scholarly journals Vitiligo-Like Depigmentation following Treatment with Imiquimod 5% Cream for Condylomata Acuminata

2021 ◽  
pp. 36-41
Author(s):  
Maram Alatabani ◽  
Yasser Ghobara ◽  
Ahmed Alissa
Keyword(s):  
Side Effect ◽  
Rare Case ◽  
Condylomata Acuminata ◽  
Genital Warts ◽  
Healthy Male ◽  
Anogenital Warts ◽  
Imiquimod Cream ◽  
Human Melanocyte ◽  
The Us ◽  
Antigen Presenting

Imiquimod cream is an immunomodulatory agent that has been approved by the US Food and Drug Administration for use in the treatment of anogenital warts (condylomata acuminata) due to its local immune effects in activating Toll-like receptors 7 and 8 on antigen-presenting cells, resulting in reduction of the viral load of human papillomavirus with subsequent wart regression. After its application, some side effects are commonly reported, including erythema, edema, scaling, erosion, and ulceration. While pigmentary changes, including vitiligo-like depigmentation, have been mentioned as a possible side effect, they have rarely been reported in the literature. Alterations in pigmentation occur because imiquimod application causes human melanocyte apoptosis and autodestruction resulting in loss of melanocytes. Herein, we report the rare case of a 34-year-old healthy male who developed vitiligo-like depigmentation following imiquimod application for his genital warts. This case report aims to increase physicians’ awareness of this possible side effect that could be irreversible and difficult for the patient to accept.

5. Condylomata Acuminata in Pre-Pubertal Children

1993 ◽  
Vol 33 (1) ◽  
pp. 78-82 ◽  
Author(s):  
J D C Ross ◽  
G R Scott ◽  
A Busuttil
Keyword(s):  
Sexual Abuse ◽  
Case Reports ◽  
Sexual Transmission ◽  
Condylomata Acuminata ◽  
Genital Warts ◽  
Review Article ◽  
Anogenital Warts ◽  
Papilloma Virus ◽  
Modes Of Transmission

The medico-legal significance of anogenital warts as a marker of sexual abuse in children is unclear. This review article presents three case reports and discusses the possible modes of transmission of papilloma virus in children. Although genital warts can indicate sexual abuse, non-sexual transmission may also occur.

Anogenital warts and human papillomavirus: knowledge, perceived nuisance and risk perception in Dutch soldiers

2012 ◽  
Vol 23 (7) ◽  
pp. 512-515 ◽  
Author(s):  
E M Van Der Snoek ◽  
A M Van Loon ◽  
A M Lammers ◽  
S M Couwenberg
Keyword(s):  
Human Papillomavirus ◽  
Risk Perception ◽  
Information Source ◽  
Condylomata Acuminata ◽  
Genital Warts ◽  
Heterosexual Men ◽  
Anogenital Warts ◽  
Sexually Transmitted ◽  
The Relationship ◽  
Incorrect Information

Genital warts are one of the most prevalent sexually transmitted infections in the Netherlands and cause both frustration and misinterpretation in young adults. Poor knowledge may be associated with shame and depression. We used questionnaires to study knowledge, perceived nuisance and risk perception in 100 predominantly heterosexual men with clinically-confirmed condylomata acuminata. Our data show that the majority of patients considered having warts as (very) bothersome. Results confirmed the Internet as a widely used information source. Incorrect information on the relationship between warts and both anogenital cancers and infertility was widespread. Results from knowledge questionnaires showed that higher knowledge scores were associated with higher perceived nuisance. We hypothesize that high levels of nuisance related to genital warts may stimulate the need to seek information and therefore increase knowledge. It does not seem likely that an increase of human papillomavirus-related knowledge would increase experiences of nuisance.

scholarly journals Use of newer disease-modifying therapies in pediatric multiple sclerosis in the US

Neurology ◽  
2018 ◽  
Vol 91 (19) ◽  
pp. e1778-e1787 ◽  
Author(s):  
Kristen M. Krysko ◽  
Jennifer Graves ◽  
Mary Rensel ◽  
Bianca Weinstock-Guttman ◽  
Gregory Aaen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Side Effect ◽  
Pediatric Patients ◽  
Dimethyl Fumarate ◽  
Short Term ◽  
Pediatric Multiple Sclerosis ◽  
Disease Modifying Therapies ◽  
The Us ◽  
Disease Modifying

