Interleukin Polymorphisms and Predisposition of Systemic Lupus Erythematosus: A Meta-Analysis

2021 ◽  
pp. 1-9
Author(s):  
Zongqing Liu ◽  
Tong Sun ◽  
Linjian Song ◽  
Xiaoxing Xue ◽  
Shuang Liu ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Web Of Science ◽  
Meta Analysis ◽  
Interleukin 1 ◽  
Interleukin 10 ◽  
Interleukin 4 ◽  
Systemic Lupus ◽  
Comprehensive Search ◽  
Meta Analyses

<b><i>Background:</i></b> It is plausible that interleukin polymorphisms may affect predisposition of autoimmune disorders such as systemic lupus erythematosus (SLE), but the results of so far published studies remain controversial. <b><i>Objectives:</i></b> The authors conducted this meta-analysis to clarify relationships between interleukin-1 (<i>IL-1</i>)<i>/</i>interleukin-4 (<i>IL-4</i>)<i>/</i>interleukin-6 (<i>IL-6</i>)<i>/</i>interleukin-10 (<i>IL-10</i>) polymorphisms and SLE by pooling the findings of eligible studies. <b><i>Methods:</i></b> A comprehensive search of PubMed, EMBASE, Web of Science, and CNKI was endorsed by the authors to identify already published studies. Fifty-seven studies were found to be eligible for meta-analyses. <b><i>Results:</i></b> The overall pooled meta-analyses yielded positive findings for <i>IL-1A</i> −889 C/T, <i>IL-1B</i> −31 T/C, <i>IL-6</i> −174 G/C, <i>IL-4</i> −590 C/T, and <i>IL-10</i> −1,082 A/G polymorphisms. In addition, we also detected similar positive findings for <i>IL-1B</i> −511 C/T, <i>IL-4</i> −590 C/T, <i>IL-10</i> −592 A/C, <i>IL-10</i> −819 C/T, and <i>IL-10</i> −1,082 A/G polymorphisms in Asians, and such positive findings were also observed for <i>IL-1A</i> −889 C/T, <i>IL-6</i> −174 G/C, and <i>IL-10</i> −1,082 A/G polymorphisms in Caucasians. <b><i>Conclusions:</i></b> The meta-analyses’ results suggest that <i>IL-1A</i> −889 C/T, <i>IL-1B</i> −31 T/C, <i>IL-6</i> −174 G/C, <i>IL-4</i> −590 C/T, and <i>IL-10</i> −1,082 A/G polymorphisms might affect predisposition of SLE.

Associations between Polymorphisms in the IL-1 Gene and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Evidence from a Meta-Analysis

2020 ◽  
pp. 1-9
Author(s):  
Lin Zhu ◽  
Peng Chen ◽  
Xuanjing Sun ◽  
Shuo Zhang
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Web Of Science ◽  
Meta Analysis ◽  
Interleukin 1 ◽  
Systemic Lupus

<b><i>Background:</i></b> Previous studies on polymorphisms in interleukin-1 (<i>IL-1</i>) and the risk of rheumatoid arthritis (RA)/systemic lupus erythematosus (SLE) yielded inconsistent results. <b><i>Objectives:</i></b> The authors performed this meta-analysis to more robustly evaluate associations between polymorphisms in the <i>IL-1</i> gene and the risk of RA/SLE. <b><i>Methods:</i></b> MEDLINE, Embase, Web of Science, Wanfang, VIP, and CNKI were systematically searched for eligible studies, and 34 relevant studies were finally selected to be eligible for inclusion. <b><i>Results:</i></b> We found that <i>IL-1A</i> +4845G/T polymorphism was significantly associated with the risk of RA in the overall population (dominant comparison: <i>p</i> = 0.02; overdominant comparison: <i>p</i> = 0.05; allele comparison: <i>p</i> = 0.04), whereas <i>IL-1B</i> +3954C/T polymorphism was significantly associated with the risk of RA in the overall population (overdominant comparison: <i>p</i> = 0.03; allele comparison: <i>p</i> = 0.01) and Asians (recessive comparison: <i>p</i> = 0.007; allele comparison: <i>p</i> = 0.002). In addition, we found that <i>IL-1A</i> –889C/T polymorphism was significantly associated with the risk of SLE in Caucasians (allele comparison: <i>p</i> = 0.04), <i>IL-1B</i> –31T/C polymorphism was significantly associated with the risk of SLE in the overall population (recessive comparison: <i>p</i> = 0.04), and <i>IL-1B</i> –511C/T polymorphism was significantly associated with the risk of SLE in Asians (recessive comparison: <i>p</i> = 0.01; allele comparison: <i>p</i> = 0.03). <b><i>Conclusions:</i></b> This meta-analysis suggests that <i>IL-1A</i> +4845G/T and <i>IL-1B</i> +3954C/T polymorphisms may influence the risk of RA, whereas <i>IL-1A</i> –889C/T, <i>IL-1B</i> –31T/C, and <i>IL-1B</i> –511C/T polymorphisms may influence the risk of SLE.

