Impact of Xenon on CLIC4 and Bcl-2 Expression in Lipopolysaccharide and Hypoxia-Ischemia-Induced Periventricular White Matter Damage

Neonatology ◽  
2018 ◽  
Vol 113 (4) ◽  
pp. 339-346 ◽  
Author(s):  
Xiangyun Yin ◽  
Jixiu Zhao ◽  
Hong Jiang ◽  
Liangliang Li ◽  
Jian Jiang ◽  
...  
Keyword(s):  
White Matter ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Hypoxia Ischemia

Expression of ephrinB2 and EphB4 in a neonatal rat model of periventricular white matter damage

2015 ◽  
Vol 43 (3) ◽  
Author(s):  
Lihua Zhu ◽  
Lijuan Qian ◽  
Shiyu Wang ◽  
Ting Wang ◽  
Li Jiang
Keyword(s):  
White Matter ◽  
Rat Model ◽  
Vascular System ◽  
Periventricular Leukomalacia ◽  
Vascular Supply ◽  
Neonatal Rat ◽  
Cerebral White Matter ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Hypoxia Ischemia

AbstractPeriventricular white matter damage (PWMD), also termed periventricular leukomalacia, is the predominant neurologic lesion in preterm infants. It appears to relate in part to the development of the vascular supply to the cerebral white matter. We investigated whether, in case of severe hypoxia-ischemia, the vascular system would be subject to severe damage or remodeled.To evaluate microvessel density (MVD) and the use of ephrinB2 and its receptor EphB4 to mark arterioles and venules to establish the correct anatomic assignment of the remodeled vessels in a hypoxia-induced PWMD rat model.Postnatal day 3 rats underwent permanent ligation of the right common carotid artery followed by 6% OCompared with sham rats, MVD, ephrinB2 and EphB4 levels were higher in the brains of hypoxic-ischemic rats. Similar percentages of vessels expressed ephrinB2 and EphB4 in sham rats, but expression of ephrinB2 was greater in brains injured by hypoxia-ischemia.Following hypoxic-ischemic injury to the rat brain, microvessels were remodeled and more arterioles than venules were acquired.

scholarly journals Circular RNA Expression in the Brain of a Neonatal Rat Model of Periventricular White Matter Damage

2018 ◽  
Vol 49 (6) ◽  
pp. 2264-2276 ◽  
Author(s):  
Lihua Zhu ◽  
Ruibin Zhao ◽  
Li Huang ◽  
Sisi Mo ◽  
Zhangbin Yu ◽  
...  
Keyword(s):  
White Matter ◽  
Target Genes ◽  
Expression Profiles ◽  
Pcr Analysis ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Qrt Pcr ◽  
Hypoxia Ischemia ◽  
The Brain ◽  
Brain Tissues

Background/Aims: Periventricular white matter damage (PWMD) is the predominant neurologic lesion in preterm infants who survive brain injury. In this study, we assessed the global changes in and characteristics of the transcriptome of circular RNAs (circRNAs) in the brain tissues of rats with PWMD. Methods: We compared the expression profiles of circRNAs in brain samples from three rats with PWMD and three paired control tissues using deep RNA sequencing. Bioinformatics analysis was applied to investigate these differentially expressed circRNAs, and quantitative reverse-transcription polymerase chain reaction (qRT-PCR) analysis was performed to confirm the results. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to predict associated cell signaling pathways and functions. Network analysis was performed to predict circRNAs-microRNAs, and target genes related to PWMD. Results: A total of 2151 more reliable circRNAs were dysregulated in the brain tissues of rats with PWMD, indicating a potential role in the condition. Of the 98 circRNAs significantly differentially expressed in rat brains with PWMD (P< 0.05), 52 were significantly over-expressed and 46 were significantly under-expressed. The expression profiles of seven of 10 randomly selected circRNAs were confirmed by qRT-PCR analysis. The glutamatergic synapse pathway and the VEGF signaling pathway, both associated with hypoxia/ischemia induced brain damage, were inriched. Relationship between miRNA (rno-miR-433-3p and rno-miR-206-3p) and HIF-1α were evident and potential associations between chr6: 48820833|48857932 and their target genes (rno-miR-433-3p and rno-miR-206-3p) were identified. Conclusion: The distinct expression patterns of circRNAs in the brain tissues of rats with PWMD suggest that circRNAs actively respond to hypoxia-ischemia. These findings could assist the development of novel diagnostic and therapeutic targets for PWMD therapy.

Ibuprofen inhibits neuroinflammation and attenuates white matter damage following hypoxia–ischemia in the immature rodent brain

2011 ◽  
Vol 1402 ◽  
pp. 9-19 ◽  
Author(s):  
M.L. Carty ◽  
J.A. Wixey ◽  
H.E. Reinebrant ◽  
G. Gobe ◽  
P.B. Colditz ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Damage ◽  
Rodent Brain ◽  
Hypoxia Ischemia

scholarly journals Circular RNA expression alteration in whole blood of premature infants with periventricular white matter damage

