scholarly journals Biological Support to Obesity Paradox in Renal Cell Carcinoma: A Review

2020 ◽  
Vol 104 (11-12) ◽  
pp. 837-848
Author(s):  
Ming Li ◽  
Renge Bu
Keyword(s):  
Renal Cell Carcinoma ◽  
Adipose Tissue ◽  
Risk Factor ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Model ◽  
Obesity Paradox ◽  
Local Tumor ◽  
Biological Association

Obesity is a proven risk factor and a debated prognostic factor in renal cell carcinoma (RCC). Termed as an “obesity paradox,” the topic has churned controversies, with a few arguing of no true biological association. Suggesting otherwise, a few studies revealed adiposity-induced altered molecular and transcriptomic signatures, at both the systemic and local (tumor and peritumoral adipose tissue) levels, in RCC patients, favoring the paradox. Summarizing such studies suggests of a considerable biological support to adiposity as a promising prognostic factor in RCC patients, although much needs to be clarified before adopting it as a valuable addition to the existing prognostic model.

Impact of obesity and adiponectin signaling in patients with renal cell carcinoma: A potential mechanism for the obesity paradox.

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 449-449
Author(s):  
Shintaro Narita ◽  
Ryuichi Ito ◽  
Mingguo Huang ◽  
Kazuyuki Numakura ◽  
Hiroshi Tsuruta ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Adipose Tissue ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Obesity Paradox ◽  
Lower Grade ◽  
Obese Patients ◽  
Total Adiponectin ◽  
Cancer Aggressiveness ◽  
The Impact

449 Background: Obesity increases the risk of renal cell carcinoma (RCC); however, obese patients experience longer survival than non-obese patients. The mechanism of this “obesity paradox” is unknown. We examined the impact of obesity, total adiponectin (AD) level, and intratumoral AD receptors expression on RCC aggressiveness and survival, and also investigated the mechanism underlying enhanced cancer aggressiveness in RCC cells with exogenous adiponectin stimulation. Methods: A total of 129 RCC patients treated with surgery were included in the analyses. Preoperative BMI, serum total adiponectin (AD) level, total AD secretion from perinephric adipose tissue, and intratumoral AD receptors mRNA and protein expression were analyzed. Caki-2 and 786- cells were used for in vitro functional analyses. Results: Overweight and obese patients had significantly lower grade cancers than normal patients in all patients and in those without metastasis (p = 0.003, and p = 0.027, respectively). Cancer-specific survival in overweight and obese patients was significantly better than in normal patients in all patients (p = 0.035). A weak inverse correlation existed between serum AD level and BMI in RCC patients (r = −0.344). Tumor size was slightly correlated with serum AD level, and high serum AD was significantly associated with poor overall survival in patients without metastasis (p = 0.035). The AD level of perinephric adipose tissue and intratumoral AdipoR1/R2 expression in tumors did not correlate with RCC aggressiveness and survival. Exogenous AD significantly enhanced proliferation, but not invasion or migration in 786-O and Caki-2 cells. Exogenous AD significantly inhibited starvation- and metformin-induced apoptosis, and up-regulated p-AMPK and Bcl-xL in these cells. Conclusions: Low BMI and high AD level are associated with cancer aggressive and poor survival in RCC patients treated surgically. AD modulates proliferation and apoptosis, which may underlie the “obesity paradox” of RCC.

C-reactive protein-albumin ratio as a prognostic factor in renal cell carcinoma – A data from multi-institutional study in Japan

2019 ◽  
Vol 37 (11) ◽  
pp. 812.e1-812.e8 ◽  
Author(s):  
Takuya Tsujino ◽  
Kazumasa Komura ◽  
Takeshi Hashimoto ◽  
Ryu Muraoka ◽  
Naoya Satake ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
C Reactive Protein ◽  
Albumin Ratio ◽  
Reactive Protein

scholarly journals Overexpression of G6PD Represents a Potential Prognostic Factor in Clear Cell Renal Cell Carcinoma

2017 ◽  
Vol 8 (4) ◽  
pp. 665-673 ◽  
Author(s):  
Qiao Zhang ◽  
Xiaojia Yi ◽  
Zhe Yang ◽  
Qiaoqiao Han ◽  
Xuesong Di ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Potential Prognostic Factor

Sarcomatoid differentiation as a prognostic factor for immunotherapy in metastatic renal cell carcinoma

2007 ◽  
Vol 95 (4) ◽  
pp. 317-323 ◽  
Author(s):  
Cheol Kwak ◽  
Yong Hyun Park ◽  
Chang Wook Jeong ◽  
Hyeon Jeong ◽  
Sang Eun Lee ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Sarcomatoid Differentiation

scholarly journals New-Onset Diabetes After Renal Transplantation (NODAT): Is It a Risk Factor for Renal Cell Carcinoma or Renal Failure?

2019 ◽  
Vol 24 ◽  
pp. 62-69 ◽  
Author(s):  
Haibo Nie ◽  
Wei Wang ◽  
Yongbin Zhao ◽  
Xiaoming Zhang ◽  
Yuansong Xiao ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Renal Failure ◽  
Risk Factor ◽  
Renal Transplantation ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Onset Diabetes ◽  
New Onset

scholarly journals Depth of Remission is a Prognostic Factor for Survival in Patients with Metastatic Renal Cell Carcinoma

2015 ◽  
Vol 67 (5) ◽  
pp. 952-958 ◽  
Author(s):  
Viktor Grünwald ◽  
Rana R. McKay ◽  
Katherine M. Krajewski ◽  
Daniel Kalanovic ◽  
Xun Lin ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Prognostic Factor ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell

Increased visceral adipose tissue in male patients with clear cell renal cell carcinoma

2018 ◽  
Vol 7 (4) ◽  
pp. 132 ◽  
Author(s):  
Federico Greco ◽  
Vincenzo Cirimele ◽  
CarloAugusto Mallio ◽  
BrunoBeomonte Zobel ◽  
RosarioFrancesco Grasso
Keyword(s):  
Renal Cell Carcinoma ◽  
Adipose Tissue ◽  
Cell Carcinoma ◽  
Visceral Adipose Tissue ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Male Patients ◽  
Visceral Adipose
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