scholarly journals Haplotype Based Analysis of XRCC3 Gene Polymorphisms in Thyroid Cancer

2017 ◽  
Vol 42 (1) ◽  
pp. 22-33 ◽  
Author(s):  
Romana Sarwar ◽  
Ishrat Mahjabeen ◽  
Kashif Bashir ◽  
Soma Saeed ◽  
Mahmood Akhtar Kayani
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Cancer Patients ◽  
Mammalian Cells ◽  
Dna Double Strand Breaks ◽  
Mutant Genotype ◽  
Specific Pcr ◽  
Common Genetic Variants ◽  
Xrcc3 Gene ◽  
Thyroid Cancer Risk

Background/Aims: In mammalian cells, XRCC3 plays an important role in the DNA double-strand breaks (DSBs) repair by homologous recombination. Genetic polymorphisms in XRCC3 gene may potentially affect the repair of DSBs and thus confer susceptibility to thyroid cancer. In this study, we used a haplotype-based approach to investigate whether 5 selected SNPs i.e. rs1799796, rs1799794, rs861539, rs709399 and rs861530 of XRCC3 gene are associated with thyroid cancer risk in 456 cancer patients and 400 cancer-free controls. Methods: Genotyping was performed using Allele-specific PCR followed by sequencing. Statistical analysis was performed to analyse gene and haplotype association. Results: After analysis, frequency of mutant genotype/alleles of SNPs (rs1799796, p<0.0001; rs1799794, p<0.0001; rs861539, p<0.001; rs709399, p <0.0001; rs861530, p<0.002) was found significantly higher in thyroid cancer patients compared to controls. Significant associations were found for most of the variant genotypes in SNPs of rs1799794, rs1799796, rs861539, rs861530 and rs709399 in papillary thyroid and follicular cancer patients compared to other histologic subtypes of thyroid carcinoma. Additionally, haplotype analysis revealed that haplotypes, AACGA (p= 0.0005), AGTAA (p= 0.008), GATAA (p= 0.001), GGCAA (p= 0.001) were linked with significant increase in thyroid cancer risk. However, haplotype AGCGG (p= 0.0009) was associated with a significant reduced thyroid cancer risk. Conclusion: Our results suggest that common genetic variants in the XRCC3 gene of DSBR pathway may modulate thyroid cancer risk.

scholarly journals Association between XRCC3 rs861539(Thr241Met) polymorphism and thyroid cancer risk (a Meta-analysis)

2021 ◽  
Author(s):  
Yayun Wu ◽  
Yun Ren ◽  
Zhimin Cao ◽  
Kai Zhang ◽  
Xiaoqiang Dong ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Recessive Model ◽  
Single Nucleotide ◽  
Knowledge Infrastructure ◽  
Xrcc3 Gene ◽  
Thyroid Cancer Risk ◽  
Chinese National Knowledge Infrastructure

Abstract Objective To explore the association between single nucleotide polymorphism (SNP) in the XRCC3 rs861539(Thr241Met) locus and thyroid cancer risk. Methods Studies investigating the association between SNP in the XRCC3 gene and thyroid cancer susceptibility were retrieved from the PubMed, Embase, Web of Science, CNKI (Chinese National Knowledge Infrastructure), WanFang, and CBM (China Biology Medicine) databases. Eligible studies were screened according to inclusion/exclusion criteria and principles of quality evaluation. Meta-analysis was performed using Stata 14.0 software. Odds ratios with their corresponding 95% confidence intervals were pooled to assess the association between SNP in the XRCC3 gene rs861539 locus and thyroid cancer susceptibility. Results 10 articles(11 studies) were eligible for this meta-analysis. Meta-analysis results were shown as follows: No significant association was found between XRCC3 rs861539 polymorphism and thyroid cancer risk in Dominant and Overdominant models〔Dominant model: CT+TT vs CC, OR=1.231, 95% CI(0.998, 1.474); Overdominant model: CT vs TT+CC, OR=1.05, 95% CI(0.94, 1.18)〕. Significant associations were found in Recessive and Allelic models〔Recessive model: TT vs CC+CT, OR=1.632, 95% CI(1.349, 1.974); Allelic model: T vs C: OR=1.263, 95% CI(1.091, 1.462)〕. Conclusion The results of this study suggest that the XRCC3 rs861539(Thr241Met) polymorphism may be associated with an increased thyroid cancer risk in overall population, and a tendency for significantly increased thyroid cancer risk in TT(Met/Met) genotype population.

