scholarly journals ENPP1 K121Q Functional Variant Enhances Susceptibility to Insulin Resistance and Dyslipidemia with Metabolic Syndrome in Asian Indians

2018 ◽  
pp. 8-15 ◽  
Author(s):  
Gurjit K. Bhatti ◽  
Sumanpreet Kaur ◽  
Rajesh Vijayvergiya ◽  
Sanjay K. Bhadada ◽  
Sarabjit S. Mastana ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Asian Indians ◽  
Functional Variant

Genetic Variants Associated with Insulin Resistance and Metabolic Syndrome in Young Asian Indians with Myocardial Infarction

2008 ◽  
Vol 6 (3) ◽  
pp. 209-214 ◽  
Author(s):  
Naresh Ranjith ◽  
Rosemary J. Pegoraro ◽  
Datshana P. Naidoo ◽  
Rebecca Shanmugam ◽  
Lee Rom
Keyword(s):  
Myocardial Infarction ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Genetic Variants ◽  
Asian Indians

Abstract P086: Circulating MicroRNAs are Associated with Abdominal Adiposity and Fatty Liver in Asian Indians

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Kevin Miles ◽  
Alka M Kanaya ◽  
Elena Flowers
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Fatty Liver ◽  
Asian Indians ◽  
Circulating Microrna ◽  
Abdominal Adiposity ◽  
Circulating Micrornas ◽  
The Metabolic Syndrome ◽  
Computed Tomography Images

Background: Fatty liver is associated with abdominal adiposity, insulin resistance, and risk for diabetes and liver disease. Asians Indians have a high prevalence of fatty liver and abdominal visceral adiposity compared to other racial groups, and the causes are not well understood. Circulating microRNAs (miRs) identify latent risk factors for diabetes and biologic mechanisms underlying disease. Previous studies identified associations between circulating microRNAs and obesity in Caucasians. No prior studies evaluated association between circulating microRNAs and fatty liver and abdominal adiposity in Asian Indians. Hypothesis: Circulating microRNAs are associated with the presence of fatty liver and elevated waist circumference in Asian Indians. Methods: We studied 136 participants (49% women, age 56 ± 8 years) from the Metabolic syndrome and Atherosclerosis in South Asians Living in America (MASALA) pilot study. Elevated waist circumference at baseline was defined as >90cm for men and >80cm for women. Fatty liver was measured using computed tomography images of the liver and spleen (in Hounsfield units) and was defined as liver to spleen ratio <1. Circulating microRNAs (n=30) were measured from plasma collected during the baseline visit using the Firefly Circulating microRNA assay. Unadjusted and multivariate-adjusted logistic regression models were created. Results: Elevated waist circumference was present in 115 (85%) and fatty liver was present in 24 (18%). In age and sex adjusted models, miR-423 was inversely associated with elevated waist circumference (p<0.05). This miR was also inversely associated with metabolic syndrome (p<0.1) in the subset of individuals not taking hypertension or diabetes medications (n=88). MiR-146a, miR-146b, miR-197, miR-20b, miR-21, miR-222, and miR-24 were inversely associated with fatty liver (p<0.05 for all). These microRNAs show moderate to high inter-correlations (r=0.4-0.9). None of these miRs were significantly associated with metabolic syndrome or diabetes. MiR-486, which is associated with glycemic impairment and progression in Asian Indians and insulin resistance and response to thiazolidenidones, was positively associated with fatty liver (p<0.1). Conclusions: We found significant relationships between fatty liver and waist circumference and numerous circulating microRNAs. MicroRNAs inversely associated with fatty liver are correlated and may be co-expressed in order to regulate biologic pathways related to fatty liver. There is no overlap between miRs associated with fatty liver and miRs associated with diabetes and metabolic syndrome. Additional studies are needed to determine whether circulating microRNAs might be useful biomarkers for the detection of fatty liver, which biologic pathways are implicated, and whether there are differences between race/ethnic groups.

scholarly journals Oxidative Stress in Obesity and Metabolic Syndrome in Asian Indians

2011 ◽  
Vol 30 (2) ◽  
pp. 115-120 ◽  
Author(s):  
Nina Veigas ◽  
Mala Dharmalingam ◽  
Sara Marcus
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
High Risk ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Asian Indians ◽  
Anthropometric Parameters ◽  
The Metabolic Syndrome ◽  
Total Antioxidant