ObjectiveTo characterize the use and safety of newer disease-modifying therapies (DMTs) in children with multiple sclerosis (MS) and clinically isolated syndrome (CIS) treated under 18 years of age.MethodsThis is a cohort study including children with MS or CIS followed at 12 outpatient practices participating in the US Network of Pediatric MS Centers. DMT use, including duration, dose, and side effects, was analyzed. Newer DMTs were defined as agents receiving Food and Drug Administration approval or with increased use in adult MS after 2005.ResultsAs of July 2017, 1,019 pediatric patients with MS (n = 748) or CIS (n = 271) were enrolled (65% female, mean onset 13.0 ± 3.9 years, mean follow-up 3.5 ± 3.1 years, median 1.6 visits per year). Of these, 78% (n = 587) with MS and 11% (n = 31) with CIS received DMT before 18 years of age. This consisted of at least one newer DMT in 42%, including dimethyl fumarate (n = 102), natalizumab (n = 101), rituximab (n = 57), fingolimod (n = 37), daclizumab (n = 5), and teriflunomide (n = 3). Among 17%, the initial DMT prescribed was a newer agent (36 dimethyl fumarate, 30 natalizumab, 22 rituximab, 14 fingolimod, 2 teriflunomide). Over the last 10 years, the use of newer agents has increased, particularly in those ≥12 years and to lesser extent in those <12 years. The short-term side effect profiles of newer DMTs did not differ from those reported in adults.ConclusionNewer DMTs are often used in pediatric MS, and have similar short-term safety, tolerability, and side effect profiles as in adults. These findings may help inform pediatric MS management.

scholarly journals Leishmania infantum and Epstein-Barr virus co-infection in a patient with hemophagocytosis

2017 ◽  
Vol 8 (4) ◽  
Author(s):  
Zied Gaifer ◽  
Mohamed-Rachid Boulassel
Keyword(s):  
Visceral Leishmaniasis ◽  
Complete Resolution ◽  
Liposomal Amphotericin ◽  
Rare Case ◽  
Epstein Barr Virus ◽  
Healthy Male ◽  
High Grade Fever ◽  
Barr Virus ◽  
Epstein Barr ◽  
Ebv Viremia

The authors describe a rare case of a 27-year old previously healthy male presenting with high grade fever, pancytopenia, hepatosplenomegaly, high levels of ferritin and triglyceride, suggesting a diagnosis of hemophagocytic lymphohistiocytosis (HLH) syndrome. Other investigations showed a positive <em>Leishmania</em> <em>infantum</em> serology and high Epstein-Barr virus (EBV) viremia. The diagnosis of a visceral leishmaniasis was confirmed by bone morrow biopsy, which showed Leishman-Donovan bodies and evidence of HLH. The patient received liposomal amphotericin B and he had a complete resolution of his symptoms and clearance of EBV viremia. This case of HLH associated with visceral leishmaniasis and EBV co-infection raises the question about the significance of EBV in patients with HLH. The treatment of actual etiological agent can lead to complete cure while using current recommend chemotherapy for HLH-related EBV in a patient with hidden infection may have deleterious effects.

An Audit of Treatment of Genital Warts: Opening the Feedback Loop

1993 ◽  
Vol 4 (4) ◽  
pp. 226-231 ◽  
Author(s):  
M Reynolds ◽  
M Murphy ◽  
M A Waugh ◽  
C J N Lacey
Keyword(s):  
Specific Treatment ◽  
Genital Warts ◽  
Therapeutic Modality ◽  
First Episode ◽  
Anogenital Warts ◽  
Treatment Protocols ◽  
Female Patients ◽  
General Infirmary ◽  
Male Patients ◽  
Time Of Presentation