scholarly journals Common Genetic Variants in Sex Hormone Pathway Genes and Papillary Thyroid Cancer Risk

Thyroid ◽  
2012 ◽  
Vol 22 (2) ◽  
pp. 151-156 ◽  
Author(s):  
Sara J. Schonfeld ◽  
Gila Neta ◽  
Erich M. Sturgis ◽  
Ruth M. Pfeiffer ◽  
Amy A. Hutchinson ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Papillary Thyroid Cancer ◽  
Genetic Variants ◽  
Sex Hormone ◽  
Papillary Thyroid ◽  
Common Genetic Variants ◽  
Thyroid Cancer Risk

Increased thyroid cancer risk in acromegaly

2013 ◽  
Author(s):  
Selcuk Dagdelen ◽  
Nese Cinar ◽  
Tomris Erbas
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Thyroid Cancer Risk

scholarly journals Fertility Drugs Associated with Thyroid Cancer Risk: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
QingAn Yu ◽  
XiaoYing Lv ◽  
KunPeng Liu ◽  
DaKun Ma ◽  
YaoHua Wu ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Clomiphene Citrate ◽  
Positive Association ◽  
Female Infertility ◽  
Cochrane Library ◽  
Significant Positive Association ◽  
Fertility Drugs ◽  
Increased Risk ◽  
Thyroid Cancer Risk

Associations have been demonstrated between fertility drugs and a variety of hormone-sensitive carcinomas. The purpose of this study was to determine the relationship between fertility drugs used in the treatment of female infertility and the risk of thyroid cancer. To investigate the clinical significance of fertility drugs used for the treatment of female infertility and the risk associated with thyroid cancer, we performed a literature search using PubMed, MEDLINE, the Cochrane Library, the Web of Science, and EBSCOHOST for comparative studies published any time prior to July 21, 2017. The studies included women who were treated for infertility with fertility drugs, such as clomiphene citrate, gonadotropins, or other unspecified fertility agents, which reported the incidence of thyroid cancer as the main outcome. Eight studies were included in the meta-analyses. Among women with infertility, there was a significant positive association between thyroid cancer risk and the use of fertility drugs (relative risk [RR] = 1.35; 95% confidence interval [CI] 1.12–1.64; P=0.002). Additionally, among women with infertility, the use of clomiphene citrate was associated with an increased risk of thyroid cancer compared to women who did not use fertility drugs (RR = 1.45; 95% CI 1.12–1.88; P=0.005). After pooling results, we found that the parity status of infertile women using fertility drugs was not associated with thyroid cancer risk (RR = 0.99; 95% CI 0.61–1.58, P=0.95). In summary, clomiphene citrate (the most commonly used fertility drug) and other fertility drugs are associated with an increased risk of thyroid cancer.

Contribution of industrial density and socioeconomic status to the spatial distribution of thyroid cancer risk in Hangzhou, China

2018 ◽  
Vol 613-614 ◽  
pp. 679-686 ◽  
Author(s):  
Xufeng Fei ◽  
Zhaohan Lou ◽  
George Christakos ◽  
Qingmin Liu ◽  
Yanjun Ren ◽  
...  
Keyword(s):  
Socioeconomic Status ◽  
Spatial Distribution ◽  
Thyroid Cancer ◽  
Cancer Risk ◽  
Thyroid Cancer Risk

scholarly journals A Study of Artificial Sweeteners and Thyroid Cancer Risk

2020 ◽  
Vol 12 (8) ◽  
pp. 492-498
Author(s):  
Navdeep Singh ◽  
Sandeep Singh Lubana ◽  
Saurabh Arora ◽  
Issac Sachmechi
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Artificial Sweeteners ◽  
Thyroid Cancer Risk
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