scholarly journals Subacute Thyroiditis in COVID-19 Patients

2020 ◽  
pp. 1-3
Author(s):  
Saeed Sohrabpour ◽  
Farrokh Heidari ◽  
Ebrahim Karimi ◽  
Reza Ansari ◽  
Ardavan Tajdini ◽  
...  
Keyword(s):  
Respiratory Illness ◽  
Subacute Thyroiditis ◽  
Imaging Data ◽  
Endocrine Glands ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
History Of ◽  
De Quervain ◽  
Novel Coronavirus ◽  
De Quervain Thyroiditis

<b><i>Introduction:</i></b> Since December 2019, novel coronavirus (COVID-19) infection has been identified as the cause of an outbreak of respiratory illness in Wuhan, China. The classic presentation of COVID-19 infection was described as fever, myalgia, cough, and fatigue. Whether coronavirus can directly attack the endocrine glands is unclear. <b><i>Objective:</i></b> Post-viral subacute thyroiditis (SAT, de Quervain thyroiditis) has been reported following other viral infection. A limited number of SAT after COVID-19 infection have been reported up to now. <b><i>Methods:</i></b> Here, we reported 6 patients with SAT and positive COVID-19 serology tests. Demographic, clinical, biochemical, and imaging data were presented. <b><i>Results:</i></b> In this study, 6 patients (4 women and 2 men) with clinician manifestations and physical examination in favor of SAT were described. Cervical ultrasonography showed bilateral hypoechoic areas in the thyroid gland which was suggestive of SAT. Elevated C-reactive protein, erythrocyte sedimentation rate, free thyroxine, free tri-iodothyronine, and undetectable thyrotropin were found in laboratory evaluations. Both IgM and IgG were positive for COVID-19 infection, but the PCR tests were negative in all patients. Patients had history of working in a COVID center and/or family member hospitalized due to COVID-19 pneumonia. Patients were followed up for 1 month and were treated effectively with steroids. <b><i>Conclusion:</i></b> This report may help physicians to identify lesser-known manifestations and complications of COVID-19. Early diagnosis of COVID-19 infection results in the prevention of further transmission.

scholarly journals SUB-ACUTE THYROIDITIS: ESR AS DIAGNOSTIC MARKER AND OPTIMUM DURATION OF PREDNISOLONE THERAPY

1969 ◽  
Vol 5 (1) ◽  
pp. 582-585
Author(s):  
ASADULLAH ◽  
MAHID IQBAL ◽  
IZAZ UR RAHMAN ◽  
S.M.NAEEM ◽  
IQBAL AHMAD
Keyword(s):  
Thyroid Gland ◽  
Steroid Therapy ◽  
Subacute Thyroiditis ◽  
Blood Picture ◽  
High Grade Fever ◽  
Prednisolone Therapy ◽  
History Of ◽  
De Quervain ◽  
De Quervain Thyroiditis ◽  
Acute Thyroiditis

BACKGROUND: Thyroiditis is an inflammation of the thyroid gland that can arise due to a variety ofcauses. Subacute thyroiditis or de Quervain thyroiditis is comparatively uncommon with recurrence rateof 5% patients over a 20-year period. It usually presents in the form of epidemics and mostly hasoverlapping symptoms, which leads to misdiagnosis.OBJECTIVE: To study sub-acute thyroiditis with the risks and benefits of treatment and consequencesof non treatment.PATIENTS AND METHODS: The study was conducted on seventy (70) patients who visited forconsultancy during April 2014 to May 2015. Their mean age was 37 years, having 28 male 42 females.Those who presented with symptoms of pain in front of neck, unilateral or bilateral, periodic generalizedbody aches, without having history of high grade fever, were included in the study after taking theirconsent. ESR, TFTs and complete blood picture of those having mildly enlarged or not palpable,painful and tender thyroid were done and recorded. They were divided into various groups for steroidtherapy. The patients were selected randomly.RESULTS: All the seventy patients having symptoms, suggestive of thyrioditis had markedly raisedESR with normal TFTs range and rest of the blood picture, were put on 40-45mg/day with tapering dosefor two to six weeks. Those who were put on six weeks steroid therapy had no recurrence, where asthose with duration less than six weeks time suffered from recurrence of symptoms.CONCLUSION: Subacute thyroditis presented with generalized bodyach and tender thyroid gland withraised ESR, when treated with 40-45mg/day prednisolone therapy for six weeks responded significantly.KEY WORDS: Thyroiditis, Subacute thyroiditis, Erythrocyte sedimentation rate, Steroid therapy.

