scholarly journals Preclinical Brown Norway Rat Models for the Assessment of Infant Formulas in the Prevention and Treatment of Cow’s Milk Allergy

2019 ◽  
Vol 178 (4) ◽  
pp. 307-314 ◽  
Author(s):  
Louise Heydenreich Jensen ◽  
Jeppe Madura Larsen ◽  
Charlotte Bernhard Madsen ◽  
Rune Rønhave Laursen ◽  
Lotte Neergaard Jacobsen ◽  
...  
Keyword(s):  
Cow’S Milk Allergy ◽  
Brown Norway ◽  
Cow’S Milk ◽  
Infant Formulas ◽  
Milk Allergy ◽  
Norway Rat ◽  
Rat Models ◽  
Cow's Milk ◽  
Prevention And Treatment ◽  
Brown Norway Rat

scholarly journals Cow’s milk allergy prevention and treatment by heat‐treated whey—A study in Brown Norway rats

2020 ◽  
Vol 50 (6) ◽  
pp. 708-721 ◽  
Author(s):  
Katrine B. Graversen ◽  
Anne‐Sofie R. Ballegaard ◽  
Louise H. Kræmer ◽  
Sofie E. Hornslet ◽  
Laila V. Sørensen ◽  
...  
Keyword(s):  
Cow’S Milk Allergy ◽  
Brown Norway ◽  
Cow’S Milk ◽  
Allergy Prevention ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy ◽  
Heat Treated ◽  
Prevention And Treatment ◽  
Norway Rats

scholarly journals Comparison of the Allergenicity and Immunogenicity of Camel and Cow’s Milk—A Study in Brown Norway Rats

Nutrients ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 1903 ◽  
Author(s):  
Natalia Maryniak ◽  
Egon Hansen ◽  
Anne-Sofie Ballegaard ◽  
Ana Sancho ◽  
Katrine Bøgh
Keyword(s):  
Protein Composition ◽  
Cross Reactivity ◽  
Camel Milk ◽  
Brown Norway ◽  
Cow’S Milk ◽  
Infant Formulas ◽  
Promising Alternative ◽  
Norway Rat ◽  
Milk Whey ◽  
Cow's Milk

Background: When breastfeeding is impossible or insufficient, the use of cow’s milk-based hypoallergenic infant formulas is an option for infants suffering from or at risk of developing cow’s milk allergy. As the Camelidae family has a large evolutionary distance to the Bovidae family and as camel milk differs from cow’s milk protein composition, there is a growing interest in investigating the suitability of camel milk as an alternative to cow’s milk-based hypoallergenic infant formulas. Methods: The aim of the study was to compare the allergenicity and immunogenicity of camel and cow’s milk as well as investigating their cross-reactivity using a Brown Norway rat model. Rats were immunised intraperitoneally with one of four products: camel milk, cow’s milk, cow’s milk casein or cow’s milk whey fraction. Immunogenicity, sensitising capacity, antibody avidity and cross-reactivity were evaluated by means of different ELISAs. The eliciting capacity was evaluated by an ear swelling test. Results: Camel and cow’s milk showed similarity in their inherent immunogenicity, sensitising and eliciting capacity. Results show that there was a lower cross-reactivity between caseins than between whey proteins from camel and cow’s milk. Conclusions: The study showed that camel and cow’s milk have a low cross-reactivity, indicating a low protein similarity. Results demonstrate that camel milk could be a promising alternative to cow’s milk-based hypoallergenic infant formulas.

Interlaboratory evaluation of a cow's milk allergy mouse model to assess the allergenicity of hydrolysed cow's milk based infant formulas

2013 ◽  
Vol 220 (1) ◽  
pp. 95-102 ◽  
Author(s):  
B.C.A.M. van Esch ◽  
J.H.M. van Bilsen ◽  
P.V. Jeurink ◽  
J. Garssen ◽  
A.H. Penninks ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cow’S Milk Allergy ◽  
Cow’S Milk ◽  
Infant Formulas ◽  
Milk Allergy ◽  
Cow's Milk ◽  
Cow's Milk Allergy
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