scholarly journals Efficacy and Tolerability of Polyphenon E in “Difficult-to-Treat” Multiple Genital Warts in an HIV-Positive Male Subject

2017 ◽  
Vol 9 (2) ◽  
pp. 55-59 ◽  
Author(s):  
Mauro Grandolfo ◽  
Massimo Milani
Keyword(s):  
Male Subject ◽  
Normal Values ◽  
Genital Warts ◽  
Hiv Positive ◽  
Initial Visit ◽  
Local Tolerability ◽  
Positive History ◽  
Present Treatment ◽  
Polyphenon E ◽  
Partial Success

A 55-year-old man, nonsmoker, with a HIV-positive history came to our attention in February 2017. He was on treatment with StribildTM, 1 capsule daily (150 mg elvitegravir, 150 mg cobicistat, 200 mg emtricitabine, and 245 mg tenofovir disoproxil). The CD4+/CD8+ cellular count was 326/µL (normal values: 404–1,612); the CD3+/CD8+ cellular count was 819/µL (normal values: 220–1,219). The CD4/CD8 ratio was 0.40 (normal value: >1). Several typical genital wart lesions were present at the penis shaft and at the level of the neck and the corona of glans. These lesions were present for 2 years. Several cryotherapy sessions (a total of 10 procedures) had been performed with partial success. At the initial visit a total of 5 lesions were present. Treatment with topical Polyphenon E 10% 3 times a day was prescribed and started. After 1 month of treatment the lesions were reduced to 2. Treatment was very well tolerated. After 8 weeks of treatment no more lesions were observed and therefore a complete clearance was obtained. Local tolerability was evaluated to be very good by the patient.

scholarly journals Efficacy and Tolerability of Topical Green Tea Extract (Polyphenon E) Application in a “Therapy-Resistant” Plantar Wart

2018 ◽  
Vol 10 (2) ◽  
pp. 127-132 ◽  
Author(s):  
Giancarlo Meloni ◽  
Massimo Milani
Keyword(s):  
Metatarsal Head ◽  
Initial Visit ◽  
Local Tolerability ◽  
Present Treatment ◽  
Plantar Wart ◽  
Polyphenon E ◽  
Therapeutic Problem ◽  
Tea Extract ◽  
Cutaneous Warts ◽  
Plantar Warts

Plantar warts account for 30% of all cutaneous warts. These lesions could be very painful, especially if the lesion is located over pressure sites such as the metatarsal head. Plantar wart treatment remains a challenging therapeutic problem. A 67-year-old immunocompetent nonsmoking man presented with a large mosaic plantar wart on his right foot. The lesion had been present for 5 years. Several cryotherapy sessions (a total of 6 procedures) had been performed with no success. The lesion was therefore treated with a 5-fluorouracil (5-FU) regimen and then with a topical combination of 5-FU and salicylic acid, but also these approaches failed. At the initial visit, a large (16 cm2) mosaic wart lesion was present. Treatment with topical Polyphenon E, 10%, twice daily was prescribed and started. After 3 months of treatment, the lesion completely disappeared. Interestingly, no curettage or mechanical pickling of the hyperkeratotic parts of the lesion were performed before the start of the treatment. Local tolerability was evaluated as very good by the patient.

scholarly journals A clinical study on genital warts and HIV in Bangladesh

2017 ◽  
Vol 4 (1) ◽  
pp. 5
Author(s):  
Md. Jakir Hossain ◽  
Muhammad Afser Siddiqi ◽  
M. Mostafizur Rahman ◽  
Khairun Nahar Khan ◽  
Ahmed Imtiaj
Keyword(s):  
Risk Factors ◽  
Risk Behaviour ◽  
Genital Warts ◽  
Sexual Partners ◽  
Hiv Positive ◽  
Age Group ◽  
Cross Sectional ◽  
Multiple Sexual Partners ◽  
Anal Warts ◽  
Hiv Negative

