scholarly journals Levonorgestrel-Releasing Intrauterine Device-Related Acute Liver Injury

2017 ◽  
Vol 11 (3) ◽  
pp. 742-747 ◽  
Author(s):  
Hira Imad Cheema ◽  
Ashutosh Gupta
Keyword(s):  
Side Effects ◽  
Liver Injury ◽  
Liver Biopsy ◽  
Oral Contraceptives ◽  
Acute Liver Injury ◽  
Intrauterine Device ◽  
Intrauterine Devices ◽  
Metabolic Side Effects ◽  
First Time

Oral contraceptives have long been associated with liver injury. However, very little attention is paid to the metabolic side effects of hormone-releasing intrauterine devices (IUDs). These devices are generally considered safe and commonly used. We report for the first time acute liver injury associated with a levonorgestrel-releasing IUD. Our patient did not have any comorbidities that could have caused or exacerbated liver injury. A detailed workup and liver biopsy remained negative for any other potential cause of liver injury. The patient’s symptoms resolved with removal of the device. She remained symptom free on subsequent outpatient follow-ups.

scholarly journals Current issues in contraception

2005 ◽  
Vol 58 (5-6) ◽  
pp. 253-257
Author(s):  
Petar Draca ◽  
Branislava Jakovljevic
Keyword(s):  
Family Planning ◽  
Side Effects ◽  
Oral Contraceptives ◽  
Health Risks ◽  
Reliable Method ◽  
Oral Contraception ◽  
Intrauterine Devices ◽  
Risks And Benefits ◽  
The World ◽  
Vaginal Wash

Introduction. The authors analyze contemporary methods of contraception. Regarding oral contraception, they point to agents which decrease the efficacy of oral contraception. They also deal with agents which increase the level of estrogen, thus increasing side effects (paracetamol, vitamin C). Oral contraceptives Oral contraceptives may also have an impact on the efficacy of some medications (anticonvulsants, antidepressants). Health risks of oral contraceptives are also mentioned, as well as WHO's, guidelines for women using contraceptives based on risks and benefits. Other methods of contraception The authors also offer criteria for use of bioactive intrauterine devices (IUD), with recommendations of WHO. Besides men's, there are women's condoms, which are very reliable protection against infections, but their negative side is that they are rather expensive. Bad sides of vaginal wash are also emphasized, although this method is rather widespread in the world. Conclusion. At the end, the authors quote the International Family Planning Fund (IFPF) which considers IUD to be the most reliable method of contraception nowadays. .

scholarly journals Preventing copper intrauterine device removals due to side effects among first-time users: randomized trial to study the effect of prophylactic ibuprofen

2006 ◽  
Vol 21 (6) ◽  
pp. 1467-1472 ◽  
Author(s):  
David Hubacher ◽  
Veronica Reyes ◽  
Sonia Lillo ◽  
Bosny Pierre-Louis ◽  
Ana Zepeda ◽  
...  
Keyword(s):  
Side Effects ◽  
Randomized Trial ◽  
Intrauterine Device ◽  
First Time ◽  
Copper Intrauterine Device

Social factors in the choice of contraceptive method: a comparsion of first clinic attenders accepting oral contraceptives with those accepting intrauterine devices

1977 ◽  
Vol 9 (2) ◽  
pp. 153-162 ◽  
Author(s):  
Su Kingsley ◽  
John McEwan
Keyword(s):  
Oral Contraceptives ◽  
Social Factors ◽  
Contraceptive Method ◽  
Contraceptive Use ◽  
Intrauterine Device ◽  
Personal Characteristics ◽  
Ethnic Origin ◽  
Intrauterine Devices ◽  
The Social ◽  
Induced Abortions

SummaryAt a hospital contraceptive clinic with between 1200 and 2400 new clients each year, regular recording is made of the social and personal characteristics of the clinic users together with their contraceptive and reproductive histories. An analysis has been made of the differences found between those accepting the pill and those the intrauterine device (IUD) at their first attendance. Age and parity show marked differences and these are related to employment and ethnic origin. Previous contraceptive use showed distinct differences; IUD acceptors were more likely to have had induced abortions. These findings are discussed in relation to the prevalent use of these two methods and it is suggested that IUD fitting should be more widely available.

scholarly journals The Protective Effects of Imperatorin on Acetaminophen Overdose-Induced Acute Liver Injury

2020 ◽  
Vol 2020 ◽  
pp. 1-17 ◽  
Author(s):  
Zhao Gao ◽  
Jiecheng Zhang ◽  
Li Wei ◽  
Xingping Yang ◽  
Yuan Zhang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Liver Injury ◽  
Farnesoid X Receptor ◽  
Sirtuin 1 ◽  
Therapeutic Effects ◽  
Dependent Manner ◽  
Protective Effects ◽  
Hepatocyte Apoptosis ◽  
Apap Overdose ◽  
First Time

