Status of Vitamin A and Related Compounds and Clinical Outcomes in Maternal-Infant Pairs in the Midwestern United States

2017 ◽  
Vol 71 (3-4) ◽  
pp. 175-182 ◽  
Author(s):  
Corrine Hanson ◽  
Marina Schumacher ◽  
Elizabeth Lyden ◽  
Jeremy Furtado ◽  
Matthew Van Ormer ◽  
...  
Keyword(s):  
Vitamin A ◽  
Clinical Outcomes ◽  
High Performance ◽  
Growth Parameters ◽  
Future Research ◽  
Serum Retinol ◽  
Logistic Regression Models ◽  
The Status ◽  
Highly Correlated ◽  
Related Compounds

Background: Vitamin A is an essential nutrient for pregnant women, and other vitamin A-related compounds, including lutein and lycopene, have been associated with maternal-infant outcomes. The objective of this study was to quantify the status of vitamin A and related compounds in maternal-infant pairs at the time of delivery, and to determine its impact on clinical outcomes. Methods: Maternal and cord blood samples were collected in 189 mother-infant pairs. Concentrations of lutein + zeaxanthin, β-cryptoxanthin, lycopene, carotenes, and retinol were measured using high-performance liquid chromatography. Descriptive statistics was calculated and Spearman coefficients were used to assess correlations between maternal and cord measurements. Kruskal-Wallis and independent samples t test were used to compare measures between retinol groups. Linear and logistic regression models were used to adjust for relevant confounders. p < 0.05 was considered statistically significant. Results: Ten percent of mothers had serum retinol concentrations ≤0.70 µmol/L; 80% of infants had serum retinol concentrations ≤0.70 µmol/L. Low maternal retinol concentrations were associated with maternal anemia (p = 0.04) and a trend toward low birth weight (p = 0.06). Maternal and infant concentrations of vitamin A compounds were highly correlated. After adjustment for confounders, maternal lutein was associated with a C-section (p = 0.03) and a diagnosis of respiratory distress syndrome in the infant (p = 0.02). Maternal lycopene was associated with growth parameters in the infant. Conclusions: As vitamin A-related compounds are modifiable by diet, future research determining the clinical impact of these compounds is warranted.

scholarly journals Status of Retinoids and Carotenoids and Associations with Clinical Outcomes in Maternal-Infant Pairs in Nigeria

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1286 ◽  
Author(s):  
Corrine Hanson ◽  
Elizabeth Lyden ◽  
Ann Anderson-Berry ◽  
Nicholas Kocmich ◽  
Amy Rezac ◽  
...  
Keyword(s):  
Vitamin A ◽  
Clinical Outcomes ◽  
Vitamin A Deficiency ◽  
Plasma Concentrations ◽  
Future Research ◽  
Linear Regression Models ◽  
Nigerian Women ◽  
Plasma Retinol ◽  
Highly Correlated ◽  
The Impact

Vitamin A is an essential nutrient in pregnancy, and other carotenoids have been independently associated with maternal-infant outcomes. The objective of this study was to quantify the status of vitamin A and carotenoids in Nigerian maternal-infant pairs at delivery, compare these to a cohort from a developed nation, and determine the impact on clinical outcomes. Maternal and cord blood samples were collected in 99 Nigerian mother-infant pairs. Concentrations of lutein + zeaxanthin, β-cryptoxanthin, lycopene, α- and β-carotenes, and retinol were measured using HPLC. Descriptive statistics were calculated and Spearman coefficients were used to assess correlations between maternal and cord measurements; Mann-Whitney tests were used to compare median plasma values between dichotomous variables. Linear regression models were used to adjust for relevant confounders. A p < 0.05 was considered statistically significant. Thirty-five percent of mothers had plasma retinol concentrations ≤0.70 µmol/L; 82% of infants had plasma retinol concentrations ≤0.70 µmol/L at delivery. Maternal and infant concentrations of vitamin A compounds were highly correlated and were associated with newborn growth and Apgar scores. Despite plasma concentrations of pro-vitamin A carotenoids higher than those reported in other populations, pregnant Nigerian women have a high prevalence of vitamin A deficiency. As vitamin A related compounds are modifiable by diet, future research determining the clinical impact of these compounds is warranted.

