scholarly journals Fetal Growth and Placental Growth Factor Umbilical Cord Blood Levels

2017 ◽  
Vol 43 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Zoe A. Broere-Brown ◽  
Sarah Schalekamp-Timmermans ◽  
Vincent W.V. Jaddoe ◽  
Eric A.P. Steegers
Keyword(s):  
Growth Factor ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Fetal Growth ◽  
Umbilical Cord Blood ◽  
Placental Growth Factor ◽  
Blood Levels

GLYCOSYLATED FIBRONECTIN AND INHIBIN ARE LOWER AND ANTI-MÜLLERIAN HORMONE IS HIGHER IN UMBILICAL CORD BLOOD WHEN MOTHERS HAVE PREECLAMPSIA

2020 ◽  
Vol 26 (3) ◽  
pp. 318-327
Author(s):  
Bridget DiPrisco ◽  
Ajay Kumar ◽  
Bhanu Kalra ◽  
Gopal V. Savjani ◽  
Zoe Michael ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Immunosorbent Assay ◽  
Plasma Protein ◽  
Umbilical Cord Blood ◽  
Enzyme Linked Immunosorbent Assay ◽  
Blood Levels ◽  
Insulin Like Growth Factor ◽  
Tertiary Teaching

Objective: Preeclampsia is a common disorder of pregnancy, causing significant morbidity and mortality for mothers and infants. Several molecules, including glycosylated fibronectin (GlyFn), the inhibin-related proteins, anti-müllerian hormone (AMH), and the insulin-like growth factor axis, are altered in maternal plasma in the setting of preeclampsia; however, these molecules have not been previously measured in cord blood of infants born to mothers with preeclampsia, which may represent changes in fetal physiology. We evaluated potential biomarkers of preeclampsia in umbilical cord blood to fill the gap in knowledge. Methods: This is a case-control study of 196 neonates born at a tertiary teaching hospital in Boston from 2010–2017. Forty-nine neonates born to mothers with preeclampsia were matched 1:3 by gestational age, sex, and birth weight z-score with 147 controls. Eleven analytes were measured in cord blood by enzyme-linked immunosorbent assay. Binary logistic regression analyses were performed to evaluate associations between preeclampsia and analytes. Results: Mean cord blood levels of GlyFn and total inhibin were significantly lower in neonates born to mothers with preeclampsia compared to controls, and AMH levels were significantly higher in males born to mothers with preeclampsia than male controls. Associations remained significant after controlling for maternal and neonatal characteristics. Conclusion: Cord blood levels of GlyFn and inhibin are decreased and AMH (male) levels are increased in infants of preeclamptic mothers, which is opposite the pattern these biomarkers show in serum of mothers with preeclampsia. These molecules may be important in the pathophysiology and long-term effects of preeclampsia on the developing fetus. Abbreviations: AMH = anti-müllerian hormone; ELISA = enzyme-linked immunosorbent assay; GlyFn = glycosylated fibronectin; IGF = insulin-like growth factor; IGFBP5 = insulin-like growth factor binding protein 5; LOD = limit of detection; PAPP-A = pregnancy-associated plasma protein A; PAPP-A2 = pregnancy-associated plasma protein A2

scholarly journals Maternal and umbilical cord blood levels of mercury, manganese, iron, and copper in southern Taiwan: A cross-sectional study

2017 ◽  
Vol 80 (7) ◽  
pp. 442-451 ◽  
Author(s):  
Shih-Hui Huang ◽  
Ken-Pen Weng ◽  
Ching-Chiang Lin ◽  
Chung-Cheng Wang ◽  
Charles Tzu-Chi Lee ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cross Sectional Study ◽  
Blood Levels ◽  
Sectional Study ◽  
Cross Sectional ◽  
Southern Taiwan

scholarly journals 778: Inflammatory cytokines in umbilical cord blood are associated with increased fetal growth in adolescent pregnancies

2017 ◽  
Vol 216 (1) ◽  
pp. S449-S450
Author(s):  
Courtney Olson-Chen ◽  
Christine Akoh ◽  
Elizabeth M. Cooper ◽  
Kimberly O. O'Brien ◽  
Eva K. Pressman
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Inflammatory Cytokines ◽  
Fetal Growth ◽  
Umbilical Cord Blood ◽  
Adolescent Pregnancies

Umbilical cord blood levels of perfluoroalkyl acids and polybrominated flame retardants

2013 ◽  
Vol 216 (2) ◽  
pp. 184-194 ◽  
Author(s):  
Tye E. Arbuckle ◽  
Cariton Kubwabo ◽  
Mark Walker ◽  
Karelyn Davis ◽  
Kaela Lalonde ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Flame Retardants ◽  
Perfluoroalkyl Acids ◽  
Blood Levels
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