scholarly journals Efficacy and Tolerability of Topical Green Tea Extract (Polyphenon E) Application in a “Therapy-Resistant” Plantar Wart

2018 ◽  
Vol 10 (2) ◽  
pp. 127-132 ◽  
Author(s):  
Giancarlo Meloni ◽  
Massimo Milani
Keyword(s):  
Metatarsal Head ◽  
Initial Visit ◽  
Local Tolerability ◽  
Present Treatment ◽  
Plantar Wart ◽  
Polyphenon E ◽  
Therapeutic Problem ◽  
Tea Extract ◽  
Cutaneous Warts ◽  
Plantar Warts

Plantar warts account for 30% of all cutaneous warts. These lesions could be very painful, especially if the lesion is located over pressure sites such as the metatarsal head. Plantar wart treatment remains a challenging therapeutic problem. A 67-year-old immunocompetent nonsmoking man presented with a large mosaic plantar wart on his right foot. The lesion had been present for 5 years. Several cryotherapy sessions (a total of 6 procedures) had been performed with no success. The lesion was therefore treated with a 5-fluorouracil (5-FU) regimen and then with a topical combination of 5-FU and salicylic acid, but also these approaches failed. At the initial visit, a large (16 cm2) mosaic wart lesion was present. Treatment with topical Polyphenon E, 10%, twice daily was prescribed and started. After 3 months of treatment, the lesion completely disappeared. Interestingly, no curettage or mechanical pickling of the hyperkeratotic parts of the lesion were performed before the start of the treatment. Local tolerability was evaluated as very good by the patient.

scholarly journals Efficacy and Tolerability of Polyphenon E in “Difficult-to-Treat” Multiple Genital Warts in an HIV-Positive Male Subject

2017 ◽  
Vol 9 (2) ◽  
pp. 55-59 ◽  
Author(s):  
Mauro Grandolfo ◽  
Massimo Milani
Keyword(s):  
Male Subject ◽  
Normal Values ◽  
Genital Warts ◽  
Hiv Positive ◽  
Initial Visit ◽  
Local Tolerability ◽  
Positive History ◽  
Present Treatment ◽  
Polyphenon E ◽  
Partial Success

A 55-year-old man, nonsmoker, with a HIV-positive history came to our attention in February 2017. He was on treatment with StribildTM, 1 capsule daily (150 mg elvitegravir, 150 mg cobicistat, 200 mg emtricitabine, and 245 mg tenofovir disoproxil). The CD4+/CD8+ cellular count was 326/µL (normal values: 404–1,612); the CD3+/CD8+ cellular count was 819/µL (normal values: 220–1,219). The CD4/CD8 ratio was 0.40 (normal value: >1). Several typical genital wart lesions were present at the penis shaft and at the level of the neck and the corona of glans. These lesions were present for 2 years. Several cryotherapy sessions (a total of 10 procedures) had been performed with partial success. At the initial visit a total of 5 lesions were present. Treatment with topical Polyphenon E 10% 3 times a day was prescribed and started. After 1 month of treatment the lesions were reduced to 2. Treatment was very well tolerated. After 8 weeks of treatment no more lesions were observed and therefore a complete clearance was obtained. Local tolerability was evaluated to be very good by the patient.

CLINICAL CHARACTERISTICS AND EVALUATION OF THE EFFECTIVE TREATMENT OF CUTANEOUS WARTS BY ELECTROSURGERY

2020 ◽  
pp. 25-29
Author(s):  
Anh Mai Ba Hoang ◽  
Duan Nguyen Duy ◽  
Cat Mai Thi Cam ◽  
Nga Le Thi Thuy ◽  
Phuong Nguyen Thi Thanh ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Wide Distribution ◽  
Healing Time ◽  
Common Disease ◽  
Clinical Form ◽  
Plantar Wart ◽  
Dermatology Clinic ◽  
Cutaneous Wart ◽  
Cutaneous Warts ◽  
Single Lesion

Background: Cutaneous wart is a common disease caused by the infection of Human Papillomavirus, this disease has diverse clinical characteristics and many different treatments. We conducted this study to evaluate the clinical features and the efficacy electrosurgery treatment. Methods: A total 75 patients was diagnosed with cutaneous wart and treated by electrosurgery method at Dermatology Clinic of Hue University of Medicine and Pharmacy Hospital. Results: The age has a wide distribution. The female/male ratio was nearly egal. Most patients had a single lesion. Plantar wart was predominate with 63.3%. After the procedure, 90.8% of patients had mild and moderate pain. The rate of post-operative bleeding was high 85.3%. In the first week, the dried wound was 64.2%. The average healing time was about 4 weeks. The infection rate was 11%. Conclusion: The most common clinical form was plantar wart; electrosurgery had many advantages but some disadvantages in wound healing related to heat damage. Keywords: cutaneous wart, electrosurgery, HPV.