Simultaneous determination of retinol and retinyl esters in serum or plasma by reversed-phase high-performance liquid chromatography.

1978 ◽  
Vol 24 (11) ◽  
pp. 1920-1923 ◽  
Author(s):  
M G DeRuyter ◽  
A P De Leenheer
Keyword(s):  
Vitamin A ◽  
High Performance ◽  
Chromatographic Determination ◽  
Reversed Phase ◽  
Retinyl Palmitate ◽  
Serum Retinol ◽  
Liquid Chromatographic Determination ◽  
Retinyl Esters ◽  
Liquid Chromatographic

Abstract We propose a single-run liquid-chromatographic determination, with ultraviolet detection at 330 nm, for serum retinol and retinyl esters. The vitamin A derivatives are extracted according to the Bligh-Dyer procedure. With 200 microliter or serum, the lower detection limit is 50 microgram/liter for retinol and about 100 microgram/liter for retinyl esters. Within-run precision (CV) was 2.3% for retinol, 4.3% for retinyl palmitate. Day-to-day percision (CV, n = 20) for retinol was 4.9% during a month. The method can be used for the assessment of vitamin A absorption tests and for the determination of serum retinol (normal, subnormal, and above-normal concentrations). Serum retinyl esters can only be measured in conditions where concentrations exceed 100 microgram/liter.

scholarly journals Metabolomics Identifies Serum Metabolites Different in Zambian Women with Adequate versus Deficient Total Liver Vitamin A Reserves Despite Adequate Serum Retinol Levels

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 73-73
Author(s):  
Catherine Johnson ◽  
Sophia Brown ◽  
Chandler Phelps ◽  
Chisela Kaliwile ◽  
Jesse Sheftel ◽  
...  
Keyword(s):  
Vitamin A ◽  
Vitamin A Deficiency ◽  
Future Research ◽  
Serum Retinol ◽  
Serum Samples ◽  
Metabolomics Data ◽  
Total Liver ◽  
Funding Sources ◽  
University Of Wisconsin ◽  
Deficient Group

Abstract Objectives Vitamin A deficiency (VAD) has remained a leading cause of morbidity and mortality throughout the world for decades, however there are still challenges defining VA status because the most common biomarker, serum retinol, is regulated homeostatically except in extreme deficiency and affected by inflammation; therefore, more accurate biomarkers to define VAD are needed. Furthermore, the effects of VAD on metabolism are still being uncovered. The objective was to investigate whether serum metabolomics profiles differed between Zambian women with adequate versus deficient VA status measured by the gold-standard biomarker total liver VA reserves (TLR) whose serum retinol concentrations did not differ. Methods Retinol isotope dilution (RID) was used to estimate TLR in Zambian women in the Rufunsa district; serum aliquots were selected for metabolomics based on adequate (TLR &gt; 0.1–1 μmol VA/g liver) or deficient (TLR &lt; 0.1 μmol/g) VA status (n = 10/group). Serum retinol levels were indicative of adequacy (&gt;0.7 μmol/L) and were not different between groups. Serum samples were analyzed by LC-MS using four metabolomics assays. Metabolomics data were covariate-adjusted for age and BMI. Results Ten metabolites were different between the adequate and deficient vitamin A groups (P &lt; 0.05). Metabolites lower in the deficient group included multiple phosphatidylcholines (PCs) and phosphatidylethanolamines (PEs), as well as lipoxygenase (LOX)-derived oxylipins (9-HODE and 17-HDoHE), choline, and anthranilic acid. One cholestryl ester was elevated in the deficient group. Conclusions The study revealed numerous metabolites altered by RID-measured VAD and adequacy despite similarly adequate serum retinol levels in both groups. Future research is required to investigate the mechanisms by which phospholipids such as PCs and PEs, as well as LOX-derived oxylipins, are altered by VA status and the potential use of these metabolites as biomarkers of VAD. Funding Sources University of Wisconsin-Madison Global Health Institute visiting scholar fellowship (CK and SAT).

scholarly journals Hidden Hunger of Vitamin E Among Healthy College Students: A CrossSectional Study

