A Study of Birth Order and Multiple Sclerosis in Multiplex Families

1995 ◽  
Vol 14 (4) ◽  
pp. 188-192 ◽  
Author(s):  
J.P.C. Gaudet ◽  
L. Hashimoto ◽  
A.D. Sadovnick ◽  
G.C. Ebers
Keyword(s):  
Multiple Sclerosis ◽  
Birth Order ◽  
Multiplex Families

Birth order in multiple sclerosis

1989 ◽  
Vol 80 (4) ◽  
pp. 354-354
Author(s):  
William H. James
Keyword(s):  
Multiple Sclerosis ◽  
Birth Order

Birth order and risk of multiple sclerosis: Are they associated and how?

2009 ◽  
Vol 63 (2) ◽  
pp. 136-138 ◽  
Author(s):  
A. Alperovitch ◽  
P. Le Canuet ◽  
R. Marteau
Keyword(s):  
Multiple Sclerosis ◽  
Birth Order

Cesarean delivery may increase the risk of multiple sclerosis

2011 ◽  
Vol 18 (4) ◽  
pp. 468-471 ◽  
Author(s):  
Amir-Hadi Maghzi ◽  
Masoud Etemadifar ◽  
Kiyan Heshmat-Ghahdarijani ◽  
Safieh Nonahal ◽  
Alireza Minagar ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cesarean Section ◽  
Birth Order ◽  
Vaginal Delivery ◽  
Conditional Logistic Regression ◽  
Mode Of Delivery ◽  
Age At Onset ◽  
Significant Risk ◽  
Significant Difference ◽  
Healthy Siblings

Background: Prenatal and perinatal factors are believed to contribute to the risk of developing multiple sclerosis (MS). Objective: This study was designed to evaluate whether mode of delivery (vaginal versus cesarean section), as a perinatal factor, affects susceptibility to MS. Methods: MS patients were recruited from the MS registry of Isfahan Multiple Sclerosis Society (IMSS) and were compared with their healthy siblings. Data regarding mode of delivery, birth order, and gestation week of birth were obtained through a specially designed questionnaire. Preterm or post term deliveries were excluded. We used conditional logistic regression statistics and adjusted for gender and birth order. Results: This study included 1349 participants (449 MS patients and 900 controls). Subjects who were born by cesarean section had significant risk of MS (odds ratio, OR = 2.51; 95% confidence interval, CI: 1.43–4.41; p = 0.001). There was significant MS risk for females who were born by cesarean section (OR = 2.69, 95% CI: 1.30–5.58; p = 0.008), but not for males (OR = 2.25, 95% CI: 0.90–5.63; p = 0.082). The mean age at onset was lower in MS patients born by cesarean section (24.58 ± 6.33) compared with that of patients born by vaginal delivery (27.59 ± 7.97; p = 0.041). There was no significant difference between the two groups for birth order ( p = 0.417). Conclusion: Our results suggest that those born by vaginal delivery are at a lower risk of subsequent MS. These preliminary findings will need to be addressed in a much larger and preferably prospective study.

scholarly journals Genomewide Scan of Multiple Sclerosis in Finnish Multiplex Families

1997 ◽  
Vol 61 (6) ◽  
pp. 1379-1387 ◽  
Author(s):  
Satu Kuokkanen ◽  
Michele Gschwend ◽  
John D. Rioux ◽  
Mark J. Daly ◽  
Joseph D. Terwilliger ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Multiplex Families

Birth order and multiple sclerosis

1982 ◽  
Vol 66 (2) ◽  
pp. 209-215 ◽  
Author(s):  
Barbara R. Visscher ◽  
Kai-Shen Liu ◽  
Constance B. Sullivan ◽  
Nora L. Valdiviezo ◽  
Roger Detels
Keyword(s):  
Multiple Sclerosis ◽  
Birth Order

The inheritance of T cell receptor genes in multiplex families with multiple sclerosis

1988 ◽  
Vol 23 (2) ◽  
pp. 139-140 ◽  
Author(s):  
M.A. Robinson ◽  
T. Ciulla ◽  
E. Seboun ◽  
T. Doolittle ◽  
T.J. Kindt ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Receptor Genes ◽  
Multiplex Families

Multiple sclerosis and birth order: a longitudinal cohort study

2005 ◽  
Vol 4 (10) ◽  
pp. 611-617 ◽  
Author(s):  
A Dessa Sadovnick ◽  
Irene ML Yee ◽  
George C Ebers
Keyword(s):  
Multiple Sclerosis ◽  
Cohort Study ◽  
Birth Order ◽  
Longitudinal Cohort Study ◽  
Longitudinal Cohort

Risk of multiple sclerosis inversely associated with birth order position

2009 ◽  
Vol 61 (6) ◽  
pp. 393-396 ◽  
Author(s):  
H. Isager ◽  
E. Andersen ◽  
K. Hyllested
Keyword(s):  
Multiple Sclerosis ◽  
Birth Order ◽  
Order Position
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