scholarly journals Primary Bone Lymphoma in Axial Skeleton in a Middle-Aged Female Presented as Recurrent Anemia

2020 ◽  
Vol 13 (1) ◽  
pp. 276-280
Author(s):  
Tala Batia ◽  
Mohamed A. Yassin ◽  
Deena S. Mudawi ◽  
Omnia A. Hamid ◽  
Ahmed M.A. Abdalhadi
Keyword(s):  
Cell Lymphoma ◽  
Case Reports ◽  
B Cell Lymphoma ◽  
Axial Skeleton ◽  
Primary Bone Lymphoma ◽  
Large B Cell Lymphoma ◽  
Pathological Type ◽  
Primary Bone ◽  
Insight Into ◽  
Bone Lymphoma

Primary bone lymphoma (PBL) is a peculiar extranodal presentation of non-Hodgkin’s lymphoma. Primary bone diffuse large B-cell lymphoma (DLBCL) is the most common pathological type, comprising about 80% of PBL. The diagnosis of PBL depends on the combined clinical examination and imaging studies and is confirmed with immunohistochemical examination. Due to the rarity of this disease, more relative studies and case reports are needed to provide insight into this obscure lymphoproliferative malignancy. Here, we report one rare case of primary bone DLBCL involving the axial skeleton in a 37-year-old female.

scholarly journals DLBCL of Clavicle: Role of FNA in diagnosis of Rare Lesion

2020 ◽  
Vol 7 (10) ◽  
pp. C133-136
Author(s):  
Cyrus Dara Jokhi ◽  
Kalpesh V Vaghela ◽  
Pruthvi Damor
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Local Area ◽  
Primary Bone Lymphoma ◽  
X Ray ◽  
Large B Cell Lymphoma ◽  
Primary Bone ◽  
Bone Lymphoma ◽  
Large B Cell

Primary bone lymphoma is rare, among which commonly involved site at time of presentation are femur, pelvic bones, tibia and most common type is Large B cell lymphoma which usually occurs in adults.  Cases of large B cell lymphoma in clavicle as primary bone lymphoma is extremely rare finding. According to our knowledge this case may be first reported case of world. We are here reporting a case of 62-year female presented as sternoclavicular joint swelling, without fever or pain in local area. Patient was diagnosed on X ray by radiologist, as well as by clinician as, osteosarcoma of right clavicle. Patient came to Department of Cytopathology for FNA for confirmation of X ray finding. On FNA diagnosis of Non-Hodgkin lymphoma was given, and advise for biopsy and immunohistochemistry (IHC) was given for confirmation of diagnosis and to subtype NHL. On IHC Ki67 index was 85%, with diffuse positivity noted for MUM1, CD79a, and CD138 along with cytoplasmic positivity for ALK 1 and patchy positivity for PAX 5. Tumor was negative for BCL6, BCL2, CD20, CD5, CD23, CD10, CD19, CD4, CD8, CD7, CD3. Diagnosis of ALK positive DLBCL was given on biopsy after IHC. Patients with PBL treated with combined modality were found to have a superior outcome, with a significantly better survival (5-year cause-specific survival 95%). So correct and timely pathological diagnosis of DLBCL as PBL is significantly important for prognosis.

scholarly journals Pediatric Primary Bone Lymphoma–Diffuse Large B-Cell Lymphoma

2007 ◽  
Vol 127 (1) ◽  
pp. 47-54 ◽  
Author(s):  
X. Frank Zhao ◽  
Ken H. Young ◽  
Dale Frank ◽  
Ami Goradia ◽  
Michael P. Glotzbecker ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Primary Bone Lymphoma ◽  
Large B Cell Lymphoma ◽  
Primary Bone ◽  
Bone Lymphoma ◽  
Large B Cell

scholarly journals Primary diffuse large B-cell lymphoma of the bone mimicking osteomyelitis

