Correlation between DNA Ploidy, Proliferation Marker Ki-67 and Early Tumor Progression in Renal Cell Carcinoma

1997 ◽  
Vol 31 (1) ◽  
pp. 49-53 ◽  
Author(s):  
Ilias Papadopoulos ◽  
Klaus Weichert-Jacobsen ◽  
Hans-Heinrich Wacker ◽  
Ernst Sprenger
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Dna Ploidy ◽  
Proliferation Marker ◽  
Ki 67 ◽  
Early Tumor

Prognostic Biomarkers in Renal Cell Carcinoma: Relevance of DNA Ploidy in Predicting Disease-Related Survival

2005 ◽  
Vol 20 (4) ◽  
pp. 249-256 ◽  
Author(s):  
A.E. Pinto ◽  
P. Monteiro ◽  
G. Silva ◽  
J.V. Ayres ◽  
J. Soares
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Prognostic Value ◽  
Dna Ploidy ◽  
Mean Value ◽  
Consecutive Series ◽  
Ki 67 ◽  
P53 Expression ◽  
Related Survival

Objective To investigate the prognostic value of DNA ploidy, Ki-67 index and p53 expression in relation to disease-related survival in a consecutive series of patients with renal cell carcinoma (RCC). Material and methods The study group consisted of 64 RCC patients treated by radical nephrectomy. Histological type, pathological staging and nuclear anaplasia were assessed according to the WHO classification, TNM system and Fuhrman grading criteria, respectively. Ploidy was determined by DNA flow cytometry using two sampling methods (frozen vs paraffin-embedded tissue). Ki-67 and p53 were evaluated by immunohistochemistry techniques using two cutoff points (10% vs mean value) for staining interpretation. Kaplan-Meier and Cox regression analyses were used for prognostic evaluation. Results Thirty-one tumors (48.4%) showed DNA diploidy and 33 (51.6%) were DNA aneuploid. Concordance between both ploidy measurement methods was found in 85.5% of cases (p=0.0455). The mean values for Ki-67 and p53 immunostaining were 3.65% (0–23.5%) and 5.90% (0–55.9%), respectively. DNA ploidy significantly correlated with staging, tumor size (pT), nuclear grading, and Ki-67 (mean value cutoff). Ki-67 (10% cutoff) correlated with staging and pT, while p53 (mean value cutoff) was associated with Ki-67 (mean value cutoff). There were significant differences between survival curves for pathological stage, pT, nuclear grade, ploidy, Ki-67 (both cutoffs), and p53 (10% cutoff). By univariate regression analysis, stage III and stage IV, pT3, aneuploidy, high Ki-67 (both cutoffs), and p53 overexpression (10% cutoff) showed significant correlations with worse disease-related survival. In addition, DNA aneuploidy significantly correlated with poor prognosis within stages I/II (p=0.0355) and stages III/IV (p=0.0138) of the disease. Conclusion The results indicate that DNA ploidy has relevant prognostic value in RCC, adding useful information to the classic histopathological indicators of clinical outcome.

DNA Content and the Proliferation Marker Ki-67 as Prognostic Indicators in Renal Cell Carcinoma

1994 ◽  
Vol 53 (4) ◽  
pp. 181-185 ◽  
Author(s):  
I. Papadopoulos ◽  
K. Weichert-Jacobsen ◽  
E. Sprenger ◽  
H.H. Wacker
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Dna Content ◽  
Renal Cell ◽  
Prognostic Indicators ◽  
Proliferation Marker ◽  
Ki 67

scholarly journals Inhibition of SMYD2 suppresses tumor progression by down-regulating microRNA-125b and attenuates multi-drug resistance in renal cell carcinoma: Erratum

Theranostics ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 419-420
Author(s):  
Libin Yan ◽  
Beichen Ding ◽  
Haoran Liu ◽  
Yangjun Zhang ◽  
Jin Zeng ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Drug Resistance ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Multi Drug Resistance

scholarly journals MMP9 and IGFBP1 Regulate Tumor Immune and Drive Tumor Progression in Clear Cell Renal Cell Carcinoma

2021 ◽  
Vol 12 (8) ◽  
pp. 2243-2257
Author(s):  
Tianbo Xu ◽  
Su Gao ◽  
Jingchong Liu ◽  
Yu Huang ◽  
Ke Chen ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Tumor Progression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma
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