Altered Hepatic Microsomal Drug-Metabolizing Enzyme Activity Resulting from Experimental Infection of Rats with Trypanosoma b. brucei

Enzyme ◽  
1983 ◽  
Vol 29 (3) ◽  
pp. 183-188 ◽  
Author(s):  
G.O. Emerole ◽  
M. Ira Thabrew ◽  
J.A. Emeh
Keyword(s):  
Enzyme Activity ◽  
Experimental Infection ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme

scholarly journals Hepatic drug-metabolizing enzyme activity in rats pretreated with (−)-emetine or (±)-2,3-dehydroemetine

1970 ◽  
Vol 117 (3) ◽  
pp. 491-498 ◽  
Author(s):  
H. H. Miller ◽  
R. K. Johnson ◽  
J. D. Donahue ◽  
W. R. Jondorf
Keyword(s):  
Enzyme Activity ◽  
Female Rats ◽  
Inhibitory Effects ◽  
Hepatic Drug ◽  
Azo Reduction ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme ◽  
Sodium Phenobarbital ◽  
Stimulation Of

1. Pretreatment of female rats with (−)-emetine or (±)-2,3-dehydroemetine (at 18μmol/kg body wt. for 24h) prolongs the hexobarbital-induced sleeping-time of the treated animals. 2. This effect is not observed on pretreating animals with other compounds closely related to (−)-emetine, such as (−)-isoemetine or (+)-O-methylpsychotrine. 3. Liver microsomal drug-metabolizing enzyme activity in vitro as measured by N-demethylation of aminopyrine and azo-reduction of Neoprontosil is inhibited in rats pretreated with (−)-emetine or with (±)-2,3-dehydroemetine. 4. These inhibitory effects on drug metabolism in vitro are not observed in corresponding experiments involving pretreatment of rats with (−)-isoemetine or (+)-O-methylpsychotrine. 5. Co-administration of emetine or 2,3-dehydroemetine and sodium phenobarbital or 1,1-dichloro-2-o-chlorophenyl-2-p-chlorophenylethane to rats abolishes or greatly diminishes the stimulation of drug-metabolizing enzyme activity in vitro usually obtained by the administration of phenobarbital or 1,1-dichloro-2-o-chlorophenyl-2-p-chlorophenylethane alone. 6. Further, in rats pretreated with sodium phenobarbital and subsequently injected with emetine or 2,3-dehydroemetine the pre-stimulated drug-metabolizing enzyme activity in vitro is diminished. 7. The inhibitory effects on drug-metabolizing enzyme activity after pretreatment with (−)-emetine or (±)-2,3-dehydroemetine do not appear to be related to NADPH generation.

Aryl hydrocarbon receptor-mediated induction of microsomal drug-metabolizing enzyme activity by indirubin and indigo

2004 ◽  
Vol 318 (2) ◽  
pp. 571-578 ◽  
Author(s):  
Kazumi Sugihara ◽  
Shigeyuki Kitamura ◽  
Tsuyoshi Yamada ◽  
Takashige Okayama ◽  
Shigeru Ohta ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Aryl Hydrocarbon Receptor ◽  
Aryl Hydrocarbon ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme

Measurement of hepatic drug-metabolizing enzyme activity in man

1980 ◽  
Vol 17 (4) ◽  
pp. 267-274 ◽  
Author(s):  
E. A. Sotaniemi ◽  
R. O. Pelkonen ◽  
M. Puukka
Keyword(s):  
Enzyme Activity ◽  
Hepatic Drug ◽  
Drug Metabolizing Enzyme ◽  
Metabolizing Enzyme
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