scholarly journals Living Kidney Donation in a Type 1 Dent’s Disease Patient from His Mother

2019 ◽  
Vol 44 (5) ◽  
pp. 1306-1312 ◽  
Author(s):  
Giovanni Gambaro ◽  
Alessandro Naticchia ◽  
Pietro Manuel Ferraro ◽  
Gionata Spagnoletti ◽  
Jacopo Romagnoli ◽  
...  
Keyword(s):  
Early Adulthood ◽  
Disease Patient ◽  
Deceased Donor ◽  
Kidney Donation ◽  
Obligate Carrier ◽  
Dent’S Disease ◽  
Dent's Disease ◽  
Deceased Donor Kidney Transplant ◽  
Stage Renal Disease

Introduction: Dent’s disease is a rare X-linked recessive disorder that manifests in childhood or early adulthood and can lead to end-stage renal disease (ESRD). It occurs in males, who are hemizygous. In patients who develop ESRD, a deceased donor kidney transplant cures the disease. Females are obligate carriers of the mutated gene, and some show a mild Dent’s disease phenotype. There may be reason for concern when considering a female obligate carrier (i.e., the mother) for kidney donation because of the risk of kidney function deterioration. Case Presentation: We describe the first successful kidney transplantation involving a patient with type 1 Dent’s disease and ESRD given a kidney by an obligate carrier of the gene mutation, his mother. Conclusions: After careful assessment of the female obligate carriers, intrafamilial kidney donation in Dent’s disease type 1 is feasible. No deteriorating renal function in the donor was observed.

scholarly journals Ureteric Trauma following Stent Removal in Kidney Transplant Recipient: A Unique Case of Prolonged Morbidity

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Ahmad Mirza ◽  
Imran Gani ◽  
Andy Shi Huang ◽  
Ravi Mallavarapu ◽  
Laura Mulloy ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Kidney Transplant Recipient ◽  
Deceased Donor ◽  
Filling Defect ◽  
Percutaneous Nephrostomy ◽  
Distal Ureter ◽  
Noncontrast Ct ◽  
Deceased Donor Kidney Transplant ◽  
Stage Renal Disease ◽  
End Stage

A 52-year-old African-American male patient with end-stage renal disease due to hypertension underwent deceased donor kidney transplant procedure with no immediate complications. The postprocedure complications, interventions, and course were abstracted by chart review. The ureteric stent was removed with flexible cystoscopy on postoperative day (POD) 24. 24 hours later, the patient presented with abdominal pain and inability to urinate. An urgent ultrasound and noncontrast CT scan showed grade 4 hydronephrosis of the transplanted kidney. A percutaneous nephrostomy stent was placed for urinary diversion. A large ureteric hematoma filling the lumen of the mid to distal ureter was identified on the nephrostogram and was evacuated. A follow-up nephrostogram on POD 44 revealed a distal ureter stricture and persistent well-formed midureter filling defect. A repeat nephrostogram performed at POD 72 was done with stricture dilatation, internalization of stents, and removal of a percutaneous nephrostomy tube. The patient was maintained on antibiotics for UTI prophylaxis throughout the course.

scholarly journals Beliefs of UK Transplant Recipients about Living Kidney Donation and Transplantation: Findings from a Multicentre Questionnaire-Based Case–Control Study

2019 ◽  
Vol 9 (1) ◽  
pp. 31 ◽  
Author(s):  
Pippa K. Bailey ◽  
Fergus J. Caskey ◽  
Stephanie MacNeill ◽  
Charles Tomson ◽  
Frank J. M. F. Dor ◽  
...  
Keyword(s):  
Case Control Study ◽  
Deceased Donor ◽  
Case Control ◽  
Kidney Donation ◽  
Living Kidney Donation ◽  
Psychosocial Effects ◽  
Donor Kidney ◽  
The United Kingdom ◽  
Deceased Donor Kidney Transplant ◽  
Control Study

Differing beliefs about the acceptability of living-donor kidney transplants (LDKTs) have been proposed as explaining age, ethnic and socioeconomic disparities in their uptake. We investigated whether certain patient groups hold beliefs incompatible with LDKTs. This questionnaire-based case–control study was based at 14 hospitals in the United Kingdom. Participants were adults transplanted between 1 April 2013 and 31 March 2017. LDKT recipients were compared to deceased-donor kidney transplant (DDKT) recipients. Beliefs were determined by the direction and strength of agreement with ten statements. Multivariable logistic regression was used to investigate the association between beliefs and LDKT versus DDKT. Sex, age, ethnicity, religion, and education were investigated as predictors of beliefs. A total of 1240 questionnaires were returned (40% response). DDKT and LDKT recipients responded in the same direction for 9/10 statements. A greater strength of agreement with statements concerning the ‘positive psychosocial effects’ of living kidney donation predicted having an LDKT over a DDKT. Older age, Black, Asian and Minority Ethnic (BAME) group ethnicity, and having a religion other than Christianity were associated with greater degree of uncertainty regarding a number of statements, but there was no evidence that individuals in these groups hold strong beliefs against living kidney donation and transplantation. Interventions should address uncertainty, to increase LDKT activity in these groups.