Associations between paraoxonase-1 and systemic lupus erythematosus

Lupus ◽  
2019 ◽  
Vol 28 (13) ◽  
pp. 1571-1576
Author(s):  
S -C Bae ◽  
Y H Lee
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Confidence Interval ◽  
Lupus Erythematosus ◽  
Meta Analysis ◽  
Small Sample ◽  
Mean Difference ◽  
Paraoxonase 1 ◽  
Systemic Lupus ◽  
Standard Mean Difference ◽  
Meta Analyses

Objective The objective of this analysis was to explore associations between paraoxonase-1 levels, gene polymorphisms and systemic lupus erythematosus. Methods Meta-analyses of paraoxonase-1 levels and Q192R and L55M and polymorphisms in systemic lupus erythematosus were conducted. Results Nine articles were incorporated in our meta-analysis, which uncovered that the paraoxonase-1 level was decreased in systemic lupus erythematosus compared to control (standard mean difference = −1.626, 95% confidence interval = −2.829–−0.424, p = 0.008). Ethnicity-specific meta-analysis demonstrated a relation tendency between decreased paraoxonase-1 activity and lupus in Europeans (standard mean difference = −1.236, 95% confidence interval = −2.634–0.163, p = 0.083). Paraoxonase-1 activity was reduced in systemic lupus erythematosus in a single Arab and African population. Decreased paraoxonase-1 activity was found in a small sample of systemic lupus erythematosus patients (standard mean difference = −1.642, 95% confidence interval = −3.076–−0.247, p = 0.021). Ethnicity-specific analysis indicated a relationship between the paraoxonase-1 55 M allele in the Arab systemic lupus erythematosus population. However, a lack of association with systemic lupus erythematosus and the paraoxonase-1 192 R allele was observed. Conclusions Meta-analyses revealed reduced paraoxonase-1 activity in patients with systemic lupus erythematosus and found possible associations between systemic lupus erythematosus and paraoxonase-1 L55M polymorphism in a specific ethnic group.

Predisposition to Hyperthyroidism May Be Influenced by Functional TNF-α, IL-1, IL-6, and IL-10 Polymorphisms: A Meta-Analysis

2020 ◽  
Vol 181 (12) ◽  
pp. 956-965
Author(s):  
Hong Ma ◽  
Ting Tan ◽  
Jie Wu ◽  
Juan Chen ◽  
Xiaohong Zhang
Keyword(s):  
Meta Analysis ◽  
Interleukin 1 ◽  
Interleukin 10 ◽  
Interleukin 4 ◽  
Asian Origin ◽  
Tnf Α ◽  
Caucasian Origin ◽  
Meta Analyses ◽  
Factor Α ◽  
Necrosis Factor