2021 ◽  
Author(s):  
abbas mofidi ◽  
Mohsen Esfandbod ◽  
Ehsan Pendar ◽  
Masoud Mortezazadeh ◽  
Alireza hadizadeh
Keyword(s):  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Bone Lesions ◽  
Open Biopsy ◽  
Core Needle ◽  
Primary Bone Lymphoma ◽  
Large B Cell Lymphoma ◽  
Primary Bone ◽  
Bone Lymphoma ◽  
Large B Cell

In this article, we report a 34-year-old man who presented with progressive hip pain and osteolytic bone lesions . Primary workup included Core needle biopsies manifested as osteomyelitis; however as no sign of remission was observed, an open biopsy considered which revealed primary bone lymphoma.

A Rare Manifestation of Primary Bone Lymphoma: Solitary Diffuse Large B-Cell Lymphoma of the Little Finger

2018 ◽  
Vol 43 (8) ◽  
pp. 779.e1-779.e4 ◽  
Author(s):  
Virginia Galati ◽  
Friederike Wortmann ◽  
Felix H. Stang ◽  
Christoph Thorns ◽  
Peter Mailänder ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Primary Bone Lymphoma ◽  
Large B Cell Lymphoma ◽  
Rare Manifestation ◽  
Primary Bone ◽  
Bone Lymphoma ◽  
Large B Cell ◽  
Little Finger

scholarly journals Successful Outcome of Patellectomy Plus Chemotherapy for Primary Bone Lymphoma of the Patella: A Case Report and Literature Review

2021 ◽  
Vol 11 ◽  
Author(s):  
Xin Cao ◽  
Hui-Jin Chen
Keyword(s):  
Clinical Evidence ◽  
Bone Biopsy ◽  
B Cell Lymphoma ◽  
Successful Outcome ◽  
Chop Chemotherapy ◽  
Primary Bone Lymphoma ◽  
Large B Cell Lymphoma ◽  
Primary Bone ◽  
Bone Lymphoma ◽  
Optimal Treatment Strategy

Primary bone lymphoma (PBL) is a rare but distinct clinicopathological disease, usually occurring in the pelvis, spine, and ribs. To date, only a few cases have been reported as beginning in the patella. Due to the lack of clinical evidence, the optimal treatment strategy has not been established. Here, we report a case that presented unexplained right knee pain. The case was diagnosed with the non-germinal center, diffuse large B cell lymphoma in the patella by imaging examinations and bone biopsy. Then, the patient received a patellectomy and eight cycles of R-CHOP chemotherapy. After treatment, the patient achieved a favorable prognosis and satisfactory functional recovery.

Primary Bone Lymphoma: A Clinical Analysis of 17 Patients in a Single Institution

2015 ◽  
Vol 134 (2) ◽  
pp. 80-85 ◽  
Author(s):  
Eiko Hayase ◽  
Mitsutoshi Kurosawa ◽  
Hiroaki Suzuki ◽  
Kohei Kasahara ◽  
Tomohiro Yamakawa ◽  
...  
Keyword(s):  
Initial Treatment ◽  
Nk Cell ◽  
Cell Lymphoma ◽  
International Prognostic Index ◽  
Prognostic Index ◽  
B Cell Lymphoma ◽  
Cell Phenotype ◽  
Primary Bone Lymphoma ◽  
Primary Bone ◽  
Bone Lymphoma

Primary bone lymphoma (PBL) comprises less than 1% of all malignant lymphomas. Because few studies of PBL have been conducted in Japan, the characteristics of Japanese patients with PBL have not been fully elucidated. We retrospectively analyzed 17 patients diagnosed with PBL at our institution between 2001 and 2011. Median patient age was 60 years. Eleven patients had diffuse large B-cell lymphoma and 2 patients had T-cell lymphoma histology. The spine was the most frequently involved site at the time of presentation. There were 11 patients with stage IV disease and 11 patients with high or high-intermediate risk according to the International Prognostic Index (IPI). Thirteen patients achieved complete response (CR) after initial treatment. At a median follow-up of 31 months, the 3-year overall survival (OS) and progression free survival were 63.5 and 49.9%, respectively. Localized disease, low or low-intermediate IPI, and CR after initial treatment were associated with a good outcome in patients with PBL and significantly associated with a better OS. Spine involvement and T/NK-cell phenotype are more frequent in Japanese than in Caucasian patients with PBL.

