scholarly journals The Number of Natural Killer Cells in the Largest Diameter Lymph Nodes Is Associated with the Number of Retrieved Lymph Nodes and Lymph Node Size, and Is an Independent Prognostic Factor in Patients with Stage II Colon Cancer

Oncology ◽  
2018 ◽  
Vol 95 (5) ◽  
pp. 288-296 ◽  
Author(s):  
Kazutake Okada ◽  
Sotaro Sadahiro ◽  
Lin Fung Chan ◽  
Takashi Ogimi ◽  
Hiroshi Miyakita ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Natural Killer Cells ◽  
Lymph Nodes ◽  
Natural Killer ◽  
Stage Ii ◽  
Lymph Node Size ◽  
Stage Ii Colon Cancer ◽  
Node Size

Association of the number of natural killer cells and B-cell area ratios in lymph nodes with survival in patients with stage II colon cancer.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 3541-3541
Author(s):  
Kazutake Okada ◽  
Sotaro Sadahiro ◽  
Gota Saito ◽  
Akira Tanaka ◽  
Toshiyuki Suzuki ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Natural Killer Cells ◽  
Lymph Nodes ◽  
B Cell ◽  
Natural Killer ◽  
Stage Ii ◽  
Cell Area ◽  
Killer Cells ◽  
Stage Ii Colon Cancer

Lymph node size as a simple prognostic factor in node negative colon cancer and an alternative thesis to stage migration

2016 ◽  
Vol 212 (4) ◽  
pp. 775-780 ◽  
Author(s):  
Bruno Märkl ◽  
Tina Schaller ◽  
Yuriy Kokot ◽  
Katharina Endhardt ◽  
Hallie Kretsinger ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Stage Migration ◽  
Node Negative ◽  
Lymph Node Size ◽  
Node Size

scholarly journals Targeting Lymph Node Retrieval and Assessment in Stage II Colon Cancer: A Quality Outcome Community-Based Cancer Center Study

2008 ◽  
Vol 4 (2) ◽  
pp. 55-58 ◽  
Author(s):  
Thomas Grote ◽  
Amy H. Hughes ◽  
Cathy C. Rimmer ◽  
Dale A. Less ◽  
Amy P. Abernethy ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Median Number ◽  
Stage Ii ◽  
Tumor Board ◽  
Cancer Center ◽  
Gastrointestinal Tumor ◽  
Tumor Boards ◽  
Stage Ii Colon Cancer

Purpose Adequate lymph node evaluation is required for the proper staging of colon cancer. The current recommended number of lymph nodes that should be retrieved and assessed is 12. Methods The multidisciplinary Gastrointestinal Tumor Board at the Derrick L. Davis Forsyth Regional Cancer Center reviewed and recommended that a minimum of 12 lymph nodes be examined in all cases of colon cancer to ensure proper staging. This recommendation occurred at the end of the first quarter of 2005. To ensure this new standard was being followed, an outcomes study looking at the number of lymph nodes evaluated in stage II colon cancer was initiated. All patients with stage II colon cancer diagnosed between 2004 and 2006 were reviewed. Results There was a statistically significant improvement in the number of stage II colon cancer patients with 12 or more lymph nodes evaluated. Before the Gastrointestinal Tumor Board's recommendation, 49% (40 out of 82 patients) had 12 or more lymph nodes sampled. The median number of lymph nodes evaluated was 11. After the Gastrointestinal Tumor Board's recommendation, 79% (70 out of 88 patients) had 12 or more lymph nodes sampled. The median number of lymph nodes was 16. Conclusion Multidisciplinary tumor boards can impact the quality of care of patients as demonstrated in this study. Although we do not yet have survival data on these patients, based on the previous literature referenced in this article, we would expect to see an improvement in survival rates in patients with 12 or more nodes retrieved and assessed.

Prognostic impact of tumor budding in stage II colon cancer: A prospective study (SACURA trial).

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 3609-3609 ◽  
Author(s):  
Hideki Ueno ◽  
Megumi Ishiguro ◽  
Eiji Nakatani ◽  
Toshiaki Ishikawa ◽  
Hiroyuki Uetake ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Prognostic Factors ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Prospective Study ◽  
Tumor Grade ◽  
Stage Ii ◽  
Tumor Budding ◽  
T Stage ◽  
Stage Ii Colon Cancer

