Serum Soluble Interleukin 2 Receptor Level as a Marker of Acute Rejection in Pediatric Kidney Transplant Recipients

Nephron ◽  
2018 ◽  
Vol 139 (1) ◽  
pp. 30-38 ◽  
Author(s):  
Amal M. Hagras ◽  
Doaa M. Salah ◽  
Dina H. Ahmed ◽  
Omnia K. Abd Elaal ◽  
Hany Ahmed Fouad Elghobary ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Kidney Transplant ◽  
Interleukin 2 ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Receptor Level ◽  
Interleukin 2 Receptor ◽  
Soluble Interleukin 2 Receptor

ELEVATED SOLUBLE INTERLEUKIN 2 RECEPTOR LEVELS FOUND AMONG KIDNEY TRANSPLANT RECIPIENTS

1997 ◽  
Vol 64 (8) ◽  
pp. 1202-1205 ◽  
Author(s):  
John J. Pickeral ◽  
Richard J. Marcus ◽  
Shyuan Hsia ◽  
Lynnette L. Miller ◽  
Dai D. Nghiem
Keyword(s):  
Kidney Transplant ◽  
Interleukin 2 ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Interleukin 2 Receptor ◽  
Soluble Interleukin 2 Receptor

Increased circulating concentrations of interleukin 2 receptor during rejection episodes in heart- or kidney-transplant recipients

1990 ◽  
Vol 36 (12) ◽  
pp. 2106-2109 ◽  
Author(s):  
G C Zucchelli ◽  
A Clerico ◽  
R De Maria ◽  
M Carmellini ◽  
R Di Stefano ◽  
...  
Keyword(s):  
Acute Rejection ◽  
Kidney Transplant ◽  
Allograft Rejection ◽  
Interleukin 2 ◽  
Clinical Markers ◽  
Kidney Transplant Recipients ◽  
Interleukin 2 Receptor ◽  
Transplant Patients ◽  
Kidney Transplant Patients ◽  
The Mean

Abstract Concentrations of interleukin 2 receptor (sIL-2R) have been suggested as a marker of rejection episodes after organ transplantation. To evaluate the analytical performance of a "sandwich-type" enzyme immunoassay method for sIL-2R and to verify whether increased concentrations of sIL-2R might be a useful marker of allograft rejection, we quantified sIL-2R in serum samples from heart- or kidney-transplant patients. The mean (+/- SD) pre-transplant value of sIL-2R (592 +/- 209 kilo-units/L) in heart-transplant patients was significantly higher (P less than 0.01) than that observed in controls (350 +/- 101 kilo-units/L). After heart transplantation, the concentrations of sIL-2R slowly decreased to baseline in successfully treated patients but increased significantly (1129 +/- 215 kilo-units/L; P less than 0.01) during acute rejection crisis. However, severe infections were also associated with a significant increase of sIL-2R, so the sIL-2R test is not specific for allograft rejection. The mean pre-transplant concentration of sIL-2R was also increased (1943 +/- 878 kilo-units/L) in 26 renal-transplant patients; after transplantation, this value returned to normal, as did that for creatinine, but persisted steadily high in five patients who experienced acute tubular necrosis. In this group of patients, the sIL-2R concentration increased by 1.5- to fourfold, both during acute rejection episodes and in clinically evident infection; thus measurement of creatinine and sIL-2R concentrations can help to distinguish between rejection, infection, and cyclosporine toxicity. In two episodes of mild cyclosporine-induced nephrotoxicity, we observed slight increases in serum creatinine (which returned to baseline when the cyclosporine dose was decreased) not associated with an increase in sIL-2R. We conclude that systematic monitoring of sIL-2R together with other biochemical and clinical markers may be useful in the management of kidney-transplant patients.

scholarly journals Interleukin 2 receptor antagonists for kidney transplant recipients

2004 ◽  
Author(s):  
Angela C Webster ◽  
Elliott Geoffrey Playford ◽  
Gail Y Higgins ◽  
Jeremy R Chapman ◽  
Jonathan C Craig
Keyword(s):  
Kidney Transplant ◽  
Interleukin 2 ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Receptor Antagonists ◽  
Interleukin 2 Receptor

scholarly journals Antithymocyte Globulin Versus Interleukin-2 Receptor Antagonist in Kidney Transplant Recipients With Hepatitis C Virus

2020 ◽  
Vol 104 (6) ◽  
pp. 1294-1303 ◽  
Author(s):  
Sunjae Bae ◽  
Christine M. Durand ◽  
Jacqueline M. Garonzik-Wang ◽  
Eric K.H. Chow ◽  
Lauren M. Kucirka ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Receptor Antagonist ◽  
Kidney Transplant ◽  
Antithymocyte Globulin ◽  
Interleukin 2 ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Interleukin 2 Receptor

scholarly journals Interleukin 2 receptor antagonists for kidney transplant recipients

2010 ◽  
Author(s):  
Angela C Webster ◽  
Lorenn P Ruster ◽  
Richard G McGee ◽  
Sandra L Matheson ◽  
Gail Y Higgins ◽  
...  
Keyword(s):  
Kidney Transplant ◽  
Interleukin 2 ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Receptor Antagonists ◽  
Interleukin 2 Receptor
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