Influence of Feeding Types during the First Months of Life on Calciuria Levels in Healthy Infants: A Secondary Analysis from a Randomized Clinical Trial

2017 ◽  
Vol 70 (2) ◽  
pp. 132-139 ◽  
Author(s):  
Natalia Ferré ◽  
Carmen Rubio-Torrents ◽  
Veronica Luque ◽  
Ricardo Closa-Monasterolo ◽  
Veit Grote ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Dietary Factors ◽  
Calcium Excretion ◽  
Dietary Intakes ◽  
Linear Regression Models ◽  
Term Infants ◽  
Spot Urine ◽  
Feeding Types ◽  
Healthy Infants

Background/Aims: Dietary factors can modify calciuria. We aim to investigate urinary calcium excretion in healthy infants according to their protein. Methods: Secondary data analysis from a randomized clinical trial where healthy term infants were randomized after birth to a higher (HP) or lower (LP) protein content formula that was consumed until age 1 year. A non-randomized group of breastfed (BF) infants was used for reference. Anthropometry, dietary intakes and calciuria (calcium/creatinine ratios) from spot urine samples were assessed at ages 3 and 6 months. At 6 months, the kidney volumes were assessed using ultrasonography, and the serum urea and creatinine levels were determined. Results: BF infants showed the highest calciuria levels, followed by the HP and the LP groups (p < 0.001 for all comparisons). Either protein intakes or formula types modulated the calciuria in linear regression models adjusted for other influencing dietary factors. The usual cut-off values classified 37.8% (BF), 16.8% (HP) and 4.9% (LP) of the infants as hypercalciuric. Conclusions: Feeding types during the first months of life affect calciuria, with BF infants presenting the highest levels. We propose new cut-off values, based on feeding types, to prevent the overestimation in hypercalciuria diagnoses among BF infants.

Efficacy of Soy-Based Formulas in Alleviating Gastrointestinal Symptoms in Infants With Milk-Based Formula Intolerance: A Randomized Clinical Trial

2020 ◽  
pp. 000992282097301
Author(s):  
John B. Lasekan ◽  
Geraldine E. Baggs
Keyword(s):  
Clinical Trial ◽  
Clinical Study ◽  
Randomized Clinical Trial ◽  
Gastrointestinal Symptoms ◽  
Milk Formula ◽  
Term Infants ◽  
Healthy Infants ◽  
Pilot Clinical Study ◽  
Poor Tolerance ◽  
Reference Cohort

A randomized, blinded pilot clinical study was conducted to assess gastrointestinal (GI) tolerance in healthy, full-term infants (2-9 weeks old), whose pediatricians recommended a formula change due to perceived cow’s milk formula intolerance. Infants were randomized and exclusively fed either a commercial control soy formula (SF; n = 22), an experimental partially hydrolyzed SF (10% hydrolyzed, n = 23), or a 5% hydrolyzed SF (n = 26) for 2 weeks. Age-matched reference cohorts (n = 72) with no GI intolerance on milk-based formula were assessed in parallel. Results indicated that all SF-fed groups contributed to reduction ( P < .05) in common GI tolerance symptoms to levels not different from the non-symptomatic reference cohort at study end. The control SF group had more reduced fussiness, gas, and crying and higher formed stools versus hydrolyzed SF groups. In conclusion, the study suggests that SFs reduced GI intolerance symptoms in otherwise healthy infants with poor tolerance on milk-based formulas.

scholarly journals Reduced crying in term infants fed high beta-palmitate formula: a double-blind randomized clinical trial

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Ita Litmanovitz ◽  
Fabiana Bar-Yoseph ◽  
Yael Lifshitz ◽  
Keren Davidson ◽  
Alon Eliakim ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Double Blind ◽  
Term Infants ◽  
High Beta

Visual function in breast-fed term infants weaned to formula with or without long-chain polyunsaturates at 4 to 6 months: A randomized clinical trial

2003 ◽  
Vol 142 (6) ◽  
pp. 669-677 ◽  
Author(s):  
Dennis R. Hoffman ◽  
Eileen E. Birch ◽  
Yolanda S. Castañeda ◽  
Sherry L. Fawcett ◽  
Dianna H. Wheaton ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Visual Function ◽  
Term Infants ◽  
Breast Fed ◽  
Long Chain

scholarly journals Urinary sodium to potassium ratio: A simple and useful indicator of diet quality in population-based studies

2019 ◽  
Author(s):  
Parvin Mirmiran ◽  
Zahra Gaeini ◽  
Zahra Bahadoran ◽  
Asghar Ghasemi ◽  
Norouzirad Reza ◽  
...  
Keyword(s):  
Diet Quality ◽  
Dietary Patterns ◽  
Dietary Pattern ◽  
Population Based ◽  
Urinary Sodium ◽  
Dash Score ◽  
Dietary Intakes ◽  
Linear Regression Models ◽  
Significant Positive Association ◽  
Spot Urine

