Apoptosis Induction by Pseudorabies Virus via Oxidative Stress and Subsequent DNA Damage Signaling

Intervirology ◽  
2019 ◽  
Vol 62 (3-4) ◽  
pp. 116-123 ◽  
Author(s):  
I-Hsiang Lai ◽  
Ching-Dong Chang ◽  
Wen-Ling Shih
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Pseudorabies Virus ◽  
Apoptosis Induction ◽  
Dna Damage Signaling

scholarly journals Oxidative Stress-Induced DNA Damage and Apoptosis in Clove Buds-Treated MCF-7 Cells

Biomolecules ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 139 ◽  
Author(s):  
Martin Kello ◽  
Peter Takac ◽  
Peter Kubatka ◽  
Tomas Kuruc ◽  
Klaudia Petrova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Migration And Invasion ◽  
Apoptosis Induction ◽  
Anticancer Effects ◽  
Stress Survival ◽  
Dependent Cell ◽  
Nitrogen Radicals ◽  
Apoptotic Pathways ◽  
Mcf 7

In recent decades, several spices have been studied for their potential in the prevention and treatment of cancer. It is documented that spices have antioxidant, anti-inflammatory, immunomodulatory, and anticancer effects. The main mechanisms of spices action included apoptosis induction, proliferation, migration and invasion of tumour inhibition, and sensitization of tumours to radiotherapy and chemotherapy. In this study, the ability of clove buds extract (CBE) to induce oxidative stress, DNA damage, and stress/survival/apoptotic pathways modulation were analysed in MCF-7 cells. We demonstrated that CBE treatment induced intrinsic caspase-dependent cell death associated with increased oxidative stress mediated by oxygen and nitrogen radicals. We showed also the CBE-mediated release of mitochondrial pro-apoptotic factors, signalling of oxidative stress-mediated DNA damage with modulation of cell antioxidant SOD (superoxide dismutase) system, and modulation activity of the Akt, p38 MAPK, JNK and Erk 1/2 pathways.

scholarly journals Induction of DNA damage signaling by oxidative stress in relation to DNA replication as detected using “click chemistry”

2011 ◽  
Vol 79A (11) ◽  
pp. 897-902 ◽  
Author(s):  
Hong Zhao ◽  
Jurek Dobrucki ◽  
Paulina Rybak ◽  
Frank Traganos ◽  
H. Dorota Halicka ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Dna Replication ◽  
Click Chemistry ◽  
Dna Damage Signaling

Serum of 8-OHdG as a potential biomarker of oxidative DNA damage in workers exposed to harmful working environments

2020 ◽  
pp. 783-783
Author(s):  
I. A. Umnyagina ◽  
L. A. Strakhova ◽  
T. V. Blinova
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Blood Serum ◽  
Oxidative Dna Damage ◽  
Working Environment ◽  
Working Environments ◽  
Potential Biomarker ◽  
High Level ◽  
Damage Marker

In the blood serum of 70% individuals exposed to harmful factors of the working environment, a high level of oxidative stress and the DNA damage marker 8-Hydroxy-2’-Deoxyguanosine (8-OHdG) were detected.

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