scholarly journals 778: Inflammatory cytokines in umbilical cord blood are associated with increased fetal growth in adolescent pregnancies

2017 ◽  
Vol 216 (1) ◽  
pp. S449-S450
Author(s):  
Courtney Olson-Chen ◽  
Christine Akoh ◽  
Elizabeth M. Cooper ◽  
Kimberly O. O'Brien ◽  
Eva K. Pressman
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Inflammatory Cytokines ◽  
Fetal Growth ◽  
Umbilical Cord Blood ◽  
Adolescent Pregnancies

scholarly journals Umbilical Cord Blood Adiponectin, Leptin, Insulin, and Ghrelin in Premature Infants and Their Association With Birth Outcomes

2021 ◽  
Vol 12 ◽  
Author(s):  
Luyan Han ◽  
Bo Li ◽  
Xiaojing Xu ◽  
Shufang Liu ◽  
Zhenghong Li ◽  
...  
Keyword(s):  
Birth Weight ◽  
Cord Blood ◽  
Preterm Infants ◽  
Umbilical Cord ◽  
Fetal Growth ◽  
Umbilical Cord Blood ◽  
Gestational Age ◽  
Metabolic Diseases ◽  
Term Infants ◽  
Preterm Group

BackgroundPremature/low-birth-weight infants are at significant risk of metabolic diseases in adulthood, which may be related to the levels of fetal adipokine. Here, we investigated the differences in the levels of umbilical cord blood adiponectin, leptin, insulin, and ghrelin in preterm and term infants and sought to elucidate the link between these hormones and fetal growth. We also evaluated the interrelationship among these metabolic hormones in both groups of newborns.MethodsA total of 149 mother–infant pairs (100 in the preterm group and 49 in the term group) were enrolled in the study. The preterm group was further subdivided according to birth weight (≤1,500, 1,501–2,000, 2,001–2,500, and >2,500 g), gestational age (<34 vs. ≥34 weeks), and appropriate for gestational age (AGA) vs. small for gestational age (SGA). The general condition of the mothers and the growth parameters of the newborns at birth were recorded.ResultsThe levels of adiponectin, leptin, and ghrelin were lower in the preterm group than those in the term group (p < 0.05). In the preterm group, the leptin levels of infants with gestational age ≥34 weeks were significantly higher than those of infants with gestational age <34 weeks (mean ln leptin = 0.63 vs. 0.36 ng/ml, p = 0.009). The levels of adiponectin were lower in the SGA group than those in the AGA group (mean ln adiponectin = 2.26 vs. 2.84 µg/ml, p = 0.001), whereas those of ghrelin displayed the opposite trend (mean ln ghrelin = 6.29 vs. 5.71 pg/ml, p < 0.001). Leptin was significantly correlated with insulin both in preterm infants with birth weight (BW) >2,000 g and in term infants. Umbilical cord blood leptin was positively correlated with the BW, birth length, and head circumference of newborns (r = 0.460, 0.311, and 0.310, respectively, all p < 0.05), whereas ghrelin was negatively correlated with the same parameters (r = −0.372, −0.415, and −0.373, respectively, all p > 0.05).ConclusionsThe lack of maturation of adipose tissue and the gastrointestinal tract by the fetus due to prematurity is associated with changes in the levels of cord blood adiponectin, leptin, and ghrelin. The dysregulation of these hormones in preterm infants may be a risk factor for fetal growth and future metabolic diseases.

690: The association of SSRIs with inflammatory cytokines in maternal cerebrospinal fluid, peripheral blood and umbilical cord blood

2017 ◽  
Vol 216 (1) ◽  
pp. S404-S405
Author(s):  
Emily S. Miller ◽  
Allie Sakowicz ◽  
Archana Roy ◽  
Carol Clayberger ◽  
John T. Sullivan ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Inflammatory Cytokines ◽  
Umbilical Cord Blood ◽  
Peripheral Blood

scholarly journals Fetal Growth and Placental Growth Factor Umbilical Cord Blood Levels

2017 ◽  
Vol 43 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Zoe A. Broere-Brown ◽  
Sarah Schalekamp-Timmermans ◽  
Vincent W.V. Jaddoe ◽  
Eric A.P. Steegers
Keyword(s):  
Growth Factor ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Fetal Growth ◽  
Umbilical Cord Blood ◽  
Placental Growth Factor ◽  
Blood Levels

Maternal Serum and Umbilical Cord Blood Leptin Concentrations With Fetal Growth Restriction

2003 ◽  
Vol 102 (3) ◽  
pp. 535-543
Author(s):  
Marcella Pighetti ◽  
Giovanni A. Tommaselli ◽  
Antonio DʼElia ◽  
Costantino Di Carlo ◽  
Angela Mariano ◽  
...  
Keyword(s):  
Cord Blood ◽  
Umbilical Cord ◽  
Fetal Growth ◽  
Umbilical Cord Blood ◽  
Fetal Growth Restriction ◽  
Maternal Serum ◽  
Growth Restriction
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