2021 ◽  
Vol 21 ◽  
Author(s):  
Zhongqi Wan ◽  
Li Wang ◽  
Yinyang Xu ◽  
Yuanyuan Wang ◽  
Tianyou Zhang ◽  
...  
Keyword(s):  
College Students ◽  
Vitamin E ◽  
Vitamin A ◽  
Dietary Habits ◽  
Vitamin A Deficiency ◽  
Serum Levels ◽  
Hplc Method ◽  
Serum Retinol ◽  
Vitamin E Deficiency ◽  
The Status

Background: College students may have risk of fat-soluble vitamins deficiencies due to unhealthy dietary habits, especially for vitamin A and E. They are important members in the human antioxidant network, deficiencies of these vitamins may increase risk of many critical diseases. Objective: The current study was undertaken to determine the status of vitamin A and E in college students. Methods: Healthy college students were recruited, and fasting blood samples of them were collected and used for determining serum levels of retinol and α-tocopherol by the HPLC method. Results: We found that there was no vitamin A deficiency in college students. However, vitamin E deficiency existed in 34.5% of college students, especially in males. All the students had no vitamin E adequacy. In addition, our findings showed that BMI was inversely associated with serum α-tocopherol, but not serum retinol. Conclusion: These results suggest that vitamin E deficiency in college students should be given more attention, and it is necessary to consider using vitamin E supplements.

scholarly journals Albendazole increases serum retinol concentration in primary schoolchildren with low serum retinol

2015 ◽  
Vol 34 (2) ◽  
pp. 121
Author(s):  
Jane Florida Kalumpiu ◽  
Yenny Djuardi ◽  
Taniawati Supali
Keyword(s):  
Vitamin A ◽  
Primary School ◽  
School Children ◽  
High Performance ◽  
Vitamin A Deficiency ◽  
Primary School Children ◽  
Serum Retinol ◽  
Serum Retinol Concentration ◽  
Retinol Concentration ◽  
Low Serum

Background<br />Soil-transmitted helminth (STH) infection is still a health problem in Indonesia. Vitamin A deficiency (VAD) is often found together with STH. The effect of the deworming program on the vitamin A status of primary school children is unknown. The objective of this study was to evaluate the effect of albendazole on serum retinol concentrations in primary school children.<br /><br />Methods<br />An experimental study of pre-post test design without control was carried out on 118 children from grades 3-5 at one primary school in North Jakarta, from July to September 2014. Flotac examination was used to determine STH infections and high performance liquid chromatography was performed to measure serum retinol concentration. Stool and blood samples were taken twice: before and three weeks after treatment with albendazole 400 mg single dose for three consecutive days given to all children either infected or uninfected. Paired t-test was used to analyze the data. <br /><br />Results<br />Of the 118 children, the prevalence of STH was 71.2%. The prevalence of low retinol serum (&lt;1.05 mmol/L) was 17 (17.2%) and of mild VAD was 2 (2.0%). Albendazole given in 3 consecutive days could not increase serum retinol concentrations (p=0.055). Serum retinol concentration significantly increased after albendazole treatment in children with low retinol serum at baseline (p=0.001). <br /><br />Conclusions<br />In children with low serum retinol concentration, treatment with albendazole increased retinol concentration. Integrated deworming and vitamin A supplementation strategies should be evaluated in this population.

Removal of supplemental vitamin A from barley-based diets improves marbling in feedlot heifers

2011 ◽  
Vol 91 (4) ◽  
pp. 669-674 ◽  
Author(s):  
D. Gibb ◽  
F. H. Van Herk ◽  
P. Mir ◽  
S. Loerch ◽  
T. McAllister
Keyword(s):  
Vitamin A ◽  
Dry Matter ◽  
Animal Health ◽  
Average Daily Gain ◽  
Serum Retinol ◽  
Marbling Score ◽  
Supplemental Vitamin ◽  
Highly Correlated ◽  
To Receive ◽  
Daily Gain

