Predictive Value and Correlation of Neuron-Specific Enolase for Prognosis in Patients with Coma: A Systematic Review and Meta-Analysis

2020 ◽  
pp. 1-11
Author(s):  
Wen Ye ◽  
Yunliang Tang ◽  
Xiaoyang Dong ◽  
Gengfa Chen ◽  
Yan Yan ◽  
...  
Keyword(s):  
Predictive Value ◽  
Meta Analysis ◽  
Life Quality ◽  
Neuron Specific Enolase ◽  
Cochrane Library ◽  
Control Group ◽  
China National Knowledge Infrastructure ◽  
Clinical Prognosis ◽  
Standard Mean Difference ◽  
Disturbance Of Consciousness

<b><i>Objective:</i></b> Coma is the most serious disturbance of consciousness, which affects the life quality of patients and increases the burden of their family. Studies to assess the prognostic value of neuron-specific enolase (NSE) in patients with coma have not led to precise, generally accepted prognostic rules. The study aims to assess the correlation between NSE and prognosis of coma and the predictive value of NSE for clinical prognosis. <b><i>Methods:</i></b> A search was conducted using PubMed, Web of Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), and WanFang Data from the establishment time of databases to December 2019. This analysis included patients with coma, regardless of how long the coma was. In total, 26 articles were retrieved and included in the review. <b><i>Results:</i></b> The meta-analysis revealed the NSE concentration of patients with coma is significantly higher than that of the control group (standard mean difference = 0.88, 95% confidence interval [CI]: 0.63–1.12, <i>p</i> &#x3c; 0.05). The pooled sensitivity and specificity of NSE in coma diagnosis was 0.5 (95% CI: 0.39–0.61) and 0.86 (95% CI: 0.71–0.94). <b><i>Conclusions:</i></b> The NSE concentration of patients with poor coma prognosis is significantly higher than that of the control group. The high NSE concentration is not necessarily a poor prognosis for coma, but low NSE concentration indicates a high probability of a good prognosis for coma.

scholarly journals Systematic review with meta-analysis: effectiveness of hyperbaric oxygenation therapy for ulcerative colitis

2021 ◽  
Vol 14 ◽  
pp. 175628482110233
Author(s):  
Pingrun Chen ◽  
Yina Li ◽  
Xian Zhang ◽  
Yan Zhang
Keyword(s):  
Ulcerative Colitis ◽  
Combination Therapy ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygenation ◽  
Meta Analysis ◽  
Serum Levels ◽  
Cochrane Library ◽  
China National Knowledge Infrastructure ◽  
Complementary Method ◽  
Standard Mean Difference

Background and aims: Hyperbaric oxygenation therapy has been used in the treatment of ulcerative colitis in the past few years. However, its efficacy still remains unclear. The aim of the study was to investigate the efficacy of hyperbaric oxygen combination therapy in patients with ulcerative colitis. Methods: We conducted a comprehensive study search up to September 2020, from the online databases Embase, PubMed, Cochrane Library, China National Knowledge Infrastructure, WanFang and VIP. Results: Thirteen studies comprising 780 patients were included. We found that compared with conventional therapy, hyperbaric oxygen combination therapy was superior in reaching clinical remission [risk ratio (RR)=1.62; 95% confidence interval (CI) 1.42 to 1.84; p < 0.001] and clinical response (RR=1.29; 95% CI 1.21 to 1.38; p < 0.001), with lower disease activity scores [standard mean difference (SMD)= −1.19; 95%CI −1.74 to −0.65; p < 0.001]. An obvious reduction of serum levels of tumor necrosis factor-α (SMD= −1.96; 95%CI −2.50 to −1.41; p < 0.001) and interleukin (IL)-6 (SMD= −2.49; 95% CI −2.84 to −2.15; p < 0.001), and elevation of IL-10 level (SMD=2.40; 95% CI 0.68 to 4.12; p = 0.006) were also observed. Conclusion: Hyperbaric oxygen combination therapy was effective in patients with ulcerative colitis, and has potential as a complementary method for its treatment.

scholarly journals The Impact of Javanica Oil Emulsion Injection on Chemotherapy Efficacy and Cellular Immune Indicators in Patients with Advanced NSCLC: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
Huilin Xu ◽  
Zhucheng Yin ◽  
Anbing He ◽  
Dedong Cao
Keyword(s):  
Advanced Nsclc ◽  
Karnofsky Performance Status ◽  
Meta Analysis ◽  
Objective Response ◽  
Cochrane Library ◽  
Combination Group ◽  
Control Group ◽  
Oil Emulsion ◽  
Standard Mean Difference ◽  
The Impact

