scholarly journals Spontaneous Keloids: A Literature Review

Dermatology ◽  
2018 ◽  
Vol 234 (3-4) ◽  
pp. 127-130 ◽  
Author(s):  
Abdulhadi Jfri ◽  
Ali Alajmi
Keyword(s):  
Literature Review ◽  
Noonan Syndrome ◽  
Case Series ◽  
Medical Conditions ◽  
Bethlem Myopathy ◽  
History Of ◽  
Patient’S History ◽  
Dubowitz Syndrome ◽  
Single Lesion

Background: Keloids are benign fibroproliferative tumors that extend beyond the original wound. Spontaneous keloids are those that result without a significant history of trauma. There are multiple reported cases in the literature. Objective: This article provides a summary and review of the cases that have been reported with spontaneous keloids and organizes them according to their associated medical conditions. Methods: A literature review was conducted using PubMed and MEDLINE that included all English published cases and case series from May 1955 to February 2018. Results: Spontaneous keloids have been reported mainly in association with syndromes such as Rubinstein-Taybi syndrome, Dubowitz syndrome, Noonan syndrome, Goeminne syndrome, Bethlem myopathy, conjunctivocorneal dystrophy, X-linked recessive polyfibromatosis and a novel X-linked syndrome with flamin A mutation. Furthermore, spontaneous keloids were reported in atopic patients and a couple of patients who are medically healthy. Conclusion: Spontaneous keloids are diagnosed clinically based on the patient’s history, and it is challenging to confirm since they might be triggered by minimal injury or inflammation especially if it is a single lesion. Reported syndromes indicate a genetic possibility in the pathogenesis of spontaneous keloids.

The natural history of laryngo‐onycho‐cutaneous syndrome: A case series of six pediatric patients and literature review

2021 ◽  
Author(s):  
Christine Prodinger ◽  
Subhanitthaya Chottianchaiwat ◽  
Jemima E. Mellerio ◽  
John A. McGrath ◽  
Linda Ozoemena ◽  
...  
Keyword(s):  
Natural History ◽  
Literature Review ◽  
Pediatric Patients ◽  
Case Series ◽  
History Of

scholarly journals Optic Disc Neovascularization in Vogt-Koyanagi-Harada Disease- A Case Series and Literature Review

2021 ◽  
Author(s):  
Lagan Paul ◽  
Shalin Shah ◽  
Manisha Agarwal ◽  
Shalini Singh
Keyword(s):  
Optic Nerve ◽  
Literature Review ◽  
Case Series ◽  
Vascular Occlusion ◽  
Autoimmune Disorder ◽  
The Body ◽  
Low Grade ◽  
Retinal Vessels ◽  
History Of ◽  
Vkh Disease

Abstract BackgroundVogt–Koyanagi–Harada (VKH) disease is an autoimmune disorder which affects numerous organs of the body. We report two cases of Optic Nerve Head neovascularisation (NVD) in diagnosed cases of Vogt Koyanagi Harada(VKH) disease.FindingsCase 1: A 40 years female presented with acute loss of vision in both eyes for 10 days. She had multiple serous detachments in both eyes and diagnosed as acute VKH disease. After treatment, she was observed to have NVD later on OCT Angiography(OCTA). Case 2: A 52 years old man presented with history of sudden blackouts in front of left eye since 4 months. He was a case of chronic VKH and NVD was seen clinically and on OCTA. ConclusionThe exact etiopathogenesis of neovascularization in Harada’s disease is unclear. The low grade inflammations acts as a stimulus and can induce disc neovascularization even in the absence of vascular occlusion. ONH vessels appear to be more susceptible to developing NVD than retinal vessels in presence of chronic inflammation.

scholarly journals Papillary Tumor of the Pineal Region: Case Report and Literature Review

2018 ◽  
Vol 37 (03) ◽  
pp. 252-257
Author(s):  
Vitor Yamaki ◽  
Felipe Vera ◽  
Renan Ribeiro ◽  
Raphael Medeiros ◽  
Manoel Teixeira ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Literature Review ◽  
Histopathological Examination ◽  
Subcommissural Organ ◽  
Tumor Resection ◽  
Case Series ◽  
Pineal Region ◽  
Papillary Tumor ◽  
Clinical Onset ◽  
History Of