<b><i>Background:</i></b> Predisposition to hyperthyroidism may be influenced by functional gene polymorphisms in tumor necrosis factor-α (<i>TNF-α</i>), interleukin-1 (<i>IL-1</i>), interleukin-4 (<i>IL-4</i>), interleukin-6 (<i>IL-6</i>), and interleukin-10 (<i>IL-10</i>). However, the results of the studies published so far remain discrepant, so we conducted a meta-analysis to more robustly investigate relationships between <i>TNF-α</i>/<i>IL-1/IL-4/IL-6/IL-10</i> polymorphisms and predisposition to hyperthyroidism. <b><i>Methods:</i></b> A comprehensive literature retrieval from PubMed, Embase, Web of Science, WanFang, VIP, and CNKI was endorsed by the authors, and 38 studies were found to be eligible for pooled meta-analyses. <b><i>Results:</i></b> We found that genotypic frequencies of <i>TNF-α</i> −308 G/A, <i>IL-1A</i> −889 C/T, <i>IL-6</i> −174 G/C, <i>IL-6</i> −572 G/C, <i>IL-10</i> −819 C/T, and <i>IL-10</i> −1082 A/G polymorphisms among cases were significantly different from those among controls. Moreover, we also found that genotypic frequencies of <i>TNF-α</i> −308 G/A and <i>IL-6</i> −174 G/C polymorphisms among cases of Caucasian origin were significantly different from those among Caucasian controls, and genotypic frequencies of <i>IL-1A</i> −889 C/T, <i>IL-1B</i> −511 C/T, <i>IL-6</i> −174 G/C, <i>IL-6</i> −572 G/C, and <i>IL-10</i> −1,082 A/G polymorphisms among cases of Asian origin were also significantly different from those among Asian controls. <b><i>Conclusions:</i></b> This meta-analysis suggests that <i>TNF-α</i> −308 G/A, <i>IL-1A</i> −889 C/T, <i>IL-1B</i> −511 C/T, <i>IL-6</i> −174 G/C, <i>IL-6</i> −572 G/C, <i>IL-10</i> −819 C/T, and <i>IL-10</i> −1,082 A/G polymorphisms may influence predisposition to hyperthyroidism in certain ethnic groups.

Association between shortened telomere length and systemic lupus erythematosus: a meta-analysis

Lupus ◽  
2016 ◽  
Vol 26 (3) ◽  
pp. 282-288 ◽  
Author(s):  
Y H Lee ◽  
J H Jung ◽  
Y H Seo ◽  
J-H Kim ◽  
S J Choi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Telomere Length ◽  
Lupus Erythematosus ◽  
Meta Analysis ◽  
Data Type ◽  
Assay Method ◽  
Control Group ◽  
Sample Type ◽  
Systemic Lupus ◽  
Meta Analyses

Objective We aimed to evaluate the relationship between telomere length and systemic lupus erythematosus (SLE). Methods PUBMED and EMBASE databases were searched; meta-analyses were performed comparing telomere length in SLE patients and healthy controls, and on SLE patients in subgroups based on ethnicity, sample type, assay method and data type. Results Eight studies including 472 SLE patients and 365 controls were ultimately selected which showed that telomere length was significantly shorter in the SLE group than in the control group (standardized mean difference (SMD) = −0.835, 95% confidence interval (CI) = −1.291 to −0.380, p = 3.3 × 10−4). Stratification by ethnicity showed significantly shortened telomere length in the SLE group in Caucasian, Asian and mixed populations (SMD = −0.455, 95% CI = −0.763 to −0.147, p = 0.004; SMD = −0.887, 95% CI = −1.261 to −0.513, p = 3.4 × 10−4; SMD = −0.535, 95% CI = −0.923 to −0.147, p = 0.007; respectively). Furthermore, telomere length was significantly shorter in the SLE group than in the control group in whole blood and peripheral blood mononuclear cell groups (SMD = −0.361, 95% CI = −0.553 to −0.169, p = 2.3 × 10−4; SMD = −1.546, 95% CI = −2.583 to −0.510, p = 0.003; respectively); a similar trend was observed in leukocyte groups (SMD = −0.699, 95% CI = −1.511 to −0.114, p = 0.092). Meta-analyses based on assay method or data type revealed similar associations. Conclusions Our meta-analysis demonstrated that telomere length was significantly shorter in patients with SLE, regardless of ethnicity, sample type or assay method evaluated.