scholarly journals A Case of Alport Syndrome with Posttransplant Antiglomerular Basement Membrane Disease despite Negative Antiglomerular Basement Membrane Antibodies by EIA Treated with Plasmapheresis and Intravenous Immunoglobulin

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Sumiko I. Armstead ◽  
Thomas Hellmark ◽  
Jorgen Wieslander ◽  
Xin J. Zhou ◽  
Ramesh Saxena ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Intravenous Immunoglobulin ◽  
Alport Syndrome ◽  
Kidney Injury ◽  
Deceased Donor ◽  
End Of Treatment ◽  
Circulating Antibodies ◽  
Deceased Donor Kidney Transplant ◽  
Stage Renal Disease ◽  
End Stage

Posttransplant antiglomerular basement membrane (anti-GBM) disease occurs in approximately 5% of Alport patients and usually ends in irreversible graft failure. Recent research has focused on characterizing the structure of the anti-GBM alloepitope. Here we present a case of a 22-year-old male with end-stage renal disease secondary to Alport syndrome, with a previously failed renal allograft, who received a second deceased-donor kidney transplant. Six days after transplantation, he developed acute kidney injury. The serum anti-GBM IgG was negative by enzyme immunoassay (EIA). On biopsy, he had crescentic glomerulonephritis with linear GBM fixation of IgG. With further analysis by western blotting, we were able to detect antibodies to an unidentified protein from the basement membrane. This patient was treated with plasmapheresis twice per week and monthly intravenous immunoglobulin (IVIG) for a total of five months. At the end of treatment, these unknown antibodies were no longer detected. His renal function improved, and he has not required dialysis. We conclude that anti-GBM disease in patients with Alport Syndrome may be caused by circulating antibodies to other components of the basement membrane that are undetectable by routine anti-GBM EIA and may respond to treatment with plasmapheresis and IVIG.

scholarly journals Surgical approach for kidney transplantation under spinal anesthesia

2020 ◽  
Vol 2020 (12) ◽  
Author(s):  
Atta Nawabi ◽  
Peter Sullivan ◽  
Martin De Ruyter ◽  
Amy Pichoff ◽  
Clay D King ◽  
...  
Keyword(s):  
Kidney Transplantation ◽  
Spinal Anesthesia ◽  
Deceased Donor ◽  
Annual Data ◽  
Short Supply ◽  
Deceased Donor Kidney ◽  
Airway Equipment ◽  
Deceased Donor Kidney Transplant ◽  
Stage Renal Disease ◽  
End Stage

Abstract Kidney transplantation is the treatment of choice for patients with end-stage renal disease (ESRD). It has been shown to improve quality of life as well as extending life of patients with ESRD as compared to renal replacement therapy (5-year survival rate of 68% after transplant vs 36% dialysis) (Hart A, Smith JM, Skeans MA. OPTN/SRTR 2015 annual data report: kidney. Am J Transplant 2017;17:21–116). Traditionally, patients undergo general endotracheal tube anesthesia for this surgery. During the COVID-19 pandemic, general anesthesia drugs and airway equipment were in short supply. Additionally, airway manipulation was avoided when possible due to concern for virus spread from aerosolizing procedures (i.e. intubation/extubation). In this case report, we review a 65-year-old female with an ESRD due to hypertension and diabetes that underwent deceased donor kidney transplant under spinal anesthesia. We will further discuss the benefits of spinal anesthesia in renal transplant operations.

scholarly journals Successful Transplantation of a Split Crossed Fused Ectopic Kidney into a Patient with End-Stage Renal Disease

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Kristin L. Mekeel ◽  
Shane M. Daley ◽  
Paul E. Andrews ◽  
Adyr A. Moss ◽  
R. L. Heilman ◽  
...  
Keyword(s):  
Deceased Donor ◽  
Technical Difficulty ◽  
Parenchymal Transection ◽  
Ectopic Kidney ◽  
Renal Anomalies ◽  
Successful Transplantation ◽  
Immediate Function ◽  
Deceased Donor Kidney Transplant ◽  
Stage Renal Disease ◽  
End Stage

Potential donors with congenital renal anomalies but normal renal function are often overlooked because of a possible increase in technical difficulty and complications associated with the surgery. However, as the waiting list for a deceased donor kidney transplant continues to grow, it is important to consider these kidneys for potential transplant. This paper describes the procurement of a crossed fused ectopic kidney, and subsequent parenchymal transection prior to transplantation as part of a combined simultaneous kidney pancreas transplant. The transplant was uncomplicated, and the graft had immediate function. The patient is now two years from transplant with excellent function.

scholarly journals The Magnitude of the Health and Economic Impact of Increased Organ Donation on Patients With End-Stage Renal Disease

