Reappraisal of HLA in Multiple Sclerosis: Close Linkage in Multiplex Families

1993 ◽  
Vol 1 (4) ◽  
pp. 257-268 ◽  
Author(s):  
Pentii J. Tienari ◽  
Juhani Wikström ◽  
Saija Koskimies ◽  
Jukka Partanen ◽  
Jorma Palo ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Close Linkage ◽  
Multiplex Families

scholarly journals Genomewide Scan of Multiple Sclerosis in Finnish Multiplex Families

1997 ◽  
Vol 61 (6) ◽  
pp. 1379-1387 ◽  
Author(s):  
Satu Kuokkanen ◽  
Michele Gschwend ◽  
John D. Rioux ◽  
Mark J. Daly ◽  
Joseph D. Terwilliger ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Multiplex Families

The inheritance of T cell receptor genes in multiplex families with multiple sclerosis

1988 ◽  
Vol 23 (2) ◽  
pp. 139-140 ◽  
Author(s):  
M.A. Robinson ◽  
T. Ciulla ◽  
E. Seboun ◽  
T. Doolittle ◽  
T.J. Kindt ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Receptor Genes ◽  
Multiplex Families

Risk alleles for multiple sclerosis in multiplex families

Neurology ◽  
2009 ◽  
Vol 72 (23) ◽  
pp. 1984-1988 ◽  
Author(s):  
M. J. D'Netto ◽  
H. Ward ◽  
K. M. Morrison ◽  
S. V. Ramagopalan ◽  
D. A. Dyment ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Risk Alleles ◽  
Multiplex Families

scholarly journals Burden of genetic risk variants in multiple sclerosis families in the Netherlands

2016 ◽  
Vol 2 ◽  
pp. 205521731664872 ◽  
Author(s):  
Julia Y Mescheriakova ◽  
Linda Broer ◽  
Simin Wahedi ◽  
André G Uitterlinden ◽  
Cornelia M van Duijn ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Weighted Genetic Risk Score ◽  
Sporadic Cases ◽  
Multiplex Families ◽  
The Difference ◽  
Multiple Sclerosis Patients ◽  
Genetic Burden

Background Approximately 20% of multiple sclerosis patients have a family history of multiple sclerosis. Studies of multiple sclerosis aggregation in families are inconclusive. Objective To investigate the genetic burden based on currently discovered genetic variants for multiple sclerosis risk in patients from Dutch multiple sclerosis multiplex families versus sporadic multiple sclerosis cases, and to study its influence on clinical phenotype and disease prediction. Methods Our study population consisted of 283 sporadic multiple sclerosis cases, 169 probands from multiplex families and 2028 controls. A weighted genetic risk score based on 102 non-human leukocyte antigen loci and HLA-DRB1*1501 was calculated. Results The weighted genetic risk score based on all loci was significantly higher in familial than in sporadic cases. The HLA-DRB1*1501 contributed significantly to the difference in genetic burden between the groups. A high weighted genetic risk score was significantly associated with a low age of disease onset in all multiple sclerosis patients, but not in the familial cases separately. The genetic risk score was significantly but modestly better in discriminating familial versus sporadic multiple sclerosis from controls. Conclusion Familial multiple sclerosis patients are more loaded with the common genetic variants than sporadic cases. The difference is mainly driven by HLA-DRB1*1501. The predictive capacity of genetic loci is poor and unlikely to be useful in clinical settings.

Linkage analysis of HLA class II Genes in Swedish multiplex families with multiple sclerosis

Neurology ◽  
1997 ◽  
Vol 48 (3) ◽  
pp. 758-762 ◽  
Author(s):  
A. Fogdell ◽  
O. Olerup ◽  
S. Fredrikson ◽  
M. Vrethem ◽  
J. Hillert
Keyword(s):  
Multiple Sclerosis ◽  
Linkage Analysis ◽  
Class Ii ◽  
Hla Class Ii ◽  
Multiplex Families

DR-DQ haplotype in multiple sclerosis: Serologic, biochemical, and RFLP study for light multiplex families

1988 ◽  
Vol 23 (2) ◽  
pp. 146
Author(s):  
G. Semana ◽  
F. Quillivic ◽  
O. Sabourad ◽  
R. Fauchet
Keyword(s):  
Multiple Sclerosis ◽  
Multiplex Families

A Study of Birth Order and Multiple Sclerosis in Multiplex Families

1995 ◽  
Vol 14 (4) ◽  
pp. 188-192 ◽  
Author(s):  
J.P.C. Gaudet ◽  
L. Hashimoto ◽  
A.D. Sadovnick ◽  
G.C. Ebers
Keyword(s):  
Multiple Sclerosis ◽  
Birth Order ◽  
Multiplex Families
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