Follow-up Study of Atypical Glandular Cells in Gynecologic Cytology Using Conventional Pap Smears and Liquid-Based Preparations

2008 ◽  
Vol 52 (2) ◽  
pp. 159-168 ◽  
Author(s):  
Chris Yick-Kwong Lee ◽  
Wai-Kuen Ng
Keyword(s):  
Pap Smears ◽  
Follow Up Study ◽  
Glandular Cells ◽  
Atypical Glandular Cells

scholarly journals More focus on atypical glandular cells in cervical screening: Risk of significant abnormalities and low histological follow-up rate

CytoJournal ◽  
2020 ◽  
Vol 17 ◽  
pp. 22
Author(s):  
Pingping Zhong ◽  
Chenghong Yin ◽  
Yulan Jin ◽  
Tianbao Chen ◽  
Yang Zhan ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Cervical Screening ◽  
Close Relation ◽  
Prior History ◽  
Pap Smears ◽  
Chi Square ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Chi Square Test

Objectives: Atypical glandular cells (AGC) detected by Papanicolaou (Pap) smears are in close relation with adenocarcinoma and precursors detected by histopathology. Yet, sometimes the cytological diagnosis of AGC has been neglected. With increase of adenocarcinoma and precursors, we need more focus on glandular abnormalities. Material and Methods: Clinicopathological data of patients who had AGC on Pap smears between April 2015 and October 2018 and underwent histological follow-up were retrieved from the computerized database of Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Patients with a prior history of cancer were excluded from the study. Statistical analyses were performed using Pearson’s Chi-square test in SPSS software version 23. P < 0.05 (two sided) was considered as statistical significance. Results: Liquid-based cytological examination of the uterine cervix was carried out in 164,080 women. Five hundred and twenty-five women were diagnosed with AGC, 314 with not otherwise specified (AGC-NOS), and 211 with favor neoplastic (AGC-FN). Only 310 cases had histological follow-up, 168 women (168/314, 53.5%) originally with AGC-NOS on Pap smears, and 142 (142/211, 67.3%) with AGC-FN. The median age of histological significant abnormalities was 46.7 years, and 126 women (126/162, 77.8%) were postmenopausal. Sixty-six cases (66/168, 39.3%) of AGC-NOS had significant abnormalities (96/142, 67.6%, AGC-FN). One hundred and sixty-two cases of significant abnormalities included 40 high-grade squamous abnormalities and 122 glandular abnormalities. AGC-FN was more likely to be associated with a clinically significant abnormalities (P < 0.001) compared to AGC-NOS. Conclusions: Patients with AGC on Pap smears are in close relation with significant abnormalities, especially with significant glandular abnormalities on histopathology slices. AGC should be evaluated vigilantly with histological workup, especially if patients are diagnosed with AGC-FN and are aged 41–60 years. We need more focus on AGC.

scholarly journals Atypical glandular cells: Help or hindrance

2018 ◽  
Vol 8 (1) ◽  
pp. 1297-1300
Author(s):  
Sanjeev Narang ◽  
Parul Dargar ◽  
Anjali Singh ◽  
Apurva Malhotra
Keyword(s):  
Retrospective Study ◽  
Positive Predictive Value ◽  
Predictive Value ◽  
Glandular Cell ◽  
Pap Smears ◽  
Histopathological Correlation ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Rare Diagnosis

Background: Atypical glandular cell is still a rare diagnosis despite refinement of the cytomorphologic criteria. This study aims to evaluate the follow up biopsies of cases diagnosed as atypical glandular cells on pap smears and to correlate with histological findings.Materials and Methods: This is a retrospective study over a period of 7 years based on cyto-histopathological correlation of AGC diagnosed cases.Results: Cytodiagnosis of atypical glandular cells was given in 212(0.05%), and 140 (0.66%) patients underwent biopsy. Among these 74(52%) were benign and 66(47%) neoplastic. Of the 39 cases reported as AGC favor neoplastic, 24(61%)  showed malignancy with a positive predictive value of 61.5% and of the101 cases classified as AGC-NOS on cytology, 59 (58%) cases showed benign features with a negative predictive value of 58.4 percent.  Conclusion: Our study highlights the immediate need of histological follow up of patients diagnosed with AGC. It is important because the range of diseases associated is very variable and includes benign as well as malignant conditions.

scholarly journals Histological follow-up in patients with atypical glandular cells on Pap smears

2017 ◽  
Vol 34 (4) ◽  
pp. 203 ◽  
Author(s):  
Gokhan Boyraz ◽  
Derman Basaran ◽  
MehmetCoskun Salman ◽  
Akbar Ibrahimov ◽  
Sevgen Onder ◽  
...  
Keyword(s):  
Pap Smears ◽  
Glandular Cells ◽  
Atypical Glandular Cells

Atypical Glandular Cells on Papanicolaou Test: The Fate and Follow-up of 51 Cases

2017 ◽  
Vol 6 (5) ◽  
pp. S23-S24
Author(s):  
Marcos Lepe ◽  
Claire Eklund ◽  
M. Ruhul Quddus ◽  
Cherie Paquette
Keyword(s):  
Papanicolaou Test ◽  
Glandular Cells ◽  
Atypical Glandular Cells

Human papillomavirus DNA detection and histological findings in women referred for atypical glandular cells or adenocarcinoma in situ in their Pap smears

2004 ◽  
Vol 95 (3) ◽  
pp. 618-623 ◽  
Author(s):  
Sophie Françoise Mauricette Derchain ◽  
Silvia Helena Rabelo-Santos ◽  
Luis Otávio Sarian ◽  
Luiz Carlos Zeferino ◽  
Eliane Regina de Oliveira Zambeli ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Dna Detection ◽  
Pap Smears ◽  
Adenocarcinoma In Situ ◽  
Histological Findings ◽  
Glandular Cells ◽  
Atypical Glandular Cells ◽  
Papillomavirus Dna
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