Temperament and Character Inventory in Bipolar Disorder versus Healthy Controls and Modulatory Effects of 3 Key Functional Gene Variants

2017 ◽  
Vol 76 (4) ◽  
pp. 209-221 ◽  
Author(s):  
Stefano Porcelli ◽  
Agnese Marsano ◽  
Elisabetta Caletti ◽  
Michela Sala ◽  
Vera Abbiati ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Functional Gene ◽  
Gene Variants ◽  
Healthy Controls ◽  
Temperament And Character Inventory ◽  
Character Inventory

Personality traits as an endophenotype in genetic studies on suicidality in bipolar disorder

2016 ◽  
Vol 29 (2) ◽  
pp. 115-121 ◽  
Author(s):  
J. Pawlak ◽  
M. Dmitrzak-Węglarz ◽  
M. Maciukiewicz ◽  
P. Kapelski ◽  
P. Czerski ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Personality Traits ◽  
Suicidal Behaviour ◽  
Tryptophan Hydroxylase ◽  
Control Group ◽  
Temperament And Character Inventory ◽  
Genetic Studies ◽  
Character Inventory ◽  
Dsm Iv ◽  
Genetically Determined

IntroductionThe influence of personality traits on suicidal behaviour risk has been well documented. Personality traits and suicidal behaviour are partially genetically determined and personality has been described as an endophenotype of suicidal behaviour. The aim of this study was to investigate a possible association between personality traits with suicidal behaviour and selected serotonergic gene polymorphisms.MethodsIn the study we included 156 patients meeting DSM-IV criteria for bipolar disorder (BP) and 93 healthy controls. The personality dimensions were assessed using the Temperament and Character Inventory (TCI). We genotyped two selected polymorphisms of the tryptophan hydroxylase 1 (TPH1) gene (rs1800532 218A>C and rs1799913 779A>C) and polymorphism in the promoter region of serotonin transporter gene (5-HTTLPR, rs25531) related to serotoninergic neurotransmission. Multiple poisson regression, logistic regression and Kruskal–Wallis tests were applied.ResultsWe found numerous differences between the BP patients and the control group in terms of their TCI dimensions/subdimensions. Significant differences were found between patients with, and without, suicidal attempts in fatigability and asthenia (Ha4), as well as in harm avoidance (Ha). We also found that the interactions between TCI subdimensions (the interaction of disordiness (Ns4) and spiritual acceptance (St3), disordiness (Ns4) and integrated conscience (C5), extravagance (Ns3) and resourcefulness (Sd3)) were significantly contributing for suicidal behaviour risk. We found association between all studied genetic polymorphisms and several TCI dimensions and subdimensions.ConclusionOur results confirm that personality traits are partially determined by genes. Both personality traits and the interactions between temperament and character traits, may be helpful in predicting suicidal behaviour.

scholarly journals Bipolar Disorder and the TCI: Higher Self-Transcendence in Bipolar Disorder Compared to Major Depression

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
James A. Harley ◽  
J. Elisabeth Wells ◽  
Christopher M. A. Frampton ◽  
Peter R. Joyce
Keyword(s):  
Bipolar Disorder ◽  
Mood State ◽  
Psychiatric Diagnoses ◽  
Personality Theory ◽  
Temperament And Character Inventory ◽  
Major Depressive ◽  
Genetic Studies ◽  
Character Inventory ◽  
Self Transcendence

Personality traits are potential endophenotypes for genetic studies of psychiatric disorders. One personality theory which demonstrates strong heritability is Cloninger's psychobiological model measured using the temperament and character inventory (TCI). 277 individuals who completed the TCI questionnaire as part of the South Island Bipolar Study were also interviewed to assess for lifetime psychiatric diagnoses. Four groups were compared, bipolar disorder (BP), type 1 and 2, MDD (major depressive disorder), and nonaffected relatives of a proband with BP. With correction for mood state, total harm avoidance (HA) was higher than unaffected in both MDD and BP groups, but the mood disorder groups did not differ from each other. However, BP1 individuals had higher self-transcendence (ST) than those with MDD and unaffected relatives. HA may reflect a trait marker of mood disorders whereas high ST may be specific to BP. As ST is heritable, genes that affect ST may be of relevance for vulnerability to BP.

Temperament and Character Inventory

1994 ◽  
Author(s):  
C. R. Cloninger ◽  
T. Przybeck ◽  
D. M. Svrakic ◽  
R. Wetzel
Keyword(s):  
Temperament And Character Inventory ◽  
Character Inventory

Junior Temperament and Character Inventory

1999 ◽  
Author(s):  
Joan L. Luby ◽  
Dragan M. Svrakic ◽  
Kimberli McCallum ◽  
Thomas R. Przybeck ◽  
C. Robert Cloninger
Keyword(s):  
Temperament And Character Inventory ◽  
Character Inventory
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