Gibb, D. J., Van Herk, F. H., Mir, P. S., Loerch, S. and McAllister, T. A. 2011. Removal of supplemental vitamin A from barley-based diets improves marbling in feedlot heifers. Can. J. Anim. Sci. 91: 669–674. The objective of this research was to determine if removing supplemental vitamin A from barley-based feedlot diets affects animal performance, health, or carcass quality. Six pens per treatment (10 heifers per pen) were randomly assigned to receive zero (–VA) or 3640 (+VA) IU kg−1 dry matter of supplemental vitamin A in barley-based feedlot diets. Initial serum retinol was similar between treatments (28 µg dL−1; P=0.34), but –VA reduced levels by 40% (30 vs. 50 µg dL−1; P<0.001) by day 217. Removal of supplemental vitamin A reduced dry matter intake during the 58 d backgrounding period (6.93 vs. 7.07 kg d−1; P=0.007) and over the 218-d trial (9.18 vs. 9.35 kg d−1; P<0.001), but had no effect on average daily gain during backgrounding (1.22 kg d−1; P=0.46) or over all (1.46 kg d−1; P=0.15). Based on camera grading, –VA increased degree of marbling (480.6 vs. 439.3; P=0.02) without affecting backfat thickness (0.74 cm; P=0.62). Ultrasound measurements were highly correlated with camera grading, but did not detect treatment difference in marbling score (P=0.99). Results from this study show that the removal of supplemental vitamin A increased marbling without affecting backfat, gains, or animal health.

scholarly journals Gestational diabetes: a risk of puerperal hypovitaminosis A?

2015 ◽  
Vol 87 (1) ◽  
pp. 463-470 ◽  
Author(s):  
FERNANDA B.S. RESENDE ◽  
LARISSA Q. DE LIRA ◽  
EVELLYN C. GRILO ◽  
MAYARA S.R. LIMA ◽  
ROBERTO DIMENSTEIN
Keyword(s):  
Gestational Diabetes ◽  
Vitamin A ◽  
High Performance ◽  
Vitamin A Deficiency ◽  
Test Group ◽  
Control Group ◽  
Serum Retinol ◽  
Cross Sectional ◽  
The Individual ◽  
Retinol Concentration

The influence of gestational diabetes on vitamin A deficiency in lactating women and, consequently, in their newborn has been verified through a cross-sectional case-control study conducted with volunteer puerperal women. The control group consisted of healthy women and the test group was composed of women with gestational diabetes. One hundred and seven women were recruited, corresponding to 71 controls and 36 cases. Personal, gestational and newborn data were collected directly from medical records during hospitalization. The retinol was determined in maternal colostrum and serum by High Performance Liquid Chromatography. Postpartum women with gestational diabetes were older, had more children and a higher prevalence of cesarean delivery. No difference was found in retinol concentration in maternal milk and serum between the groups. However, it was observed that 16.7% had vitamin A deficiency in the group of patients with diabetes and only 4.1% had such deficiency in the control group. Although no difference was found in colostrum and serum retinol concentration between women with and without gestational diabetes, the individual analysis shows that those with diabetes are at higher risk of being vitamin A deficient.

Measles Severity and Serum Retinol (Vitamin A) Concentration Among Children in the United States

PEDIATRICS ◽  
1993 ◽  
Vol 91 (6) ◽  
pp. 1176-1181
Author(s):  
Jay C. Butler ◽  
Peter L. Havens ◽  
Susan E. Day ◽  
Michael J. Chusid ◽  
Anne L. Sowell ◽  
...  
Keyword(s):  
United States ◽  
Vitamin A ◽  
High Performance ◽  
The United States ◽  
Illness Severity ◽  
Serum Retinol ◽  
Prism Score ◽  
Serum Retinol Concentration ◽  
Record Review ◽  
Retinol Concentration

