scholarly journals Repeated Combined Chemotherapy with Cisplatin Lowers Carnitine Levels in Gastric Cancer Patients

2017 ◽  
Vol 71 (3-4) ◽  
pp. 261-265 ◽  
Author(s):  
Akimasa Kawai ◽  
Hideo  Matsumoto ◽  
Youko Endou ◽  
Yui Honda ◽  
Hisako Kubota ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Organic Cation ◽  
Organic Cation Transporter ◽  
Combined Chemotherapy ◽  
Carnitine Level ◽  
Upper Gastrointestinal Cancer ◽  
The Mean ◽  
Total Carnitine ◽  
Gastric Cancer Patients ◽  
Upper Gastrointestinal

Background/Aims: Carnitine plays an important role in the metabolism of fatty acids. It has also been reported that the administration of anticancer drugs may lead to reductions in serum carnitine levels due to decreased activity of organic cation transporter novel 2, which plays a role in the reabsorption of carnitine in the tubules of the kidney. We therefore studied the change in carnitine levels when chemotherapy was administered repeatedly to patients with gastric cancer. Methods: Ten patients with upper gastrointestinal cancer were enrolled in this study between December 2014 and August 2015. All patients were administered chemotherapy consisting of TS-1 and cisplatin every 3 weeks: 3 received it as adjuvant therapy post resection, the remaining 7 received it as treatment for unresectable tumors. Before the start of each chemotherapy cycle, serum was collected. Results: The mean total carnitine level was 54.5 ± 13.7 μmol/L prior to commencing chemotherapy; it was 46.7 ± 13.5 and 41.4 ± 14.8 μmol/L at the second and third cycles respectively. The total carnitine level was decreased in a statistically significant manner (p = 0.0039). The serum level of total protein and cholinesterase was also decreased significantly (p = 0.0218 and p = 0.0418). Conclusion: Carnitine levels decreased during repeated chemotherapy in patients with gastric cancer, and they are associated with the nutritional status.

scholarly journals A Novel Model Based on Deep Convolutional Neural Network Improves Diagnostic Accuracy of Intramucosal Gastric Cancer (With Video)

2021 ◽  
Vol 11 ◽  
Author(s):  
Dehua Tang ◽  
Jie Zhou ◽  
Lei Wang ◽  
Muhan Ni ◽  
Min Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Diagnostic Accuracy ◽  
Diagnostic Performance ◽  
Training Dataset ◽  
Deep Convolutional Neural Networks ◽  
Testing Dataset ◽  
Kappa Value ◽  
The Mean ◽  
Gastric Cancer Patients ◽  
Novel Model

Background and AimsPrediction of intramucosal gastric cancer (GC) is a big challenge. It is not clear whether artificial intelligence could assist endoscopists in the diagnosis.MethodsA deep convolutional neural networks (DCNN) model was developed via retrospectively collected 3407 endoscopic images from 666 gastric cancer patients from two Endoscopy Centers (training dataset). The DCNN model’s performance was tested with 228 images from 62 independent patients (testing dataset). The endoscopists evaluated the image and video testing dataset with or without the DCNN model’s assistance, respectively. Endoscopists’ diagnostic performance was compared with or without the DCNN model’s assistance and investigated the effects of assistance using correlations and linear regression analyses.ResultsThe DCNN model discriminated intramucosal GC from advanced GC with an AUC of 0.942 (95% CI, 0.915–0.970), a sensitivity of 90.5% (95% CI, 84.1%–95.4%), and a specificity of 85.3% (95% CI, 77.1%–90.9%) in the testing dataset. The diagnostic performance of novice endoscopists was comparable to those of expert endoscopists with the DCNN model’s assistance (accuracy: 84.6% vs. 85.5%, sensitivity: 85.7% vs. 87.4%, specificity: 83.3% vs. 83.0%). The mean pairwise kappa value of endoscopists was increased significantly with the DCNN model’s assistance (0.430–0.629 vs. 0.660–0.861). The diagnostic duration reduced considerably with the assistance of the DCNN model from 4.35s to 3.01s. The correlation between the perseverance of effort and diagnostic accuracy of endoscopists was diminished using the DCNN model (r: 0.470 vs. 0.076).ConclusionsAn AI-assisted system was established and found useful for novice endoscopists to achieve comparable diagnostic performance with experts.

