Insulin resistance syndrome (metabolic syndrome) and obesity in Asian Indians: evidence and implications

Nutrition ◽  
2004 ◽  
Vol 20 (5) ◽  
pp. 482-491 ◽  
Author(s):  
Anoop Misra ◽  
Naval K Vikram
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Asian Indians ◽  
Insulin Resistance Syndrome

Genetic Variants Associated with Insulin Resistance and Metabolic Syndrome in Young Asian Indians with Myocardial Infarction

2008 ◽  
Vol 6 (3) ◽  
pp. 209-214 ◽  
Author(s):  
Naresh Ranjith ◽  
Rosemary J. Pegoraro ◽  
Datshana P. Naidoo ◽  
Rebecca Shanmugam ◽  
Lee Rom
Keyword(s):  
Myocardial Infarction ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Genetic Variants ◽  
Asian Indians

Metabolic Syndrome/Insulin Resistance Syndrome

2019 ◽  
Author(s):  
Julie Adkins ◽  
Jill C. Cash ◽  
Mellis A. Hall ◽  
Cheryl A. Glass ◽  
Angelito Tacderas ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Insulin Resistance Syndrome

scholarly journals ENPP1 K121Q Functional Variant Enhances Susceptibility to Insulin Resistance and Dyslipidemia with Metabolic Syndrome in Asian Indians

2018 ◽  
pp. 8-15 ◽  
Author(s):  
Gurjit K. Bhatti ◽  
Sumanpreet Kaur ◽  
Rajesh Vijayvergiya ◽  
Sanjay K. Bhadada ◽  
Sarabjit S. Mastana ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Asian Indians ◽  
Functional Variant

scholarly journals The Mechanistic and Pathophysiological Role of Adiponectin and Resistin Towards Regulation of Food Intake and Appetite in Cardiovascular Associated Risk Factor of Metabolic Syndrome

2021 ◽  
Author(s):  
Mimie Noratiqah Jumli ◽  
Muhammad Ilyas Nadeem
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Food Intake ◽  
Urban Population ◽  
Insulin Resistance Syndrome ◽  
Mediating Effect ◽  
Syndrome X ◽  
Therapeutic Approaches ◽  
Pathophysiological Role

Insulin resistance syndrome or syndrome X is also known as metabolic syndrome (MetS). It is an emerging problem globally with the surge of increasing prevalence among urban population of developing countries. The etiology of pathophysiology of metabolic syndrome includes the inflammatory pathways of insulin resistance, deregulated appetite, diet-induced, inflammation-induced obesity, and cardiovascular diseases (CVD). Adipose tissue is an endocrine organ that secrets adipokines like adiponectin and resistin during physiological and pathological states. Moreover, the adipokines associated with diet-induced and inflammation-induced obesity have secondary deteriorating effects on cardiovascular system. Although, the adiponectin and resistin were potentially found in regulating food intake and appetite but their mediating effect on pathophysiology of CVD still needs future investigations. However, the prior studies reported the association of adiponectin and resistin levels with CVD complications related to food intake but still there is need to understand its multifactorial heterogeneity. Therefore, literature suggests figuring out potential target mechanistic and therapeutic approaches of adiponectin and resistin hormone towards food intake and appetite involvement in metabolic syndrome and CVD.

Lipid behavior in metabolic syndrome pathophysiology

2021 ◽  
Vol 17 ◽  
Author(s):  
Basheer Marzoog
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Lipid Level ◽  
Visceral Obesity ◽  
Insulin Resistance Syndrome ◽  
Chronic Inflammatory Response ◽  
Cell Dysfunction ◽  
Commensal Microbiota ◽  
The Metabolic Syndrome

: Undeniably, lipid plays an extremely important role in the homeostasis balance, since lipid contributes to the regulation of the metabolic processes. The metabolic syndrome pathogenesis is multi-pathway that composes neurohormonal disorders, endothelial cell dysfunction, metabolic disturbance, genetic predisposition, in addition to gut commensal microbiota. The heterogenicity of the possible mechanisms gives the metabolic syndrome its complexity and limitation of therapeutic accesses. The main pathological link that lipid contributes to the emergence of metabolic syndrome via central obesity and visceral obesity that consequently lead to oxidative stress and chronic inflammatory response promotion. Physiologically, a balance is kept between the adiponectin and adipokines level to maintain the lipid level in the organism. Clinically, extremely important to define the borders of the lipid level in which the pathogenesis of the metabolic syndrome is reversible, otherwise will be accompanied by irreversible complications and sequelae of the metabolic syndrome (cardiovascular, insulin resistance). The present paper is dedicated to providing novel insights into the role of lipid in the development of metabolic syndrome hence dyslipidemia is the initiator of insulin resistance syndrome (metabolic syndrome).

scholarly journals HYPERTENSION MANAGEMENT IN METABOLIC SYNDROME

2019 ◽  
Vol 9 (5) ◽  
pp. 327-347
Author(s):  
E. V. Reznik ◽  
I. G. Nikitin
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Insulin Resistance Syndrome ◽  
Effective Control ◽  
Peripheral Tissues ◽  
The Metabolic Syndrome ◽  
Cardiovascular Morbidity And Mortality ◽  
Therapy Target ◽  
Based Medicine

Hypertension is one of the key risk factors for cardiovascular morbidity and mortality. Metabolic syndrome (synonyms: syndrome X, insulin resistance syndrome) is characterized by increased visceral fat mass, decreased sensitivity of peripheral tissues to insulin (insulin resistance) and hyperinsulinemia, which cause disorders of carbohydrate, lipid, and purine metabolism. Hypertension is an integral component of the metabolic syndrome. The severity of hypertension in patients with metabolic syndrome is higher in comparison with patients without metabolic disorders. In patients with metabolic syndrome, the probability of cardiac and brain damage increases fivefold, kidney damage threefold, and the vessels twofold. The presence of diabetes reduces the likelihood of achieving effective control of blood pressure by 1.4 times, hypercholesterolemia — by 1.5 times, obesity — by 1.7 times. In the presence of any three factors, the effectiveness of treatment is reduced twofold. In this article, approaches to the management of patients with hypertension and metabolic syndrome, aspects of non-drug therapy, target blood pressure levels, and the choice of drugs are presented in accordance with evidence-based medicine and current recommendations.

scholarly journals Methods for guantificative assessment of insulin resistance

2009 ◽  
Vol 6 (2) ◽  
pp. 19-23 ◽  
Author(s):  
A Yu Mayorov ◽  
K A Urbanova ◽  
G R Galstyan ◽  
A Yu Mayorov ◽  
K A Urbanova ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Insulin Sensitivity ◽  
Mathematical Models ◽  
Insulin Action ◽  
Quantitative Assessment ◽  
Insulin Resistance Syndrome ◽  
Indirect Measurement ◽  
Golden Standard ◽  
Definition Of

The article delineates the definition of concept of insulin resistance as well as the factors that determine tissue insulin sensitivity; defines the conception of «insulin resistance syndrome» (metabolic syndrome), its criteria and diseases that it accompanies. It is pointed that the golden standard for quantitative assessment of insulin action is hyperinsulinemic euglycemic clamp. Different indexes for indirect measurement of insulin resistance and possibilities of use of mathematical models for this matter are discussed.

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