Background. This meta-analysis aimed to evaluate the efficacy and safety of Javanica oil emulsion injection (JOI) combined with chemotherapy versus chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC). Methods. Electronic databases including EMBASE, PUBMED, the Cochrane library, and Chinese Biological Medical disc (CBM) were searched until May 2018. The clinical trials reporting efficacy and immune function of JOI combined with chemotherapy versus chemotherapy in advanced NSCLC were included according to the inclusion and exclusion criteria. Stata 11 and RevMan 5.3 were used for meta-analysis. Results. Twenty-four studies involving 2089 cases were included. The results of the meta-analysis showed that there were significant differences in objective response rate (risk ratio (RR) = 1.17; 95% confidence interval (CI): 1.05–1.29; P<0.05), improvement in Karnofsky Performance Status (standard mean difference (SMD) = 1.59; 95% CI: 1.41–1.77; P<0.01), incidence of adverse events (RR = 0.78; 95% CI: 0.7–0.87; P<0.05), percentage changes of CD3+ cells (SMD = 2.0; 95% CI: 1.49–2.50; P<0.01), CD4+ cells (SMD = 1.55; 95% CI, 1.2–1.9; P<0.01), natural killer cells (SMD = 1.98; 95% CI: 1.15–2.82; P<0.01), but not CD8+ (SMD = −1.44; 95% CI: −4.53–1.65; P=0.36), and value of CD4+/CD8+ (SMD = 0.32; 95% CI: 0.28–0.36; P<0.01) between the JOI combination group and control group. Funnel plot and Begg’s and Egger’s analysis indicated that there was no significant publication bias (P>0.05). Conclusions. JOI may be effective to improve the efficacy of chemotherapy in advanced NSCLC patients, accompanied with better levels of immune cells.

scholarly journals Combination between Mifepristone and Methotrexate to Treat Ectopic Pregnancy: A Systematic Review Protocol

2021 ◽  
Author(s):  
Qiling Su ◽  
Huiyan Feng ◽  
Tian Tian ◽  
Xiaoqian Liao ◽  
Yunhui Li ◽  
...  
Keyword(s):  
Ectopic Pregnancy ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Secondary Outcome ◽  
Control Group ◽  
China National Knowledge Infrastructure ◽  
Advantages And Disadvantages ◽  
Randomized Controlled ◽  
Outcome Index

Background: In recent years, the morbidity of ectopic pregnancy and the proportion of young and childless patients have increased year by year, which makes it important to early diagnose EP, effectively save patients' lives and furthest preserve their fertility. Methotrexate and mifepristone are most widely used in conservative treatments, however, there is no accurate conclusion about which therapy is better. Therefore, the aims in this meta-analysis are, on the one hand, to systematically analyze the efficacy of mifepristone combined with methotrexate in the treatment of ectopic pregnancy through existing studies, and to draw scientific conclusions. On the other hand, to fill the gap of relevant analysis in China and abroad, to evaluate the advantages and disadvantages of inclusion trials and propose improvement measures and scientific designing schemes. Methods: Six electronic databases will be searched, including PubMed, Embase, Cochrane Library, the China National Knowledge Infrastructure(CNKI), Chinese Science and Technology Periodical Database (VIP), and Wanfang Database (WF). Literature from October 2015 to October 2020 on randomized controlled trials will be searched, without any language or publication restriction. Search terms include mifepristone, methotrexate, ectopic pregnancy, and random (free word/synonym expansion). Included in a randomized controlled trial, the treatment group was treated with mifepristone combined with methotrexate, and the control group was treated with mifepristone alone. Revman 5.4 (provided by Cochrane) will be used to evaluate the quality of the literature, and the corresponding effect model will be selected to analyze the results. The cure rate will be the main outcome index, and the remaining outcome measures after literature inclusion will be the secondary outcome indexes. Result: Only when we finish this meta-analysis can we get the result. Discussion: The results of this study will provide reliable evidence for the efficacy of mifepristone combined with methotrexate therapy in the treatment of ectopic pregnancy.

scholarly journals Effects of walking exercise on bowel preparation in patients undergoing colonoscopy: evidence from systematic review and meta-analysis

2020 ◽  
Vol 7 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Yuan-Yuan Zhang ◽  
Min Yan ◽  
Jing Li ◽  
Min-Li Fu ◽  
Ling Xie ◽  
...  
Keyword(s):  
Systematic Review ◽  
Abdominal Pain ◽  
Bowel Preparation ◽  
Meta Analysis ◽  
Exercise Group ◽  
Cochrane Library ◽  
Control Group ◽  
China National Knowledge Infrastructure ◽  
Walking Exercise ◽  
The Cochrane Library

