scholarly journals The Clinical Efficacy and Safety of Autologous Activated Platelet-Rich Plasma Injection in Androgenetic Alopecia

2019 ◽  
Vol 6 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Niluka Dilrukshi Paththinige ◽  
Janaka K.W. Akarawita ◽  
Geetha Jeganathan
Keyword(s):  
Clinical Efficacy ◽  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Efficacy And Safety ◽  
Plasma Injection

scholarly journals Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia

2020 ◽  
Vol 21 (18) ◽  
pp. 6516
Author(s):  
Elena E. Pakhomova ◽  
Irina O. Smirnova
Keyword(s):  
Cell Proliferation ◽  
Clinical Efficacy ◽  
Comparative Evaluation ◽  
Proliferative Activity ◽  
Immunohistochemical Study ◽  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Hair Morphology ◽  
Promising Treatment ◽  
Cd34 Expression

Platelet-rich plasma (PRP) therapy has been considered as a promising treatment for androgenetic alopecia (AGA). The aim of the study was comparative evaluation of the clinical efficacy of PRP-therapy, minoxidil, and their combination in the treatment of men with AGA and to evaluate the effects of PRP on the proliferation of hair follicle (HF) cells in skin biopsy. Materials and Methods: The study involved 69 men who were divided into 3 groups who received PRP therapy, minoxidil, and their combination. The clinical efficacy of the therapy was evaluated by the dynamics of morphometric of hairs. To assess cell proliferation antibodies to β-catenin, CD34, Ki67, and to Dkk-1 were used. Results. PRP treatment was more effective than minoxidil therapy (p = 0.005). Complex therapy turned out to be more effective than minoxidil monotherapy (p < 0.0001) and PRP monotherapy (p = 0.007). After applying PRP the absolute and relative values of the β-catenin and CD34 expression area increased; an increase in Ki67+ index was also significant. Conclusions: PRP can be considered as a treatment option for AGA. Combined PRP and minoxidil use seems promising for the treatment of AGA. PRP increase in the proliferative activity of HF cells and improves hair morphology in patients with AGA.

The effect of platelet‐rich plasma injection in the treatment of androgenetic alopecia

2019 ◽  
Vol 18 (6) ◽  
pp. 1624-1628 ◽  
Author(s):  
Mousa Bayat ◽  
Mohammad Javad Yazdanpanah ◽  
Daryoush Hamidi Alamdari ◽  
Mahnaz Banihashemi ◽  
Maryam Salehi
Keyword(s):  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Plasma Injection

Evaluation of the Efficacy and Safety of Platelet Rich Plasma injection in treatment of Rosacea

2021 ◽  
Author(s):  
Maysa T. Ghoz ◽  
Dareen A. Mohamed ◽  
Zainab A. Ibrahim ◽  
Ghada F. R. Hassan
Keyword(s):  
Platelet Rich Plasma ◽  
Efficacy And Safety ◽  
Plasma Injection

scholarly journals Morphological substantiation of clinical efficacy of platelet rich plasma in males with androgenic alopecia

2018 ◽  
Vol 20 (3) ◽  
pp. 67-71
Author(s):  
E E Pakhomova ◽  
I O Smirnova ◽  
I N Telichko
Keyword(s):  
Clinical Efficacy ◽  
Growth Parameters ◽  
Platelet Rich Plasma ◽  
Hair Follicles ◽  
Androgenetic Alopecia ◽  
Sweat Glands ◽  
Androgenic Alopecia ◽  
Hair Density ◽  
Plasma Therapy ◽  
Four Levels

Morphological substantiation of the clinical efficacy of platelets rich plasma was carried out in the treatment of 22 men with androgenetic alopecia from the 1st to the 4th stage according to the Norwood-Hamilton scale were included. All patients received intradermal injections of platelets rich plasma 0,15 ml per injection. The course of treatment consisted of 4 procedures with an interval of 4 weeks. Clinical efficacy was assessed by the dynamics of morphometric indices of hair growth. Histological examination was carried out on horizontal sections, stained with hematoxylin and eosin, the morphology of the hair was counted at four levels. Evaluation of morphometric growth parameters conducted before treatment and 4 months after the onset of it. It was established that the therapy of platelet-rich plasma has a pronounced clinical efficacy, consisting in a significant (p=0,00025) increase in hair density by 11% and average hair diameter by 10% (p=0,00766), a 14% decrease in the share of hair follicles (p=0,00959). Histologically, the increase in hair density was significant at the level of the bulb of the hair follicles by 148% (p=0,0034) and at the level of the sweat glands by 65% (p=0,0326), and also by the tendency to increase their number at the level of the sebaceous glands. This was combined with a significant decrease in the proportion of telogen hair at 47% (p=0,0153). Thus, the positive clinical effect of plasma-rich plasma therapy in men suffering from androgenetic alopecia is based on reliable morphofunctional changes in the hair follicles.

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