Glandular Cell Abnormalities on SurePath Preparations: A Retrospective Review with Cytology-Histology Correlations

2018 ◽  
Vol 62 (5-6) ◽  
pp. 423-429 ◽  
Author(s):  
Gabor Fischer ◽  
Karen Cormier
Keyword(s):  
Pap Test ◽  
Test Methods ◽  
Glandular Cell ◽  
Histologic Diagnosis ◽  
Detection Rates ◽  
Diagnostic Categories ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Malignant Lesions

Objective: Detecting glandular lesions is challenging by all Pap test methodologies. As the availability of data on identifying glandular abnormalities by SurePath is scarce, we investigated the detection rates and the correlation with histology follow-up. Study Design: A total of 105,927 cases (SurePath and conventional) were searched for the diagnosis of atypical glandular cells or higher glandular abnormalities (AGC+) with the corresponding histologic diagnosis. The associations between the Pap test methods and diagnostic categories were assessed by χ2 test. Results: Overall, 0.32% of SurePath (159/49,375) and 0.29% of conventional (164/56,552) cases showed AGC+ (p = 0.38). Histology confirmed significant abnormalities in 42 versus 53.5% of the cases, respectively (p = 0.064); 72.7% (SurePath) versus 65.2% (conventional) of these were glandular in nature (p = 0.37). The diagnosis of neoplasia (favored or definitive) showed malignancy on follow-up in 100% of SurePath cases (12/12). In contrast, 82.1% of these conventional cases disclosed premalignant or malignant lesions by histology (p = 0.12). Conclusions: AGC+ cases showed higher prevalence on SurePath preparations. Conventional cases had more abnormalities on follow-up, while glandular lesions represented a higher proportion of abnormal histologies following SurePath AGC+s. The positive predictive value of favored or definite neoplasia was higher in SurePath cases. Overall, these differences were not statistically significant.

scholarly journals Atypical endometrial cells and atypical glandular cells favor endometrial origin in Papanicolaou cervicovaginal tests: Correlation with histologic follow-up and abnormal clinical presentations

CytoJournal ◽  
2014 ◽  
Vol 11 ◽  
pp. 29 ◽  
Author(s):  
Longwen Chen ◽  
Christine N. Booth ◽  
Julie A. Shorie ◽  
Jennifer A. Brainard ◽  
Matthew A. Zarka
Keyword(s):  
Vaginal Bleeding ◽  
Pap Test ◽  
Pap Tests ◽  
Endometrial Cells ◽  
Clinical Presentations ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Abnormal Vaginal Bleeding ◽  
Endometrial Pathology

The 2001 Bethesda system recommends further classifying atypical glandular cells (AGCs) as either endocervical or endometrial origin. Numerous studies have investigated the clinical significance of AGC. In this study, we investigated the incidence of clinically significant lesions among women with liquid-based Papanicolaou cervicovaginal (Pap) interpretations of atypical endometrial cells (AEMs) or AGC favor endometrial origin (AGC-EM). More importantly, we correlated patients of AEM or AGC-EM with their clinical presentations to determine if AEM/AGC-EM combined with abnormal vaginal bleeding is associated with a higher incidence of significant endometrial pathology. All liquid-based Pap tests with an interpretation of AEM and AGC-EM from July, 2004 through June, 2009 were retrieved from the database. Women with an interpretation of atypical endocervical cells, AGC, favor endocervical origin or AGC, favor neoplastic were not included in the study. The most severe subsequent histologic diagnoses were recorded for each patient. During this 5-year period, we accessioned 332,470 Pap tests of which 169 (0.05%) were interpreted as either AEM or AGC-EM. Of the 169 patients, 133 had histologic follow-up within the health care system. The patients ranged in age from 21 to 71 years old (mean 49.7). On follow-up histology, 27 (20.3%) had neoplastic/preneoplastic uterine lesions. Among them, 20 patients were diagnosed with adenocarcinoma (18 endometrial, 1 endocervical, and 1 metastatic colorectal), 3 with atypical endometrial hyperplasia, and 4 with endometrial hyperplasia without atypia. All patients with significant endometrial pathology, except one, were over 40 years old, and 22 of 25 patients reported abnormal vaginal bleeding at the time of endometrial biopsy or curettage. This study represents a large series of women with liquid-based Pap test interpretations of AEM and AGC-EM with clinical follow-up. Significant preneoplastic or neoplastic endometrial lesions were identified in 20.3% of patients. Patients with Pap test interpretations of AEM or AGC-EM and the clinical presentation of abnormal vaginal bleeding should be followed closely.