AbstractObjectiveThis meta-analysis aimed to evaluate the effects of walking exercise on bowel preparation in patients undergoing colonoscopy.MethodsPubMed, Web of Science, EMBASE, Ovid, The Cochrane Library, Wanfang Data, China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database, and Chinese BioMedical Database were searched from their inception to January 2019. Randomized controlled trials (RCTs) and controlled clinical trials (CCTs) examining the effects of walking exercise in patients undergoing colonoscopy were considered for inclusion. After screening literature, extracting data and evaluating methodological quality, RevMan 5.3 software was used for meta-analysis.ResultsFive studies (four RCTs and one CCTs) involved 984 participants were included. The results of meta-analysis demonstrated that the walking exercise group showed significantly higher improvements in the rate of adequate bowel preparation than the control group (risk ratio [RR] = 1.28, 95% confidence interval [CI] [1.03–1.58], P < 0.05). In addition, the walking exercise group had lower incidence of vomiting (RR = 0.39, 95% CI [0.23–0.68], P < 0.01) and abdominal pain (RR = 0.51, 95% CI [0.29–0.90], P < 0.05) with lower heterogeneity.ConclusionsThis systematic review and meta-analysis provided specific evidence that walking exercise during bowel preparation can improve the rate of adequate bowel preparation and reduce the incidence of vomiting and abdominal pain in patients undergoing colonoscopy. Since the conclusion of this meta-analysis was drawn based on the limited number of high-quality RCTs, more rigorous RCTs should be conducted in the future.

Acupuncture for the Adjunctive Therapy of Post-stoke Fatigue: A Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Yupei Chen ◽  
Meidi Peng ◽  
Yanqing Li
Keyword(s):  
Systematic Review ◽  
Assessment Tool ◽  
Meta Analysis ◽  
Scientific Journal ◽  
Cochrane Library ◽  
Control Group ◽  
China National Knowledge Infrastructure ◽  
Obvious Effect ◽  
Rehabilitation Therapy ◽  
Post Stroke

The aim of this research is to assess the effectiveness and safety of acupuncture combined with rehabilitation therapy for post-stroke fatigue. The methods used in this research are as follows: systematically retrieving China National Knowledge Infrastructure, Chinese Scientific Journal Database, Chinese Biological Medicine Database, Cochrane Library, Medline and Embase were electronically searched from inception to Dec 2020. The dataset included randomized controlled trials (RCTs) with Chinese and English only that compared acupuncture as an adjunct to rehabilitation in stroke patients with fatigue. The methodological quality of the included trials was assessed using the Cochrane risk of bias assessment tool. Statistical analyses were performed by RevMan V.5.4.A total of 6 RCTs were included in this study, including 426 cases (213 cases in the treatment group and 213 cases in the control group). The results of meta-analysis showed that compared with conventional treatment, acupuncture as an adjuvant therapy can significantly reduce the incidence of post-stroke fatigue [MD = -5.45, 95% CI = (-6.75, -4.14), Z= 8.19 (P < 0.001)]. In terms of energy, acupuncture also has an obvious effect [MD = 1.69, 95% CI = (0.27, 3.12), Z = 2.33 (P < 0.02)]. Our systematic review and meta-analysis suggests that acupuncture combined with conventional rehabilitation therapy is an effective therapy for patients suffering from post-stroke fatigue, which is suitable for clinical promotion and use. However, due to methodological weakness and limited number of RCTs, the results should be interpreted cautiously. Further clinical trials with large sample sizes and a rigorous design are needed.

scholarly journals The Predictive Value of Urinary Kidney Injury Molecular 1 for the Diagnosis of Contrast-Induced Acute Kidney Injury after Cardiac Catheterization: A Meta-Analysis

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Qing Li ◽  
Yimin Huang ◽  
Weifeng Shang ◽  
Ying Zhang ◽  
Yanyan Liu ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Catheterization ◽  
Predictive Value ◽  
Meta Analysis ◽  
Characteristic Curve ◽  
Kidney Injury ◽  
Population Characteristics ◽  
Cochrane Library ◽  
China National Knowledge Infrastructure ◽  
Summary Receiver Operating Characteristic