Association between periodontitis and systemic lupus erythematosus: a meta-analysis

Lupus ◽  
2020 ◽  
Vol 29 (10) ◽  
pp. 1189-1197
Author(s):  
Hao-Jie Zhong ◽  
Hui-Xin Xie ◽  
Xiao-Min Luo ◽  
Er-Hua Zhang
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Web Of Science ◽  
Meta Analysis ◽  
Mean Difference ◽  
Gingival Index ◽  
Systemic Lupus ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Pooled Data

Objective The objective of this study was to explore the association between periodontitis and systemic lupus erythematosus (SLE). Methods To identify eligible studies, the PubMed, EMBASE and Web of Science databases were searched from inception to 19 September 2019. Associations of periodontitis, and other periodontal parameters, with SLE were assessed. Results Ten studies involving 80,633 subjects were included in this meta-analysis. Pooled data showed a significant association between periodontitis and SLE (odds ratio=5.32, 95% confidence interval (CI) 1.69–16.78, p = 0.004). In addition, SLE patients had a higher prevalence of bleeding on probing (mean difference = 0.03, 95% CI 0.00–0.06, p = 0.02) and higher mean clinical attachment loss (mean difference = 0.69, 95% CI 0.39–1.00, p < 0.001). However, there were no significant differences between SLE and reference subjects in mean plaque index, gingival index, pocket depth or decayed, missing or filled teeth. Conclusions This study demonstrates a significant association between periodontitis and SLE, which indicates that avoidance of periodontitis by maintaining oral health may be a simple and economical way to prevent SLE.

Systemic lupus erythematosus and risk of sexual dysfunction: A systematic review and Meta-Analysis

Lupus ◽  
2020 ◽  
pp. 096120332097408
Author(s):  
Zhao Jin ◽  
Cong Yang ◽  
Chu Xiao ◽  
Zizhen Wang ◽  
Suxin Zhang ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Sexual Dysfunction ◽  
Lupus Erythematosus ◽  
Web Of Science ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Control Group ◽  
Systemic Lupus ◽  
Increased Risk

Objective To systematically review and summarize the available literature regarding the association between systemic lupus erythematosus (SLE) and sexual dysfunction (SD) in both sexes. Methods We retrieved relevant studies from the following databases: PubMed, Embase, Cochrane Library, and Web of Science. Two reviewers independently reviewed the studies in our sample, assessed their validity, and extracted relevant data. Sensitivity and subgroup analyses were performed to distinguish sources of heterogeneity. Results Our search resulted in a sample of eight eligible studies, which involved 758 patients in the SLE group and 1724 individuals in the control group. The pooled RR for the increased risk for SD compared to those in the control group was 1.80 (95%CI 1.12-2.87). Subgroup analysis by sex revealed that males (pooled RR = 2.98, 95%CI 2.41-3.68) had a higher risk of SD compared to females (pooled RR = 1.56, 95%CI 0.99-2.48). Females with SLE had significantly lower values in FSFI compared to the healthy individuals (WMD=-0.224, 95%CI -0.441 to -0.078). Age of participants and the quality of studies might influence the results. Conclusions Our meta-analysis suggests that SLE is significantly associated with an increased risk of sexual dysfunction. It is of great urgency to implement for active interventions that aimed to treat or prevent SD among SLE patients.

Association of the interleukin-10 gene polymorphism (–1082A/G) with systemic lupus erythematosus: a meta-analysis

Lupus ◽  
2012 ◽  
Vol 22 (2) ◽  
pp. 128-135 ◽  
Author(s):  
M Zhou ◽  
L Ding ◽  
H Peng ◽  
B Wang ◽  
F Huang ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Gene Polymorphism ◽  
Lupus Erythematosus ◽  
Meta Analysis ◽  
Interleukin 10 ◽  
Systemic Lupus

Associations between interleukin 1 polymorphisms and susceptibility to systemic lupus erythematosus: A meta-analysis

2014 ◽  
Vol 75 (1) ◽  
pp. 105-112 ◽  
Author(s):  
Gwan Gyu Song ◽  
Jae-Hoon Kim ◽  
Young Ho Seo ◽  
Sung Jae Choi ◽  
Jong Dae Ji ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Meta Analysis ◽  
Interleukin 1 ◽  
Systemic Lupus
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