Baked Tolerance in Cow’s Milk Allergy: Quite Frequent, Hard to Predict!

2020 ◽  
pp. 1-5
Author(s):  
Lisis Karine Vilar ◽  
Flávia Alves Araújo ◽  
Thalita Pereira Santos ◽  
Thatiana Tavares Menezes ◽  
Marina F. Cheik ◽  
...  
Keyword(s):  
Food Challenge ◽  
Specific Ige ◽  
Cross Sectional Study ◽  
Cow’S Milk ◽  
Cross Sectional ◽  
Prick Test ◽  
Cow's Milk ◽  
Baked Goods ◽  
Baked Foods ◽  
Baked Milk

<b><i>Introduction:</i></b> Cow’s milk protein allergy (CMA) is the most common type of food allergy in childhood and exclusion diet is a challenge for patients. <b><i>Objective:</i></b> The study aim was to investigate the frequency of tolerance to baked foods containing milk and evaluate immediate skin prick test (SPT) and specific IgEs for different cow’s milk (CM) protein types as predictors of tolerance to baked foods containing milk for CMA patients. <b><i>Methods:</i></b> A cross-sectional study was performed. Fifty-four CMA patients were enrolled and oral food challenge (OFC) was performed with baked product, 6 different milk SPTs and specific IgEs to CM, casein, α-lactalbumin, and β-lactoglobulin. <b><i>Results:</i></b> Thirty-nine (72.2%) patients tolerated OFC with baked milk cupcake. CM-specific IgE and casein SPT showed statistical difference between positive and negative OFC groups. Probability curves for baked milk tolerance were created for specific CM IgE (<i>Z</i> = 2.542, <i>p</i> &#x3c; 0.0110) and casein SPT (<i>Z</i> = 2.290, <i>p</i> &#x3c; 0.0220) using logistic regression. <b><i>Conclusions:</i></b> The high percentage of patients able to tolerate baked goods enables an improvement in intake possibilities and quality of life of CMA patients and families. Specific CM IgE and casein SPT demonstrated to be useful predictors in relation to baked milk tolerance.

scholarly journals Evaluation of some predictive parameters for baked milk tolerance in children with cow's milk allergy

2021 ◽  
Vol 49 (2) ◽  
pp. 53-59
Author(s):  
Mehmet Kilic ◽  
Lütfiye Çilkol ◽  
Erdal Taşkın
Keyword(s):  
Immunoglobulin E ◽  
Food Challenge ◽  
Cow’S Milk ◽  
Milk Products ◽  
Prick Test ◽  
Cow's Milk ◽  
Predictive Parameters ◽  
Decision Points ◽  
Ige Mediated ◽  
Baked Milk

Background: Inclusion of baked-milk products to the diet appears to markedly accelerate tolerance to unheated milk compared to a strict avoidance diet.Objective: The present study aims to investigate the predictors of baked-milk tolerance in children with Immunoglobulin E (IgE)-mediated cow’s milk (CM) allergy.Methods: The study included 80 patients diagnosed with IgE-mediated CM allergy upon oral food challenge (OFC) testing at our clinic. Patients who developed and did not develop reactions during OFC with baked milk were compared considering clinical and laboratory parameters.Results: Eighty patients with CM allergy comprised 48 male and 32 female infants with an average age of 7.25 ± 2.45 (3–13) months. We found that 62.5% of them showed tolerance to baked milk in the OFC test performed with cakes containing 2.6-g milk protein. When the patients who tolerated and could not tolerate baked-milk products were compared for test results, we detected a statistically significant intergroup difference regarding diameter of wheal in skin prick test (SPT) performed with muffin slurry, levels of specific Immunoglobulin E (sIgE) in CM, sheep’s milk (SM), goat’s milk (GM), casein, and the amount of unheated milk consumed until a reaction developed in the OFC test performed with unheated milk (P < 0.05).Conclusion: We defined novel decision points based on CM, SM, GM, casein sIgE levels, wheal diameter in SPT with muffin slurry, and the amount of milk ingested during OFC performed with unheated milk that may be useful in predicting outcomes of baked-milk ingestion.

scholarly journals Cow’s milk exposure and atopic dermatitis after six months of age