Acetaminophen (APAP) toxicity leads to severe acute liver injury (ALI) by inducing excessive oxidative stress, inflammatory response, and hepatocyte apoptosis. Imperatorin (IMP) is a furanocoumarin from Angelica dahurica, which has antioxidant and anti-inflammatory effects. However, its potential to ameliorate ALI is unknown. In this study, APAP-treated genetic knockout of Farnesoid X receptor (FXR) and Sirtuin 1 (SIRT1) mice were used for research. The results revealed that IMP could improve the severity of liver injury and inhibit the increase of proinflammatory cytokines, oxidative damage, and apoptosis induced by overdose APAP in an FXR-dependent manner. We also found that IMP enhanced the activation and translocation of FXR by increasing the expression of SIRT1 and the phosphorylation of AMPK. Besides, single administration of IMP at 4 h after APAP injection can also improve necrotic areas and serum transaminase, indicating that IMP have both preventive and therapeutic effects. Taken together, it is the first time to demonstrate that IMP exerts protective effects against APAP overdose-induced hepatotoxicity by stimulating the SIRT1-FXR pathway. These findings suggest that IMP is a potential therapeutic candidate for ALI, offering promise for the treatment of hepatotoxicity associated with APAP overdose.

scholarly journals Acute Liver Failure Associated with Levetiracetam and Lacosamide Combination Treatment for Unspecified Epileptic Disorder

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Ylse Gutiérrez-Grobe ◽  
Jose Antonio Bahena-Gonzalez ◽  
Magali Herrera-Gomar ◽  
Pedro Mendoza-Diaz ◽  
Sandra García-López ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Biopsy ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Liver Enzymes ◽  
Acute Liver Injury ◽  
Adjunctive Treatment ◽  
Drug Induced ◽  
Epileptic Disorder ◽  
Secondary Generalization

Background and Aim. Levetiracetam is a second-generation antiepileptic drug. It is approved as an adjunctive treatment of partial onset seizures with or without secondary generalization. It is considered safe with less than 1% of patients with transient elevations of liver enzymes.Methods. We report a case of acute liver failure secondary to Levetiracetam in combination with Lacosamide documented with a liver biopsy.Results. Liver biopsy demonstrated acute liver injury with a predominant submassive necrosis pattern and features of a drug-induced hepatitis.Conclusions. This is the first published case of acute liver failure due to antiepileptic therapy with Levetiracetam in combination with Lacosamide.

Social characteristics of diaphragm users in a family planning clinic

1978 ◽  
Vol 10 (2) ◽  
pp. 159-167 ◽  
Author(s):  
John McEwan
Keyword(s):  
Family Planning ◽  
Marital Status ◽  
Oral Contraceptives ◽  
Intrauterine Device ◽  
Fertility Control ◽  
Social Characteristics ◽  
Family Planning Clinic ◽  
Intrauterine Devices ◽  
Family Building

SummaryThe use of the diaphragm and other vaginal caps has declined in the last decade with the rise of oral contraceptives and intrauterine devices. This is particularly clearly shown in the group of women attending family planning clinics. These changes have been accompanied by a shift in predominance from male methods to those initiated and managed by women.Various characteristics of diaphragm acceptors at the King's group of hospital clinics have been studied from January 1972 to May 1976 and compared with those of women accepting other methods such as the pill and intrauterine device. There are marked differences in age at first attendance, and at various stages of family building; there are also differences in marital status and whether working outside the home or not. In the group of housewives accepting the diaphragm, there is an increased proportion whose partners are in non-manual occupations.These differences are discussed in relation to the acceptability of vaginal barriers, the duration of their use and their effectiveness in the long term. If immediate acceptability could be improved by a new design, they might play a more useful part as a women's method of fertility control.

Oral contraceptives worsen endotoxin induced liver injury in rats

2001 ◽  
Vol 120 (5) ◽  
pp. A116-A116
Author(s):  
A KONNO ◽  
N ENOMOTO ◽  
M HIROSE ◽  
K IKEJIMA ◽  
S MATSUYAMA ◽  
...  
Keyword(s):  
Liver Injury ◽  
Oral Contraceptives

Aloe-Emodin Quinone Pretreatment Reduces Acute Liver Injury Induced by Carbon Tetrachloride

2000 ◽  
Vol 87 (5) ◽  
pp. 229-233 ◽  
Author(s):  
Beatrice Arosio ◽  
Nicoletta Gagliano ◽  
Lorena Maria Pia Fusaro ◽  
Luciano Parmeggiani ◽  
Jacopo Tagliabue ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Aloe Emodin
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