
Pregnant Women ◽  
Organ Failure ◽  
Clinical Case ◽  
Clinical Observation ◽  
Infectious Agent ◽  
Modern Medicine ◽  
Multiple Organ ◽  
Number Of Patients

One of the most serious problems of modern medicine is sepsis. The number of patients undergoing this complication is 20–30 million (WHO) annually and has no tendency to decrease. Sepsis is characterized by severe multiple organ failure due to a violation of the response of the macroorganism to an infectious agent. Moreover, it is dangerous with high mortality. Sepsis often develops in patients with immunodeficiency conditions, which primarily include pregnant women. The article presents a clinical observation of a case of periostitis in a pregnant woman complicated by a septic state.

scholarly journals High-dose diquat poisoning: a case report

2021 ◽  
Vol 49 (6) ◽  
pp. 030006052110261
Author(s):  
Yanxia Huang ◽  
Renjing Zhang ◽  
Mei Meng ◽  
Dechang Chen ◽  
Yunxin Deng
Keyword(s):  
Renal Failure ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
High Dose ◽  
Severe Respiratory Failure ◽  
Aggressive Treatment ◽  
Lung Lesions ◽  
Pulmonary Lesions ◽  
New Treatment

Diquat is a widely used herbicide that is substituted for paraquat. With paraquat off the market, cases of diquat poisoning have been gradually increasing. The kidney is the most frequently impaired organ in diquat poisoning. Few cases of multiple organ failure caused by diquat have been reported. We herein describe a 30-year-old man who orally ingested about 160 mL of enriched diquat. Despite aggressive treatment, the patient’s condition progressed to multiple organ failure and death. The pulmonary lesions in this patient were different from those previously reported. This patient did not die of renal failure but of severe respiratory failure. He exhibited three different stages of pulmonary disease. The lung lesions in this case were unique. We hope that doctors will pay more attention to the lung lesions in patients with diquat poisoning in future and find new treatment methods to save the lives of such patients.

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