2017 ◽  
Vol 56 (6) ◽  
pp. 325
Author(s):  
Surya Jayanti Kadek ◽  
Dewi Kumara Wati Ketut ◽  
Karyana Putu Gede
Keyword(s):  
Atopic Dermatitis ◽  
Maternal Diet ◽  
Multiple Logistic Regression Analysis ◽  
Cross Sectional Study ◽  
Cow’S Milk ◽  
Milk Formula ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cow's Milk ◽  
Study Population

Background About 60% of individuals with atopic dermatitis (AD) develop their first manifestation during infancy. Cow’s milk (CM) exposure is considered to be a risk factor for AD.Objective To evaluate for an association between cow’s milk exposure and atopic dermatitis in infants > 6 months of age.  Methods This cross-sectional study consisted of subjects from a previous study and new subjects recruited in order to meet the minimum required number of subjects. Our study population comprised 120 infants, born between 1 February and 30 November, 2012 in Sanglah Hospital, Denpasar. Subjects were divided into CM and non-CM groups and analyzed for their risk of AD. Subjects were included to CM group if they were fed with cow’s milk/formula  and included to non-CM group if they were breastfeed exclusively in the first six months of life. Other possible risk factors were assessed by multivariate analysis. Results One hundred twenty subjects were enrolled and analyzed (59 in the CM and 61 in the non-CM groups). The prevalence of AD was 30%. Multiple logistic regression analysis revealed a significant association between CM exposure and AD, with odds ratio (OR) 2.37 (95%CI 1.036 to 5.420; P=0.04). In addition, maternal diet including eggs and/or cow’s milk during the breastfeeding period was significantly associated with AD in infants (OR 3.18; 95%CI 1.073 to 9.427; P=0.04).Conclusion Cow’s milk exposure is significantly associated with atopic dermatitis in infants  > six months of age. 

scholarly journals Milk and cow’s meat allergy in a child: A clinical case

2021 ◽  
Vol 29 (4) ◽  
Author(s):  
Maria Marques ◽  
◽  
Inês Falcão ◽  
Moisés Labrador-Horrillo ◽  
Helena Falcão ◽  
...  
Keyword(s):  
Bovine Serum Albumin ◽  
Serum Albumin ◽  
Bovine Serum ◽  
Milk Proteins ◽  
Food Challenge ◽  
Specific Ige ◽  
Oral Food Challenge ◽  
Cow’S Milk ◽  
Cow's Milk ◽  
Cow’S Milk Proteins

Allergy to bovine serum albumin is the main predictor of beef allergy associated with cow’s milk proteins allergy. We report a case of a 3-year-old child with cow’s milk proteins allergy since the age of 6 months who, after some ingestions of beef, developed episodes of irritability, urticaria and syncope. Specific IgE to beef, oral food challenge with medium rare cooked beef and specific IgE to bovine serum albumin were all positive, but an oral food challenge with well cooked beef was tolerated. Allergy to bovine serum albumin is not usually associated with severe reactions, since it is a thermolabile protein, however, the process of cooking meat may be insufficient to have an effect on the complex matrix of meat and associated serum albumins. The irregular pattern of the episodes and the previous diagnosis of cow’s milk proteins allergy may act as confounding factors leading to a delayed diagnosis.

The patch test, skin prick test, and serum milk-specific IgE as diagnostic tools in cow's milk allergy in infants

Allergy ◽  
1999 ◽  
Vol 54 (8) ◽  
pp. 837-842 ◽  
Author(s):  
T Vanto ◽  
A Koivikko ◽  
E Valovirta ◽  
K Juntunen-backman ◽  
T Klemola ◽  
...  
Keyword(s):  
Skin Prick Test ◽  
Patch Test ◽  
Specific Ige ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Diagnostic Tools ◽  
Milk Allergy ◽  
Prick Test ◽  
Cow's Milk ◽  
Cow's Milk Allergy

scholarly journals Dietary Determinants of Anemia in Children Aged 6–36 Months: A Cross-Sectional Study in Indonesia