Abstract Background Urinary sodium (Na) and potassium (K) are related to dietary intakes of Na and K, and well-known risk factors of hypertension and cardiovascular events. This study aimed to evaluate the associations between urinary Na/K ratio and different dietary patterns. Methods we recruited 1864 adult men and women (aged 18-93 years), participated in the sixth examination of Tehran Lipid and Glucose Study. Fasting spot urine samples were collected and concentrations of Na and K were determined. The principle component analysis (PCA) was conducted to drive major dietary patterns among population. Mediterranean dietary pattern score, as well as DASH score, were calculated. Linear regression models adjusted for potential confounding variables were used to assess associations between dietary patterns scores and urinary Na/K ratio. Results Mean age of participants was 43.7±13.9 years, and 47% were men. Mean urinary Na and K concentrations were 139±41.0 and 57.9±18.6 mmol/L, respectively. Mean urinary Na/K was 2.40±0.07. A significant positive association was found between Western dietary pattern and urinary Na/K ratio (β=0.06; 95% CI= 0.01, 0.16). Traditional dietary pattern derived from usual dietary intakes of Iranian adults, as well as Mediterranean and DASH dietary pattern scores were inversely associated to urinary Na/K ratio (β= –0.14; 95% CI= –0.24, –0.11, β=–0.07; 95% CI= –0.09, –0.01, β=–0.12; 95% CI= –0.05, –0.02, respectively). Conclusions Urinary Na/K ratio may suggest as a simple, inexpensive and helpful method to monitor and improve diet quality in population-based studies.

Dietary Long-Chain Polyunsaturated Fatty Acids Do Not Influence Growth of Term Infants: A Randomized Clinical Trial

PEDIATRICS ◽  
1999 ◽  
Vol 104 (3) ◽  
pp. 468-475 ◽  
Author(s):  
Maria Makrides ◽  
Mark A. Neumann ◽  
Karen Simmer ◽  
Robert A. Gibson
Keyword(s):  
Clinical Trial ◽  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Randomized Clinical Trial ◽  
Term Infants ◽  
Long Chain

scholarly journals Neurodevelopmental Outcomes and Gut Bifidobacteria in Term Infants Fed an Infant Formula Containing High sn-2 Palmitate: A Cluster Randomized Clinical Trial

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 693
Author(s):  
Wei Wu ◽  
Ai Zhao ◽  
Biao Liu ◽  
Wen-Hui Ye ◽  
Hong-Wen Su ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Palmitic Acid ◽  
Randomized Clinical Trial ◽  
Motor Skills ◽  
Relative Abundance ◽  
Fine Motor ◽  
Control Group ◽  
Neurodevelopmental Outcomes ◽  
Term Infants ◽  
Cluster Randomized

A few studies suggested high stereo-specifically numbered (sn)-2 palmitate in a formula might favor the gut Bifidobacteria of infants. The initial colonization and subsequent development of gut microbiota in early life might be associated with development and later life functions of the central nervous system via the microbiota–gut–brain axis, such as children with autism. This study aims to assess the hypothesized effect of increasing the amount of palmitic acid esterified in the sn-2 position in infant formula on neurodevelopment in healthy full-term infants and to explore the association of this effect with the altered gut Bifidobacteria. One hundred and ninety-nine infants were enrolled in this cluster randomized clinical trial: 66 breast-fed (BF group) and 133 formula-fed infants who were clustered and randomly assigned to receive formula containing high sn-2 palmitate (sn-2 group, n = 66) or low sn-2 palmitate (control group, n = 67), where 46.3% and 10.3% of the palmitic acid (PA) was sn-2-palmitate, respectively. Infants’ neurodevelopmental outcomes were measured by the Ages and Stages Questionnaire, third edition (ASQ-3). Stool samples were collected for the analysis of Bifidobacteria (Trial registration number: ChiCTR1800014479). At week 16, the risk of scoring close to the threshold for fine motor skills (reference: scoring above the typical development threshold) was significantly lower in the sn-2 group than the control group after adjustment for the maternal education level (p = 0.036) but did not differ significantly versus the BF group (p = 0.513). At week 16 and week 24, the sn-2 group (week 16: 15.7% and week 24: 15.6%) had a significantly higher relative abundance of fecal Bifidobacteria than the control group (week 16: 6.6%, p = 0.001 and week 24:11.2%, p = 0.028) and did not differ from the BF group (week 16: 14.4%, p = 0.674 and week 24: 14.9%, p = 0.749). At week 16, a higher relative abundance of Bifidobacteria was associated with the decreased odds of only one domain scoring close to the threshold in the formula-fed infants group (odds ratio (OR), 95% confidence interval (CI): 0.947 (0.901–0.996)). Elevating the sn-2 palmitate level in the formula improved infants’ development of fine motor skills, and the beneficial effects of high sn-2 palmitate on infant neurodevelopment was associated with the increased gut Bifidobacteria level.

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