The influence of a composite hospital volume of upper gastrointestinal cancer resections on outcomes of gastric cancer surgery.

2016 ◽  
Vol 34 (7_suppl) ◽  
pp. 305-305 ◽  
Author(s):  
Linde A.D. Busweiler ◽  
Johan L. Dikken ◽  
Mark I. van Berge Henegouwen ◽  
Vincent K.Y. Ho ◽  
Daniel Henneman ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
The Netherlands ◽  
Hospital Volume ◽  
Cancer Surgery ◽  
Lymph Node Yield ◽  
Gastric Cancer Surgery ◽  
Volume Outcome ◽  
Gastric Cancer Patients ◽  
Complex Surgical Procedures ◽  
Upper Gastrointestinal

305 Background: There is a known volume-outcome association for complex surgial procedures such as oncologic gastric resections. The aim of this study was to describe the process of centralization for gastric cancer surgery in the Netherlands in relation to other types of upper gastrointestinal (GI) cancer resections and to investigate whether the quality of gastric cancer surgery is affected by the overall experience with those related complex surgical procedures. Methods: Data on all patients (n = 4251) who underwent surgical treatment for non metastatic invasive gastric cancer between 2005-2013 were obtained from the Netherlands Cancer Registry. Annual hospital volume categories were based on the overall volume of gastrectomies, esophagectomies and pancreatectomies together (composite hospital volume). Volume-outcome analyses were performed for lymph node yield, 30-day mortality, and overall survival. Results: The percentage of gastric cancer patients who underwent a resection in a hospital with a volume of at least 20 gastrectomies per year increased. At the same time, the percentage of gastric cancer patients who underwent surgery in hospitals with an annual composite hospital volume of at least 20 upper GI cancer resections, such as esophageal and pancreatic cancer resections, increased. A higher composite hospital volume was associated with a higher lymph node yield, a lower 30-day mortality, and an increased overall survival. Conclusions: In the Netherlands, an increasing proportion of gastric cancer resections is performed in hospitals that are high volume centers for esophagectomies and pancreatectomies for cancer. Experience with these complex surgical procedures has a favorable effect on the outcomes of gastric cancer surgery.

Clinical features, treatments and survival of HER2 positive gastric cancer with elevated alpha-fetoprotein: An analysis of 16 cases.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e16000-e16000
Author(s):  
Shaohua Ge ◽  
Yi Ba ◽  
Ting Deng ◽  
Yuchong Yang ◽  
Tao Ning ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Immune Checkpoint ◽  
Clinical Characteristics ◽  
Immune Checkpoint Inhibitors ◽  
Checkpoint Inhibitors ◽  
Elevated Serum ◽  
Her2 Positive ◽  
The Mean ◽  
Gastric Cancer Patients

e16000 Background: Gastric cancer with elevated alpha-fetoprotein (AFP) is a special type of gastric cancer with elevated serum AFP. It is often misdiagnosed as primary hepatic cancer due to abnormal AFP and liver metastasis. The AFP level is related to the prognosis of these patients in whom there is prone to high HER2 positive rate. Therefore, anti-HER2 treatment is optional, as well as the emerging immunotherapy with immune checkpoint inhibitors. Methods: Gastric cancer patients with HER2 and serum AFP examination were collected in our hospital from May 2017 till now. Serum AFP level over 7 ng/ml was defined as elevated AFP. The clinical characteristics, treatments and survival of the patients with HER2 positive and elevated AFP were picked and analyzed. Results: Among 135 gastric cancer patients with elevated AFP, 16 (11.9%) were HER-2 positive (12 with HER2 3+, 3 with HER2 2+/FISH+ and 1 with HER2 gene amplification in NGS). The mean serum AFP is 201.4± 476.7ng/ml (range: 7.74 -1335). There were 9 males and 7 females. The mean age was 55 years (range: 38-90). The tumors were located in stomach cardia and fundus in 5 cases, body in 5 cases, antrum in 4 cases, body and antrum in 1 case and whole stomach in 1 case. There were 2 patients in stage III and 14 patients in stage IV with metastasis to lymph node metastasis in 15, liver in 9, abdominal cavity in 3 and peritoneum in 3. As for the treatments, three patients underwent surgery, one of whom with exploratory laparotomy (no antitumor treatment after surgery, died from infection). In 13 advanced patients, 12 patients received systemic antitumor therapies (8 with chemotherapy+Trastuzumab+ immunotherapy, 2 with chemotherapy+Trastuzumab, 1 with chemotherapy+ immunotherapy and 1 with chemotherapy). The chemotherapy regimens were XELOX in 5 cases, SOX in 4 cases and FLOT in 2 cases. The response rate was 50% (6 in 12 patients) and the disease control rate was 100%. The median PFS was 7.5 months in first line therapy with six patients without progression disease yet. The longest PFS with PR lasted for 16.5 months with chemotherapy, trastuzumab and immune checkpoint inhibitor. Conclusions: Gastric cancer with HER2 positive and elevated serum AFP is a disease with special clinical characteristics. Patients with advanced diseases can be treated with chemotherapy, trastuzumab +/- immune checkpoint inhibitors. This combination is expected to become a new regimen to improve survival of such special patients.