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2397
Author(s):  
Diana Sunardi ◽  
Saptawati Bardosono ◽  
Ray W. Basrowi ◽  
Erika Wasito ◽  
Yvan Vandenplas
Keyword(s):  
Risk Factors ◽  
Venous Blood ◽  
Cross Sectional Study ◽  
Cow’S Milk ◽  
Milk Formula ◽  
Sectional Study ◽  
Cross Sectional ◽  
Zinc Intake ◽  
Cow's Milk ◽  
Determinant Factors

Anemia has been acknowledged as worldwide problem, including in Indonesia. This cross-sectional study aims to explore dietary determinants as risk factors for anemia in children aged 6–36 months living in a poor urban area of Jakarta. The study was done in Kampung Melayu sub-district in Jakarta, Indonesia. Data was collected within two weeks in September–October 2020. A structured questionnaire for a 24-h recall and a semi-quantitative Food Frequency Questionnaire (FFQ) were used to collect the dietary intake data, and venous blood was withdrawn to determine the hemoglobin levels. Bivariate chi-square and multiple logistic regression tests were executed to explore the dietary determinant factors for anemia. We recruited 180 subjects. The average hemoglobin concentration was 11.4 ± 1.7 mg/dL; the anemia prevalence was 29.4%. The following variables were significantly associated with higher risk of anemia: no cow’s milk formula consumption, inadequate intake of fats, protein, calcium, vitamin D, iron, zinc, vitamin A, vitamin C, vitamin B6, and vitamin B12. Only cow’s milk formula consumption and zinc intake were revealed as the determinant factors of anemia. In conclusion, the prevalence of anemia was 29.4% among children aged 6–36 months old. Anemia was significantly associated with two dietary determinants as risk factors that are cow’s milk formula consumption and zinc intake.

scholarly journals Breastfeeding Knowledge, Altitude and Practices of Lactating Mothers in Mwanakia-A Case of Nairobi Metropolis

2019 ◽  
Vol 7 (08) ◽  
Author(s):  
Dr. Evayline Muthoni Nkirigacha
Keyword(s):  
Breast Milk ◽  
Feeding Habits ◽  
Pearson Correlation ◽  
Cross Sectional Study ◽  
Cow’S Milk ◽  
Cross Sectional ◽  
Cow's Milk ◽  
Breastfeeding Knowledge ◽  
Lactating Mothers ◽  
Increase Milk Production

The objective of the study to examine the breastfeeding knowledge, altitude and practices of lactating mothers 0-6 postpartum. This cross sectional study was conducted on 260 lactating women living in Mwanamukia, Nairobi Kenya. A structured questionnaire was used on social, socio-economic characteristics. SPSS version 20 and analyzed using descriptive statistics and Pearson correlation coefficient determined associations. More than half of the respondents were literate, married and lived in male headed households. Others business people, single and Meru ethnicity. Majority 36-40 years age category. Majority (61.6%) participated in urban agriculture.  57.3% of the respondents owned land.  88.5% had heard about exclusive breastfeeding, 96.2% breastfed exclusively for 4 months, 57.7 knew infant should be breastfed immediately after birth, 26.5% breastfeed after2-24 hours of delivery.67.3% frequent suckling does not increase milk production. 46.9% agreed an infant first food breastmilk, 26.5% cow’s milk and 23.8% porridge. 94.2% altitude exclusively breastfeed 6 months, 46.1% believed feed infant breast milk while 30.4% cow’s milk, 23.4% porridge. 48.1% breast milk sufficient, 82.7%  colostrum  be fed to infant, 17.3% colostrum.81.2% felt good giving infant something to eat before 6 months, 18.8%  afraid  child well cry. 52.7% felt exclusively breastfed not healthier than exclusively breastfed.94.1% breastfed last child. 50% breastfed immediately, 29.2% gave something after one month, 48.1% gave something after 2 months. 52.3% breastfed on demand, 34.2% when child cried. Illiterate Mothers had inappropriate feeding practices (OR1.578, CI 1.762-2.292). The study concludes that knowledge and practice did not have any relationship, altitude influenced feeding habits. 

scholarly journals Socioeconomic, hygienic, and sanitation factors in reducing diarrhea in the Amazon