Background. Urinary kidney injury molecule 1 (uKIM-1) is a proximal tubular injury biomarker for predicting acute kidney injury (AKI); its prognostic value varies depending on the clinical and population characteristics. However, the predictive value of uKIM-1 for diagnosis of contrast-induced acute kidney injury (CI-AKI) remains unclear. Method. Medline, Embase, ClinicalTrials.gov, Cochrane Library database, and the China National Knowledge Infrastructure (CNKI) were used to identify relevant studies from their inception to November 31, 2019. Studies that met the inclusion criteria were included. Relevant data were extracted to obtain pooled sensitivity (SEN) and specificity (SPE), summary receiver operating characteristic curve (ROC), and area under the ROC (AUC or AUROC). A bivariate mixed-effects regression model was used for data analysis. Results. A total of 946 patients from 8 eligible studies were included. Across all the studies, the diagnostic odds ratio (DOR) for uKIM-1 level to predict CI-AKI was 19 (95% CI 10–39), with SEN and SPE of 0.84 and 0.78, respectively. The AUROC for uKIM-1 in predicting CI-AKI was 0.88 (95% CI 0.85–0.90). There was a substantial heterogeneity across the studies (I2 was 37.73% for the summary sensitivity and 69.31% for the summary specificity). Conclusion. Urinary KIM-1 has a high predictive value for diagnosis of CI-AKI in patients who have undergone cardiac catheterization.

scholarly journals Statin use and the overall survival of renal cell carcinoma: A meta-analysis

2020 ◽  
Vol 43 (4) ◽  
pp. E17-23
Author(s):  
Ping Wu ◽  
Tingting Xiang ◽  
Jing Wang ◽  
Run Lv ◽  
Yimeng Zhuang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Overall Survival ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Meta Analysis ◽  
Cochrane Review ◽  
Cochrane Library ◽  
Control Group ◽  
China National Knowledge Infrastructure ◽  
Statin Use

Purpose: Statins are commonly prescribed drugs that reduce cholesterol levels and the risk of cardiovascular and cerebrovascular events. Clinical studies have shown that statins also possess cancer-preventive properties. Two studies have reported that statins also possess cancer-preventive properties; however, whether statins improve the prognosis of patients with renal cell carcinoma is still unclear. In this study, we used meta-analysis to evaluate the association between statin use and overall survival risk in patients with renal cell carcinoma. Methods: Published studies on statin-treated renal cell carcinoma were retrieved from PubMed, Embase, The Cochrane Library, China National Knowledge Infrastructure and Wanfang databases from inception to July 2019. The relevant data were extracted and a meta-analysis was performed using Cochrane Review Manager (RevMan 5.3) software. Results: Data from five studies, which reported on 5,299 patients, were analysed. The application of statins showed no effects on the overall survival of patients with renal cell carcinoma compared with the control group (OR = 1.07, 95% CI:0.77 to 1.49, P = 0.68). Conclusions: The findings of this meta-analysis suggest that statin application does not affect the overall survival of patients with renal cell carcinoma.

scholarly journals Moxibustion for Chronic Pelvic Inflammatory Disease：A systematic review and meta-analysis

2021 ◽  
Author(s):  
Fanghui Hua ◽  
Jun Xiong ◽  
Shouqiang Huang ◽  
Jie Xiang
Keyword(s):  
Meta Analysis ◽  
Scientific Journal ◽  
Cochrane Collaboration ◽  
Effective Rate ◽  
Cochrane Library ◽  
Control Group ◽  
Inflammatory Factor ◽  
China National Knowledge Infrastructure ◽  
Evidence Level ◽  
Control Therapy

Background: This study was performed to strictly evaluate the quality of RCTs and thus test the effect of moxibustion on CPID. Methods: Seven databases (PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure, WangFang Database, Chinese Scientific Journal Database, Chinese Biomedical Literatures Database were reviewed for RCTs on CPID treated by moxibustion up to September 2020. Methodological quality and evidence level was assessed on the basis of the RoB tool from Cochrane collaboration and the GRADE instrument, respectively. RevMan5.4.1 and Stata 12.0 software were used for further meta-analysis.Results: A total of 17 RCTs were included (1315 participants, 515 treated by moxibustion and 515 treated by control therapy). The meta-analysis showed that, in comparison to control group, moxibustion had a higher total effective rate (RR = 1.21; 95% CI [1.31, 1.29]; P = 0.007; I2 = 53%); and lower total symptom score (MD = -3.72; 95% CI [-4.38, -3.06]; P =0.02; I2 = 66%). As for the total sign score, the participants treated by moxibustion had lower scores than those treated by control therapy(SMD = -0.72; 95% CI [ -1.07, -0.37]; P = 0.36; I2 = 0%). For the VAS score, pelvic fluid and inflammatory factor level, only one trial showed that there was a significant effect, respectively. Conclusions: This study shows that moxibustion is more effective and safe for CPID. The findings we obtained must be interpreted with caution due to universal low quality and low evidence level of the eligible trials.

