scholarly journals Impaired Mucosal Integrity in Proximal Esophagus Is Involved in Development of Proton Pump Inhibitor-Refractory Nonerosive Reflux Disease

Digestion ◽  
2020 ◽  
pp. 1-11
Author(s):  
Kazuaki Norita ◽  
Kiyotaka Asanuma ◽  
Tomoyuki Koike ◽  
Tomoki Okata ◽  
Taku Fujiya ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Reflux Disease ◽  
Nonerosive Reflux Disease ◽  
Mucosal Integrity ◽  
Proximal Esophagus

Evaluation of Proton Pump Inhibitor-Resistant Nonerosive Reflux Disease by Esophageal Manometry and 24-Hour Esophageal Impedance and pH Monitoring

Digestion ◽  
2015 ◽  
Vol 91 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Osamu Kawamura ◽  
Hiroko Hosaka ◽  
Yasuyuki Shimoyama ◽  
Akiyo Kawada ◽  
Shiko Kuribayashi ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Reflux Disease ◽  
Esophageal Manometry ◽  
Ph Monitoring ◽  
Nonerosive Reflux Disease ◽  
Esophageal Impedance

Usefulness of baseline impedance in patients with proton pump inhibitor-refractory nonerosive reflux disease

2015 ◽  
Vol 30 ◽  
pp. 36-40 ◽  
Author(s):  
Yukie Kohata ◽  
Yasuhiro Fujiwara ◽  
Hirokazu Yamagami ◽  
Tetsuya Tanigawa ◽  
Masatsugu Shiba ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Reflux Disease ◽  
Nonerosive Reflux Disease

scholarly journals Current management of proton pump inhibitor-refractory gastroesophageal reflux disease

2020 ◽  
Vol 5 (2) ◽  
pp. 93-100
Author(s):  
V. V. Tsukanov ◽  
A. V. Vasyutin ◽  
Yu. L. Tonkikh
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Proton Pump Inhibitor ◽  
Gastroesophageal Reflux ◽  
Proton Pump ◽  
Reflux Disease ◽  
Ph Monitoring ◽  
Developed Countries ◽  
Acid Exposure ◽  
Functional Heartburn ◽  
Nonerosive Reflux Disease

Here we review current concepts in diagnosis and treatment of proton pump inhibitor (PPI)-refractory gastroesophageal reflux disease (PPIGERD) which includes an insufficient response to daily PPI 8-week therapy in combination with pathological gastroesophageal reflux. Patients with PPI-GERD frequently suffer from non-acidic and asymptomatic gastroesophageal reflux. In developed countries, PPI-GERD accounts for 30-40% of all patients receiving PPIs. Diagnosis of PPIGERD is performed by means of clinical anamnesis, esophagogastroscopy and impedance-pH monitoring. PPI-GERD needs to be differentiated with functional heartburn, reflux hypersensitivity and nonerosive reflux disease. Functional heartburn is characterised by reference time with a esophageal pH < 4 and the absence of a link between reflux episodes and GERD symptoms. Reflux hypersensitivity is diagnosed with normal esophageal acid exposure and association of reflux episodes with symptoms of GERD. Nonerosive reflux disease can be diagnosed solely by evaluating pathological acid exposure (pH < 4 for > 6% of the time). Treatment of PPI-GERD includes diet and lifestyle modification to reduce weight in obese patients, optimization of PPI use, and administration of alginate, prokinetics, baclofen and other drugs. Surgical treatment is also widely used and provide good results.

scholarly journals Washed microbiota transplantation reduces proton pump inhibitor dependency in nonerosive reflux disease

2021 ◽  
Vol 27 (6) ◽  
pp. 513-522
Author(s):  
Ya-Mei Zheng ◽  
Xian-Yun Chen ◽  
Jie-Yi Cai ◽  
Yu Yuan ◽  
Wen-Rui Xie ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Reflux Disease ◽  
Nonerosive Reflux Disease
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