Removal and Inactivation of Hepatitis A Virus (HAV) during Processing of Factor VIII Concentrates

Vox Sanguinis ◽  
1994 ◽  
Vol 67 (1) ◽  
pp. 72-77
Author(s):  
J. Hamman ◽  
J. Zou ◽  
B. Horowitz
Keyword(s):  
Factor Viii ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Factor Viii Concentrates

scholarly journals Hepatitis A Virus Infection in Tamarins: Experimental Transmission via Contaminated Factor VIII Concentrates

2002 ◽  
Vol 185 (8) ◽  
pp. 1170-1173 ◽  
Author(s):  
Michael Chudy ◽  
Christiane Stahl‐Hennig ◽  
Annemarie Berger ◽  
C. Micha Nübling ◽  
Gerhard Hunsmann ◽  
...  
Keyword(s):  
Virus Infection ◽  
Factor Viii ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Experimental Transmission ◽  
Factor Viii Concentrates

Hepatitis A virus antibody levels in factor VIII concentrates

The Lancet ◽  
1994 ◽  
Vol 344 (8916) ◽  
pp. 202-203 ◽  
Author(s):  
D.J. Wood ◽  
C.R. Bird ◽  
R. Thorpe ◽  
T.W. Barrowcliffe
Keyword(s):  
Factor Viii ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Virus Antibody ◽  
Factor Viii Concentrates ◽  
Antibody Levels

Failure to Detect Hepatitis A Virus RNA in Factor VIII Concentrates Using the Polymerase Chain Reaction

Vox Sanguinis ◽  
1994 ◽  
Vol 67 (1) ◽  
pp. 47-50
Author(s):  
F. McOmish ◽  
P.L. Yap ◽  
H. Hart ◽  
K. Peerlinck ◽  
S.M. Burns ◽  
...  
Keyword(s):  
Polymerase Chain Reaction ◽  
Factor Viii ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Chain Reaction ◽  
Virus Rna ◽  
Factor Viii Concentrates ◽  
Polymerase Chain

“In vitro” and in Animal Model Studies on a Double Virus- Inactivated Factor VIII Concentrate

1995 ◽  
Vol 74 (03) ◽  
pp. 868-873 ◽  
Author(s):  
Silvana Arrighi ◽  
Roberta Rossi ◽  
Maria Giuseppina Borri ◽  
Vladimir Lesnikov ◽  
Marina Lesnikov ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Animal Model ◽  
Factor Viii ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Virus Inactivation ◽  
Enveloped Viruses ◽  
Model Studies ◽  
Heat Treated

SummaryTo improve the safety of plasma derived factor VIII (FVIII) concentrate, we introduced a final super heat treatment (100° C for 30 min) as additional virus inactivation step applied to a lyophilized, highly purified FVIII concentrate (100 IU/mg of proteins) already virus inactivated using the solvent/detergent (SID) method during the manufacturing process.The efficiency of the super heat treatment was demonstrated in inactivating two non-lipid enveloped viruses (Hepatitis A virus and Poliovirus 1). The loss of FVIII procoagulant activity during the super heat treatment was of about 15%, estimated both by clotting and chromogenic assays. No substantial changes were observed in physical, biochemical and immunological characteristics of the heat treated FVIII concentrate in comparison with those of the FVIII before heat treatment.

Detection of Hepatitis A Virus in a Factor VIII Preparation by Antigen Capture/PCR

Vox Sanguinis ◽  
1994 ◽  
Vol 67 (1) ◽  
pp. 57-61 ◽  
Author(s):  
Andrea Normann ◽  
Judith Graff ◽  
Bertram Flehmig
Keyword(s):  
Factor Viii ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Antigen Capture
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