De Quervain thyroiditis. Corner points of the diagnosis

2014 ◽  
Vol 155 (17) ◽  
pp. 676-680 ◽  
Author(s):  
Roland Oláh ◽  
Péter Hajós ◽  
Zsuzsanna Soós ◽  
Gábor Winkler
Keyword(s):  
Needle Aspiration ◽  
Clinical Feature ◽  
Special Treatment ◽  
Reactive Protein ◽  
Viral Respiratory Infection ◽  
History Of ◽  
De Quervain ◽  
Needle Aspiration Cytology ◽  
Destructive Inflammation ◽  
De Quervain Thyroiditis

Inflammatory disorders of the thyroid gland are divided into three groups according to their duration (acute, subacute and chronic). De Quervain’s thyroiditis (also termed giant cell or granulomatous thyroiditis) is a subacute inflammation of the thyroid, which accounts for 5% of thyroid disorders. The etiology is unknown, it usually appears two weeks after an upper viral respiratory infection. The clinical feature includes neck pain, which is aggraviated during swallowing, and radiates to the ear. On palpation, the thyroid is exquisitely tender. The erythrocyte sedimentation rate is markedly elevated, the leukocyte count, C-reactive protein are normal or slightly elevated. The natural history of granulomatous thyroiditis involves four phases: the destructive inflammation results temporarily in hyperthyroidism followed by euthyroidism. After a transient hypothyroidism the disease becomes inactive and the thyroid function is normalised. Ultrasonographic findings are diffuse hypoechogenic structures, but nodules may also occur. The disease often remains unrecognised, or the first phase of the disease is diagnosed and treated as hyperthyroidism. The diagnosis can be confirmed by the presence of the thyroid autoantibodies, radioiodine uptake and fine needle aspiration cytology. There is no special treatment, non-steroid anti-inflammatory drugs or steroid should be given to relieve the pain. The aim of the authors is to shed light the key points of diagnosis and differential diagnosis by the presentation of four slightly different cases. Orv. Hetil., 2014, 155(17), 676–680.

scholarly journals EXPRESS: Serum biomarkers for prediction of mortality in patients with COVID-19

2021 ◽  
pp. 000456322110142
Author(s):  
Rohit S Loomba ◽  
Enrique G Villarreal ◽  
Juan S Farias ◽  
Gaurav Aggarwal ◽  
Saurabh Aggarwal ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Hepatic Function ◽  
Pooled Analysis ◽  
Cardiac Biomarkers ◽  
Limited Information ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Prediction Of Mortality ◽  
Novel Coronavirus

Background There is limited information regarding the role of biomarker levels at predicting mortality in patients with the novel coronavirus pandemic (Covid-19). The purpose of this study is to determine the differences in serum biomarker levels in adults with Covid-19 who survived hospitalization from those who did not. Methods A comprehensive search was completed on PubMed, EMBASE, and Cochrane libraries to identify studies of interest. Endpoints of interest were blood counts, hepatic function test, acute phase reactants, cytokines and cardiac biomarkers. Results A total of 10 studies with 1,584 patients were included in the pooled analyses. Biomarkers that were noted to be significantly higher in those who died from Covid-19 (coronavirus disease 2019) included: white blood cell count, neutrophil count, C-reactive protein, high sensitivity C-reactive protein, procalcitonin, ferritin, D-dimer, interleukins 6, lactate dehydrogenase, creatine kinase, prothrombin time, aspartate aminotransferase, alanine aminotransferase, total bilirubin, and creatinine. Lymphocyte count, platelet count, and albumin were significantly lower in patients who died. Conclusion This pooled analysis of 10 studies including 1,584 patients identified significant differences in biomarkers on admission in patients who survived from those who did not. Further research is needed to develop risk stratification models to help with judicious use of limited healthcare resources.

A Comparison Between Two Imaging Techniques for the Diagnosis of Subacute Thyroiditis (De Quervain Thyroiditis)

2010 ◽  
Vol 35 (11) ◽  
pp. 862-864 ◽  
Author(s):  
Patricio González Espinoza ◽  
Claudio Liberman Guendelman ◽  
Lidya Nieves Quevedo Limón ◽  
Rodrigo Jaimovich Fernández
Keyword(s):  
Imaging Techniques ◽  
Subacute Thyroiditis ◽  
De Quervain ◽  
De Quervain Thyroiditis

scholarly journals Chondrosternal Arthritis in Infant: An Unusual Entity

2014 ◽  
Vol 2014 ◽  
pp. 1-4
Author(s):  
Athina Nikolarakou ◽  
Dana Dumitriu ◽  
Pierre-Louis Docquier
Keyword(s):  
Clinical Symptoms ◽  
Therapeutic Option ◽  
White Blood Cells ◽  
Laboratory Data ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
History Of ◽  
Local Tenderness ◽  
Wait And See

Primary arthritis of chondrosternal joint is very rare and occurs in infants less than 18 months of age. Presentation is most often subacute but may be acute. Child presents with a parasternal mass with history of fever and/or local signs of infection. Clinical symptoms vary from a painless noninflammatory to a painful mass with local tenderness and swelling, while fever may be absent. Laboratory data show low or marginally raised levels of white blood cells and C-reactive protein, reflecting, respectively, the subacute or acute character of the infection. It is a self-limiting affection due to the adequate immune response of the patient. Evolution is generally good without antibiotherapy with a progressive spontaneous healing. A wait-and-see approach with close follow-up in the first weeks is the best therapeutic option.

scholarly journals Synchronous cytomegalovirus infection in a newly diagnosed ulcerative colitis patient

