Theta-Burst Stimulation Is Able to Impact Cognitive Processing: A P300 and Neuropsychological Test Study

2021 ◽  
pp. 1-11
Author(s):  
Nuno Filipe Cardoso Pinto ◽  
Marta Duarte ◽  
Helena Gonçalves ◽  
Ricardo Silva ◽  
Jorge Gama ◽  
...  
Keyword(s):  
Neuropsychological Tests ◽  
Group Performance ◽  
Event Related Potentials ◽  
Outcome Evaluation ◽  
Controlled Study ◽  
Oddball Paradigm ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Related Potentials ◽  
Theta Burst

<b><i>Introduction:</i></b> Theta-burst stimulation (TBS) is a safe non-invasive neurostimulation technique used to improve cognitive and neuropsychiatric impairments. Combined outcome evaluation using event-related potentials (ERPs) and neuropsychological tests may allow a more thorough assessment of TBS treatment efficacy; however, some mixed results have been found, and their use remains scarce. Our main objective was to evaluate whether a session of TBS to the left dorsolateral prefrontal cortex (DLPFC) can impact upon the performance of both neuropsychological and neurophysiological tests. <b><i>Methods:</i></b> This double-blind sham-controlled study involved 28 healthy adults, between 18 and 30 years. Volunteers were randomly allocated to receive excitatory (intermittent [iTBS]), inhibitory (continuous TBS [cTBS]) or sham stimulation on the left DLPFC. Subjects were evaluated using ERPs (auditory oddball paradigm P300) and neuropsychological tests (Trail making test [TMT] and Stroop test of words and colours [STWC]), using a pre-post stimulation protocol. <b><i>Results:</i></b> Inhibitory stimulation led to significantly delayed P300 peak latencies (<i>p</i> &#x3c; 0.001), with no consistent change in N2P3 amplitudes. cTBS also significantly influenced the expected group performance in Stroop C and Stroop interference (<i>p</i> = 0.025) compared to the iTBS and sham groups. No significant results were found in TMT tests after TBS. <b><i>Conclusion:</i></b> Our results suggest that P300 and specific Stroop colour and words test parameters can be similarly influenced by the same TBS protocol. This emphasizes the importance of mixed evaluation using neuropsychological and neurophysiological resources in research associated with the use of transcranial magnetic stimulation and cognition.

scholarly journals Effect of Anodal-tDCS on Event-Related Potentials: A Controlled Study

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Ahmed Izzidien ◽  
Sriharasha Ramaraju ◽  
Mohammed Ali Roula ◽  
Peter W. McCarthy
Keyword(s):  
Parietal Lobe ◽  
Event Related Potentials ◽  
Controlled Study ◽  
Oddball Paradigm ◽  
Anodal Tdcs ◽  
Neurologically Impaired ◽  
Double Blind ◽  
Significant Difference ◽  
Related Potentials ◽  
The Difference

We aim to measure the postintervention effects of A-tDCS (anodal-tDCS) on brain potentials commonly used in BCI applications, namely, Event-Related Desynchronization (ERD), Event-Related Synchronization (ERS), and P300. Ten subjects were given sham and 1.5 mA A-tDCS for 15 minutes on two separate experiments in a double-blind, randomized order. Postintervention EEG was recorded while subjects were asked to perform a spelling task based on the “oddball paradigm” while P300 power was measured. Additionally, ERD and ERS were measured while subjects performed mental motor imagery tasks. ANOVA results showed that the absolute P300 power exhibited a statistically significant difference between sham and A-tDCS when measured over channel Pz (p=0.0002). However, the difference in ERD and ERS power was found to be statistically insignificant, in controversion of the the mainstay of the litrature on the subject. The outcomes confirm the possible postintervention effect of tDCS on the P300 response. Heightening P300 response using A-tDCS may help improve the accuracy of P300 spellers for neurologically impaired subjects. Additionally, it may help the development of neurorehabilitation methods targeting the parietal lobe.

Inhibitory theta burst stimulation of affected hemisphere in chronic stroke: A proof of principle, sham-controlled study

2013 ◽  
Vol 553 ◽  
pp. 148-152 ◽  
Author(s):  
Vincenzo Di Lazzaro ◽  
John C. Rothwell ◽  
Penelope Talelli ◽  
Fioravante Capone ◽  
Federico Ranieri ◽  
...  
Keyword(s):  
Chronic Stroke ◽  
Controlled Study ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst ◽  
Proof Of Principle ◽  
Stimulation Of

scholarly journals Reversed Effects of Intermittent Theta Burst Stimulation following Motor Training That Vary as a Function of Training-Induced Changes in Corticospinal Excitability

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Tino Stöckel ◽  
Jeffery J. Summers ◽  
Mark R. Hinder
Keyword(s):  
Motor Learning ◽  
Sham Group ◽  
Group Performance ◽  
Motor Task ◽  
Corticospinal Excitability ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Before And After ◽  
And Performance ◽  
Theta Burst

Intermittent theta burst stimulation (iTBS) has the potential to enhance corticospinal excitability (CSE) and subsequent motor learning. However, the effects of iTBS following motor learning are unknown. The purpose of the present study was to explore the effect of iTBS on CSE and performance following motor learning. Therefore twenty-four healthy participants practiced a ballistic motor task for a total of 150 movements. iTBS was subsequently applied to the trained motor cortex (STIM group) or the vertex (SHAM group). Performance and CSE were assessed before motor learning and before and after iTBS. Training significantly increased performance and CSE in both groups. In STIM group participants, subsequent iTBS significantly reduced motor performance with smaller reductions in CSE. CSE changes as a result of motor learning were negatively correlated with both the CSE changes and performance changes as a result of iTBS. No significant effects of iTBS were found for SHAM group participants. We conclude that iTBS has the potential to degrade prior motor learning as a function of training-induced CSE changes. That means the expected LTP-like effects of iTBS are reversed following motor learning.

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