Reliability of a New Symptom Score in a Titrated Quantitative Conjunctival Provocation Test Supported by an Objective Photodocumentation

2018 ◽  
Vol 176 (3-4) ◽  
pp. 215-224 ◽  
Author(s):  
Oliver Pfaar ◽  
Dan Philipp Claßen ◽  
Anatoli Astvatsatourov ◽  
Ludger Klimek ◽  
Ralph Mösges
Keyword(s):  
Symptom Score ◽  
Provocation Test ◽  
Conjunctival Provocation Test

scholarly journals Azelastine and Budesonide (Nasal Sprays): Effect of Combination Therapy Monitored by Acoustic Rhinometry and Clinical Symptom Score in the Treatment of Allergic Rhinitis

2014 ◽  
Vol 5 (2) ◽  
pp. ar.2014.5.0089 ◽  
Author(s):  
Natalia Zanellato Fabbri ◽  
Eduardo Abib ◽  
Ricardo de Lima Zollner
Keyword(s):  
Allergic Rhinitis ◽  
Combination Therapy ◽  
Symptom Score ◽  
Provocation Test ◽  
Subjective Symptom ◽  
Acoustic Rhinometry ◽  
Nasal Patency ◽  
Histamine Concentration ◽  
Treatment Comparison ◽  
Therapeutic Benefits

The aim of this study was to objectively evaluate the effects of intranasal therapy with azelastine (AZE), budesonide (BUD), and combined AZE plus BUD (AZE/BUD) using a nasal provocation test (NPT) and acoustic rhinometry in patients with allergic rhinitis. A randomized, single-blind, crossover study with three treatment sequences was used. Thirty patients with persistent AR received the three treatments using a nasal spray twice daily for 30 days and were evaluated by an NPT with histamine before and after each period of treatment. The treatment comparison, assessed by the nasal responsiveness to histamine, was monitored based on subjective (symptom score) and objective parameters (acoustic rhinometry). The minimal cross-area 2 (MCA2) was measured by acoustic rhinometry at 1, 4, 8, and 12 minutes after NPT for each histamine concentration administered (0.5,1, 2, 4, and 6 mg/mL) up to at least a 20% reduction in the MCA2 from baseline (NPT20). The subjects were scored regarding nasal response encompassing histamine dose and time after histamine administration that caused nasal obstruction (NPT20 score) to assess the treatments' effects. Combination therapy produced a significant increase in baseline MCA2, viz., the improvement of nasal patency (p = 0.005). The symptoms score was significantly decreased after treatment with AZE (p = 0.03), BUD (p < 0.0001), and AZE/BUD (p < 0.0001), compared with pretreatment. The NPT20 score was significantly higher (p = 0.0009) after AZE/BUD, compared with AZE and BUD on their own. Thus, AZE therapy combined with BUD might provide more therapeutic benefits than the isolated drugs for improving nasal patency.

Protective Effect of Loratadine on Specific Conjunctival Provocation Test

1991 ◽  
Vol 96 (4) ◽  
pp. 344-347 ◽  
Author(s):  
G. Ciprandi ◽  
S. Buscaglia ◽  
G.P. Pesce ◽  
E. Marchesi ◽  
G.W. Canonica
Keyword(s):  
Protective Effect ◽  
Provocation Test ◽  
Conjunctival Provocation Test

Conjunctival Provocation Test for the Diagnosis of Ocular Hypersensitivity to Chlorobutanol

Cornea ◽  
2007 ◽  
Vol 26 (1) ◽  
pp. 94-97 ◽  
Author(s):  
José Javier García-Medina ◽  
Manuel García-Medina ◽  
Vicente Calixto Zanon-Moreno ◽  
Gabriel Scalerandi ◽  
María Dolores Pinazo-Duran
Keyword(s):  
Provocation Test ◽  
Conjunctival Provocation Test

Automatic conjunctival provocation test combining Hough circle transform and self-calibrated color measurements

2013 ◽  
Author(s):  
Suman Raj Bista ◽  
István Sárándi ◽  
Serkan Dogan ◽  
Anatoli Astvatsatourov ◽  
Ralph Mösges ◽  
...  
Keyword(s):  
Provocation Test ◽  
Color Measurements ◽  
Conjunctival Provocation Test

Conjunctival Provocation Test in Daily Practice: Four Ocular Symptoms Vs Ocular Pruritus Score System

2016 ◽  
Vol 137 (2) ◽  
pp. AB61
Author(s):  
Carmen Rondon ◽  
Paloma Campo ◽  
Esther Barrionuevo ◽  
Ana Prieto del Prado ◽  
Gador Bogas ◽  
...  
Keyword(s):  
Provocation Test ◽  
Daily Practice ◽  
Score System ◽  
Ocular Symptoms ◽  
Conjunctival Provocation Test
Sign in / Sign up

Export Citation Format

Share Document