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Jin Yu Chieng ◽  
Yasotha Sugumaran ◽  
Sellymiah Adzman ◽  
Pan Yan
Keyword(s):  
Ulcerative Colitis ◽  
Medical Illness ◽  
C Reactive Protein ◽  
Colitis Patient ◽  
Intravenous Ganciclovir ◽  
Reactive Protein ◽  
Chronic Medical Illness ◽  
History Of ◽  
Cmv Colitis

A 61-year-old Punjabi female patient presented with six months history of mild abdominal discomfort with bloody diarrhea. She did not have underlying chronic medical illness; she neither took steroid nor immunosuppressant. She was found anemic, thrombocytosis, and elevated C-reactive protein. Colonoscopy showed moderate left sided colitis, with histopathology evidence of ulcerative colitis (UC) with cytomegalovirus (CMV) infection. Her serum anti-CMV IgM antibody was detected. She was treated with intravenous ganciclovir, together with 5-ASA and tapering dose of steroid. Anemia was corrected. Subsequent clinic reviews and follow up endoscopies showed dramatically improvement. CMV colitis should be considered for the patients presenting with moderate to severe UC. Early prescription of antiviral would be beneficial in the treatment of flare of UC.

scholarly journals Retrospective analysis of the clinical features of outpatients with novel coronavirus in areas outside Wuhan, China

2020 ◽  
Author(s):  
Yong-Tao Li ◽  
Mei-Lian Peng ◽  
Jia-dan Fu ◽  
Li Liu ◽  
Yong-zheng Guo ◽  
...  
Keyword(s):  
Pathogen Detection ◽  
Clinical Performance ◽  
The Novel ◽  
C Reactive Protein ◽  
Early Screening ◽  
Reactive Protein ◽  
Ct Findings ◽  
Epidemic Area ◽  
Novel Coronavirus ◽  
Lung Ct

Abstract Objective: The novel coronavirus pneumonia (COVID-19) has spread rapidly across the globe with the movement of people. How to diagnose COVID-19 quickly and accurately is a concern for all. We retrospectively assessed the clinical characteristics of patients with COVID-19 detected by outpatient screening in areas outside Wuhan, China, to guide early screening outside the epidemic area, to isolate and treat COVID-19-positive patients, and to control the spread of this virus in the region.Results: Among the 213 patients treated in the fever clinic of our hospital, 41 tested positive for novel coronavirus (2019-nCoV) and 172 were negative. Among the positive patients, 13 (31.7%) of the patients had been to Wuhan, while 28 (68.3%) had not been to Wuhan. There were 4 cases of clustering occurrence. The main symptoms exhibited by COVID-19-positive patients were fever (87.8%), cough (68.3%), and expectoration (34.1%). The C-reactive protein (CRP) levels were increased in 35 (85.3%) positive patients; the hydroxybutyrate dehydrogenase in the myocardial zymogram was increased in 22 positive patients (53.6%) and 38 negative patients (22.1%); computed tomography (CT) findings revealed lung lesions in all 41 positive patients (100%).Conclusion: We classified the patient population and analyzed the data to understand the early clinical performance of COVID-19. Our research illustrate that screening for COVID-19 outside Wuhan should focus on early symptoms such as fever and cough, in combination with lung CT findings, epidemiological history, and sputum pathogen detection to determine whether patients need further isolation.

scholarly journals The impact of COVID-19 pandemic on the treatment of acute appendicitis in China

2021 ◽  
Author(s):  
ZhiXue Zheng ◽  
Jing Tao Bi ◽  
Ya Qi Liu ◽  
Xuan Cai
Keyword(s):  
Acute Appendicitis ◽  
White Blood Cells ◽  
Onset Time ◽  
The Novel ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Number Of Patients ◽  
Hospital Visits ◽  
Novel Coronavirus ◽  
The Impact

Abstract Objective This research aims to analyze the impact of the novel coronavirus pandemic on the hospital visits of patients with acute appendicitis. Methods The retrospective analysis was designed to look at the treatment of acute appendicitis in the Department of General Surgery in Beijing Jishuitan Hospital before and during the COVID-19 pandemic (2019–2020). Data was analyzed by the numbers of patients, sex, age, onset time, fever or not, laboratory examination, imaging test, and treatment. And we analyzed the differences between the “pre-COVID group” and “during-COVID group”. Results Compared with the year 2019, the number of acute appendicitis patients has diminished substantially during the COVID-19 pandemic (2020), but the number elevated with the control of the pandemic. Even if we did not find the differences of the treatment before and during the pandemic (P = 0.932), the onset time to emergency was significantly longer (P < 0.001), and more patients had showed fever (P < 0.001) during the COVID-19 pandemic. And the total number of white blood cells and C reactive protein level were significantly higher in 2020 than those in 2019 (P = 0.006, 0.003). And the same result was found in patients with appendiceal fecalith (P = 0.047). Conclusion During the pandemic of the new coronavirus pneumonia, the number of patients with acute appendix treatment dropped significantly, mainly because it took longer than before, and the condition was more severe. It can be seen that the new coronary pneumonia has a great impact on the patients’ medical treatment behavior, and the active prevention and treatment of the new coronavirus pneumonia is currently an important and urgent issue.

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