scholarly journals Azelastine and Budesonide (Nasal Sprays): Effect of Combination Therapy Monitored by Acoustic Rhinometry and Clinical Symptom Score in the Treatment of Allergic Rhinitis

2014 ◽  
Vol 5 (2) ◽  
pp. ar.2014.5.0089 ◽  
Author(s):  
Natalia Zanellato Fabbri ◽  
Eduardo Abib ◽  
Ricardo de Lima Zollner
Keyword(s):  
Allergic Rhinitis ◽  
Combination Therapy ◽  
Symptom Score ◽  
Provocation Test ◽  
Subjective Symptom ◽  
Acoustic Rhinometry ◽  
Nasal Patency ◽  
Histamine Concentration ◽  
Treatment Comparison ◽  
Therapeutic Benefits

The aim of this study was to objectively evaluate the effects of intranasal therapy with azelastine (AZE), budesonide (BUD), and combined AZE plus BUD (AZE/BUD) using a nasal provocation test (NPT) and acoustic rhinometry in patients with allergic rhinitis. A randomized, single-blind, crossover study with three treatment sequences was used. Thirty patients with persistent AR received the three treatments using a nasal spray twice daily for 30 days and were evaluated by an NPT with histamine before and after each period of treatment. The treatment comparison, assessed by the nasal responsiveness to histamine, was monitored based on subjective (symptom score) and objective parameters (acoustic rhinometry). The minimal cross-area 2 (MCA2) was measured by acoustic rhinometry at 1, 4, 8, and 12 minutes after NPT for each histamine concentration administered (0.5,1, 2, 4, and 6 mg/mL) up to at least a 20% reduction in the MCA2 from baseline (NPT20). The subjects were scored regarding nasal response encompassing histamine dose and time after histamine administration that caused nasal obstruction (NPT20 score) to assess the treatments' effects. Combination therapy produced a significant increase in baseline MCA2, viz., the improvement of nasal patency (p = 0.005). The symptoms score was significantly decreased after treatment with AZE (p = 0.03), BUD (p < 0.0001), and AZE/BUD (p < 0.0001), compared with pretreatment. The NPT20 score was significantly higher (p = 0.0009) after AZE/BUD, compared with AZE and BUD on their own. Thus, AZE therapy combined with BUD might provide more therapeutic benefits than the isolated drugs for improving nasal patency.

Evaluation of acoustic rhinometry in a nasal provocation test with allergic rhinitis

2008 ◽  
Vol 139 (1) ◽  
pp. 120-123 ◽  
Author(s):  
Young Hyo Kim ◽  
Tae Yong Yang ◽  
Dong Youl Lee ◽  
Kook Jin Ko ◽  
Seung Ho Shin ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Provocation Test ◽  
Acoustic Rhinometry ◽  
Nasal Provocation Test ◽  
Nasal Provocation

scholarly journals Acoustic rhinometry and rhinomanometry as objective tools for the assessment of nasal patency in nasal septal surgery

2017 ◽  
Vol 7 (25) ◽  
pp. 11-18
Author(s):  
Frodita Jakimovska ◽  
Marina Davceva Cakar ◽  
Dejan Dokic
Keyword(s):  
Binary Logistic Regression ◽  
Subjective Symptom ◽  
Acoustic Rhinometry ◽  
Preoperative Screening ◽  
Nasal Patency ◽  
Cross Sectional ◽  
Predictive Values ◽  
Subjective Complaint ◽  
Septal Surgery ◽  
Objective Evidence

AbstractBACKGROUND.Septal deviations are usually diagnosed by a patient’s subjective complaint of nasal stuffiness and a physical examination by the otorhinolaringologist. The decision for surgery is not always based on objective measurements. Acoustic rhinometry and rhinomanometry are objective tools for assessment of nasal patency but is still a controversial subject. In our populations, there are no general accepted methods for screening patients for septal surgery.OBJECTIVE.To analyse the effectiveness of acoustic rhinometry and rhinomanometry in predicting the outcomes of septoplasty and rhinoseptoplasty and their usefulness in preoperative screening of septal deviations.MATERIAL AND METHODS.69 patients were included in this prospective study. Acoustic rhinometry and rhinomanometry were performed before and one year after surgery for the investigation of nasal obstruction. Several parameters were analysed before and after decongestion of the nasal mucosa. VAS (visual analogue scale) was also included for evaluation of the subjective symptom score pre- and postoperatively. After surgery, a short questionnaire was applied to investigate patients’ postoperative satisfaction.RESULTS.The mean subjective scores of nasal patency improved significantly after surgery with 77%. Several parameters of acoustic rhinometry and rhinomanometry were analysed with binary logistic regression, to evaluate the predictive values on the postoperative satisfaction. The preoperative decongested overall MCA (minimal cross-sectional area) on the deviation side, the decongested bilateral MCA and the decongested Flow ratio had significantly the highest impact on the postoperative satisfaction (p<0.001).CONCLUSION.Acoustic rhinometry and rhinomanometry as objective tools can serve as objective evidence for the efficacy of septoplasty and rhinoseptoplasty. The parameters of rhinomanometry and anterior rhinometry are useful in the preoperative screening for septal deviations and in predicting postoperative satisfaction between different degrees of nasal septal deviations.