Genomics ◽  
2020 ◽  
Vol 112 (4) ◽  
pp. 2875-2885
Author(s):  
Lixing Qiao ◽  
Sisi Mo ◽  
Yan Zhou ◽  
Yi Zhang ◽  
Bangbang Li ◽  
...  
Keyword(s):  
White Matter ◽  
Premature Infants ◽  
Whole Blood ◽  
Circular Rna ◽  
Periventricular White Matter ◽  
Rna Expression ◽  
White Matter Damage

scholarly journals Immediate remote ischemic postconditioning after hypoxia ischemia in piglets protects cerebral white matter but not grey matter

2015 ◽  
Vol 36 (8) ◽  
pp. 1396-1411 ◽  
Author(s):  
Mojgan Ezzati ◽  
Alan Bainbridge ◽  
Kevin D Broad ◽  
Go Kawano ◽  
Aaron Oliver-Taylor ◽  
...  
Keyword(s):  
White Matter ◽  
Corpus Callosum ◽  
Grey Matter ◽  
Ischemia Reperfusion ◽  
Ischemic Postconditioning ◽  
White Female ◽  
Resonance Spectroscopy ◽  
Periventricular White Matter ◽  
Remote Ischemic Postconditioning ◽  
Hypoxia Ischemia

Remote ischemic postconditioning (RIPostC) is a promising therapeutic intervention whereby brief episodes of ischemia/reperfusion of one organ (limb) mitigate damage in another organ (brain) that has experienced severe hypoxia-ischemia. Our aim was to assess whether RIPostC is protective following cerebral hypoxia-ischemia in a piglet model of neonatal encephalopathy (NE) using magnetic resonance spectroscopy (MRS) biomarkers and immunohistochemistry. After hypoxia-ischemia (HI), 16 Large White female newborn piglets were randomized to: (i) no intervention ( n = 8); (ii) RIPostC – with four, 10-min cycles of bilateral lower limb ischemia/reperfusion immediately after HI ( n = 8). RIPostC reduced the hypoxic-ischemic-induced increase in white matter proton MRS lactate/N acetyl aspartate ( p = 0.005) and increased whole brain phosphorus-31 MRS ATP ( p = 0.039) over the 48 h after HI. Cell death was reduced with RIPostC in the periventricular white matter ( p = 0.03), internal capsule ( p = 0.002) and corpus callosum ( p = 0.021); there was reduced microglial activation in corpus callosum ( p = 0.001) and more surviving oligodendrocytes in corpus callosum ( p = 0.029) and periventricular white matter ( p = 0.001). Changes in gene expression were detected in the white matter at 48 h, including KATP channel and endothelin A receptor. Immediate RIPostC is a potentially safe and promising brain protective therapy for babies with NE with protection in white but not grey matter.

scholarly journals Defective motion processing in children with cerebral visual impairment due to periventricular white matter damage

2011 ◽  
Vol 54 (7) ◽  
pp. e1-e8 ◽  
Author(s):  
JOEL M WEINSTEIN ◽  
RICK O GILMORE ◽  
SUMERA M SHAIKH ◽  
ALLEN R KUNSELMAN ◽  
WILLIAM V TRESCHER ◽  
...  
Keyword(s):  
White Matter ◽  
Visual Impairment ◽  
Motion Processing ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Cerebral Visual Impairment

scholarly journals Characterization of Cerebral White Matter Damage in Preterm Infants Using 1H and 31P Magnetic Resonance Spectroscopy

2000 ◽  
Vol 20 (10) ◽  
pp. 1446-1456 ◽  
Author(s):  
Nicola J. Robertson ◽  
Jacob Kuint ◽  
Serena J. Counsell ◽  
Mary A. Rutherford ◽  
Glyn A. Coutts ◽  
...  
Keyword(s):  
White Matter ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Preterm Infants ◽  
Term Infant ◽  
Cerebral White Matter ◽  
Resonance Spectroscopy ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Term Infants

The biochemical characteristics of white matter damage (WMD) in preterm infants were assessed using magnetic resonance spectroscopy (MRS). The authors hypothesized that preterm infants with WMD at term had a persisting cerebral lactic alkalosis and reduced N-acetyl aspartate (NAA)/creatine plus phosphocreatine (Cr), similar to that previously documented in term infants weeks after perinatal hypoxia–ischemia (HI). Thirty infants (gestational age 27.9 ± 3.1 weeks, birth weight 1122 ± 445 g) were studied at postnatal age of 9.8 ± 4.1 weeks (corrected age 40.3 ± 3.9 weeks). Infants were grouped according to the presence or absence of WMD on magnetic resonance (MR) images. The peak area ratios of lactate/Cr, NAA/Cr, myo-inositol/Cr, and choline (Cho)/Cr were measured from an 8-cm3 voxel in the posterior periventricular white matter (WM) using proton MRS. Intracellular pH (pHi) was calculated using phosphorus MRS. Eighteen infants had normal WM on MR imaging; 12 had WMD. For infants with WMD, lactate/Cr and myo-inositol/Cr were related ( P < 0.01); lactate/Cr and pHi were not ( P = 0.8). In the WMD group, mean lactate/Cr and myo-inositol/Cr were higher ( P < 0.001, P < 0.05, respectively) than the normal WM group. There was no difference in the NAA/Cr, Cho/Cr, or pHi between the two groups, although pHi was not measured in all infants. These findings suggest that WMD in the preterm infant at term has a different biochemical profile compared with the term infant after perinatal HI.

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