Primary Bone Lymphoma: A Clinical Analysis of 17 Patients in a Single Institution

2015 ◽  
Vol 134 (2) ◽  
pp. 80-85 ◽  
Author(s):  
Eiko Hayase ◽  
Mitsutoshi Kurosawa ◽  
Hiroaki Suzuki ◽  
Kohei Kasahara ◽  
Tomohiro Yamakawa ◽  
...  
Keyword(s):  
Initial Treatment ◽  
Nk Cell ◽  
Cell Lymphoma ◽  
International Prognostic Index ◽  
Prognostic Index ◽  
B Cell Lymphoma ◽  
Cell Phenotype ◽  
Primary Bone Lymphoma ◽  
Primary Bone ◽  
Bone Lymphoma

Primary bone lymphoma (PBL) comprises less than 1% of all malignant lymphomas. Because few studies of PBL have been conducted in Japan, the characteristics of Japanese patients with PBL have not been fully elucidated. We retrospectively analyzed 17 patients diagnosed with PBL at our institution between 2001 and 2011. Median patient age was 60 years. Eleven patients had diffuse large B-cell lymphoma and 2 patients had T-cell lymphoma histology. The spine was the most frequently involved site at the time of presentation. There were 11 patients with stage IV disease and 11 patients with high or high-intermediate risk according to the International Prognostic Index (IPI). Thirteen patients achieved complete response (CR) after initial treatment. At a median follow-up of 31 months, the 3-year overall survival (OS) and progression free survival were 63.5 and 49.9%, respectively. Localized disease, low or low-intermediate IPI, and CR after initial treatment were associated with a good outcome in patients with PBL and significantly associated with a better OS. Spine involvement and T/NK-cell phenotype are more frequent in Japanese than in Caucasian patients with PBL.

scholarly journals Primary Bone Lymphoma: An Experience of a Regional Cancer Center from India

2020 ◽  
Vol 09 (04) ◽  
pp. 227-229
Author(s):  
Rohit Mahajan ◽  
Budhi Singh Yadav ◽  
Suresh Chander Sharma ◽  
Ankita Gupta ◽  
Shikhar Kumar
Keyword(s):  
International Prognostic Index ◽  
Prognostic Index ◽  
B Cell Lymphoma ◽  
Clinical Staging ◽  
Histologic Subtype ◽  
Primary Bone Lymphoma ◽  
Number Of Patients ◽  
Primary Bone ◽  
Hodgkin's Lymphomas ◽  
Bone Lymphoma

Abstract Background Primary bone lymphoma (PBL) is a rare disease, representing <5% of all extranodal non-Hodgkin’s lymphomas (NHLs). The optimal treatment strategy is still unclear. Here, we report our institutional outcome analysis of patients diagnosed with PBL. Materials and Methods From 2007 to 2014, the medical records of 22 patients with PBL were reviewed. Analysis was done for symptom-, patient-, disease-, and treatment-related characteristics. All patients were treated with chemotherapy with or without radiotherapy. Treatment response and impact of different prognostic factors on clinical outcome were analyzed. Results The median age of presentation was 44 years (range: 18–70 years). A total of 19 (86.4%) patients were ≤60 years of age and 3 (13.6%) patients were >60 years. Out of all, 18 were males and 4 were females. Ann Arbor clinical staging at diagnosis was Stage I in 13 (59.1%), Stage II in 3 (13.6%), Stage III in 2 (9.1%), and Stage IV in 4 (18.2%) patients. Spine was the most common site of involvement seen in 12 (54.5%) patients. Diffuse large B cell lymphoma histology was seen in 8 (36.4%) patients and 8 (36.4%) had high-grade NHL. Chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone was given to 20 (90.9%) patients, whereas 2 (9.1%) patients received cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab. Radiotherapy (30-40 Gy) was delivered to 19 (86.4%) patients. The median follow-up period was 40 months (range: 8–105 months). The overall response rate was 86.3% with complete response (CR) in 15 (68.1%) and partial response in 4 (18.2%) patients. Relapses were seen in three (13.5%) patients: two nodal, and one in the bone. Disease-free survival (DFS) and overall survival (OS) at 5 years were 56.6 and 72.7%, respectively. CR after initial treatment was associated with a significant better OS, 80 and 25%, respectively (p < 0.0001). Age, sex, stage, International Prognostic Index, histologic subtype, and number of sites had no significant influence on OS. Combining radiation therapy with chemotherapy (with or without rituximab) also did not improve the OS or DFS of patients. Conclusion In spite of small number of patients reported in this study, conventional chemotherapy remains an effective treatment option for patients with PBL. OS was found to be affected by the initial response to treatment.

scholarly journals Primary Bone Lymphoma in Axial Skeleton in a Middle-Aged Female Presented as Recurrent Anemia

2020 ◽  
Vol 13 (1) ◽  
pp. 276-280
Author(s):  
Tala Batia ◽  
Mohamed A. Yassin ◽  
Deena S. Mudawi ◽  
Omnia A. Hamid ◽  
Ahmed M.A. Abdalhadi
Keyword(s):  
Cell Lymphoma ◽  
Case Reports ◽  
B Cell Lymphoma ◽  
Axial Skeleton ◽  
Primary Bone Lymphoma ◽  
Large B Cell Lymphoma ◽  
Pathological Type ◽  
Primary Bone ◽  
Insight Into ◽  
Bone Lymphoma