AbstractPapillary tumor of the pineal region (PTPR) is a neuroectodermal tumor thought to originate from cells of the subcommissural organ. Its oncologic properties are still under investigation, as well as the most suitable therapeutic measures for this type of neoplasm. We report the case of a 36-year-old woman with a 1-year history of headache and intermittent diplopia. The magnetic resonance imaging (MRI) scan showed a heterogeneously enhancing mass in the pineal region that caused an acute hydrocephalus, and an emergency shunt derivation was necessary. One week later, the patient was submitted to subtotal tumor resection, and remained asymptomatic in the post-operative period. In the follow-up, the patient remained asymptomatic; in the imaging control 3.5 years after the surgical resection, local recurrence was identified, and the patient was submitted to a local radiation protocol. Our literature review showed an early clinical onset due to intracranial hypertension signs. Definitive clinical onset might be reached only through a histopathological examination. Gross total resection followed by radiotherapy is the current standard of care. Local recurrence is often observed, with rare dissemination to the cerebral spinal fluid. The natural history of the PTPR remains unknown, as well as the best treatment strategy. Large case series with longer follow-ups are necessary for further conclusions.

scholarly journals Breast Carcinoma After Ocrelizumab Therapy in Multiple Sclerosis Patients: A Case Series and Literature Review

2021 ◽  
Vol 13 ◽  
pp. 117957352110377
Author(s):  
Andrew Kelsey ◽  
Gabriella Casinelli ◽  
Medha Tandon ◽  
Shitiz Sriwastava
Keyword(s):  
Breast Cancer ◽  
Multiple Sclerosis ◽  
Breast Carcinoma ◽  
Literature Review ◽  
Case Reports ◽  
Case Series ◽  
Progressive Multiple Sclerosis ◽  
Primary Progressive Multiple Sclerosis ◽  
History Of ◽  
Multiple Sclerosis Patients

Ocrelizumab is a humanized CD20 monoclonal antibody which was approved for management of Relapsing Remitting Multiple Sclerosis (RRMS) and Primary Progressive Multiple Sclerosis (PPMS) in 2017. We present 2 patients, a 67-year-old woman with history of PPMS and a 42-year-old woman with RRMS, who were started on ocrelizumab and were diagnosed with invasive ductal cell breast carcinoma after 2 years of ocrelizumab infusion followed by discontinuation of the drug. Large trials conducted for ocrelizumab showed malignancies in a total of 4 cases with RRMS in OPERA 1 trial conducted over 2 years from 2011 to 2013 (breast cancer, renal cell carcinoma, and melanomas) and in 11 cases with PPMS seen in ORATORIO trial conducted in 2017. There are currently no other published case reports of breast cancer in setting of ocrelizumab use for MS outside of large trials on literature review.

Natural History of Untreated Transverse/Sigmoid Sinus Thrombosis Following Posterior Fossa Surgery: Case Series and Literature Review

Neurosurgery ◽  
2021 ◽  
Vol 89 (Supplement_2) ◽  
pp. S140-S140
Author(s):  
Alon Orlev ◽  
Christopher M Jackson ◽  
Andrew Luksik ◽  
Tomas Garzon-Muvdi ◽  
Wuyang Yang ◽  
...  
Keyword(s):  
Natural History ◽  
Literature Review ◽  
Posterior Fossa ◽  
Sinus Thrombosis ◽  
Case Series ◽  
Sigmoid Sinus ◽  
Posterior Fossa Surgery ◽  
History Of

scholarly journals Blastoschizomyces capitatus pulmonary infections in immunocompetent patients: case report, case series and literature review

2017 ◽  
Vol 146 (1) ◽  
pp. 58-64 ◽  
Author(s):  
M. B. TANABE ◽  
S. A. PATEL
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Treatment Options ◽  
Case Series ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Infectious Risk ◽  
History Of ◽  
Blastoschizomyces Capitatus ◽  
Immunocompetent Patients

SUMMARYBlastoschizomyces capitatus is an uncommon opportunistic yeast associated with infections in neutropaenic patients secondary to haematological malignancies, with a special predilection for the lungs. Globalisation and population migration impact on the epidemiology of infection with this organism but its effect on the immunocompetent population has rarely been described. We present here a case report, an overview of 11 other cases published between 2000 and 2016, and a comprehensive literature review of Blastoschizomyces pneumonia in the non-immunocompromised. The median age at diagnosis was 68 years (range 40–86 years) and more than half the cases reported a positive history of either current or past tobacco smoking. Six cases had either clinical or radiological evidence of chronic obstructive pulmonary disease and three had a history of prior treated tuberculosis. Fluconazole and itraconazole, alone or in combination, was the most utilised treatment. We conclude that unlike most other invasive yeast species, B. capitatus poses an infectious risk for immunocompetent patients, usually of middle to older age with risk factors for distorted lung architecture. Further research is warranted into the pathophysiology of Blastoschizomyces infections in the immunocompetent, including standardised treatment options.

scholarly journals The natural history of fetal gallstones: a case series and updated literature review

2020 ◽  
pp. 1-8
Author(s):  
Marisa E. Schwab ◽  
Hillary J. Braun ◽  
Vickie A. Feldstein ◽  
Amar Nijagal
Keyword(s):  
Natural History ◽  
Literature Review ◽  
Case Series ◽  
History Of
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