Ibuprofen inhibits neuroinflammation and attenuates white matter damage following hypoxia–ischemia in the immature rodent brain

2011 ◽  
Vol 1402 ◽  
pp. 9-19 ◽  
Author(s):  
M.L. Carty ◽  
J.A. Wixey ◽  
H.E. Reinebrant ◽  
G. Gobe ◽  
P.B. Colditz ◽  
...  
Keyword(s):  
White Matter ◽  
White Matter Damage ◽  
Rodent Brain ◽  
Hypoxia Ischemia

Impact of Xenon on CLIC4 and Bcl-2 Expression in Lipopolysaccharide and Hypoxia-Ischemia-Induced Periventricular White Matter Damage

Neonatology ◽  
2018 ◽  
Vol 113 (4) ◽  
pp. 339-346 ◽  
Author(s):  
Xiangyun Yin ◽  
Jixiu Zhao ◽  
Hong Jiang ◽  
Liangliang Li ◽  
Jian Jiang ◽  
...  
Keyword(s):  
White Matter ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Hypoxia Ischemia

Expression of ephrinB2 and EphB4 in a neonatal rat model of periventricular white matter damage

2015 ◽  
Vol 43 (3) ◽  
Author(s):  
Lihua Zhu ◽  
Lijuan Qian ◽  
Shiyu Wang ◽  
Ting Wang ◽  
Li Jiang
Keyword(s):  
White Matter ◽  
Rat Model ◽  
Vascular System ◽  
Periventricular Leukomalacia ◽  
Vascular Supply ◽  
Neonatal Rat ◽  
Cerebral White Matter ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Hypoxia Ischemia

AbstractPeriventricular white matter damage (PWMD), also termed periventricular leukomalacia, is the predominant neurologic lesion in preterm infants. It appears to relate in part to the development of the vascular supply to the cerebral white matter. We investigated whether, in case of severe hypoxia-ischemia, the vascular system would be subject to severe damage or remodeled.To evaluate microvessel density (MVD) and the use of ephrinB2 and its receptor EphB4 to mark arterioles and venules to establish the correct anatomic assignment of the remodeled vessels in a hypoxia-induced PWMD rat model.Postnatal day 3 rats underwent permanent ligation of the right common carotid artery followed by 6% OCompared with sham rats, MVD, ephrinB2 and EphB4 levels were higher in the brains of hypoxic-ischemic rats. Similar percentages of vessels expressed ephrinB2 and EphB4 in sham rats, but expression of ephrinB2 was greater in brains injured by hypoxia-ischemia.Following hypoxic-ischemic injury to the rat brain, microvessels were remodeled and more arterioles than venules were acquired.

scholarly journals Circular RNA Expression in the Brain of a Neonatal Rat Model of Periventricular White Matter Damage

2018 ◽  
Vol 49 (6) ◽  
pp. 2264-2276 ◽  
Author(s):  
Lihua Zhu ◽  
Ruibin Zhao ◽  
Li Huang ◽  
Sisi Mo ◽  
Zhangbin Yu ◽  
...  
Keyword(s):  
White Matter ◽  
Target Genes ◽  
Expression Profiles ◽  
Pcr Analysis ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Qrt Pcr ◽  
Hypoxia Ischemia ◽  
The Brain ◽  
Brain Tissues

Background/Aims: Periventricular white matter damage (PWMD) is the predominant neurologic lesion in preterm infants who survive brain injury. In this study, we assessed the global changes in and characteristics of the transcriptome of circular RNAs (circRNAs) in the brain tissues of rats with PWMD. Methods: We compared the expression profiles of circRNAs in brain samples from three rats with PWMD and three paired control tissues using deep RNA sequencing. Bioinformatics analysis was applied to investigate these differentially expressed circRNAs, and quantitative reverse-transcription polymerase chain reaction (qRT-PCR) analysis was performed to confirm the results. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to predict associated cell signaling pathways and functions. Network analysis was performed to predict circRNAs-microRNAs, and target genes related to PWMD. Results: A total of 2151 more reliable circRNAs were dysregulated in the brain tissues of rats with PWMD, indicating a potential role in the condition. Of the 98 circRNAs significantly differentially expressed in rat brains with PWMD (P< 0.05), 52 were significantly over-expressed and 46 were significantly under-expressed. The expression profiles of seven of 10 randomly selected circRNAs were confirmed by qRT-PCR analysis. The glutamatergic synapse pathway and the VEGF signaling pathway, both associated with hypoxia/ischemia induced brain damage, were inriched. Relationship between miRNA (rno-miR-433-3p and rno-miR-206-3p) and HIF-1α were evident and potential associations between chr6: 48820833|48857932 and their target genes (rno-miR-433-3p and rno-miR-206-3p) were identified. Conclusion: The distinct expression patterns of circRNAs in the brain tissues of rats with PWMD suggest that circRNAs actively respond to hypoxia-ischemia. These findings could assist the development of novel diagnostic and therapeutic targets for PWMD therapy.

Accumulation of 4-hydroxy-2-nonenal-modified proteins in the white matter damage in chronic cerebral hypo-perfusion rat mode

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S262-S262
Author(s):  
Terubumi Watanabe ◽  
Yoshiko Yanagi ◽  
Takao Urabe ◽  
Yoshikuni Mizuno
Keyword(s):  
White Matter ◽  
White Matter Damage ◽  
Modified Proteins

Cognitive dysfunctions associated with white matter damage due to cardiovascular burden – determinants and interpretations

2014 ◽  
Vol 45 (3) ◽  
pp. 334-345 ◽  
Author(s):  
Paweł Krukow
Keyword(s):  
Cerebral Cortex ◽  
White Matter ◽  
Cardiovascular Diseases ◽  
Cognitive Disorder ◽  
Theoretical Background ◽  
Dynamic Aspect ◽  
Pathological Changes ◽  
White Matter Damage ◽  
Neuropsychological Disorders ◽  
Considerable Research

AbstractAlthough considerable research has been devoted to cognitive functions deteriorating due to diseases of cardiovascular system, rather less attention has been paid to their theoretical background. Progressive vascular disorders as hypertension, atherosclerosis and carotid artery stenosis generate most of all pathological changes in the white matter, that cause specific cognitive disorder: disconnection syndromes, and disturbances in the dynamic aspect of information processing. These features made neuropsychological disorders secondary to cardiovascular diseases different than the effects of cerebral cortex damage, which may be interpreted modularly.

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