Primary bone lymphoma (PBL) is a peculiar extranodal presentation of non-Hodgkin’s lymphoma. Primary bone diffuse large B-cell lymphoma (DLBCL) is the most common pathological type, comprising about 80% of PBL. The diagnosis of PBL depends on the combined clinical examination and imaging studies and is confirmed with immunohistochemical examination. Due to the rarity of this disease, more relative studies and case reports are needed to provide insight into this obscure lymphoproliferative malignancy. Here, we report one rare case of primary bone DLBCL involving the axial skeleton in a 37-year-old female.

BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration

Blood ◽  
2000 ◽  
Vol 96 (13) ◽  
pp. 4328-4334
Author(s):  
Ricardo C. T. Aguiar ◽  
Yoshihiro Yakushijin ◽  
Samir Kharbanda ◽  
Ravi Salgia ◽  
Jonathan A. Fletcher ◽  
...  
Keyword(s):  
Cell Migration ◽  
High Risk ◽  
B Cell ◽  
Cell Lymphoma ◽  
International Prognostic Index ◽  
Prognostic Index ◽  
B Cell Lymphoma ◽  
Cellular Migration ◽  
Cell Phenotype ◽  
Large B Cell

Clinical risk factor models such as the International Prognostic Index are used to identify diffuse large B-cell lymphoma (DLB-CL) patients with different risks of death from their diseases. To elucidate the molecular bases for these observed clinical differences in outcome, differential display was used to identify a novel gene, termed BAL (B-aggressivelymphoma), which is expressed at significantly higher levels in fatal high-risk DLB-CLs than in cured low-risk tumors. The major BAL complementary DNA encodes a previously uncharacterized 88-kd nuclear protein with a duplicated N-terminal domain homologous to the nonhistone portion of histone-macroH2A and a C-terminal alpha-helical region with 2 short coiled-coil domains. Of note, the BAL N-terminus and secondary structure resemble those of a recently identified human protein, KIAA1268. In addition, bothBAL and KIAA1268 map to chromosome 3q21, further suggesting that these genes belong to a newly identified family. BAL is expressed at increased levels in DLB-CL cell lines with an activated peripheral B cell, rather than a germinal center B cell, phenotype. This observation and the characteristic dissemination of high risk DLB-CLs prompted studies regarding the role of BAL in B-cell migration. In classical transwell assays, stable BAL-overexpressing B-cell lymphoma transfectants had significantly higher rates of migration than vector-only transfectants, indicating that the risk-related BAL gene promotes malignant B-cell migration.

scholarly journals DLBCL of Clavicle: Role of FNA in diagnosis of Rare Lesion

2020 ◽  
Vol 7 (10) ◽  
pp. C133-136
Author(s):  
Cyrus Dara Jokhi ◽  
Kalpesh V Vaghela ◽  
Pruthvi Damor
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Local Area ◽  
Primary Bone Lymphoma ◽  
X Ray ◽  
Large B Cell Lymphoma ◽  
Primary Bone ◽  
Bone Lymphoma ◽  
Large B Cell

Primary bone lymphoma is rare, among which commonly involved site at time of presentation are femur, pelvic bones, tibia and most common type is Large B cell lymphoma which usually occurs in adults.  Cases of large B cell lymphoma in clavicle as primary bone lymphoma is extremely rare finding. According to our knowledge this case may be first reported case of world. We are here reporting a case of 62-year female presented as sternoclavicular joint swelling, without fever or pain in local area. Patient was diagnosed on X ray by radiologist, as well as by clinician as, osteosarcoma of right clavicle. Patient came to Department of Cytopathology for FNA for confirmation of X ray finding. On FNA diagnosis of Non-Hodgkin lymphoma was given, and advise for biopsy and immunohistochemistry (IHC) was given for confirmation of diagnosis and to subtype NHL. On IHC Ki67 index was 85%, with diffuse positivity noted for MUM1, CD79a, and CD138 along with cytoplasmic positivity for ALK 1 and patchy positivity for PAX 5. Tumor was negative for BCL6, BCL2, CD20, CD5, CD23, CD10, CD19, CD4, CD8, CD7, CD3. Diagnosis of ALK positive DLBCL was given on biopsy after IHC. Patients with PBL treated with combined modality were found to have a superior outcome, with a significantly better survival (5-year cause-specific survival 95%). So correct and timely pathological diagnosis of DLBCL as PBL is significantly important for prognosis.

scholarly journals Clinical features of cardiac lymphoma: an analysis of 37 cases

2021 ◽  
Vol 49 (3) ◽  
pp. 030006052199955
Author(s):  
Yu Zhao ◽  
Sai Huang ◽  
Chao Ma ◽  
Haiyan Zhu ◽  
Jian Bo
Keyword(s):  
Pericardial Effusion ◽  
Clinical Features ◽  
Nk Cell ◽  
Cell Lymphoma ◽  
International Prognostic Index ◽  
Prognostic Index ◽  
B Cell Lymphoma ◽  
Primary Objective ◽  
Cardiac Lymphoma ◽  
The Right