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Like other sexually<strong> </strong>transmitted diseases (STD), ano-genital warts (AGW) is associated with human immunodeficiency virus (HIV) infection and this study of AGW was conducted among HIV positive and HIV negative patients. The aim of the study was to study the risk factors and clinical presentations of ano-genital warts in HIV infected patients</span>.</p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">A comparative, cross-sectional, descriptive study of 25 HIV positive and 25 HIV negative (n=50) AGW patients between 15-60 years of both sex was conducted in Northern part of Bangladesh from July 2015 to December 2016. </span><span lang="EN-IN"> </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Significant association of HIV positivity (p&lt;0.05) was<strong> </strong>observed between age group of 15-30 years and HIV negative status (p&lt;0.05) in age group of 31-45 years. HIV positive status significantly higher in patients with self-admitted multiple sexual partners (p&lt;0.01), homosexuality (p&lt;0.05) and presentation with anal warts (p&lt;0.01). HIV negative status correlated significantly with single sexual partner admission (p&lt;0.01) and hetero-sexuality (p&lt;0.05). Gender did not show significant association with number of sexual partners or HIV positivity. Extra-genital or only genital warts had no association with HIV status. Co-STDs though more in number in seropositive group, did not show any significant association with HIV positivity (p&gt;0.05). No patient presented with changes of malignancy. Four were adolescents below 19 years. Two patients had atypical presentations of giant condylomata i.e., Buschke-Lowenstein tumour (BLT)</span>.</p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">HIV positivity was significantly associated with<strong> </strong>the risk factors of age below 30 years, homo sexuality and multiple sexual partners. Anal warts were significantly common in HIV positive patients. Four adolescents with AGW underline the need for high risk behaviour counselling. No patient had malignant AGW. Follow up of these patients with human papilloma virus (HPV) sub-typing is necessary. </span></p>

Relapses After Treatment of External Genital Warts Are More Frequent in HIV-Positive Patients Than in HIV-Negative Controls

2002 ◽  
Vol 29 (3) ◽  
pp. 121-125 ◽  
Author(s):  
GIUSEPPE DE PANFILIS ◽  
GIULIA MELZANI ◽  
GIOVANNI MORI ◽  
ALESSANDRA GHIDINI ◽  
SEVERO GRAIFEMBERGHI
Keyword(s):  
Genital Warts ◽  
Hiv Positive ◽  
External Genital Warts ◽  
Negative Controls ◽  
Hiv Negative

Successful treatment of profuse recalcitrant extra-genital warts in an HIV-positive patient using 5% imiquimod cream

2009 ◽  
Vol 20 (9) ◽  
pp. 657-658 ◽  
Author(s):  
M Walzman
Keyword(s):  
Case Report ◽  
Successful Treatment ◽  
Genital Warts ◽  
Positive Patient ◽  
Hiv Positive ◽  
Imiquimod Cream ◽  
Common Warts ◽  
Plantar Warts

Common warts, particularly plantar warts, are difficult to treat at the best of times and are likely to be even more difficult to treat when the patient is HIV positive. This case report highlights the successful treatment of profuse common warts of both hands and both feet in an HIV-positive patient using imiquimod 5% cream, following unsuccessful regular cryocautery therapy.

Risk Factors Associated with Genital Warts in Hiv-Positive Brazilian Women

2003 ◽  
Vol 89 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Maria Alice G Gonçalves ◽  
Marcelo N Burattini ◽  
Eduardo A Donadi ◽  
Eduardo Massad
Keyword(s):  
Risk Factors ◽  
Genital Warts ◽  
Hpv Infection ◽  
Hiv Positive ◽  
Cervix Carcinoma ◽  
Female Population ◽  
Factors Associated ◽  
Hiv Positive Women ◽  
History Of ◽  
Cancer Precursors

Aims and Background In Brazil, the female population has been increasingly infected with human immunodeficiency virus (HIV), and uterine cervix carcinoma now represents the second highest cause of mortality. Although HIV infection among women is associated with an increased prevalence of cervical cancer precursors, the co-infection with human papillomavirus (HPV) is considered to be a necessary but not sufficient factor to induce genital lesions. This study was conducted to identify risk factors associated with the history of genital warts among HIV-positive women. Methods A comparative cross-sectional evaluation was applied to 141 HIV-positive women. All patients were submitted to colposcopy, smear cytology, directed biopsy, and HPV-DNA detection. The chi-square, Fisher's exact test, and the odds ratio (OR, 95%; confidence interval, CI) were used to evaluate associations between history of genital warts and risk factors. Results A history of genital warts presented associations with: a) age at first sexual intercourse ≤17 years (OR, 0.42; CI, 0.16-1.11); b) history of genital warts in sex partners (OR, 11.39; CI, 4.21–30.76), especially with recurrent episodes (OR, 6.60; CI, 2.69–16.12); c) drug addiction (OR, 2.38; CI, 1.09–5.19), especially in crack users (OR, 5.34; CI, 1.64–17.41); d) cervical HPV infection (OR, 2.75; CI 1.09–6.90); e) cervical infection caused by only one HPV type (OR, 2.77; CI 1.06–7.20); f) perianal HPV infection (OR, 2.30; CI, 0.70–7.56), associated with negative results for undetermined risk HPV (OR, 8.41; P = 0.04); and g) no antiretroviral therapy (OR, 3.41; P = 0.07). Conclusions Evaluation of behavioral risk factors associated with a genital wart history is an important tool to prevent and reduce persistent HPV infection, and consequently genital cancer precursors in HIV infected women.