Background. Studies in developing countries have shown that children with measles have low serum retinol concentrations and that lower retinol levels are associated with measles-related mortality. Vitamin A therapy has been shown to reduce mortality among African children with acute measles. Objectives. To determine whether serum retinol concentration is low among children with measles in the United States and to determine whether retinol concentration is associated with illness severity. Setting. Pediatric referral hospital and clinic in Milwaukee, WI, during the measles outbreak of 1989-1990. Patients. One hundred fourteen patients ≤5 years of age evaluated for serologically confirmed measles with serum obtained within 5 days following rash onset. Methods. Serum retinol concentration was determined by high-performance liquid chromatography. Clinical data were collected by hospital record review. A modified Pediatric Risk of Mortality (PRISM) score was used to assess physiologic instability as a measure of illness severity. Results. Retinol concentrations ranged from 0.25 to 1.18 µmol/L (median 0.58 µmol/L); 82 (72%) patients had low retinol concentration (≤0.70 µmol/L). Median retinol concentrations were lower among hospitalized patients (0.56 vs 0.70, P = .006) and patients with pneumonia (0.52 vs 0.64, P = .02) but higher among children with otitis media (0.63 vs 0.54, P = .01). Higher modified PRISM scores, reflecting greater physiologic instability, were associated with lower retinol concentration (β coefficient -.0147, P = .025). In multivariate analysis, higher modified PRISM scores were associated with lower retinol concentration (β coefficient -.0144, P = .025) even after controlling for hospitalization, presence of complications, race, age, receipt of Aid to Families With Dependent Children, gender, and interval from rash onset until serum was collected. Conclusions. Among these children with measles in an urban United States community, retinol concentrations were depressed, and the degree of depression was associated with illness severity. Vitamin A therapy should be considered for children with measles in the United States who require hospitalization.

Liquid-chromatographic assay for retinol (vitamin A) and retinol analogs in therapeutic trials.

1982 ◽  
Vol 28 (4) ◽  
pp. 693-696 ◽  
Author(s):  
S W McClean ◽  
M E Ruddel ◽  
E G Gross ◽  
J J DeGiovanna ◽  
G L Peck
Keyword(s):  
Retinoic Acid ◽  
Vitamin A ◽  
High Performance ◽  
High Performance Liquid Chromatographic ◽  
Reference Intervals ◽  
Serum Retinol ◽  
Retinyl Acetate ◽  
Therapeutic Trials ◽  
All Trans Retinoic Acid ◽  
Liquid Chromatographic

Abstract A "high-performance" liquid-chromatographic separation of retinoids (retinol, isotretinoin, all-trans retinoic acid, retinal, etretinate, and retinyl acetate) in serum is described. The separation was used in developing a quantitative assay for retinol (vitamin A) and two therapeutic analogs, isotretinoin (13-cis-retinoic acid) and etretinate (Ro 10-9359). The procedure requires 1 mL of serum. Overall analytical recovery for retinol, isotretinoin, and etretinate from serum was 100% (SD 7%). The between-day coefficient of variation for specimens with concentrations ranging from 0.70 to 0.95 mg/L was less than 4%. Normal reference intervals for serum retinol in men and women are 0.61 to 1.33 and 0.44 to 1.19 mg/L, respectively.

scholarly journals The relationship between serum retinol concentrations and subclinical infection in rural Brazilian children

2018 ◽  
Vol 31 (3) ◽  
pp. 299-310
Author(s):  
Laísla França da Silva TELES ◽  
Adriana de Azevedo PAIVA ◽  
Liania Alves LUZIA ◽  
Flávia Emília Leite de LIMA-FERREIRA ◽  
Cecilia Maria Resende Gonçalves de CARVALHO ◽  
...  
Keyword(s):  
Vitamin A ◽  
High Performance ◽  
Vitamin A Deficiency ◽  
Subclinical Infection ◽  
Rural Settlements ◽  
Serum Retinol ◽  
C Reactive Protein ◽  
Cross Sectional ◽  
Reactive Protein ◽  
The Relationship

ABSTRACT Objective To evaluate the relationship between serum retinol concentrations and subclinical infection in children from rural settlements. Methods A cross-sectional population-based study was carried out in nine rural settlements in the northeastern region of Brazil, involving 118 children aged 6 to 59 months. The relationship between serum retinol and C-Reactive Protein levels, an important marker of infectious and inflammatory processes, was investigated by multiple linear regression, controlling for demographic, socioeconomic and nutritional variables. Serum retinol and C-Reactive Protein were measured, respectively, by High Performance Liquid Chromatography and immunoturbidimetric assay in automated equipment. Results Vitamin A deficiency (retinol <0.70μmol/L) was identified in 9.3% of the children. C-Reactive Protein was the only predictor of retinol concentrations in the final regression model, causing a 0.728μmol/L reduction in retinol concentrations in the studied children (p=0.008). Conclusion Vitamin A deficiency is a problem of mild/moderate severity and measures to control infectious diseases in this population are fundamental to prevent and/or combat this problem.

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