scholarly journals Efficacy of Qigong Exercise for Treatment of Fatigue: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 8 ◽  
Author(s):  
Rui Wang ◽  
Xueyan Huang ◽  
Yeqi Wu ◽  
Dai Sun
Keyword(s):  
Meta Analysis ◽  
Chronic Fatigue ◽  
Cochrane Library ◽  
China National Knowledge Infrastructure ◽  
Patients With Cancer ◽  
Fatigue Syndrome ◽  
Knowledge Infrastructure ◽  
Standard Mean Difference ◽  
Significant Difference

Objective: Several studies suggested that Qigong exercise (QE) can relieve fatigue in patients diagnosed with various diseases. Our review aimed to evaluate the efficacy of QE for alleviating fatigue.Methods: A related literature search was performed in the PubMed, Web of Science, Embase, Cochrane Library, China Biology Medicine disc (CBM), China National Knowledge Infrastructure (CNKI), Wanfang, and VIP data bases from inception to November 2020. Information on fatigue, malaise, tiredness, and Qigong research data was collected.Results: Sixteen randomized controlled trials (RCTs) were reported in patients with cancer (n = 4), chronic fatigue syndrome (n = 2), and other diseases (n = 10). The QE groups showed significant improvements in total fatigue intensity [15 RCTs, p &lt; 0.00001; standard mean difference (SMD) −0.69 (−0.95 to −0.44)]. The QE groups did not show significant improvement in quality of life [4 RCTs, p = 0.08; SMD 0.53 (−0.07 to 1.14)]. The statistically significant difference of the subgroup analyses (different primary diseases, QE types, and study quality) also remained unchanged.Conclusion: The findings of this meta-analysis indicate that QE may be beneficial for improving fatigue in patients diagnosed with various diseases. Considering the limitations of the study, we draw a very cautious conclusion regarding the resulting estimate of the effect. Further studies are warranted to better understand the benefits of QE in primary medical care.

Effects of Sodium Valproate Monotherapy on Blood Liver Enzyme Levels in Patients with Epilepsy: A Meta-Analysis

2021 ◽  
Vol 53 (07) ◽  
pp. 425-434
Author(s):  
Jie Fu ◽  
Tao Tao ◽  
Zuoxiao Li ◽  
Yangmei Chen ◽  
Xiu Chen ◽  
...  
Keyword(s):  
Sodium Valproate ◽  
Early Stage ◽  
Meta Analysis ◽  
Group Versus ◽  
Cochrane Library ◽  
Control Group ◽  
China National Knowledge Infrastructure ◽  
Asian Patients ◽  
Knowledge Infrastructure ◽  
Patients With Epilepsy

AbstractWe conducted this meta-analysis to assess the effects of sodium valproate (VPA) monotherapy on blood liver enzymes in patients with epilepsy. PubMed, Web of Science, EBSCO, Cochrane Library, Wanfang, China national knowledge infrastructure databases were searched. Nine studies were included. Results showed: (1) The overall SMD for blood AST, ALT, and GGT levels of VPA monotherapy group versus control group were 0.70 (95% CI=0.31 to 1.09, Z=3.52, p=0.0004), 0.47 (95% CI=− 0.01 to 0.95, Z=1.91, p=0.06), 0.44 (95% CI=0.29 to 0.60, Z=5.55, p<0.00001), respectively. (2) In subgroup meta-analysis, increased blood AST and GGT levels were observed in epileptic minors (AST: total SMD=0.85, 95% CI=0.40 to 1.30, Z=3.69, p=0.0002; GGT: total SMD=0.46, 95% CI=0.29 to 0.63, Z=5.25, p<0.00001). Elevated blood ALT level was observed in Asian patients receiving VPA monotherapy (total SMD=0.70, 95% CI=0.51 to 0.90, Z=7.01, p<0.00001), and the early stage of VPA monotherapy (total SMD=0.93, 95% CI=0.57 to 1.29, Z=5.09, p<0.00001). Overall, our results indicated that blood AST and GGT were significantly increased in epileptic minors receiving VPA monotherapy. The elevation of blood ALT was observed in Asian patients and the early stage of VPA monotherapy. However, due to the small number of included studies, our results should be considered with caution.

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