2016 ◽  
Vol 50 (0) ◽  
Author(s):  
Katiuscia Shirota Imada ◽  
Thiago Santos de Araújo ◽  
Pascoal Torres Muniz ◽  
Valter Lúcio de Pádua
Keyword(s):  
Family Health ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cow’S Milk ◽  
Cross Sectional ◽  
Public Network ◽  
Cow's Milk ◽  
The Public ◽  
Family Health Program ◽  
The City

ABSTRACT OBJECTIVE To analyze the contributions of the socioeconomic, hygienic, and sanitation improvements in reducing the prevalence of diarrhea in a city of the Amazon. METHODS In this population-based cross-sectional study, we analyzed data from surveys conducted in the city of Jordão, Acre. In 2005 and 2012, these surveys evaluated, respectively, 466 and 826 children under five years old. Questionnaires were applied on the socioeconomic conditions, construction of houses, food and hygienic habits, and environmental sanitation. We applied Pearson’s Chi-squared test and Poisson regression to verify the relationship between origin of water, construction of homes, age of introduction of cow’s milk in the diet, place of birth and the prevalence of diarrhea. RESULTS The prevalence of diarrhea was reduced from 45.1% to 35.4%. We identified higher probability of diarrhea in children who did not use water from the public network, in those receiving cow’s milk in the first month after birth, and in those living in houses made of paxiúba. Children born at home presented lower risk of diarrhea when compared to those who were born in hospital, with this difference reversing for the 2012 survey. CONCLUSIONS Sanitation conditions improved with the increase of bathrooms with toilets, implementation of the Programa de Saúde da Família (PSF – Family Health Program), and water treatment in the city. The multivariate regression model identified a statistically significant association between use of water from the public network, construction of houses, late introduction of cow’s milk, and access to health service with occurrence of diarrhea.

The Distinguishing Clinical Features of Nonallergic Rhinitis Patients

2019 ◽  
Vol 33 (5) ◽  
pp. 524-530 ◽  
Author(s):  
Aneeza W. Hamizan ◽  
Mark Azer ◽  
Raquel Alvarado ◽  
Peter Earls ◽  
Henry P. Barham ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Clinical Characteristics ◽  
Immunoglobulin E ◽  
Inferior Turbinate ◽  
Specific Ige ◽  
Cross Sectional Study ◽  
Nonallergic Rhinitis ◽  
Cross Sectional ◽  
Prick Test ◽  
Inhalant Allergy

Background Not all rhinitis patients are affected by an immunoglobulin E (IgE)-mediated inflammatory process. Skin and serum allergy assessments are limited in their ability to define local allergic rhinitis (LAR). Thus, patients with negative systemic allergy assessments comprise a mix of those who truly have nonallergic rhinitis (NAR) and patients with LAR. Objective To determine the clinical characteristics of patients with NAR. Methods A cross-sectional study was performed on consecutive adults with rhinitis symptoms who underwent turbinate surgery. NAR patients were defined by excluding allergy using both systemic (serum-specific IgE and/or skin prick test) and local (inferior turbinate tissue-specific IgE) tests. Allergic rhinitis (AR) patients were defined by any positive systemic or local test toward aeroallergens. The clinical characteristics studied included allergic comorbidities (asthma, eczema, allergic conjunctivitis), inhalant allergen triggers (dust, pollen, animal dander), and environmental triggers (Cincinnati Irritant Index [CII]). Results There were 154 participants (41.79 ± 14.78 years, 37.7% female). NAR patients (11.7%) were older (49.33 ± 15.99 vs 40.78 ± 14.38 years, P = .02), had less self-reported asthma (5.6% vs 36.3%, P < .01) and house dust inhalant trigger (38.9 vs 65.2%, P = .03) compared to AR patients. The CII score was similar for NAR and AR (31.06 ± 28.88 vs 35.49 ± 24.70, P = .61). Conclusion Patients who were older, without asthma, and lacked an inhalant allergy trigger were more likely to have true NAR. Environmental triggers are not distinguishing features of NAR. This may be used as a guide to identify rhinitis patients whose symptoms are truly nonallergic etiology compared to those with falsely negative systemic allergy assessment but may still need management for LAR.

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