scholarly journals Evaluation of the Prevalence of Upper Gastrointestinal Cancers in Khorramadad

2021 ◽  
Author(s):  
Saleh Azadbakht ◽  
Morteza Azadbakht ◽  
Salehe Azadbakht
Keyword(s):  
Esophageal Cancer ◽  
Gastrointestinal Cancer ◽  
Distal Part ◽  
Demographic Data ◽  
Histopathological Analysis ◽  
Gastrointestinal Cancers ◽  
Upper Gastrointestinal Cancer ◽  
Regional Population ◽  
The Mean ◽  
Upper Gastrointestinal

Abstract BackgroundGastrointestinal cancer is one of the leading causes of cancer-related deaths and its incidence varies based on geographical, demographic, genetic and clinical factors. In this study, we aim to investigate the frequency of upper gastrointestinal cancers in patients referred to the endoscopy department Shohada Ashayer and Shahid Rahimi Hospital of Khorramabad from 2015-2019.MethodsThis research is a descriptive observational study where patients suspected for gastrointestinal cancer were included. These patients underwent endoscopy where samples from suspected cancer patient were subjected to histopathological analysis for confirmation. Demographic data along with the findings from endoscopy and pathology and details regarding the lesions (type and location) and the causes of lesions were recorded in the checklist for all the patients. ResultsOf 1274 patients, 630 (49/5%) were male and 644 (50/5%) were female. The mean age of the patients was 50 years. The Frequency of stomach cancer was 194 (16.7%) and that of esophageal cancer was 123 (9.7%).The most common type of pathology in esophageal cancer was squamous cell carcinoma with 91 cases (73.9%) and in the stomach were all cases were of adenocarcinoma. The distal part of the esophagus was most affected, 88 cases (72.2%) and cardiac end in the stomach. with 98 cases (50.5%) . The frequency of cancer was significantly higher in men and in patients aged above 60 years, p<0.05, respectively.ConclusionAccording to the results of the study, gastric cancer is the most common upper gastrointestinal cancer in regional population, followed by esophageal cancer.

scholarly journals Epidemiology of Gastric Cancer in the Gangetic Areas of West Bengal

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ashis Kumar Saha ◽  
Somnath Maitra ◽  
Subhas Chandra Hazra
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
West Bengal ◽  
Gastrointestinal Symptoms ◽  
Significant Relation ◽  
Symptom Profile ◽  
Upper Gastrointestinal Symptoms ◽  
H Pylori ◽  
Gastric Cancer Patients ◽  
Upper Gastrointestinal

There is marked geographical variation in the distribution and incidence of stomach cancer. We tried here to describe the pattern of relationships of age, sex, religion distribution, symptom profile, histological subtypes and Helicobacter pylori (H. pylori) infection with gastric cancer in Gangetic West Bengal. This study was done over a period of five years (2006–2010). The patients residing in the Gangetic areas of West Bengal presenting with upper gastrointestinal symptoms underwent UGI endoscopy. Among gastric cancer patients, demographic characteristics, symptomatology, macroscopic and histologic lesions and H. pylori status were analyzed. At confidence level 95%, “” and “” value were calculated to find significance. Among 23851 patients underwent UGI endoscopy, 14106 were males, 9745 females, 17889 Hindus and 5962 Muslims. Among 462 gastric cancer patients, Male : Female 2.7 : 1, Hindus : Muslim 3 : 1, abdominal pain, indigestion, and weight-loss were commonest presentations. Antrum was the commonest site whereas ulceroproliferative type was commonest type. H. pylori positivity was 80.89% in adenocarcinoma with statistically significant relation with intestinal type. In future, our target will be to modify risk factors; it will need further demographic studies and analysis, so that we can detect it earliest.