2021 ◽  
Vol 6 (2) ◽  
pp. 238146832110634
Author(s):  
Huey-Fen Chen ◽  
Hayatt Ali ◽  
Wesley J. Marrero ◽  
Neehar D. Parikh ◽  
Mariel S. Lavieri ◽  
...  
Keyword(s):  
United States ◽  
Renal Disease ◽  
Economic Impact ◽  
End Stage Renal Disease ◽  
Deceased Donor ◽  
The United States ◽  
Kidney Donation ◽  
Life Years ◽  
Stage Renal Disease ◽  
End Stage

Objectives. There are several approaches such as presumed consent and compensation for deceased donor organs that could reduce the gap between supply and demand for kidneys. Our objective is to evaluate the magnitude of the economic impact of policies to increase deceased donor organ donation in the United States. Methods. We built a Markov model and simulate an open cohort of end-stage renal disease patients awaiting kidney transplantation in the United States over 20 years. Model inputs were derived from the United States Renal Data System and published literature. We evaluate the magnitude of the health and economic impact of policies to increase deceased donor kidney donation in the United States. Results. Increasing deceased kidney donation by 5% would save $4.7 billion, and gain 30,870 quality-adjusted life years over the lifetime of an open cohort of patients on dialysis on the waitlist for kidney transplantation. With an increase in donations of 25%, the cost saved was $21 billion, and 145,136 quality-adjusted life years were gained. Policies increasing deceased kidney donation by 5% could pay donor estates $8000 or incur a onetime cost of up to $4 billion and still be cost-saving. Conclusions. Increasing deceased kidney donation could significantly impact national spending and health for end-stage renal disease patients.

scholarly journals Evaluation of the Recipient and Donor in Living Kidney Transplantation

2020 ◽  
Vol 95 (4) ◽  
pp. 260-265
Author(s):  
Ha Yeol Park ◽  
Byung Chul Shin
Keyword(s):  
Kidney Transplantation ◽  
Supply And Demand ◽  
Deceased Donor ◽  
Good Health ◽  
Kidney Donation ◽  
Living Kidney Donation ◽  
Number Of Patients ◽  
Stage Renal Disease ◽  
End Stage

Kidney transplantation is the treatment of choice for end-stage renal disease. A successful kidney transplant improves the quality of life and reduces the mortality risk of patients, as compared to maintenance dialysis. The number of patients awaiting kidney transplantation has steadily increased, and the gap between allograft supply and demand continues to widen despite initiatives to expand the use of nonstandard deceased-donor allografts. The use of organs from living donors is one strategy to address the need for transplants. A medical, surgical, and psychosocial evaluation is mandatory prior to living kidney donation to ensure that the donor candidate is in good health and has normal kidney function, is not a risk to the recipient with respect to transmission of infections and malignancy, and will not face unacceptable risks after donation.

Alterations of CLC-5 expression, function and trafficking in Dent's disease

2013 ◽  
pp. 1-1
Author(s):  
Caroline Gorvin ◽  
Martijn Wilmer ◽  
Sian Piret ◽  
Brian Harding ◽  
Lambertus van den Heuvel ◽  
...  
Keyword(s):  
Dent’S Disease ◽  
Dent's Disease

scholarly journals Long-term risks after kidney donation: how do we inform potential donors? A survey from DESCARTES and EKITA transplantation working groups

2021 ◽  
Author(s):  
Geir Mjøen ◽  
Umberto Maggiore ◽  
Nicos Kessaris ◽  
Diederik Kimenai ◽  
Bruno Watschinger ◽  
...  
Keyword(s):  
Evaluation Process ◽  
Kidney Donation ◽  
Kidney Donors ◽  
Living Kidney Donors ◽  
Relative Risks ◽  
Written Information ◽  
The Difference ◽  
Stage Renal Disease ◽  
End Stage

Abstract Background Publications from the last decade have increased knowledge regarding long-term risks after kidney donation. We wanted to perform a survey to assess how transplant professionals in Europe inform potential kidney donors regarding long-term risks. The objectives of the survey were to determine how they inform donors and to what extent, and to evaluate the degree of variation. Methods All transplant professionals involved in the evaluation process were considered eligible, regardless of the type of profession. The survey was dispatched as a link to a web-based survey. The subjects included questions on demographics, the information policy of the respondent and the use of risk calculators, including the difference of relative and absolute risks and how the respondents themselves understood these risks. Results The main finding was a large variation in how often different long-term risks were discussed with the potential donors, i.e. from always to never. Eighty percent of respondents stated that they always discuss the risk of end-stage renal disease, while 56% of respondents stated that they always discuss the risk of preeclampsia. Twenty percent of respondents answered correctly regarding the relationship between absolute and relative risks for rare outcomes. Conclusions The use of written information and checklists should be encouraged. This may improve standardization regarding the information provided to potential living kidney donors in Europe. There is a need for information and education among European transplant professionals regarding long-term risks after kidney donation and how to interpret and present these risks.

Sign in / Sign up

Export Citation Format

Share Document