Acoustic rhinometry in nasal provocation test in perennial allergic rhinitis

2006 ◽  
Vol 263 (10) ◽  
pp. 910-916 ◽  
Author(s):  
Tilman Keck ◽  
Kerstin Wiesmiller ◽  
Joerg Lindemann ◽  
Ajnacska Rozsasi
Keyword(s):  
Allergic Rhinitis ◽  
Provocation Test ◽  
Acoustic Rhinometry ◽  
Perennial Allergic Rhinitis ◽  
Nasal Provocation Test ◽  
Nasal Provocation

scholarly journals Comparison of nasal patency after nose-blowing between pinch versus no pinch method: a randomized controlled trial

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Patorn Piromchai ◽  
Jakkrit Netnoi ◽  
Supaporn Srirompotong ◽  
Panida Thanawirattananit
Keyword(s):  
Randomized Controlled Trial ◽  
Allergic Rhinitis ◽  
Common Cold ◽  
Controlled Trial ◽  
Objective Evaluation ◽  
Acoustic Rhinometry ◽  
Objective Test ◽  
Nasal Discharge ◽  
Nasal Patency ◽  
Randomized Controlled

AbstractWe proposed that nose-blowing without pinching was safer and able to get rid of mucus and maintain nasal patency as effective as the pinch and blow method. The objective of this study was to evaluate the nasal patency after nose-blowing by pinching the nose versus no pinching. The patients who have nasal discharge such as allergic rhinitis or common cold were recruited. The patients were randomized to perform pinching or no pinching nose-blowing. Fifty patients were enrolled in this study. The objective evaluation using acoustic rhinometry found no difference in nasal patency between the two groups (p > 0.05). The subjective patency score was significantly higher in the pinch one nostril shut group (mean difference 0.88, 95% CI 0.20–1.55). The patency of the two methods were comparable according to the objective test. However, the patients felt that their nose was clearer when pinching and blowing.

scholarly journals Intralymphatic immunotherapy with tyrosine-adsorbed allergens: a double-blind, placebo-controlled trial

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Hye Jung Park ◽  
Sae-Hoon Kim ◽  
Yoo Seob Shin ◽  
Chul Hwan Park ◽  
Eun-Suk Cho ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Injection Site ◽  
Symptom Score ◽  
Therapeutic Efficacy ◽  
Controlled Trial ◽  
Life Questionnaire ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Medication Score ◽  
Allergen Extracts

Abstract Background Most previous studies used aluminum hydroxide-absorbed allergen extracts in evaluating the potential therapeutic roles of intralymphatic allergen-specific immunotherapy (ILAIT). In this study, we evaluated the therapeutic efficacy and safety of ILAIT with L-tyrosine-adsorbed allergen extracts of Dermatophagoides farinae, D. pteronyssinus, cat, dog, or mixtures thereof, in patients with allergic rhinitis induced by these allergens. Methods In this randomized, double-blind, placebo-controlled trial, study subjects received three intralymphatic injections of L-tyrosine-adsorbed allergen extracts (active group) or saline (placebo group) at 4-week intervals. Results Although ILAIT reduced daily medication use and skin reactivity to HDM and cat allergens at 4 months after treatment, overall symptom score on a visual analog scale (VAS), sinonasal outcome test-20 (SNOT-20), rhinoconjunctivitis quality of life questionnaire (RQLQ), daily symptom score (dSS), daily medication score (dMS), daily symptom medication score (dSMS), nasal reactivity to HDM allergen, and basophil activity to HDM, cat, and dog allergens at 4 months and 1 year after treatment were similar between the treatment and control groups. Intralymphatic injection was more painful than a venous puncture, and pain at the injection site was the most frequent local adverse event (12.8%); dyspnea and wheezing were the most common systemic adverse events (5.3%). Conclusions ILAIT with L-tyrosine-adsorbed allergen extracts does not exhibit profound therapeutic efficacy in allergic rhinitis and can provoke moderate-to-severe systemic reactions and cause pain at the injection site. Trial registration: clinicaltrials.gov: NCT02665754; date of registration: 28 January 2016

Symptom Score for Allergic Rhinitis

2013 ◽  
Vol 148 (4) ◽  
pp. 557-563 ◽  
Author(s):  
Foluwasayo Emmanuel Ologe ◽  
Stephen Oluwatosin Adebola ◽  
Adekunle David Dunmade ◽  
Kayode Adebamiji Adeniji ◽  
Benjamin Agboola Oyejola
Keyword(s):  
Allergic Rhinitis ◽  
Symptom Score
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