Oxidative Stress in Obesity and Metabolic Syndrome in Asian IndiansOxidative stress is associated with the individual components of metabolic syndrome and has been implicated in the development of complications of these metabolic disorders. In this study oxidative stress levels have been compared in obese Indians (a high-risk population for diabetes and cardiovascular disorders) with and without metabolic syndrome. 30 adult normotensive, normoglycemic obese subjects and 35 adults with metabolic syndrome of either sex with BMI >23 kg/m2were compared with 30 adult, healthy volunteers with BMI <23 kg/m2. Anthropometric parameters, blood pressure, biochemical parameters, hydroperoxides levels and total antioxidant capacity were estimated. The obese groups with and without metabolic syndrome had significantly increased anthropometric parameters like waist circumference and index of central obesity and aqueous phase hydroperoxides when compared with normal controls. The metabolic syndrome group also had significantly increased blood sugar levels, lipid profile and hydroperoxide levels when compared to obese or control groups. There was no alteration in the total antioxidant capacity in any of the groups. The Triglyceride/HDL-Cholesterol ratio (>3), a surrogate marker of insulin resistance, indicates insulin resistance in the metabolic syndrome group. The anthropometric profile, insulin resistance and oxidative stress seen in obesity are further elaborated in metabolic syndrome. Thus, the early identification of high-risk individuals based on anthropometric parameters, lipid profile, insulin resistance and indices of oxidative stress may help to prevent the development of complications of metabolic syndrome.

scholarly journals Role of Retinol-Binding Protein 4 in Obese Asian Indians with Metabolic Syndrome

2012 ◽  
Vol 31 (1) ◽  
pp. 40-46
Author(s):  
Nirupama Shivakumar ◽  
Meghanaa Kumar ◽  
Manasa Aswathanarayan ◽  
Maanasa Venkatesh ◽  
Manasa Sheshadri ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Asian Indians ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
C Reactive Protein ◽  
Retinol Binding Protein 4 ◽  
Reactive Protein ◽  
Potential Marker

Role of Retinol-Binding Protein 4 in Obese Asian Indians with Metabolic SyndromeRetinol-binding protein 4 is an adipocytokine separately implicated in the development of obesity-related insulin resistance and proatherogenic lipid profile, however, its role in humans is unclear. This study was carried out to assess the role of retinol-binding protein 4 as a potential marker of metabolic syndrome in obese Asian Indians (a high-risk population for diabetes). 52 obese (BMI >23 kg/m2) Asian Indians were grouped into those with and without metabolic syndrome based on IDF criteria and compared with healthy controls. The anthropometric and biochemical parameters (fasting blood sugar, lipid profile, serum insulin, high-sensitivity C-reactive protein, and retinol-binding protein 4) were estimated. The obese groups had significantly altered adiposity indices, insulin resistance parameters (fasting blood sugar (only in the metabolic syndrome group), serum insulin, HOMA-IR and QUICKI), index of inflammation (C-reactive protein) and proatherogenic dyslipidemic profile (serum triglycerides, VLDL-cholesterol, and triglyceride/HDL-cholesterol ratio). Retinol-binding protein 4 levels were elevated in the obese groups, but were not significant. Retinol-binding protein 4 levels were correlated with anthro-pometric parameters and atherogenic lipids, while C-reactive protein was correlated with anthropometric and insulin resistance parameters in the entire group of subjects. Although these correlations were not observed in the obese groups, in the control group, retinol-binding protein 4 was correlated to the lipid parameters and C-reactive protein to adiposity indices. Thus, the role of retinol-binding protein 4 as a potential marker of metabolic syndrome is limited to the prediction of proatherogenic risk among Asian Indians.

scholarly journals South Asian diets and insulin resistance

2008 ◽  
Vol 101 (4) ◽  
pp. 465-473 ◽  
Author(s):  
Anoop Misra ◽  
Lokesh Khurana ◽  
Sumit Isharwal ◽  
Swati Bhardwaj
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Asian Indians ◽  
South Asians ◽  
Food Choices ◽  
Rural Populations ◽  
High Intake ◽  
The Metabolic Syndrome

A role of dietary nutrients in relation to insulin resistance has been suggested but conclusive evidence in human beings is lacking. Asian Indians and South Asians are prone to develop insulin resistance and the metabolic syndrome. In the present paper, data pertaining to nutrient intake, insulin resistance and cardiovascular risk factors in Asian Indians and South Asians have been reviewed. In these populations, several dietary imbalances have been reported: low intake of MUFA, n-3 PUFA and fibre, and high intake of fats, saturated fats, carbohydrates and trans-fatty acids (mostly related to the widespread use of Vanaspati, a hydrogenated oil). Some data suggest that these nutrient imbalances are associated with insulin resistance, dyslipidaemia and subclinical inflammation in South Asians. Specifically, in children and young individuals, a high intake of n-6 PUFA is correlated with fasting hyperinsulinaemia, and in adults, high-carbohydrate meal consumption was reported to cause hyperinsulinaemia, postprandial hyperglycaemia and hypertriacylglycerolaemia. Dietary supplementation with n-3 PUFA leads to an improved lipid profile but not insulin sensitivity. Inadequate maternal nutrition in pregnancy, low birth weight and childhood ‘catch-up’ obesity may be important for the development of the metabolic syndrome and diabetes. Even in rural populations, who usually consume traditional frugal diets, there is an increasing prevalence of cardiovascular risk factors and the metabolic syndrome due to changes in diets and lifestyle. Nationwide community intervention programmes aimed at creating awareness about the consequences of unhealthy food choices and replacing them by healthy food choices are urgently needed in urban and rural populations in India, other countries in South Asia and in migrant South Asians.

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