scholarly journals Intravascular Lymphoma in Patient With Celiac Disease With Multi Glandular Involvement

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A938-A939
Author(s):  
Mustafa Alam ◽  
Mohamad Hosam Horani
Keyword(s):  
Celiac Disease ◽  
B Cell ◽  
Cell Lymphoma ◽  
Case Reports ◽  
B Cell Lymphoma ◽  
Diagnostic Challenge ◽  
Pituitary Microadenoma ◽  
Non Hodgkin Lymphoma ◽  
Large B Cell Lymphoma ◽  
History Of

Abstract Case Presentation: The patient is a 60 year old male with a past medical history of celiac disease, paroxysmal Afib, iron deficiency, and CAD who presented with lightheadedness, dizziness, and fatigue. Notable workup revealed that the patient had Afib with RVR, a TSH of 0.189, Free t4 0.51an LDH of 2726, hemoglobin of 8.7, AST of 155, ALT of 19, WBC of 4.5, and serum iron of 20. The patient’s cardizem dose was adjusted and repeat transthoracic echocardiogram was unremarkable compared to history. The patient presented again with complaints of abdominal distension, postural dizziness, occasional night sweats, and fevers. Repeat workups revealed pancytopenia, proteinuria, hypotension, and anasarca most pronounced in the lower extremity and scrotum. Ultimately, a kidney biopsy revealed an intravascular B cell non-Hodgkin lymphoma (IVBCL). Notable repeat labs include a CRP of 44 and a failed ACTH stimulation test. A brain MRI revealed a 6mm pituitary microadenoma. The patient placed on an R-CHOP regiment and is scheduled for repeat MRI to rule out pituitary involvement. Discussion: IVBCL’s are a rare form of diffuse B cell lymphoma and remain a diagnostic challenge due to the variety of involved systems including skin, CNS, and endocrine. IVBCL is also known to not produce a mass or lymphadenopathy. Celiac disease is a known risk factor for non-Hodgkin’s lymphoma. A literature search reveals a few case reports with common themes of increased LDH and inflammatory markers, anemia, and hepatic and renal dysfunction. Postural hypotension can also be a presenting symptom due to IVBCL’s ability to infiltrate neurovascular tissue to cause autonomic neuropathy. However, in this case, the patient’s history of primary adrenal insufficiency makes this unlikely. Hypothyroidism secondary to pituitary and thyroid involvement was suspected due to TSH level suppressed enough for central hypothyroidism. Repeated MRI showed resolution of Pituitary Microadenoma post Chemo therapy. Sylvain Raoul Simeni Njonnou, Bruno Couturier, Yannick Gombeir, Sylvain Verbanck, France Devuyst, Georges El Hachem, Ivan Theate, Anne-Laure Trepant, Virginie De Wilde, Frédéric-Alain Vandergheynst, “Pituitary Gland and Neurological Involvement in a Case of Hemophagocytic Syndrome Revealing an Intravascular Large B-Cell Lymphoma”, Case Reports in Hematology, vol. 2019, 6 pages, 2019. https://doi.org/10.1155/2019/9625075 Catassi C, Fabiani E, Corrao G, et al. Risk of Non-Hodgkin Lymphoma in Celiac Disease. JAMA. 2002;287(11):1413 Khan MS, McCubbin M, Nand S. Intravascular Large B-Cell Lymphoma: A Difficult Diagnostic Challenge. J Investig Med High Impact Case Rep. 2014 Mar 6;2(1):2324709614526702. Pearce C, Hope S, Butchart J. Intravascular lymphoma presenting with postural hypotension. BMJ Case Rep. Published 2018 Jan 29.

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