3609 Background: Growing number of studies indicate tumor budding is a significant prognostic factor in colorectal cancer (van Wyk, et al. Cancer Treat Rev 2015), but this has been shown only in retrospective studies. We prospectively evaluated prognostic factors in stage II colon cancer to determine their prognostic value in a multi-institutional phase III study (SACURA trial, ASCO2016 abst#3617). Methods: A total of 991 patients with curatively resected stage II colon cancer (2006–2010; 136 institutions) were included in the study. Tumor budding was defined as an isolated cancer cell or a cluster composed of fewer than five cells in the invasive frontal region, and was graded based on its number within a microscopic field of a 20x objective lens (0.785 mm2) in the hotspot. Tumors with < 5, 5–9, and ≥10 budding foci were classified as grades G1, G2, and G3, respectively. All clinical and pathological data including the grade of budding were prospectively recorded and prognostic analyses were performed at 5 years after the completion of registration. Results: According to budding grading, 376, 331 and 284 tumors were classified as G1, G2, and G3, and 5-year relapse-free survival (RFS) rate was 90.9%, 85.1%, and 74.4%, respectively ( P < 0.0001). Budding grade was significantly associated with the incidence of recurrence in the liver, lung, lymph node, and peritoneum ( P < 0.0001–0.01). Among conventional factors, T stage and the serum CEA levels were associated with RFS, however, tumor grade, lymphatic and venous invasions, and the number of lymph node examined were not significant factors. Multivariate analysis for RFS showed budding, along with T stage, exerted an independent influence on prognostic outcome. Budding grade surpassed T stage and tumor grade in the ability to stratify patients by RFS (Harrell’s c-index, 0.63, 0.59, and 0.54, respectively). Conclusions: Our prospective study indicates that the grade of tumor budding is more informative for prognostic prediction than conventional prognostic factors in stage II colon cancer. The role of this prognostic factor should be highlighted in the adjuvant treatment setting, and conversely, some of prognostic factors adopted in clinical guidelines may need to be reconsidered. Clinical trial information: NCT00392899.

scholarly journals Optimal number of lymph nodes to be examined in stage II colon cancer

2019 ◽  
Vol 9 (1) ◽  
pp. 42-50
Author(s):  
M. Yu. Fedyanin ◽  
A. A. Tryakin ◽  
A. A. Bulanov ◽  
S. S. Gordeev ◽  
D. V. Kuzmichev ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Nodes ◽  
Optimal Number ◽  
Stage Ii ◽  
Stage Ii Colon Cancer

Lymph node micrometastases do not predict relapse in stage II colon cancer

2000 ◽  
Vol 7 (8) ◽  
pp. 601-608 ◽  
Author(s):  
Jorg Tschmelitsch ◽  
David S. Klimstra ◽  
Alfred M. Cohen
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Stage Ii ◽  
Lymph Node Micrometastases ◽  
Stage Ii Colon Cancer

scholarly journals Omental Vascularized Lymph Node Flap: A Radiographic Analysis

2018 ◽  
Vol 34 (07) ◽  
pp. 472-477 ◽  
Author(s):  
Sarah Sasor ◽  
Sunil Tholpady ◽  
Michael Chu ◽  
Julia Cook
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Donor Site ◽  
Gaussian Mixture ◽  
Omental Flap ◽  
Node Number ◽  
Lymph Node Size ◽  
Lymph Node Transfer ◽  
Node Size ◽  
Vascularized Lymph Node Transfer

Background Vascularized lymph node transfer is an increasingly popular option for the treatment of lymphedema. The omental donor site is advantageous for its copious soft tissue, well-defined collateral circulation, and large number of available nodes, without the risk of iatrogenic lymphedema. The purpose of this study is to define the anatomy of the omental flap in the context of vascularized lymph node harvest. Methods Consecutive abdominal computed tomography angiography (CTA) images performed at a single institution over a 1-year period were reviewed. Right gastroepiploic artery (RGEA) length, artery caliber, lymph node size, and lymph node location in relation to the artery were recorded. A two-tailed Z-test was used to compare means. A Gaussian Mixture Model confirmed by normalized entropy criterion was used to calculate three-dimensional lymph node cluster locations along the RGEA. Results In total, 156 CTA images met inclusion criteria. The RGEA caliber at its origin was significantly larger in males compared with females (p < 0.001). An average of 3.1 (1.7) lymph nodes were present per patient. There was no significant gender difference in the number of lymph nodes identified. Average lymph node size was significantly larger in males (4.9 [1.9] × 3.3 [0.6] mm in males vs. 4.5 [1.5] × 3.1 [0.5] mm in females; p < 0.001). Three distinct anatomical variations of the RGEA course were noted, each with a distinct lymph node clustering pattern. Total lymph node number and size did not differ among anatomical subgroups. Conclusion The omentum is a reliable lymph node donor site with consistent anatomy. This study serves as an aid in preoperative planning for vascularized lymph node transfer using the omental flap.

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