Sensitization to Cat: Why Not Use Molecular Diagnostics instead of the Nasal Challenge in Clinical Practice?

2019 ◽  
Vol 180 (2) ◽  
pp. 142-143
Author(s):  
Gennaro Liccardi ◽  
Luigino Calzetta ◽  
Manlio Milanese ◽  
Maria Beatrice Bilò ◽  
Paola Rogliani
Keyword(s):  
Clinical Practice ◽  
Molecular Diagnostics ◽  
Nasal Challenge

Molecular diagnostics and targeted treatment approaches in pediatric oncology (literature review)

2021 ◽  
pp. 29-33
Author(s):  
A. A. Rozhkov ◽  
R. I. Nuriev ◽  
M. I. Sekacheva
Keyword(s):  
Clinical Practice ◽  
Targeted Therapy ◽  
Side Effects ◽  
Molecular Diagnostics ◽  
New Technologies ◽  
Patient Survival ◽  
Targeted Drugs ◽  
Specific Drug ◽  
Oncological Diseases ◽  
Personalized Approach

The continuous evolution of new technologies in the field of molecular diagnostics and genome analysis, the development of new approaches in pharmacogenetics and the emergence of a range of different targeted drugs have expanded the possibilities of clinical practice, resulting in personalized approaches to treatment. The diagnosis and therapy of pediatric oncological diseases are some of the vivid examples of the successful application of a personalized approach in clinical practice. Today, many pediatric neoplastic diseases are successfully treated with targeted drugs, which significantly increases patient survival. Targeted therapy allows to choose a specific drug for each patient, thereby increasing the effectiveness of treatment, reducing the risk of side effects, and also reducing the likelihood of a relapse of the disease.

scholarly journals Nasal challenge with ketorolac: utility and safety in clinical practice

2019 ◽  
Vol 143 (2) ◽  
pp. AB283 ◽  
Author(s):  
Marta Sanchez-Jareño ◽  
Pilar Barranco ◽  
Magdalena Lluch-Bernal ◽  
Valentin López-Carrasco ◽  
Santiago Quirce
Keyword(s):  
Clinical Practice ◽  
Nasal Challenge

scholarly journals Advances in Lymphoma Molecular Diagnostics

Diagnostics ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 2174
Author(s):  
Igor Age Kos ◽  
Lorenz Thurner ◽  
Joerg Thomas Bittenbring ◽  
Konstantinos Christofyllakis ◽  
Dominic Kaddu-Mulindwa
Keyword(s):  
Clinical Practice ◽  
Molecular Diagnostics ◽  
Genetic Alterations ◽  
Molecular Techniques ◽  
World Health ◽  
Accurate Identification ◽  
Treatment Algorithms ◽  
Lymphoid Neoplasms ◽  
Wide Range ◽  
Treatment Prognosis

Lymphomas encompass a diverse group of malignant lymphoid neoplasms. Over recent years much scientific effort has been undertaken to identify and understand molecular changes in lymphomas, resulting in a wide range of genetic alterations that have been reported across all types of lymphomas. As many of these changes are now incorporated into the World Health Organization’s defined criteria for the diagnostic evaluation of patients with lymphoid neoplasms, their accurate identification is crucial. Even if many alterations are not routinely evaluated in daily clinical practice, they may still have implications in risk stratification, treatment, prognosis or disease monitoring. Moreover, some alterations can be used for targeted treatment. Therefore, these advances in lymphoma molecular diagnostics in some cases have led to changes in treatment algorithms. Here, we give an overview of and discuss advances in molecular techniques in current clinical practice, as well as highlight some of them in a clinical context.

The miR-21 potential of serving as a biomarker for liver diseases in clinical practice

2020 ◽  
Vol 48 (5) ◽  
pp. 2295-2305
Author(s):  
Jiawei Zhang ◽  
Dandan Li ◽  
Rui Zhang ◽  
Peng Gao ◽  
Rongxue Peng ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Liver Diseases ◽  
Hepatic Disease ◽  
Noninvasive Detection ◽  
Diagnosis And Prognosis ◽  
Expected Performance ◽  
Potential Biomarker ◽  
Disease Condition ◽  
Complex Regulatory Network

The role of miR-21 in the pathogenesis of various liver diseases, together with the possibility of detecting microRNA in the circulation, makes miR-21 a potential biomarker for noninvasive detection. In this review, we summarize the potential utility of extracellular miR-21 in the clinical management of hepatic disease patients and compared it with the current clinical practice. MiR-21 shows screening and prognostic value for liver cancer. In liver cirrhosis, miR-21 may serve as a biomarker for the differentiating diagnosis and prognosis. MiR-21 is also a potential biomarker for the severity of hepatitis. We elucidate the disease condition under which miR-21 testing can reach the expected performance. Though miR-21 is a key regulator of liver diseases, microRNAs coordinate with each other in the complex regulatory network. As a result, the performance of miR-21 is better when combined with other microRNAs or classical biomarkers under certain clinical circumstances.

Meeting the Best Practice for Hearing Aid Verification in Children: Challenges and Future Directions

2019 ◽  
Vol 28 (4) ◽  
pp. 877-894
Author(s):  
Nur Azyani Amri ◽  
Tian Kar Quar ◽  
Foong Yen Chong
Keyword(s):  
Clinical Practice ◽  
Hearing Aids ◽  
Best Practice ◽  
Hearing Aid ◽  
Evidence Based ◽  
Future Directions ◽  
Major Barrier ◽  
Klang Valley ◽  
Age Range ◽  
Fitting Hearing Aids

Purpose This study examined the current pediatric amplification practice with an emphasis on hearing aid verification using probe microphone measurement (PMM), among audiologists in Klang Valley, Malaysia. Frequency of practice, access to PMM system, practiced protocols, barriers, and perception toward the benefits of PMM were identified through a survey. Method A questionnaire was distributed to and filled in by the audiologists who provided pediatric amplification service in Klang Valley, Malaysia. One hundred eight ( N = 108) audiologists, composed of 90.3% women and 9.7% men (age range: 23–48 years), participated in the survey. Results PMM was not a clinical routine practiced by a majority of the audiologists, despite its recognition as the best clinical practice that should be incorporated into protocols for fitting hearing aids in children. Variations in practice existed warranting further steps to improve the current practice for children with hearing impairment. The lack of access to PMM equipment was 1 major barrier for the audiologists to practice real-ear verification. Practitioners' characteristics such as time constraints, low confidence, and knowledge levels were also identified as barriers that impede the uptake of the evidence-based practice. Conclusions The implementation of PMM in clinical practice remains a challenge to the audiology profession. A knowledge-transfer approach that takes into consideration the barriers and involves effective collaboration or engagement between the knowledge providers and potential stakeholders is required to promote the clinical application of evidence-based best practice.

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