Abstract B65: Biomarker effects of an oral green tea extract, Polyphenon E, in women with a history of hormone receptor-negative breast cancer

2012 ◽  
Vol 5 (11 Supplement) ◽  
pp. B65-B65
Author(s):  
Katherine D. Crew ◽  
Kimberly A. Ho ◽  
Powel Brown ◽  
Heather Greenlee ◽  
Therese B. Bevers ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Green Tea ◽  
Hormone Receptor ◽  
Green Tea Extract ◽  
Polyphenon E ◽  
History Of ◽  
Tea Extract

Polyphenon E, a Green Tea Extract, Increases Brain NAA Levels in MS: A Pilot Six Month Open Label Study (P03.050)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P03.050-P03.050
Author(s):  
A. Ramos ◽  
V. Garrison ◽  
D. Koop ◽  
W. Rooney ◽  
D. Bourdette ◽  
...  
Keyword(s):  
Green Tea ◽  
Green Tea Extract ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
Polyphenon E ◽  
Tea Extract

scholarly journals Ultrasound Therapy in the Treatment of Plantar Wart: A Case Study

2021 ◽  
Vol SP (1) ◽  
Author(s):  
Poonam Dhankher ◽  
Sakshi ◽  
Dimple Choudhry
Keyword(s):  
Case Report ◽  
Weight Bearing ◽  
Previous History ◽  
Skin Condition ◽  
Papilloma Virus ◽  
Plantar Wart ◽  
Plantar Surface ◽  
History Of ◽  
Plantar Warts

Verucae or plantar warts is a painful skin condition that demonstrates a high resistance to various treatments. They can be caused by trauma or human papilloma virus. The infection is mostly caused by a breach in the skin. The virus is usually contacted by walking barefoot in community swimming pool areas. The condition is common in sports persons. Our research focused on warts that occur on plantar surface of foot also known as plantar warts. They result in pain with pressure on weight bearing surfaces so walking is difficult and painful. Risk factors include using community showers barefoot, previous history of warts and decreased immune function. Case Report: We present a case report of a female aged 24 years who was clinically diagnosed with plantar wart. She developed recurrent plantar warts. For a year she was treated with pairing and punch excision with no success. Then ultrasound program was initiated with dosage of 0.6 watt /cm2 and increased up to 1 watt/cm2 for 15 min given at 1-week interval for 15 weeks. At the end of 15th week, the plantar wart had completely disappeared.

scholarly journals Efficacy and Tolerability of Topical Polyphenon E in Multiple “Seborrheic Keratosis-Like” Lesions of the Groin in an Immunocompetent 26-Year-Old Man

2019 ◽  
Vol 11 (3) ◽  
pp. 310-316 ◽  
Author(s):  
Luigi Pizzini ◽  
Graziano De Luca ◽  
Massimo Milani
Keyword(s):  
Green Tea ◽  
Clinical Effect ◽  
Epigallocatechin Gallate ◽  
Green Tea Extract ◽  
Topical Formulation ◽  
Seborrheic Keratosis ◽  
Polyphenon E ◽  
The Subject ◽  
Tea Extract ◽  
Conclusive Diagnosis

Polyphenon E 10%, a green tea extract containing epigallocatechin gallate (EGCG) as the main active compound, is a topical formulation indicated for the treatment of genital warts. Polyphenon E has also shown to be very effective in the treatment of periungual and plane warts. Here, we report a dramatic clinical effect of topical treatment with polyphenon E in a subject with multiple “seborrheic keratosis-like” lesions of the genital area. An immunocompetent 26-year-old Caucasian man came to our attention in October 2018. The subject, a regular blood donor, presented several (more than 100) light brown dome-shaped papular lesions in the groin area and in the penile shaft. A clinical diagnosis of Bowenoid papulosis-like multiple condylomata of the groin was made. A 2-month imiquimod treatment did not induce any relevant improvement in terms of volume and number of lesions. A treatment with Polyphenon E, a topical green tea extract with 10% of EGCG (Veregen®), was therefore started. After 2 months of Polyphenon E treatment, a dramatic reduction of the majority of the lesions was observed. After 3 months of treatment, all the lesions disappeared with only hyperchromic residues. Histological and immunohistological findings supported seborrheic keratosis as the conclusive diagnosis. This case report suggests that topical green tea extract could be very effective in the treatment of “seborrheic keratosis-like” lesions of the inguinal area.