Objective To summarize the clinical and pathological features of patients with cardiac lymphoma. Methods The general conditions, clinical features, pathological types, and prognostic indices of 37 patients with cardiac lymphoma treated in our hospital were analyzed. Results Among the 37 patients, only one had primary cardiac lymphoma, and the other 36 patients had secondary cardiac lymphoma. The cardiac manifestations were mainly chest tightness, shortness of breath, increased heart rates, and electrocardiographic abnormality caused by pericardial effusion, but myocardial enzyme levels were normal in all patients. Only three patients displayed solid heart-occupying manifestations. These lesions were mainly located in the right atrium, and the masses were all larger than 5 cm. The pathological type was diffuse large B cell lymphoma that did not arise from the germinal center in all three patients. Conclusions Cardiac lymphoma was mostly secondary, and pericardial effusion was the primary objective sign. Moreover, cardiac lymphoma was characterized by a high international prognostic index, late stage, and high rates of T and NK cell lymphoma. Most cases were accompanied by serous cavity effusion, extranodal involvement of important organs, elevated lactate dehydrogenase levels, hypoalbuminemia, and normal myocardial enzyme levels.

scholarly journals Pediatric Primary Bone Lymphoma–Diffuse Large B-Cell Lymphoma

2007 ◽  
Vol 127 (1) ◽  
pp. 47-54 ◽  
Author(s):  
X. Frank Zhao ◽  
Ken H. Young ◽  
Dale Frank ◽  
Ami Goradia ◽  
Michael P. Glotzbecker ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Primary Bone Lymphoma ◽  
Large B Cell Lymphoma ◽  
Primary Bone ◽  
Bone Lymphoma ◽  
Large B Cell

Primäres Knochenlymphom: Klinische Analyse von 17 Patienten in derselben Institution

2015 ◽  
Vol 2 (2) ◽  
pp. 90-91
Keyword(s):  
International Prognostic Index ◽  
Prognostic Index ◽  
Complete Response ◽  
Clinical Analysis ◽  
Single Institution ◽  
Primary Bone Lymphoma ◽  
Stadium Iv ◽  
Primary Bone ◽  
Bone Lymphoma

Primäre Knochenlymphome (primary bone lymphomas; PBL) machen weniger als 1% aller malignen Lymphome aus. Da in Japan erst wenige Studien zu PBL durchgeführt wurden, sind die Merkmale der PBL bei japanischen Patienten nicht vollständig geklärt. Wir analysierten retrospektiv 17 Patienten, bei denen zwischen 2001 und 2011 in unserer Einrichtung ein PBL diagnostiziert worden war. Der Altersmedian der Patienten betrug 60 Jahre. Elf Patienten hatten ein diffuses großzelliges B-Zell-Lymphom und 2 eine T-Zell-Lymphom-Histologie. Die Wirbelsäule war zum Zeitpunkt der Erstvorstellung am häufigsten betroffen. Bei 11 Patienten war die Krankheit im Stadium IV, und 11 Patienten wiesen laut dem International Prognostic Index (IPI) ein hohes oder mittleres bis hohes Risiko auf. 13 Patienten erreichten nach der initialen Therapie eine Vollremission (complete response; CR). Nach einer medianen Nachbeobachtungszeit von 31 Monaten betrug die 3-Jahres-Rate des Gesamtüberlebens (OS) und des progressionsfreien Überlebens 63,5 bzw. 49,9%. Eine lokal begrenzte Erkrankung, ein niedriges oder niedriges bis mittleres IPI-Risiko und eine CR nach initialer Therapie waren bei den PBL-Patienten mit einem guten Verlauf und signifikant mit einem besseren OS assoziiert. Eine Beteiligung der Wirbelsäule und der T-/NK-Zell-Phänotyp kommen bei japanischen PBL-Patienten häufiger vor als bei solchen kaukasischen Ursprungs. Übersetzung aus Hayase E, et al: Primary Bone Lymphoma: A Clinical Analysis of 17 Patients in a Single Institution. Acta Haematol 2015;134:80-85 (DOI: 10.1159/000375437)

scholarly journals Primary diffuse large B-cell lymphoma of the bone mimicking osteomyelitis

2021 ◽  
Author(s):  
abbas mofidi ◽  
Mohsen Esfandbod ◽  
Ehsan Pendar ◽  
Masoud Mortezazadeh ◽  
Alireza hadizadeh
Keyword(s):  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Bone Lesions ◽  
Open Biopsy ◽  
Core Needle ◽  
Primary Bone Lymphoma ◽  
Large B Cell Lymphoma ◽  
Primary Bone ◽  
Bone Lymphoma ◽  
Large B Cell

In this article, we report a 34-year-old man who presented with progressive hip pain and osteolytic bone lesions . Primary workup included Core needle biopsies manifested as osteomyelitis; however as no sign of remission was observed, an open biopsy considered which revealed primary bone lymphoma.

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