scholarly journals Atypical glandular cells: Help or hindrance

2018 ◽  
Vol 8 (1) ◽  
pp. 1297-1300
Author(s):  
Sanjeev Narang ◽  
Parul Dargar ◽  
Anjali Singh ◽  
Apurva Malhotra
Keyword(s):  
Retrospective Study ◽  
Positive Predictive Value ◽  
Predictive Value ◽  
Glandular Cell ◽  
Pap Smears ◽  
Histopathological Correlation ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Rare Diagnosis

Background: Atypical glandular cell is still a rare diagnosis despite refinement of the cytomorphologic criteria. This study aims to evaluate the follow up biopsies of cases diagnosed as atypical glandular cells on pap smears and to correlate with histological findings.Materials and Methods: This is a retrospective study over a period of 7 years based on cyto-histopathological correlation of AGC diagnosed cases.Results: Cytodiagnosis of atypical glandular cells was given in 212(0.05%), and 140 (0.66%) patients underwent biopsy. Among these 74(52%) were benign and 66(47%) neoplastic. Of the 39 cases reported as AGC favor neoplastic, 24(61%)  showed malignancy with a positive predictive value of 61.5% and of the101 cases classified as AGC-NOS on cytology, 59 (58%) cases showed benign features with a negative predictive value of 58.4 percent.  Conclusion: Our study highlights the immediate need of histological follow up of patients diagnosed with AGC. It is important because the range of diseases associated is very variable and includes benign as well as malignant conditions.

scholarly journals More focus on atypical glandular cells in cervical screening: Risk of significant abnormalities and low histological follow-up rate

CytoJournal ◽  
2020 ◽  
Vol 17 ◽  
pp. 22
Author(s):  
Pingping Zhong ◽  
Chenghong Yin ◽  
Yulan Jin ◽  
Tianbao Chen ◽  
Yang Zhan ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Cervical Screening ◽  
Close Relation ◽  
Prior History ◽  
Pap Smears ◽  
Chi Square ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Chi Square Test

Objectives: Atypical glandular cells (AGC) detected by Papanicolaou (Pap) smears are in close relation with adenocarcinoma and precursors detected by histopathology. Yet, sometimes the cytological diagnosis of AGC has been neglected. With increase of adenocarcinoma and precursors, we need more focus on glandular abnormalities. Material and Methods: Clinicopathological data of patients who had AGC on Pap smears between April 2015 and October 2018 and underwent histological follow-up were retrieved from the computerized database of Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Patients with a prior history of cancer were excluded from the study. Statistical analyses were performed using Pearson’s Chi-square test in SPSS software version 23. P < 0.05 (two sided) was considered as statistical significance. Results: Liquid-based cytological examination of the uterine cervix was carried out in 164,080 women. Five hundred and twenty-five women were diagnosed with AGC, 314 with not otherwise specified (AGC-NOS), and 211 with favor neoplastic (AGC-FN). Only 310 cases had histological follow-up, 168 women (168/314, 53.5%) originally with AGC-NOS on Pap smears, and 142 (142/211, 67.3%) with AGC-FN. The median age of histological significant abnormalities was 46.7 years, and 126 women (126/162, 77.8%) were postmenopausal. Sixty-six cases (66/168, 39.3%) of AGC-NOS had significant abnormalities (96/142, 67.6%, AGC-FN). One hundred and sixty-two cases of significant abnormalities included 40 high-grade squamous abnormalities and 122 glandular abnormalities. AGC-FN was more likely to be associated with a clinically significant abnormalities (P < 0.001) compared to AGC-NOS. Conclusions: Patients with AGC on Pap smears are in close relation with significant abnormalities, especially with significant glandular abnormalities on histopathology slices. AGC should be evaluated vigilantly with histological workup, especially if patients are diagnosed with AGC-FN and are aged 41–60 years. We need more focus on AGC.

Atypical Glandular Cells on Papanicolaou Test: The Fate and Follow-up of 51 Cases

2017 ◽  
Vol 6 (5) ◽  
pp. S23-S24
Author(s):  
Marcos Lepe ◽  
Claire Eklund ◽  
M. Ruhul Quddus ◽  
Cherie Paquette
Keyword(s):  
Papanicolaou Test ◽  
Glandular Cells ◽  
Atypical Glandular Cells

scholarly journals Factors affecting the histopathological outcomes of atypical glandular cells on pap test

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Esra Keles ◽  
UgurK Ozturk ◽  
CihatM Alinca ◽  
Burak Giray ◽  
Canan Kabaca ◽  
...  
Keyword(s):  
Pap Test ◽  
Factors Affecting ◽  
Glandular Cells ◽  
Atypical Glandular Cells
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