scholarly journals Factors associated with repeat visits among clients attending a clinic for sexually transmitted infections in Kisumu, Kenya

2011 ◽  
Vol 22 (11) ◽  
pp. 640-644 ◽  
Author(s):  
E Pultorak ◽  
E Odoyo-June ◽  
J Hayombe ◽  
F Opiyo ◽  
W Odongo ◽  
...  
Keyword(s):  
Sexually Transmitted Infections ◽  
Odds Ratio ◽  
Hiv Positive ◽  
Initial Visit ◽  
Sexually Transmitted ◽  
Urethral Discharge ◽  
Factors Associated ◽  
Male Clients ◽  
Focus Intervention ◽  
Repeat Visits

Summary To identify factors associated with repeat visits among patients attending a clinic for sexually transmitted infections (STIs) in Kisumu, Kenya, we examined records of clinic visits from March 2009 to May 2010. Multivariable logistic regression identified factors associated with repeat visits occurring >30 days after the initial visit. Among 1473 clients (1296 single-visit individuals versus 177 individuals with repeat visits), the median age was 24 years, 67% were men and 8.6% self-reported being HIV-positive. In adjusted analyses, men with repeat visits were more likely to report ≥2 recent sexual partners (adjusted odds ratio [aOR] = 1.60) and being HIV-positive (aOR = 2.35). They were less likely to have been referred from other health facilities (aOR = 0.14) and more likely to have urethral discharge at their initial visit (aOR = 2.46). Among women, repeat visits were associated with vaginal discharge (aOR = 2.22), but attending the clinic with a partner was protective (aOR = 0.38). The association between sexual risk, HIV positivity and repeat visits among male clients highlights the need to focus intervention efforts on this group. For women, attending with a partner may reflect a decreased risk of re-infection if both partners are treated and counselled together.

scholarly journals High rates of sexually transmissible infections in HIV-positive patients in the Australian HIV Observational Database: a prospective cohort study

Sexual Health ◽  
2014 ◽  
Vol 11 (4) ◽  
pp. 291 ◽  
Author(s):  
Brian P. Mulhall ◽  
Stephen Wright ◽  
Debbie Allen ◽  
Katherine Brown ◽  
Bridget Dickson ◽  
...  
Keyword(s):  
Cohort Study ◽  
Confidence Interval ◽  
Prospective Cohort ◽  
Patient Characteristics ◽  
Genital Warts ◽  
Incidence Rates ◽  
Hiv Positive ◽  
Observational Database ◽  
Sexually Transmissible Infections ◽  
Sex With Men

Background In HIV-positive people, sexually transmissible infections (STIs) probably increase the infectiousness of HIV. Methods: In 2010, we established a cohort of individuals (n = 554) from clinics in the Australian HIV Observational Database (AHOD). We calculated retrospective rates for four STIs for 2005–10 and prospective incidence rates for 2010–11. Results: At baseline (2010), patient characteristics were similar to the rest of AHOD. Overall incidence was 12.5 per 100 person-years. Chlamydial infections increased from 3.4 per 100 person-years (95% confidence interval (CI): 1.9–5.7) in 2005 to 6.7 per 100 person-years (95% CI: 4.5–9.5) in 2011, peaking in 2010 (8.1 per 100 person-years; 95% CI: 5.6–11.2). Cases were distributed among rectal (61.9%), urethral (34%) and pharyngeal (6.3%) sites. Gonococcal infections increased, peaking in 2010 (4.7 per 100 person-years; 95% CI: 5.6–11.2; Ptrend = 0.0099), distributed among rectal (63.9%), urethral (27.9%) and pharyngeal (14.8%) sites. Syphilis showed several peaks, the largest in 2008 (5.3 per 100 person-years; 95% CI: 3.3–8.0); the overall trend was not significant (P = 0.113). Genital warts declined from 7.5 per 100 person-years (95% CI: 4.8–11.3) in 2005 to 2.4 per 100 person-years (95% CI: 1.1–4.5) in 2011 (Ptrend = 0.0016). Conclusions: For chlamydial and gonococcal infections, incidence was higher than previous Australian estimates among HIV-infected men who have sex with men, increasing during 2005–2011. Rectal infections outnumbered infections at other sites. Syphilis incidence remained high but did not increase; that of genital warts was lower and decreased.

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