An audit of the treatment of patients (100 men and 90 women) presenting with a first episode of anogenital warts to the Genitourinary Medicine Department at Leeds General Infirmary was performed. Treatment of patients was monitored for a period of 6 months from the time of presentation. The management of patients with genital warts lacked a clearly defined strategy and treatment was unselective and poorly monitored. Excluding patients who defaulted, at follow-up 44 (44%) men and 36 (38%) women still had genital warts at 3 months. Of those patients clear of warts at 3 months, the mean time to remission for men and women was 7.1 and 8.3 weeks respectively. Podophyllin 25% in tincture of benzoin was by far the predominant therapeutic modality used. A total of 96 (96%) men and 76 (84%) women received treatment with podophyllin. Both male and female patients had a mean of 5 treatments with podophyllin 25% (range 1–19 and 1–12 respectively). Physical methods of treatment i.e. cryotherapy and electrocautery, were underutilized, both as primary therapies and when topical agents had failed. Patients saw an average of 3 (range 1–7) doctors over the course of their treatment. Patients with warts affecting 2 or more sites, male patients with anal/perianal warts, and female patients with cervical and vaginal warts had higher failure rates from treatment at 3 months. On the basis of these findings, specific treatment protocols for the management of anogenital warts have been devised.

scholarly journals Ocular side effect of tinidazole: A rare case report

2014 ◽  
Vol 3 (4) ◽  
pp. 467
Author(s):  
Hina Kauser ◽  
Maniah Qadir ◽  
Waseem Anwar
Keyword(s):  
Case Report ◽  
Side Effect ◽  
Rare Case ◽  
Ocular Side ◽  
Rare Case Report ◽  
Ocular Side Effect

scholarly journals Anogenital Warts: A Modern Idea of the Problem

Doctor Ru ◽  
2021 ◽  
Vol 20 (8) ◽  
pp. 28-35
Author(s):  
G.R. Bayramova ◽  
◽  
I.I. Baranov ◽  
D.A. Dobrovolskaya ◽  
V.A. Pronina ◽  
...  
Keyword(s):  
Human Papilloma Virus ◽  
Clinical Manifestations ◽  
Condylomata Acuminata ◽  
Efficacy And Safety ◽  
Anogenital Warts ◽  
Papilloma Virus ◽  
Obstetrics And Gynaecology ◽  
Key Points ◽  
Surgical Methods ◽  
Benign Nature

Objective of the Review: To expand the understanding of the possibilities of complex personalized therapy for anogenital warts (AW). Key Points. Human papilloma virus (HPV) is a widespread viral infection that causes genital precancer and cancer. Clinical manifestations of low-risk HPV can include anogenital warts, the therapy of which, despite the benign nature of the process, should be multicomponent, interdisciplinary and individualized. Conclusion. Numerous studies have proven the high clinical efficacy and safety of VIFERON® (Russia), which is actively used in various fields of medicine, including obstetrics and gynaecology. Currently, conservative management in combination with other surgical and non-surgical methods is fundamental for the treatment of patients with AWs. Keywords: anogenital warts, human papilloma virus, НPV, vulvar condylomata acuminata, cervical cancer.

scholarly journals A Rare Case of Statin-Induced Diplopia: An Often-Overlooked but Reported Side Effect

Cureus ◽  
2021 ◽  
Author(s):  
Randa Abdelmasih ◽  
Ramy Abdelmaseih ◽  
Justin Reed
Keyword(s):  
Side Effect ◽  
Rare Case

Topical medication as an initial therapeutic option for protruding and non-protruding condylomata acuminata of the distal urethra

2021 ◽  
Vol 14 (9) ◽  
pp. e243618
Author(s):  
Tomislav Mestrovic ◽  
Mario Sviben ◽  
Sanja Zember ◽  
Domagoj Drenjancevic
Keyword(s):  
Human Papillomavirus ◽  
Therapeutic Option ◽  
Condylomata Acuminata ◽  
Genital Warts ◽  
The Other ◽  
Urethral Meatus ◽  
Tissue Destruction ◽  
Topical Medication ◽  
Sexually Transmitted ◽  
Current Guidelines

Genital warts (also known as condylomata acuminata) caused by the human papillomavirus (HPV) represent one of the most common sexually transmitted infections. Although they are usually found in the outer genital region, a small proportion of men can present with (often unrecognised) intraurethral warts, generally limited to the distal urethra and urethral meatus. This poses a treatment challenge not adequately addressed by the current guidelines. Here, we present two cases of low-risk HPV-positive patients with protruding and non-protruding condylomata acuminata of the distal urethra, which were treated successfully by using two different topical regimens (ie, a combination of policresulen and imiquimod for one patient and 5-fluorouracil monotherapy for the other). Although this type of management results in lower rates of tissue destruction and complications and may be given preference as an initial therapeutic option, additional prospective comparative clinical studies are needed to elucidate its potential in similar cases.

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