scholarly journals A study of HPV 1, 2 and 4 antibody prevalence in patients presenting for treatment with cutaneous warts to general practitioners in N. Ireland

1988 ◽  
Vol 101 (3) ◽  
pp. 537-546 ◽  
Author(s):  
K. Steele ◽  
P. V. Shirodaria ◽  
H. Pfister ◽  
B. Pollock ◽  
P. Fuchs ◽  
...  
Keyword(s):  
Multiple Infection ◽  
Antibody Prevalence ◽  
Papilloma Virus ◽  
Igm Antibody ◽  
Hpv Types ◽  
Hpv 1 ◽  
Cutaneous Warts ◽  
Plantar Warts

SUMMARYThree hundred and seventy-six patients attending their general practitioner with cutaneous warts at five health centres in Northern Ireland were screened for human papilloma virus (HPV) types 1 and 2 IgM antibody using an indirect immunofluorescence test. Eighty-eight (23·4%) patients were positive for HPV type 1 IgM and 156 (41·5%) for HPV type 2 IgM. HPV 1 IgM antibody was significantly more likely to be associated with plantar warts than warts elsewhere (P 0·0001). HPV 2 IgM was present in 45 (34·1%) patients with plantar warts and 99 (45·6%) patients with warts at other sites (P=0·1). Evidence of multiple infection by HPV types 1 and 2 was demonstrated by the finding of HPV 1 and 2 IgM antibodies in the sera of 16 (4·3%). HPV 4 was found in only 1 out of 30 biopsies and HPV 4 IgM was undetectable in 50 randomly chosen sera.

scholarly journals Polyphenon E®, a standardized green tea extract, induces endoplasmic reticulum stress, leading to death of immortalized PNT1a cells by anoikis and tumorigenic PC3 by necroptosis

2013 ◽  
Vol 35 (4) ◽  
pp. 828-839 ◽  
Author(s):  
Federica Rizzi ◽  
Valeria Naponelli ◽  
Alessandro Silva ◽  
Alice Modernelli ◽  
Ileana Ramazzina ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Green Tea ◽  
Green Tea Extract ◽  
Polyphenon E ◽  
Tea Extract

scholarly journals Treatment of Recalcitrant Plantar Wart Unresponsive to Cryotherapy with Acupuncture and Moxibustion: A Case Report

2021 ◽  
Vol 42 (4) ◽  
pp. 248-253
Author(s):  
Soo Bo Shim ◽  
Hyun Kyung Sung ◽  
Hye Lim Lee
Keyword(s):  
Case Report ◽  
Complete Resolution ◽  
Therapeutic Strategies ◽  
Plantar Wart ◽  
Acupuncture And Moxibustion ◽  
Human Papillomavirus Infection ◽  
Papillomavirus Infection ◽  
Wide Range ◽  
Plantar Warts

Objectives: Plantar wart is a common viral skin disease caused by human papillomavirus infection and poses a therapeutic challenge in the paediatric patient population. Acupuncture and moxibustion are effective treatments for a wide range of skin conditions.Case report: This study presents the case of a 9-year-old girl for whom complete resolution of recalcitrant warts was achieved with acupuncture and moxibustion treatment.Results: After 20-week treatment, the wart lesions and pain were completely resolved. At the 6-month follow-up, the lesions remained fully resolved.Conclusion: This result suggests that acupuncture and moxibustion could be effective therapeutic strategies for plantar warts.

The treatment of plantar warts

1972 ◽  
Vol 10 (4) ◽  
pp. 13-14
Keyword(s):  
Children And Adolescents ◽  
Plantar Wart ◽  
Multiple Lesions ◽  
Plantar Warts

Plantar warts, caused by the DNA-containing human papilloma (wart) virus, are very common in children and adolescents and account for nearly 5% of attendances in a dermatological clinic. Clinically the plantar wart may be solitary or multiple. If multiple lesions are close together they coalesce, forming so-called mosaic warts. The infecting virus is probably the same in the discrete and mosaic forms of infection.

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