scholarly journals Biomarkers for Antidepressant Efficacy of Electroconvulsive Therapy: An Exploratory Cerebrospinal Fluid Study

2018 ◽  
Vol 77 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Laura Kranaster ◽  
Carolin Hoyer ◽  
Suna S. Aksay ◽  
J. Malte Bumb ◽  
Norbert Müller ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Electroconvulsive Therapy ◽  
Antidepressant Efficacy

scholarly journals The Longitudinal Effects of Electroconvulsive Therapy on Ictal Interhemispheric Coherence and Its Associations With Treatment Outcome: A Naturalistic Cohort Study

2018 ◽  
Vol 50 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Freek ten Doesschate ◽  
Guido A. van Wingen ◽  
Boudewijn J. H. B. de Pont ◽  
Martijn Arns ◽  
Jeroen A. van Waarde
Keyword(s):  
Cohort Study ◽  
Electroconvulsive Therapy ◽  
Treatment Efficacy ◽  
Rating Scale ◽  
Eeg Coherence ◽  
Mixed Effect ◽  
Frequency Bands ◽  
Interhemispheric Coherence ◽  
Longitudinal Effects ◽  
Antidepressant Efficacy

Objectives. Electroconvulsive therapy (ECT) is an effective treatment for severe depression. Electroencephalogram (EEG) measures between ECT sessions seem to be related to the antidepressant efficacy of ECT. In this naturalistic cohort study, we examine longitudinal effects of ECT on interhemispheric EEG coherence measures during seizure activity and its relation to the antidepressant efficacy. Methods. This study included 65 patients diagnosed with severe depressive disorder. Depressive symptoms were rated according to the Montgomery-Åsberg Depression Rating Scale before and after the course of ECT. Frequency-specific ictal interhemispheric (fp1-fp2) EEG coherence measures were established during the first and each consecutive sixth treatment session. Linear mixed-effect models were used to determine longitudinal changes in ictal coherence measures during the course of ECT and its relation to treatment efficacy. Results. Ictal interhemispheric coherence in the theta and alpha frequency bands increased over the course of treatment, whereas no significant change was found for the delta and beta frequency bands. A main effect of treatment efficacy on the interhemispheric coherence in the delta and theta band was revealed. However, the longitudinal effects of ECT were not associated with treatment efficacy. Conclusion. The current study suggests that interhemispheric coherence during ECT-induced seizures increases over the course of treatment. Furthermore, these longitudinal effects seem to be unrelated to the antidepressant efficacy of ECT. These findings contribute to the understanding of the mechanism of action of ECT.

scholarly journals Psychosis Crisis Associated with Thyrotoxicosis due to Graves’ Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Lilibet Urias-Uribe ◽  
Emmanuel Valdez-Solis ◽  
Claudia González-Milán ◽  
Claudia Ramírez-Rentería ◽  
Aldo Ferreira-Hermosillo
Keyword(s):  
Cerebrospinal Fluid ◽  
Electroconvulsive Therapy ◽  
Psychiatric Illness ◽  
Psychiatric Symptoms ◽  
Thyroid Storm ◽  
Graves Disease ◽  
Thyroid Antibodies ◽  
Hashimoto’S Encephalopathy

We present the case of a patient with previous psychiatric illness, acutely exacerbated by thyroid storm due to Graves’ disease, in whom treatment with antipsychotics induced catatonia. These associations are extremely rare and may be confused with Hashimoto’s encephalopathy, especially in the presence of anti-thyroid antibodies in cerebrospinal fluid. The treatment consists in the control of the triggering disease (in this case the resolution of the thyrotoxicosis) and the use of benzodiazepines. However, in some cases, the resolution of psychiatric symptoms is partial and may require the use of electroconvulsive therapy.

Effects of Low-Dose Ketamine on the Antidepressant Efficacy and Suicidal Ideations in Patients Undergoing Electroconvulsive Therapy

2020 ◽  
Vol 36 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Qibin Chen ◽  
Jun Dong ◽  
Jie Luo ◽  
Li Ren ◽  
Su Min ◽  
...  
Keyword(s):  
Electroconvulsive Therapy ◽  
Low Dose ◽  
Antidepressant Efficacy

Cerebrospinal fluid monoamine metabolism in a case of neuroleptic malignant syndrome improved by electroconvulsive therapy

1996 ◽  
Vol 39 (5) ◽  
pp. 383-384 ◽  
Author(s):  
Koichi Nisijima ◽  
Katumi Oyafuso ◽  
Tatuhiro Shimada ◽  
Hitoshi Hosino ◽  
Takeo Ishiguro
Keyword(s):  
Cerebrospinal Fluid ◽  
Neuroleptic Malignant Syndrome ◽  
Electroconvulsive Therapy ◽  
Monoamine Metabolism

Technical Aspects of Electroconvulsive Therapy: An Update

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
P. Sienaert
Keyword(s):  
Side Effects ◽  
Electroconvulsive Therapy ◽  
Pulse Width ◽  
Additional Treatment ◽  
Electrode Placement ◽  
Treatment Conditions ◽  
Antidepressant Efficacy ◽  
Remission Criteria ◽  
Standard Pulse ◽  
Cognitive Side Effects

In an ongoing attempt to improve efficacy of electroconvulsive therapy (ECT) while minimizing side-effects, both different electrode placements and stimulus parameters have been studied. It has been shown that the traditional bitemporal electrode placement and modern techniques such as bifrontal and unilateral ECT are efficacious, depending on the stimulus used. Modern ECT-devices deliver a square wave brief pulse stimulus. An unresolved issue in the use of brief pulse stimulation concerns the optimal pulse width. It has been suggested that the use of a stimulus with an ultra brief (UB) pulse width, i.e. 0.3 ms, is substantially more efficient in seizure induction, thus needing less energy, and producing less cognitive side-effects than standard pulse width (i.e. 0.5-2 ms) stimulation. There has been a concern, however, of lower antidepressant efficacy of UB ECT, with patients needing additional treatment sessions. Moreover, it has been suggested that the diminished antidepressive efficacy is encountered solely with the combination of an ultra-brief pulse width and bilateral electrode placement, as compared to unilateral UB ECT or standard pulse ECT. In a randomized trial, the antidepressive efficacy and cognitive side-effects of bifrontal and right unilateral UB ECT were compared. It was shown that, using an ultra-brief pulse width, BF ECT is as efficacious as UL ECT, although patients receiving UL ECT achieved response/remission-criteria after a smaller number of treatments. In both treatment conditions there was an improvement of cognitive function, both during and after the treatment course.

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