The Protective Roles of Folic Acid in Preventing Diabetic Retinopathy Are Potentially Associated with Suppressions on Angiogenesis, Inflammation, and Oxidative Stress

2019 ◽  
Vol 62 (2) ◽  
pp. 80-92 ◽  
Author(s):  
Xun-Wen Lei ◽  
Qiang Li ◽  
Jin-Zhi Zhang ◽  
Yue-Mei Zhang ◽  
Yang Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Folic Acid ◽  
And Oxidative Stress

scholarly journals Eicosanoids and Oxidative Stress in Diabetic Retinopathy

Antioxidants ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 520 ◽  
Author(s):  
Mong-Heng Wang ◽  
George Hsiao ◽  
Mohamed Al-Shabrawey
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Renin Angiotensin System ◽  
Microvascular Dysfunction ◽  
Microvascular Damage ◽  
Angiotensin System ◽  
Ras Activation ◽  
Long Time ◽  
And Oxidative Stress

Oxidative stress is an important factor to cause the pathogenesis of diabetic retinopathy (DR) because the retina has high vascularization and long-time light exposition. Cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymes can convert arachidonic acid (AA) into eicosanoids, which are important lipid mediators to regulate DR development. COX-derived metabolites appear to be significant factors causative to oxidative stress and retinal microvascular dysfunction. Several elegant studies have unraveled the importance of LOX-derived eicosanoids, including LTs and HETEs, to oxidative stress and retinal microvascular dysfunction. The role of CYP eicosanoids in DR is yet to be explored. There is clear evidence that CYP-derived epoxyeicosatrienoic acids (EETs) have detrimental effects on the retina. Our recent study showed that the renin-angiotensin system (RAS) activation augments retinal soluble epoxide hydrolase (sEH), a crucial enzyme degrading EETs. Our findings suggest that EETs blockade can enhance the ability of RAS blockade to prevent or mitigate microvascular damage in DR. This review will focus on the critical information related the function of these eicosanoids in the retina, the interaction between eicosanoids and reactive oxygen species (ROS), and the involvement of eicosanoids in DR. We also identify potential targets for the treatment of DR.

Nitrosative and oxidative stress is associated with severity of diabetic retinopathy and retinal structural alterations

2014 ◽  
Vol 2 (4) ◽  
Author(s):  
Shashi Sharma ◽  
Sandeep Saxena ◽  
Vinay K Khanna ◽  
Rajendra Shukla ◽  
Khushboo Srivastav ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
Structural Alterations ◽  
And Oxidative Stress

Diabetic retinopathy pathogenesis and the ameliorating effects of melatonin; involvement of autophagy, inflammation and oxidative stress

Life Sciences ◽  
2018 ◽  
Vol 193 ◽  
pp. 20-33 ◽  
Author(s):  
Ehsan Dehdashtian ◽  
Saeed Mehrzadi ◽  
Bahman Yousefi ◽  
Azam Hosseinzadeh ◽  
Russel J. Reiter ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Retinopathy ◽  
And Oxidative Stress
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