Perioperative Blood Transfusion, Age at Surgery, and Prognosis in a Database of 526 Upper Gastrointestinal Cancers

2015 ◽  
Vol 32 (6) ◽  
pp. 445-453 ◽  
Author(s):  
Keisuke Kosumi ◽  
Yoshifumi Baba ◽  
Kazuto Harada ◽  
Naoya Yoshida ◽  
Masayuki Watanabe ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Blood Transfusion ◽  
Cancer Patients ◽  
Gastrointestinal Cancer ◽  
Disease Free Survival ◽  
Upper Gastrointestinal Cancer ◽  
Age At Surgery ◽  
Gastric Cancer Patients ◽  
Upper Gastrointestinal ◽  
Perioperative Blood Transfusion

Aims: It is demonstrated that older animals have significantly weaker responses to new alloantigen stimulation than young animals, but the effect on prognosis of perioperative blood transfusion in relation to patient age is unknown. This study is retrospective review to investigate the relationship between perioperative blood transfusion, age at surgery, and clinical outcome in upper gastrointestinal cancer patients. Methods: We analyzed data of 526 upper gastrointestinal cancer patients who underwent curative resection from 2005 to 2010. Results: In esophageal cancer patients, patients with blood transfusion experienced significantly shorter overall survival (OS; univariate HR 2.50, p = 0.0006) and disease-free survival (DFS; univariate HR 1.71, p = 0.016) than patients without. Similar results were observed in gastric cancer patients (OS; univariate HR 3.35, p = 0.0001 and DFS; univariate HR = 3.18, p < 0.0001). Furthermore perioperative blood transfusion may be an independent prognostic factor in esophageal cancer patients (multivariate HR = 2.07, p = 0.026). Interestingly, age at surgery significantly affected the influence of blood transfusion on patient outcome in esophageal cancer patients (p for interaction = 0.022). Conclusion: The negative effect of perioperative blood transfusion was particularly evident among younger patients with esophageal cancer.

scholarly journals Mast Cells Positive to Tryptase and c-Kit Receptor Expressing Cells Correlates with Angiogenesis in Gastric Cancer Patients Surgically Treated

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Michele Ammendola ◽  
Rosario Sacco ◽  
Giuseppe Sammarco ◽  
Giuseppe Donato ◽  
Valeria Zuccalà ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Mast Cells ◽  
Cancer Patients ◽  
Tumour Tissue ◽  
7Th Edition ◽  
Complex Process ◽  
Kit Receptor ◽  
The Mean ◽  
Gastric Cancer Patients ◽  
Tryptase Inhibitors

Background. Angiogenesis is a complex process involved in both growth and progression of several human and animal tumours. Tryptase is a serin protease stored in mast cells granules, which plays a role in tumour angiogenesis. Mast cells (MCs) can release tryptase following c-Kit receptor (c-KitR) activation.Method. In a series of 25 gastric cancer patients with stage T3N2-3M0(by AJCC for Gastric Cancer 7th Edition), immunohistochemistry and image analysis methods were employed to evaluate in the tumour tissue the correlation between the number of mast cells positive to tryptase (MCPT), c-KitR expressing cells (c-KitR-EC), and microvascular density (MVD).Results. Data demonstrated a positive correlation between MCPT, c-KitR-EC, and MVD to each other. In tumour tissue the mean number of MCPT was 15, the mean number of c-KitR-EC was 20, and the mean number of MVD was 20. The Pearson test correlating MCPT and MVD, c-KitR-EC and MVD was significantly (r=0.64,P=0.001;r=0.66,P=0.041, resp.).Conclusion. In this pilot study, we suggest that MCPT and c-KitR-EC play a role in gastric cancer angiogenesis, so we think that several c-KitR or tryptase inhibitors such as gabexate mesilate and nafamostat mesilate might be evaluated in clinical trials as a new antiangiogenetic approach.

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